Contact: Heather Fournier
Location: Advance-CTR Headquarters »See on the MapAffiliated Centers: Advance-CTR (Clinical Translational Research)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Advance-CTR Administration Contact: Research Resources Request a Service | Clinical Research Service, Advance-CTR Service Coordination | Advance-CTR works to support researchers at the state level by developing the infrastructure and resources investigators need to conduct clinical and translational research in Rhode Island. Through its interdisciplinary and inter-institutional model, Advance-CTR funds and supports research across the translational science spectrum, including basic science, clinical, and public health efforts. Ultimately, Advance-CTR seeks to connect researchers and support institutions in Rhode Island in order to advance clinical and translational research that improves public health in the state. |
Biostatistical Consulting, Epidemiology & Clinical Research Design Services Contact: Heather Fournier Biostatistical Consulting, Epidemiology & Clinical Research Design Services Webpage Request a Service | Clinical Research Service, Advance-CTR | A team of experienced statisticians and methodological experts are on-hand to help investigators prepare their proposals pre-award, and plan their projects upon receipt of funding. Pre-award services include, positioning of specific aims and hypotheses, measure selection, power analysis and data analysis planning. Post-award services include decision support services, data acquisition and management and consultations to assess the impact of potential design changes on final statistical influence. Data analysis and results interpretation services include implementing data analysis plans, statistical analysis consultations, selecting and accessing statistical analysis software, and coaching to best utilize statistical analysis software. Manuscript and grant proposal writing services include assistance with write-ups, data visualizations, integration of interpretations in the broader context of the project, and addressing comments from peer reviewers |
Clinical Research Resources and Facilities (CRC) Contact: Heather Fournier Clinical Research Services Webpage Request a Service | Clinical Research Service, Advance-CTR | The Clinical Research Resources and Facilities Core is based at the Lifespan Clinical Research Center (CRC). Clinical Research Support is offered to Rhode Island investigators by highly trained research staff including clinical research coordinators and registered nurses. Investigators seeking Advance-CTR services have access to regulatory support, subject recruitment, space and support for the conduct for study visits, specimen collection and biobanking. |
Biomedical Informatics Services Contact: Heather Fournier Biomedical Informatics Services Webpage Request a Service | Clinical Research Service, Advance-CTR | Researchers may request, access, and use data available through the Unified Research data Sharing Access (URSA) infrastructure. The data include information originating from electronic health data systems at Lifespan, Care New England, and the Rhode Island Quality Institute, as well as from publicly accessible biological and health data sets. |
Psychometric Services Contact: Heather Fournier Psychometric Services Webpage Request a Service | Clinical Research Service, Advance-CTR | This service includes assistance with survey design, original measure development, exploratory dimensional analysis, confirmatory factor analysis, and reliability and validity analysis. |
Qualitative Methods Services Contact: Heather Fournier Qualitative Services Webpage Request a Service | Clinical Research Service, Advance-CTR | This service provides qualitative and mixed methods and data analysis design research support. Qualitative and mixed methods support includes; study design and preparation, original measure development, coaching on qualitative methods design decisions (focus groups, interviews, cognitive interviews), NVivo qualitative software training, help with grant writing of qualitative methods and analysis sections, manuscript and grant proposal review, post interview/focus group debriefing. Data analysis design support includes applied thematic analysis and framework matrix analysis. |
Contact: Brian Ott
Location: Rhode Island Hospital, Ambulatory Patient Center (APC Building) »See on the MapAffiliated Centers: Alzheimer's Disease & Memory Disorders Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Alzheimer's Disease & Memory Disorders Center Contact: Alzheimer's Disease and Memory Disorders Center | Clinical Research Resources, Alzheimer's | The Rhode Island Hospital’s Alzheimer's Disease and Memory Disorders Center (ADMDC) provides a comprehensive and integrated program of research and education focused on brain aging and dementia. The ADMDC participates in multicenter clinical trials of investigational drugs to prevent or treat the symptoms of Alzheimer’s Disease and is a primary site for studies sponsored by the Alzheimer's Disease Cooperative Study, funded by the National Institutes of Health, and the Alzheimer's Therapeutic Research Institute. Investigator-initiated studies are an important component of the ADMDC’s research activities; the Center is currently conducting innovative clinical trials for cognitively impaired older drivers and mind-body intervention, as well as studies of the roles of neuroimaging, biologic, and cognitive biomarkers in understanding the preclinical and prodromal stages of Alzheimer's disease. A major thrust of current and future dementia research is primary and secondary prevention. The ADMDC is the primary site for the Rhode Island Alzheimer Prevention Registry, a statewide project that enrolls individuals interested in Alzheimer’s disease prevention trials. To further research into the pathology of Alzheimer’s disease and related dementias, the Center supports the brain donation program at the Brown Brain Tissue Resource Center and operates the Biospecimen Bank, a repository for blood and cerebrospinal fluid specimens stored for future collaborative translational research projects. Intra- and inter-institutional research collaborations are a vital part of the ADMDC’s work. The Center hosts a monthly research seminar co-sponsored by the Norman Prince Neurosciences Institute, which provides a forum for aging and dementia researchers to discuss current research and plan future projects. |
Contact: Gerard Nau, MD
Location: Lifespan-The Miriam HospitalAffiliated Centers: COBRE Center for Antimicrobial Resistance and Therapeutic Discovery (CARTD)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Imaging System - fluorescent and bioluminescent | PerkinElmer IVIS Lumina III in vivo imaging system | The IVIS Lumina III is capable of imaging both fluorescent and bioluminescent reporters. The system is equipped with up to 26 filter sets that can be used to image reporters that emit from green to near-infrared. Superior spectral unmixing can be achieved by Lumina III’s optional high resolution short cut off filters. |
Affiliated Centers: Carney Institute for Brain Science, COBRE Center for Central Nervous System Function
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Support, training and assistance | Clinical Research Resources, Behavior and Neuroimaging | The mission of the Behavior and Neuroimaging Core (BNC) is to provide a coherent set of resources that will facilitate the implementation of each of the COBRE Project Leader’s research aims. The BNC provides ongoing support, training, assistance and advice to COBRE project leaders in the practical aspects of data collection, data management and data processing across a wide variety of neuroscience related methodologies. The BNC also serves as a resource to the broader neuroscience community at Brown and its affiliated hospitals and the broader Rhode Island academic community by providing formal and informal training, accessible data processing pipelines, and documentation of these and related resources. The support provided by the BNC is distinct from but complementary to services provided by the Design and Analysis Core (DAC). Whereas the DAC is focused primarily on study design, analytical modeling, and techniques for inference, the focus of the BNC is on practical aspects of research conduct such as efficient and high-quality data acquisition, implementation and deployment of standard and newly developed tools for analysis of large neuroimaging datasets, and lowering barriers to the use of such tools through direct assistance, training and documentation. Because the missions of the BNC and DAC are highly complementary, the effectiveness of each core is strengthened by collaborative relationships between them. The analytical techniques developed by the DAC in partnership with the Project Leaders are predicated upon robust high-quality data. Similarly, realization of study design principles requires practical expertise with the tools necessary to implement those principles. The BNC and DAC will share a full-time staff member with expertise in research design, statistical modeling, data management and high-performance computing. |
Facilitate Experimental Implementations | Clinical Research Resources, Behavior and Neuroimaging | Control experiments, Eye tracking, EEG guidance |
MRI Assistance | Clinical Research Resources, Behavior and Neuroimaging | Design of experiments, Analysis pipelines, EEG in the MRI scanner, Timing verification |
Generalized Data Storage Solutions | Clinical Research Resources, Behavior and Neuroimaging | xNAT database, Containers for data presentation, Beyond the desktop with VMs |
Assistance with High Performance Computing (HPC) | Clinical Research Resources, Behavior and Neuroimaging | Assistance with High Performance Computing (HPC) |
Contact: Steven Clemens
Location: Geological Sciences »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Mass Spectrometer, Isotope Ratio | ThermoFisher (Finnigan) 253+ dual inlet Isotope Ratio Mass Spectrometer with automated sample reaction device for up to 48 samples and with Kiel IV Carbonate interface and PoraPak purification trap. | Instrument primarily dedicated to the measurement of the stable isotopes of carbon and oxygen on inorganic carbonates as well as clumped oxygen isotopes. The facility accommodates projects both internal and external to Brown including analysis of terrestrial and marine material. The vast majority of samples analyzed are funded through external grants but we also facilitate a significant number of small unfunded, exploratory, analyses to help construct proof-of-concept data sets in preparation for proposals. |
Contact: Ivana Delalle, MD, PhD
Location: Rhode Island Hospital Ambulatory Patient Center (APC) 12 »See on the MapAffiliated Centers: Alzheimer's Disease & Memory Disorders Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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BioBank - Brain Tissue Resource Center | Clinical Research Resources, Brain Tissues | A brain tissue resource center (BTRC) (often referred to as a brain bank) is a collection of human tissue specimens from the nervous system: the brain, spinal cord, muscle and peripheral nerves. The facility is engaged in a variety of functions; rapid specimen transport, tissue processing, state-of-the-art preservation methods and database management. A variety of experts, research doctors, neuropathologists and laboratory specialists, plan and manage the BTRC. Strict protocol is imposed on outside vendors whenever their services are required, particularly with respect to rapid specimen transport. |
Contact: AdvanceRI@brown.edu
Location: Lifespan Clinical Research CenterAffiliated Centers: Advance-CTR (Clinical Translational Research), Clinical Reseach Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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BioBank - Covid-19 Biospecimen Banking Biobank – Covid -19 Biospecimen Banking | Service - Covid -19 BioBank | The biobank includes the following samples: Plasma (0.5mLs); LI plasma (0.5mLs); Serum (0.5mLs); PBMCs (0.25mLs / ~2.5M cells) |
Contact: Garrett Sullivan
Location: BioMedical Center Building »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Bioinformatics Analysis - Freezerworks | Software: Freezerworks 2019 Ver 11.01.00 | Sample management software |
BioBank - Biospecimen Banking | Service | Service to store biospecimens at -80 degrees, 4 degrees and in liquid nitrogen. All equipment is connected to back-up generator power and monitored 24/7 by a Rees alarm system. |
BioBank - Biospecimen Banking - Freezer - Liquid Nitrogen | Taylor Wharton LABS 40K Liquid Nitrogen Storage System | (2) Liquid nitrogen biospecimen storage system. Holds up to 40,000 1ml samples |
BioBank - Biospecimen Banking - Freezer - -80 degrees | Thermo Scientific HERAfreezer 24 cu. Ft. -80 degree freezer | (3) Biospecimen Storage at -80 degrees. Holds up to 50,000 1ml samples |
BioBank - Biospecimen Banking - Refrigerator | LABREPCO FUTURA Platinum Series 52 cu. ft. glass door refrigerator | (3) Biospecimen Storage Refrigerators at 4 degrees. 4 degree hinged glass door refrigerator |
BioBank - Robotic Workstation - Sample Preparation | Qiagen QiaCube | DNA, RNA or Protein Purification |
Contact: Dean Melcher
Location: Aldrich Building , 6th Floor, Rhode Island Hospital Campus »See on the MapAffiliated Centers: COBRE Center for Cancer Research and Development at Rhode Island Hospital
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Bioinformatics Analysis - Database | Software: Database developed in Filemaker Pro | Database and tissue inventory management on a Dell computer workstation |
Biological Safety Cabinet - BioBank - Biospecimen Banking | Dissecting hood | Hood dedicated to sterile tissue cutting with biohazard protection. |
BioBank - Biospecimen Banking - Freezer System | Forma 195878 LN2 backup for bank freezers | Systems inject liquid LN2 into cabinet when cabinet temperature warms to preset level, adjustable in 1 C increments to -150 C. |
Biospecimen Banking - Freezing Bath | Low temp isopentane bath | Bath with min. temperature of -160 C by addition of liquid nitrogen to isopentane. |
Histology/Tissue Processing - Freezing Bath | Low temp isopentane bath | Bath with min. temperature of -160 C by addition of liquid nitrogen to isopentane. |
Contact: Braden Fleming, PhD
Location: CORO Center West, Suite 404 »See on the MapAffiliated Centers: COBRE Center for Skeletal Health and Repair
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Analysis System - Gait | Noldus | Catwlak small animal system |
Analysis System - Force Plate | Kistler | 5 KN portable (6 channel) |
EMG monitor | Noraxon | Wireless EMG system (8 channel) |
Testing Systems | Bose Corp Biaxial ELF 3200 material test system | Force Testers (Tension, Compression, Pull Testers). The ELF 3200 Series perform basic materials tests including axial, axial/torsion, fretting, biaxial, and planar biaxial fatigue tests. |
Testing Systems | Instron Electropuls E1000 | All-Electric Dynamic Test Instrument designed for dynamic and static testing on a wide range of materials and components. |
Testing Systems | Instron 8521S | Axial-Torsional Fatigue Testing System |
Testing Systems | MTS Bionix Electromechanical Torsion System | Torsion Test System |
Testing Systems | Instron E10000LT | Biaxial material test system |
Microscope | Asylum Research MFP-3D-BIO | Atomic Force Microscope |
Microscope | Nikon TiU inverted microscope | Inverted Microscope |
Imaging System - Camera | Qualisys Oqus 5-Series | The Oqus cameras are designed to capture accurate mocap data with very low latency and works with both passive and active markers. |
Analyzer - Motion | Northern Digital Optotrak System | Track and analyze kinetics and dynamic motion in real-time |
Analysis System - Force Plate | Tekscan Force Plate Walkway | Low profile floor walkway system that captures multiple sequential foot strikes of animals. |
Analyzer - Pressure | Tekscan I-scan | Pressure Mapping System |
Mapping System | Fuji Film Prescale Pressuregraph (FPD-901E) | Pressure Distribution Mapping System |
Pendulum | Custom Active pendulum (small animal joint) | System to induce frictional wear in arthrodial joints |
Pendulum | Custom Passive pendulums (small and large animal joints) | System to measure the whole joint coefficient of friction |
Loading Device | Custom Biaxial Loading Device | Tissue Engineering |
Tissue Engineering System | ICCT Technologies Bio-Stretch Uniaxial System | Mechanical Stretching for Tissue Engineering |
Analysis System - Gait | Tekscan High Resolution Walkway (HRV6) | Modular pressure measurement platform for gait analysis. |
Testing Equipment | KUKA KR6 700 SIXX | 6 DOF joint motion testing |
Contact: Christopher Hemme, PhD
Location: Pharmacy Building »See on the MapAffiliated Centers: RI-INBRE
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Bioinformatics Analysis Contact: Christopher Hemme Bioinformatics Core Contact Form | Service | We provide bioinformatics consultation and services to the Rhode Island INBRE community and to the general scientific community of Rhode Island. In addition to traditional bioinformatic services, our Core is expanding to 3D/VR/AR visualization services in conjunction with the URI 3D Visualization Laboratory. We are currently developing 3D/VR visualization apps for a variety of platforms including smartphones, Vive/SteamVR, and others. We also have access to the 3D printer at the URI 3D Visualization Core for printing of marcomolecules at a reasonable price. |
Contact: Neil Sarkar, PhD
Affiliated Centers: Advance-CTR (Clinical Translational Research), COBRE Center for Computational Biology of Human Disease
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Biomedical Informatics Services | Clinical Research Resources, Biomedical Informatics | Data Requests Storage and management Processing and analysis Submission and dissemination Software and Applications Requests Development REDCap Studies/Projects Project setup Education 5x5 Clinical Informatics elective Biomedical Informatics Learning Series Grant Support |
Biomedical Informatics Resources | Clinical Research Resources, Biomedical Informatics | Cohort Identification i2b2 tranSMART [local] i2b2/SHRINE [regional] TriNetX [national] Data Collection and Management Statewide REDCap instance Wrike and SPARCRequest Data Access and Use Unified Data Sharing & Analysis (URSA) Initiative URSA stronghold URSA data requests URSA governance URSA computational tools Subject Recruitment Research Networking and Resources |
Contact: April Bobenchik
Location: Lifespan-The Miriam HospitalAffiliated Centers: COBRE Center for Antimicrobial Resistance and Therapeutic Discovery (CARTD)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Procurement, storage, tracking and release of clinical isolates | Clinical Research Resources, Biorepository | |
Confirmation of microorganism identification | Clinical Research Resources, Biorepository | |
Genotypic / phenotypic resistance profiling | Clinical Research Resources, Biorepository |
Contact: Jason Machan, PhD
Location: 130 Plain Street Providence, RI 20903 »See on the MapAffiliated Centers: Clinical Reseach Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Technical Assistance - Biostatistical Consulting Contact: Jason Machan, PhD | Service | The Biostatistics Core at Rhode Island Hospital offers centralized biostatistics consultation services to clinical, basic, and translational researchers. We provide, or can often steer, investigators to a broad array of resources during all phases of research. During planning, the core can provide high quality trial design, including final sculpting of specific aims and hypotheses, measure selection, power analysis, data analysis planning, and grant/proposal preparation. At the beginning of the project, the core can assist in construction of REDCap data collection tools, databases, and data management protocols, and provide help navigating approvals for special technology needs, such as purchasing non-standard equipment. Throughout the trial, the core can provide decision support, assessing the impact of potential design additions or changes on final statistical inference. It can serve on or help find individuals to serve on data and safety monitoring boards (DSMB). At the conclusion of the trial, the core can assist with implementation of the data analysis plan, either by providing access to contemporary statistical analysis software and coaching, or by conducting analyses for or with investigators. During reporting/publication preparation, the core can assist in write-up, data visualization, and integration of interpretations in the broader context of the project, and help address comments from peer reviewers. |
Contact: Gregory K. Fritz, MD
Location: Bradley Hospital »See on the MapAffiliated Centers: Bradley Hasbro Children's Research Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Child Development and Mental Health Research Contact: Gregory K. Fritz, MD Child Development and Mental Health Research | Clinical Research Resources, Child Development | The Bradley Hasbro Children's Research Center (BHCRC) encompasses a broad spectrum of research programs that share a commitment to studying the impact of psychological factors on the growth and development of children and their families. BHCRC investigators are exploring new insights into the genetic roots of autism; finding pediatric bio-behavioral markers of bipolar disorder; creating effective therapies for OCD; devising effective prevention strategies for adolescent sexual risk behaviors and obesity; and much more. Areas of interest include child and adolescent psychiatric disorders, forensic issues and juvenile justice, pediatric behavioral health, biological basis of psychiatric disorders, prevention and early intervention, and health services research. |
Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program Contact: Daniel Dickstein, MD Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program | Clinical Research Service, Pediatric Imaging | The goal of the Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program is to identify biological and behavioral markers of psychiatric illness in children and adolescents in order to improve diagnosis, treatment, and prevention of these conditions. |
Rhode Island Consortium for Autism Research & Treatment (RI-CART) Contact: RICART RI-CART Website | Clinical Research Resources, Autism | The Rhode Island Consortium for Autism Research & Treatment (RI-CART) is working to improve the lives of Rhode Islanders with autism spectrum disorder and related neurodevelopmental disorders by promoting collaborative, cutting-edge research, improving health care and support services, and providing data-driven education and advocacy. We’re a community of families and individuals, researchers, clinicians, educators, and local agencies focused on both today’s and future generations. |
Bradley Hospital Sleep and Chronobiology Research Laboratory (Sleep Lab) Contact: Mary A. Carskadon, MD Sleep for Science (Sleep Research Lab) Website | Clinical Research Resources, Sleep | Sleep for Science is a program of research focusing on understanding how sleep patterns are shaped and how they affect other activities, functions, and biological processes. Our research is chiefly about sleep patterns and processes in young humans – children, teens, and young adults. |
Developmental Disorders Genetics Research Contact: Eric Morrow DDGRP Website | Clinical Research Resources, Developmental Genetics | The Developmental Disorders Genetics Research Program was established in the fall of 2009 by Brown University to facilitate advances in translational research concerned with the genetics of developmental disorders. |
Contact: Rebecca Kartzinel
Location: Biomed Center »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Herbarium | Dried and pressed plant specimens mounted on sheets of archival paper. Plant data. | The collection includes around 100,000 plant specimens and is an important depository of Rhode Island and New England collections. It is also rich in western and southern North American plants and includes special sets of historically valuable specimens from 19th and early 20th century western US expeditions. Among other important collections, the herbarium also includes a full set of Charles Wright's Cuban plants (1856-1867) and a unique and classic collection of Carex |
Contact: Howard Safran, MD
Location: 233 Richmond Street, Providence, RI 02903 »See on the MapAffiliated Centers: Brown University Oncology Research Group (BrUOG)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Brown University Oncology Group (BRUOG) Contact: Kayla Rosati, EdM, CCRP | Clinical Trials Support, Oncology Research | The Brown University Oncology Research Group (BrUOG) mission is to improve cancer care through the implementation of innovative, multidisciplinary cancer clinical trials. BrUOG provides the infrastructure for the efficient development and implementation of these trials, which are created by Brown University faculty. BrUOG’s administrators and physicians provide support for the initial study concept and validation of trial design, and are responsible for trial administration, safety monitoring, data analysis, and the presentation and publication of findings. The trials sponsored by BrUOG investigate novel, cutting-edge applications of chemotherapy, biologic agents and other cancer treatments. Clinical trials are available for a broad range of disorders in hematology/oncology and these include treatment for cancers of the breast, brain, lung, gastrointestinal tract, skin, and prostate as well as trials in leukemia and lymphoma. |
Contact: Megan Ranney MD, MPH
Affiliated Centers: Emergency Digital Health Innovation Program (EDHI)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Emergency Digital Health Resources | Clinical Research Resources, Emergency Digital Health | EDHI’s mission is to use digital health to transform the care of patients with acute care needs before, during, and after their visit by developing and deploying effective, evidence-based digital health tools. The goal is to use technology to improve access to patients and increase the efficiency of health care delivery. As this field rapidly expands, it is critical for us to develop theoretically based interventions and to provide evidence that digital health tools are acceptable and effective, for both clinicians and patients. EDHI’s vision is for digital health to be an evidence-based, effective and well-integrated tool for creating and restoring health. |
Contact: Christopher Reid
Location: Unistructure »See on the MapAffiliated Centers: RI-NSF EPSCoR , RI-INBRE
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Gas Chromatograph - Mass Spectrometer (GC - MS) Contact: Christopher Reid | Agilent Technologies 7890A GC and 5975C MSD | Analyze for volatile organics; pyrolysis; MSD and FID |
Sample Preparation - Sample Concentrator, Purge & Trap Contact: Christopher Reid | Teledyne Tekmar velocity XPT sample concentrator and AQUATek 70 vial autosampler | Analyze for highly volatile organics; accessory for the GC-MS |
High Performance Liquid Chromatography (HPLC) Contact: Christopher Reid | Shumatzu | Analyze for non-volatile organics |
Mass Spectrometer (MS) - Inductively coupled plasma (ICP) Contact: Christopher Reid | Agilent Technologies 7700 series ICP-MS with ASX-500 series autosampler | Analyze for trace elements |
Sample Preparation - Chromatography - Solvent Extractor Contact: Christopher Reid | Dionex ASE 350 Accelerated Solvent Extractor (ASE) | Accelerated extractions |
Worstation - Concentrator Contact: Christopher Reid | Caliper LifeSciences Turbo Vap LV Concentration Workstation | Concentrator |
Sample Preparation - Freeze Dry System Contact: Christopher Reid | Labconco FreeZone 4.5 | Freeze dryer |
Spectrophotometer Contact: Christopher Reid | Shimazdzu HPLC--equipped with UV/Vis and Evaporative light scattering detectors | UV/Vis spectrophotometer for quantifying concentrations |
Spectrophotometer Contact: Christopher Reid | Thermo Scientific AquaMate Plus | UV/Vis spectrophotometer for quantifying concentrations |
Microscope - Electron Contact: Christopher Reid | JEOL JSM 6010LA Scanning Electron Microscope (SEM) | Scanning electron microscope with EDS |
Sample Preparation - Critical Point Dryer Contact: Christopher Reid | Tousimis Sandri-PVT-3D Critical Point Dryer (CPD) | Maintain structural integrity for soft tissue use of the SEM |
Sample Preparation - Sputter Coater System Contact: Christopher Reid | Denton Vacuum Desk V gold sputter coater and carbon coater | Coat non-conducting samples with gold or carbon for use on the SEM |
Microscope Contact: Christopher Reid | Zeiss A1 AXIO Polarized Light Microscope and Q imaging RETIGA 400R Imager | Recordable polarized light imaging |
Microscope Contact: Christopher Reid | Zeiss Axiovert 40CFL Inverted Microscope | Recordable inverted microscopy |
Microscope Contact: Christopher Reid | Zeiss Primo Star with AxioCam | Recordable imaging |
Workstation - Anaerobic Chamber Contact: Christopher Reid | Microbiology International Whitley DG250 Anaerobic Workstation | Simulate anoxic environments for anaerobic work |
Workstation - Anaerobic Chamber Contact: Christopher Reid | MBRAUN Labstar Anaerobic Glovebox Workstation | simulate anoxic environments for anaerobic work |
PCR Thermal Cycler Contact: Christopher Reid | Bio-Rad PCR Thermocycler C1000 Touch | DNA amplifier |
Biological Safety Cabinet Contact: Christopher Reid | LABGARD ES class II, type A2 Biological Safety Cabinet | Maintain sterility and contain infectious work |
Biospecimen Banking - Freezer Contact: Christopher Reid | Thermo Scientific Isotemp Basic U86-13A41 minus 70 degree freezer | Long term storage of biological specimens |
Ion Chromatograph Contact: Christopher Reid | Dionex IC2100 with ED50 electrochemical detector | Isocratic and gradient IC separations |
PCR Thermal Cycler Contact: Christopher Reid | BioRad CFX96 touch RT-PCR | This real-time pcr instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format. |
Contact: Howard Safran, MD
Location: Rhode Island Hospital Ambulatory Patient Center (APC Building) »See on the MapAffiliated Centers: Lifespan Cancer Institute
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Clinical Trials Support, Cancer Research | Clinical Research Resources | The Lifespan Cancer Institute at Rhode Island, The Miriam, and Newport hospitals is an active clinical trials site, committed to providing patients with the latest protocols.Our patients have access to groundbreaking new immunotherapies and other new and emerging cancer treatments at various stages of diagnosis and across many cancer types. Cancer treatments include the latest chemotherapy, biologic agents, radiation oncology, surgery, and image-guided procedures. Many of these are not available elsewhere in New England. The Dana-Farber Cancer Institute and the Lifespan Cancer Institute have created a strategic alliance to advance cancer treatment and research. |
Affiliated Centers: Cardiovascular Research Institute
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Cardiovascular Research Center (CVRC) Contact: Gideon Koren Cardiovascular Research Center (CVRC) Website | Clinical Research Resources, Cardiovascular | The mission of the CVRC is to unravel fundamental mechanisms of heart disease and to discover novel cardiac therapies. The research focus of CVRC investigators is on the molecular mechanisms of rhythm disorders of the heart (cardiac arrhythmias), sudden cardiac arrest, heart enlargement (hypertrophy) and heart failure. CVRC facilities include a sophisticated invasive animal catheterization and electrophysiology laboratory, and a brand new state-of-the-art research facility that is used for the studying of genetically modified mouse and rabbit models of cardiac diseases. These studies include cellular electrophysiology, optical mapping, single cell analyses of calcium transients and contractility, sophisticated imaging tools, as well as biochemical, molecular and cell biological experimental approaches. An important goal of the CVRC is to enhance and promote education and training in molecular cardiology and life sciences. |
Vascular Disease Research Center Contact: Efaza Siddiqui Vascular Disease Research Center Website | Clinical Research Resources, Vascular | The Vascular Disease Research Center at Rhode Island Hospital develops clinical trials and basic science research, and has a demonstrated track record in obtaining funding for these initiatives from the federal government through the National Institutes of Health (NIH). The center also coordinates a number of Food and Drug Administration (FDA). We can help investigators seeking to develop ideas in the vascular disease arena into fundable grant applications, either formally with center involvement or informally. We also can serve in this capacity for the medical device or drug industry, helping to plan and execute all aspects of FDA studies. Our mission is to advance scientific understanding and improve public health by developing and performing pivotal clinical and basic scientific research in peripheral vascular disease. |
Contact: Carney Institute
Location: 164 Angell St., 4th Floor Providence, RI 02912 »See on the MapAffiliated Centers: Carney Institute for Brain Science
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Brain Science Research | Clinical Research Resources, Brain Science | The Carney Institute for Brain Science (formerly the Brown Institute for Brain Science –BIBS) advances multidisciplinary research, technology development, and training in the brain sciences and works to establish Brown University as an internationally recognized leader in brain research. The Institute unites more than 100 faculty from a diverse group of departments at Brown, spanning basic and clinical departments, and physical and biological sciences. The Carney Institute provides a mechanism to advance interdisciplinary research efforts among this broad group and provides essential support to obtain and administer multi-investigator grants for research, infrastructure, and training. The Institute actively seeks new training funds to support interdisciplinary education that transcends that available in individual academic departments. |
Contact: David Vito
Location: Warwick, RI »See on the MapAffiliated Centers: RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Autoclave | Consolidated Stills & Sterilizers 24D36 | Sterilization. Chamber size is 24inch x36inch, Volume 9.4 cu. Ft |
Balance - Analytical | Orion Analytical Balance | Weight determination with capacity of 60g. |
Balance - Top Loading | EK-I Compact Balance | Weight determination (2 units) |
Incubator | Fisher Scientific Isotemp Digital & Analog Dry Bath Incubator | Provide controlled dry heat environment for clinical & general chemistry applications |
Electrophoresis System | Bio-Rad Mini-Protean Tetra Cell, Vertical protein electrophoresis gel boxes | Running Protein or DNA polyacrylamide gels |
Microscope | Lieder MI-500 Series Compound Inverted Microscope | Tissue Culture |
pH Meter | Thermo Scientific Orion 2-Star Bench Top pH Meter | General purpose measurements |
Western Blotting System, Semi-Dry | Shelton Scientific Semi-Dry Blotting System | Transfer of protein, RNA & DNA gels to a solid membrane support for visualization, 24cmx30cm. |
Spectrophotometer | Thermo Scientific Genesis 20 Visible Spectrophotometer | UV spectrophotometer for quantifying concentrations |
Imaging System - Gel Imager - Transilluminator | FOTODYNE Foto Phoresis UV Transilluminator | Imaging-protein gel analysis, GFP Analysis |
Incubator - Shaker | Lab Companion IS-971 Floor Model Incubator Shaker | Growing of bacteria, 250 L chamber |
Biological Safety Cabinet | NuAire Class II Type A2 | Maintain sterility and contain infectious work |
Contact: Alan Rothman, M.D., Research Professor
Location: 80 Washington Street (Shepard Bldg) »See on the MapAffiliated Centers: Institute for Immunology and Informatics (iCubed), COBRE Immune-Based Interventions Against Infectious Diseases
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Magnetic-Activated Cell Sorter (MACS) Contact: Alan Rothman | Miltenyi MACSQuant-10 Analytical Flow Cytometer | Analytical flow cytometry- 3 lasers, 10 parameters (8 colors, FSC, SSC) |
Imaging System - Plate Reader Contact: Alan Rothman | Biotek Cytation 3 | Imaging plate reader; 5 colors (brightfield, GFP, RFP, DAPI, Cy5); 10x, 20x, 60x objectives |
Microscope Contact: Alan Rothman | Life Technologies Evos FL, Fluorescence Microscope | Fluorescence microscope; 4 colors (GFP, RFP, DAPI, Cy5); 10x, 40x, 100x objectives |
Magnetic-Activated Cell Sorter (MACS) Contact: Alan Rothman | Miltenyi AutoMACS | Automated cell sorter for cell suspensions labeled with magnetic beads. |
Microplate Reader Contact: Alan Rothman | Perkin-Elmer Envision | Multimodal plate reader- absorbance, luminescence, fluorescence, time-resolved fluorescence, AlphaScreen |
Fluorescence Activated Cell Sorter (FACS) Contact: Alan Rothman | BD LSRII Flow Cytometer | Analytical flow cytometric analysis; 4 lasers (blue (2), violet (4), red (3) and yellow green (5)) which allows for analysis of up to 14 different fluors (# listed in parentheses for each laser) |
Contact: Vicki C. Godleski
Location: The Miriam Hospital, CFAR Building, Room 134 »See on the MapAffiliated Centers: Center for AIDS Research (CFAR) - Providence/Boston
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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BioBehavioral Research Support, HIV Contact: Curt Beckwith BioBehavioral Sciences Webpage | Clinical Research Service, HIV Research | The BioBehavioral Sciences Core (BBSC) provides help with participant recruitment, enrollment, and retention to advance biobehavioral research; services to support innovative medical and behavioral data collection approaches, including methods, tools, and assessments; expertise and services related to regulatory and human subjects’ compliance, and the ethical conduct of research for vulnerable populations; provide expertise and services to support the development, implementation, and evaluation of interventions to improve HIV prevention and continuum of care outcomes; specialized services for the conduct of implementation science research and for performing cost-effectiveness research; PrEP related services and information; and guidance and support for accessing EMR data. |
Biostatistics, HIV Research Contact: Joseph Hogan, ScD Biostatistics Webpage | Clinical Research Service, HIV Research | The Biostatistics Core ensures that all research undertaken by Center for AIDS Research (CFAR) investigators uses optimal methods for study design and analysis. The Core provides guidance and collaboration in developing grant applications; collaboration on study design, conduct, and statistical analyses; statistical training and mentoring; facilitation of linkages to potential collaborators; provides guidance and support for accessing EMR data; facilitates access to HIV databases from other centers/programs, and develops novel statistical and epidemiological methods for HIV research. |
Substance Use Research Core, HIV Contact: Christopher Kahler, PhD Substance Use Research Core Webpage | Clinical Research Service, HIV Research | The Substance Use Research Core (SURC) offers services and expertise on the methods needed to conduct effective Substance Use (SU)/HIV research. The SURC offers expertise in innovative methods for assessing and analyzing SU, and developing and implementing interventions to address alcohol, tobacco, and other drug use. Services include: expertise in developing research projects that address gaps in SU/HIV priority issues both domestically and globally; advice on training on the most appropriate methods for assessing SU; advice and training on incorporating effective and up-to-date SU interventions; and guidance on addressing ethical issues with SU research including input on IRB protocols and human subject sections of grant applications and access to group trainings. |
Administration - CFAR Contact: Vicki C. Godleski Administrative Core Webpage | Clinical Research Service, CFAR Coordinating Center | The CFAR Administrative Core has built an HIV infrastructure across the partner institutions and provides oversight of the entire CFAR community with responsibility for sound management, organizational structure, appropriate resource allocation, evaluation and the promotion of inter/multi-disciplinary translational HIV research. Through efficient communication to CFAR membership, the Core manages a highly interactive and collaborative scientific environment across geographically dispersed settings in domestic, national and international sites. |
Basic Sciences, HIV research Contact: Rami Kantor, MD Basic and Translational Sciences Webpage | Clinical Research Service, HIV Research | The Basic Sciences Core builds and supports collaborative research and synergy between basic, translational clinical and behavioral investigators as well as other multidisciplinary scientists, by providing laboratory, consultation and mentoring services. Services include; Viral load measurement, STI testing, Genital tract specific assays, Biologic specimens collection techniques, HIV-1 and 2 drug resistance assays, Identification of HIV dependency factors (HDF), Cell culture, Viral stocks, Immune activation, Laboratory Consulting, Training and Mentoring. Additional assays may be developed as necessary, please contact the Core Director. |
Contact: Center for Alcohol and Addiction Studies
Location: 121 South Main Street, Providence, RI 02903 »See on the MapAffiliated Centers: Center for Alcohol and Addiction Studies
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Alcohol and Addiction Research Contact: CAAS Center for Alcohol and Addiction Studies | Clinical Research Resources, | The Brown University Center for Alcohol and Addiction Studies (CAAS) in the School of Public Health is an internationally renowned research center in alcohol research. The mission is twofold: to conduct collaborative research that will lead to more effective treatment for alcohol and drug abuse, and to create a nationwide program in substance abuse, education and training for psychologists, physicians, medical students, and health care professionals. CAAS faculty conduct empirical research in a variety of areas of alcohol abuse/dependence, drug abuse/dependence and tobacco use, ranging from laboratory investigations of mechanisms through treatment or early intervention to policy. Funding comes from the federal government and a variety of foundations. |
Contact: Linnea Wolfe
Location: Center for Computation and Visualization »See on the MapAffiliated Centers: Center for Computation and Visualization, RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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High Performance Computing Cluster | Various including IBM idataPlex High Performance Computing Cluster | HPC cycles, software development, storage, backups, high speed network hub, visualization, virtual reality, data management, server colocation, scientific support |
Research Data Storage | Service | RData is a high-performance storage system for research data at CCV that is accessible from all CCV systems, can be mounted on PC or Mac computers on Brown’s campus network, is backed up on a nightly incremental basis. |
Contact: CGHR
Affiliated Centers: Center for Gerontology and Healthcare Research
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Gerontology and Healthcare Research Resource Contact: Center for Gerontology and Healthcare Research Website | Clinical Research Resources, Gerontology and Healthcare Research |
Contact: Jake Kurtis
Location: 55 Claverick Street Providence, RI 02903 »See on the MapAffiliated Centers: Center for International Health Research
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Center for International Health Research Contact: Danielle Barbery | Clinical Research Resources, Tropical Infectious Diseases | The Center's mission is to address these urgent global health challenges, the Center for International Health Research (CIHR) at Rhode Island Hospital was founded. The center's mission is to understand the pathogenesis of tropical infectious diseases, specifically malaria and schistosomiasis, and to harness this knowledge to design improved treatments and vaccines. ChildrenTo combat these infections, the center is engaged in studies integrating community-based epidemiologic studies in endemic countries with laboratory-based, basic science investigations. The center's research approach is rooted in the belief that the discoveries of tomorrow will come at the intersection of field and lab science. |
Affiliated Centers: Center for Long-Term Care Quality & Innovation
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Long-Term Care Quality & Innovation | Clinical Research Resources, Long-Term Care Quality & Innovation | Q&I partners with innovators – people who may or may not be researchers – who have promising interventions, but lack the skills or data necessary to establish the evidence base. |
Contact: Leigh Hochberg
Location: The Providence VA Medical Center »See on the MapAffiliated Centers: Center for Neurorestoration and Neurotechnology (CfNN)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Center for Neurorestoration and Neurotechnology (CfNN) Contact: Leigh Hochberg Center for Neurorestoration and Neurotechnology (CfNN) Resources Website | Clinical Research Resources, Neurorestoration and Neurotechnology | The Center for Neurorestoration and Neurotechnology (CfNN) is a collaboration between the Providence VA Medical Center, Brown University, Butler Hospital, Lifespan, and Massachusetts General Hospital. CfNN unifies distinguished researchers and clinicians to advance and translate neurotechnology to restore lost function. Through its three focus areas and three support cores, CfNN seeks to develop, test and implement new therapies and technologies that restore function for Veterans with disorders affecting the nervous system. |
Restoring Communication and Mobility Restoring Communication and Mobility | Clinical Research Resources, Neurorestoration and Neurotechnology | Research in this CfNN Focus Area aims to restore function for Veterans with severe communication or movement impairment resulting from amyotrophic lateral sclerosis (ALS), spinal cord injury (SCI), stroke, seizure disorders or disorders of consciousness. With the direct research participation of Veterans and others, this research aims to improve the independence and well-being of those with severe motor disability through the development of novel neurotechnologies and innovative medical approaches based on fundamentally new views of the neural processes underlying these conditions. One area of research is BrainGate, an investigational neural interface system that uses a small sensor implanted in a motor-related area of the brain to record neural activity associated with intended arm and hand movements of an individual with paralysis and translate these into commands for assistive devices. |
Neurotechnology: Clinical Study Assessment, Outcome Measurement and Implementation Service Contact: Marguerite Bowker BSN, RN, CIP Assessment, Outcome Measurement and Implementation Service Website | Clinical Trials Support, CfNN Neurotechnology and Neurorestoration | The Assessment, Outcome Measurement, and Implementation service oversees research related procedures in support of Center for Neurorestoration and Neurotechnology (CfNN) PIs and Project Coordinators, and facilitates the continuity of care and access to care for CfNN’s complex study participants. The core assists with developing protocol related documents (e.g. case report forms, manual of operations etc.), evaluates and helps prepare IRB submission documents, research study protocols, checks training compliance, develops and reviews data entry processes, advises on selection of reliable and valid assessment instruments and outcome measures, and assists in identifying personnel to analyze research outcomes. The Core provides expertise in development and implementation of standardized protocols for data collection, and assists in training research staff to insure uniformity and fidelity to testing and intervention procedures. Core resources include neuropsychological assessments, clinical trials/multisite study management, regulatory assistance (device, intellectual property, technology transfer), statistics and a research assistant/research coordinator pool |
Neurotechnology: Recording, Decoding and Computational Neuroscience Service Contact: Stephanie Jones, PhD Recording, Decoding, and Computational Neuroscience Website | Clinical Research Service, CfNN Computational Neuroscience | The Recording, Decoding and Computational Neuroscience core helps VA affiliated researchers deepen their understanding of how device-based neurotherapies act on brain circuits and networks by providing expertise in statistical and computational neuroscience methods. We advise on computational neuroscience methods to reveal mechanisms of action of both invasive and noninvasive brain stimulation therapies, and on decoding strategies to reveal computational functions of neural circuits. To this end, we are developing a software tool that will allow researchers and clinicians to interpret the circuit mechanisms underlying human electroencephalography (EEG) brain signals and the impact of brain stimulation on these signals. We have also created an open-source flexible cost platform for EEG data acquisition and analysis whose development specs are available to the greater neuroscience community. Instruments include a unique computational model of neocortical function, EEG, and somatosensory stimulus probe devices (for touch (in-house), thermal pain, Medoc). |
Neurotechnology: Neuromodulation and Neuroimaging Service Contact: Jerome Sanes, PhD Neuromodulation and Imaging Website | Clinical Research Service, CfNN Neuromodulation and Neuroimaging | The CfNN Neuromodulation and Neuroimaging Core supports Center projects that use MRI technology, including functional MRI and structural MRI and non-invasive brain stimulation (transcranial magnetic stimulation and transcranial direct and alternating current stimulation) for research with human participants. Core facility users must have a VA appointment or a collaborative agreement with a VA employee. Instrumentation includes a 3T Verio MRI System (Siemens), BOLD Screen (Cambridge Research Systems), Transcranial magnetic and electrical stimulation devices (Magstim, Neuronetics, neuroConn, Soterix, and Neuroelectrics), Brainsight neuronavigation software (Rogue Resolutions). |
Restoring Limb Function Restoring Limb Function | Clinical Research Resources, Neurorestoration and Neurotechnology | Investigators conduct research on rehabilitation in upper limb amputation and neuro-rehabilitation methods to address limb function post stroke. Topic areas include: Design and evaluation of upper limb prosthetic devices National study of needs and preferences of Veterans and service members with upper limb amputation Outcome Measurement for Persons with Amputation Development, evaluation and deployment of rehabilitation outcomes measures. |
Contact: Chuck Eaton
Location: Memorial Hospital of Rhode Island »See on the MapAffiliated Centers: Center for Primary Care and Prevention
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Center for Primary Care and Prevention | Clinical Research Resources, Primary Care | The Brown University Center for Primary Care and Prevention was established to improve the health of individuals and communities by promoting research, enriching knowledge, and improving practice in primary care and prevention. The mission of the Center is to (1) promote interdisciplinary research in community, public health, and clinical aspects of primary care medicine, (2) stimulate innovations in the primary care education for medical students, residents and fellows; and (3) provide technical assistance to private foundations, state and federal agencies on matters of health policy, and to international organizations on matters regarding the development of primary care systems in other countries. |
Contact: Alexandria Macmadu, MSc
Location: The Miriam Hospital »See on the MapAffiliated Centers: Center for Prisoner Health and Human Rights
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Center for Prisoner Health and Human Rights | Clinical Research Resources, Prisoner Health | The Center for Prisoner Health and Human Rights seeks to advance the health and human rights of criminal justice-involved populations, among which minority populations are disproportionately represented. The Center aims to achieve its goal through research, education, and advocacy. The Center identifies, initiates, and supports projects that respond to the epidemic of incarceration and recidivism in the criminal justice system and the associated complex public health crisis, among other things. Extensive and fruitful clinical, behavioral, and social research has been carried out within the prison and jail setting by Brown University investigators. The Center supports investigators by connecting them with undergraduate- and graduate-level research assistants, and participates in dissemination activities. |
Contact: Barry Lester
Location: 50 Holden Street, Providence, RI »See on the MapAffiliated Centers: Center for the Study of Children at Risk
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Center for the Study of Children at Risk | Clinical Research Resources, Child Development | The mission of the Center for the Study of Children at Risk is to stimulate outstanding interdisciplinary research, education, and clinical services on the biological and social factors that determine the developmental outcome of at-risk children. Our objective is to nurture, promote and coordinate research, training, education, and clinical service in child development and developmental psychopathology. Our group is interdisciplinary spanning the disciplines of developmental and clinical psychology, pediatrics, psychiatry, nursing, occupational therapy, social work, substance abuse and public health. We are excited by the translational work that occurs at the boundaries where disciplines intersect leading to new science and the handshaking between science and clinical practice. Current research at the Center includes studies of children with various risk factors including prenatal drug exposure, autism, prematurity, and maternal depression. We also study epigenetic mechanisms that affect outcome in children at risk. |
Contact: James Rudolph
Location: The Providence VA Medical Center »See on the MapAffiliated Centers: Center of Innovation in Long Term Services and Supports (LTSS COIN)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Center of Innovation in Long Term Services and Supports (LTSS COIN) Contact: Debra D'Allesandro | Clinical Research Resources, Veteran Population | The Center of Innovation in Long Term Services and Supports (LTSS-COIN) is an emerging health services research center with a focus on aging and other vulnerable Veteran populations. The Center includes an analytic core dedicated to Health Services Research in Long Term Supports. LTSS-COIN Research Concentrations include (1) Quality of Care in Nursing Homes and Home and Community Based Services, (2) High Risk Veteran Populations (Palliative Care, Dialysis, and Cognitive Impairment) (3)Policy and Economic Analysis of Long - Term Care Programs, (4) Antimicrobial Stewardship Research in the Long-Term Care Community, (5) Mental Health and Homelessness Research. |
Contact: behavioralmed@lifespan.org
Location: Coro West, Suite 309 »See on the MapAffiliated Centers: Centers for Behavioral and Preventive Medicine (CBPM)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Behavioral and Preventive Medicine (CBPM) Resources Contact: Michael Carey, PhD | Clinical Research Resources, Behavioral Medicine | The Centers for Behavioral and Preventive Medicine (CBPM) research scientists and their teams work to discover new and improved health promotion and disease management approach, focusing on the role of human behavior in health and disease. The Centers' research draws upon the social and behavioral sciences as well as biomedical and public health sciences to address the leading lifestyle causes of disease burden and death. The research portfolio includes both primary prevention (e.g., tobacco cessation, weight management, physical activity) and chronic disease management. The Center develops, implements, and evaluates interventions to reduce health risks, promotes active participation in medical care, and enhances quality of life. The Center works with healthy volunteers as well as people living with a chronic illness or condition, such as cancer, heart disease, diabetes, or HIV. |
Contact: Al Bach
Location: Pharmacy Rm 405 »See on the MapAffiliated Centers: RI-INBRE
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
---|---|---|
Nuclear Magnetic Resonance (NMR) Spectrometer | Bruker Avance III 300 with BBO probe | Optimized for small molecule NMR |
Analyzer - Protein Quality | Tycho NT.6 | The Tycho NT.6 verifies protein quality by looking at the structural integrity (or foldedness) of a protein. Changes in the intrinsic fluorescence of the sample are measured as a thermal ramp is applied. Changes in the fluorescence signal indicate transitions in the folding state of the protein. The Tycho can be used to study the stability of protein samples in different buffers or at different pH values. The measurement is completed in three minutes and uses a capillary tube to hold the sample. |
Surface Plasmon Resonance | Biacore T200 SPR | The Biacore T200 is a surface plasmon resonance instrument which can be used to characterize molecular interactions between biomolecules ranging in size from ions to viruses. The Biacore software provides a range of tools for kinetic analyses. These analyses can be performed using a multicycle approach (many samples against one ligand or when different ligands are immobilized), or alternatively, using fast, single cycle kinetics. |
Analyzer - Live Cell | Roche xCELLigence Real-Time Cell Analysis System | Label free live cell analyzer |
Biological Safety Cabinet | NuAire, Laminar Flow Hood | Cell culture facility |
Cell Counter | Nexcellom Cellometer Vision Cell Counter | Automated cell counter |
Centrifuge | Beckman Avante High Speed Centrifuge | High speed centrifuge |
Centrifuge | Thermo MultiFuge Centrifuge table-top | Centrifuge |
Centrifuge - Ultra | Beckman Coulter Optima | Ultra centrifuge |
Centrifuge - Ultra | Sorvall Micro Ultra Centrifuge | Ultra centrifuge |
Fluorescence Activated Cell Sorter (FACS) | Becton Dickinson (BD) Biosciences FACS Verse Flow cytometer | Fluorescence-activated cell sorting |
Electrophoresis System - Gel Electrophoresis | Bio-Rad 2D Gel System | Two Dimensional (2D) Gel Electrophoresis |
Ultra-High Performance Liquid Chromatography (UHPLC) | Hitachi UPLC System | Ultra-High Performance Liquid Chromatography |
Liquid Chromatograph | GE AKTA Fast Protein Liquid Chromatograph (FPLC) | FPLC |
Chromatography | Teledyne-ISCO CombiFlash System | Flash Chromatography |
Imaging System - Gel Imager | Li-Cor Odyssey IR Imager | IR gel imager |
Liquid Chromatography - Mass Spectrometer (LC - MS) | AB SCIEX TripleTOF 4600 and Shimadzu Prominence UFLC sytem | ESI-TOF MS |
Mass Spectrometer | Shimazu Axima MALDI-TOF MS/MS | MALDI MS |
Mass Spectrometer | Thermo iCAPQ-a ICP-MS | Elemental Analyzer |
Microplate Reader | Molecular Devices SpectraMax M2 | Fluorescence/UV/VIS |
Microplate Reader | Promega GlowMax System | Chemiluminescence |
Microscope | Nikon Eclipse E600 Upright Microscope | Microscope |
Microscope | Nikon TE2000E /C2 Inverted Confocal | Confocal Microscope |
PCR Thermal Cycler | Applied Biosystems/Life Technologies ABI Vii7- RT-PCR | Real Time-PCR |
PCR Thermal Cycler | Eppendorf Mastercycler PCR | PCR |
Spectropolarimeter | Jasco J-1100 Circular Dichroism (CD) Spectropolarimeter | CD |
Spectrometer | Thermo Nicolet 380 Fourier Transformed Infrared Spectrometer (FT-IR) | FT-IR |
Chromatography | Metrohm Ion Chromatography 940 Vario | Ion Chromatography |
Spectrophotometer | Thermo Scientific NanoDrop | UV/VIS |
Electroporation System - Transfection Platform | Lonza Nucleofactor System | High-throughput transfection |
Water Purification System - Deionized (DI) | Millipore Milli-Q Water System | DI Water System |
Western Blotting System | Bio-Rad Turbo Trans Blot system | Western Blotting |
Synthesizer, DNA/RNA | MerMade-4 Oligonucleotide synthesizer | DNA/RNA Synthesizer |
High Performance Liquid Chromatography (HPLC) | Shimadzu Nexera-i HPLC system | High Performance Liquid Chromatography |
Microscope | EVOS FL Auto Cell Imaging System | Cell-based imaging applications—including live-cell imaging, image tiling, and Z-stacking |
Spectrometer | Jasco Digital Polarimeter P2000 | Polarimeter |
Imager - Biomolecular | Azure Sapphire Biomolecular Imager | The Azure Sapphire Biomolecular Imager is a laser scanning system has four lasers (488, 520, 658 and 784 nm) giving a wide range of excitation. The instrument supports long and short wavelength Near IR fluorescence, red/green/blue imaging, and chemiluminescent imaging. Multiple detectors are used depending on the excitation wavelength and application for maximum sensitivity. It can accommodate gels up to 25cm by 25 cm. |
Incubator | Heraeus Heracell Double Stacked Incubator | The Heraeus Heracell Double Stacked Incubator has Copper Chambers, which protects samples while optimizing cell growth with fast recovery characteristics. |
Nuclear Magnetic Resonance (NMR) Spectrometer | Agilent NMRS 500 with OneNMR probe | Optimized for small molecule NMR |
Mass Spectrometer | ABSciex Qtrap 4500 Triple Quadrapole LC/MS | Has Shimadzu HPLC system attached |
Plate Reader | Molecular Devices ID3 | Uv/vis, Chemilumenesence, fluorescence |
Spectrophotomer | Genesysy 50 | UV/Vis |
Imager - Biomolecular | Biotek Cytation | fluorescence imaging |
Analyzer - Metabolism Analysis | Agilent Seahorse XFe96 Analyzer | 96 well plate metabolism analysis |
Affiliated Centers: Childhood Asthma Research Program
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Childhood Asthma Research Resources | Clinical Research Resources, Childhood Asthma | The Childhood Asthma Research Program at Hasbro Children's Hospital is a research group that conducts asthma-related studies with the goal of helping children and their families better manage asthma. |
Contact: Gaurav Choudhary, MD
Location: Coro Center West »See on the MapAffiliated Centers: Clinical and Translational Research Center (CVI-CTRC)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Cardiovascular Institute's (CVI) Clinical and Translational Research Center (CTRC) Contact: Gaurav Choudhary Cardiovascular Research Institute Website | Clinical Research Resources, Cardiovascular | The mission of the Cardiovascular Institute’s Clinical and Translational Research Center (CVI-CTRC) is to enhance, support and facilitate the conduct of high quality clinical and translational research in cardiovascular diseases by investigators at Lifespan. In partnership with Lifespan Office of Research Administration, CVI-CTRC will provide the following services to our investigators: assistance with investigator-initiated research grant preparation; contract and budget initiation; negotiation and execution for industry sponsored trials and subcontracts; assistance with IRB including initial application, continuing review and amendments; coordinating logistics of protocol implementation; assistance with screening and recruitment; regulatory documentation collection and submission; providing access to lab processing, freezers and exam and conference area; nursing and research assistant staff to collect biopecimens, perform exams and follow up; data entry, creating and maintaining source documents and maintaining regulatory binder(s); database searches for retrospective trials; and setting up databases using Redcap. |
Contact: Fatemeh Akhlaghi
Location: Laboratory 490, Avedisian Hall »See on the MapAffiliated Centers: College of Pharmacy, University of Rhode Island
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Pharmacokinetics Consultation Contact: Fatemeh Akhlaghi | Clinical Research Resources, Pharmakokinetics | The laboratory is capable of providing support for the design and implementation of pre-clinical and clinical pharmacokinetics studies as well as design and conduct of ancillary in vitro studies (protein binding and microsomal incubations to characterize phase 1 or 2 metabolism). With extensive background in pharmacokinetics modeling and simulation using NONMEM, WinNonlin and Simcyp softwares, the laboratory can provide a valuable resource for on-going or completed clinical studies. Additional data analysis capabilities includes in-vitro in-vivo correlation (IVIVC) and bioequivalence analysis. |
Pharmacokinetics, Bioanalytical support Contact: Fatemeh Akhlaghi | Clinical Research Resources, Pharmakokinetics | The Clinical Pharmacokinetics Research Laboratory is equipped with two UPLC-MS/MS and one quadrupole-time-of-flight mass spectrometer (ESI-QTOFMS) systems capable of measuring the concentration of small molecule xenobiotics and their metabolites as well as endogenous or therapeutic peptides and proteins. To date, this laboratory has developed various assays for the quantification of up to 60 different compounds and validated these assays according to guidelines by the Food and Drug Administration of the United States. The laboratory is proficient in providing analytical support for on-going pre-clinical and clinical studies and during different stages of a drug development project. |
Contact: Gaurav Choudhary
Location: The Providence VA Medical Center »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Clinical Research and Development Service Resources | Clinical Research Resources, Veteran Population | The VA Research's fundamental mission is to advance the healthcare of Veterans. The Providence VA Medical Center has a large funded research and development program, including studies in Rehabilitation Medicine, Cardiology, Mental Health, Neuroscience, Substance Abuse, Health Services & Economics, and Pulmonary Disease. These studies enhance our ability to provide state-of-the-art techniques and treatments to our patients. At the same time, the research program helps Providence VAMC recruit and retain the highest quality health care professionals who treat our Veterans in the VA Clinics on a daily basis. |
Contact: Andrew Schumacher
Location: Coro Center West »See on the MapAffiliated Centers: Clinical Reseach Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Clinical Research Center Resources Contact: Andrew Schumacher Lifespan Clinical Research Center Services | Clinical Trials Support, Coordinating Center | In partnership with Lifespan Office of Research Administration, the Clinical Translational Research Center (CTRC) will provide the following services to our investigators: assistance with investigator-initiated research grant preparation; contract and budget initiation; negotiation and execution for industry sponsored trials and subcontracts; assistance with IRB including initial application, continuing review and amendments; coordinating logistics of protocol implementation; assistance with screening and recruitment; regulatory documentation collection and submission; providing access to lab processing, freezers and exam and conference area; nursing and research assistant staff to collect biopecimens, perform exams and follow up; data entry, creating and maintaining source documents and maintaining regulatory binder(s); database searches for retrospective trials; and setting up databases using Redcap. |
Contact: Chris Schmid, PhD
Affiliated Centers: Advance-CTR (Clinical Translational Research)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Biostatistics Services | Clinical Research Resources, Biomedical Informatics | Quantitative Research Support, Qualitative and Mixed Method Research Support |
Workshops, Seminars, Trainings | Clinical Research Resources, Biomedical Informatics | Symposia, REDCap Workshop, Online Tutorials, Biostatistics Core Seminar Series, Drop-In Sessions |
Contact: Ashok Ragavendran
Affiliated Centers: COBRE Center for Computational Biology of Human Disease
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
---|---|---|
Data Analysis Contact: CBC help | Service | The core provides assistance in experimental design and data processing pipelines for high-throughput datasets generated in individual projects, particularly for DNA/RNA sequencing data. |
Standardized Data Analysis | Service | Develop/Implement Bioinformatic Pipelines; GATK whole exome, Cut and run. Develop/Implement Standardized QC for Workflows. Experimental Design Support; Power Analysis for Microbiome and RNAseq. Exploratory Data Analysis; RNAseq, scRNA seq. |
Tooling qckitfastq | Software - R-Qckit | A comprehensive quality control R package for Next Generation Sequencing FASTQ data. |
Tooling RSeqAn | Software - RSeqAn | Wrappers for the SeqAn library for use in R with Rcpp |
Tooling bioflows | Software - Bioflows | A bioinformatics workflow engine that streamlines the most common analysis pipelines. Key features include: 1) Provision of standardized workflows 2) A module for automating SRA downloads and 3) External tools are made available as CONDA packages alongwith the tool. |
Tooling | Software - Scripts | Access Genbank, BioCookBook.jl |
Tooling NMRdock | Containerization with Docker - NMRDock | NMRdock is a Docker container image for processing raw NMR time domain data into frequency domain spectra and analyzing the spectra. The image includes NMRPipe and NMRFAM-Sparky for processing and analysis, respectively. NMRdock can be installed on any operating system (OSX, Windows, or Linux) and has the full functionality of both NMRPipe and NMRFAM-Sparky. For guides on processing BioNMR data in NMRdock, please access our Walkthrough Section |
Tooling | Containerization with Docker | IDeP |
Tooling | Infrastructure | Conda, Web applications, Automation of best practices |
Custom Analysis | Methods Development | mvMAPIT |
Custom Analysis | Collaborative Analysis | Mixed effects modeling for RNAseq |
Custom Analysis Ingenuity Pathway Analysis Request a Service | IPA white paper for best practices | IPA is a software application that enables biologists and bioinformaticians to identify the biological mechanisms, pathways, and functions most relevant to their experimental datasets or genes of interest. It allows researchers to graphically view, analyze, and query data in a comprehensive and seamless manner to understand molecular interactions, biological functions and disease on multiple levels. For more details go to qiagen IPA website and also access their webinars. |
Data Management | Service - Database | QCDB, ?DB Resource Table |
Data Management RefChef | CCV - RefChef | RefChef is a reference management tool used to: (1) document the exact steps undertaken in the retrieval of genomic references; (2) maintain the associated metadata; (3) provide a mechanism for automatically reproducing retrieval and creation of an exact copy of genomic references. |
Training and Support Workshops | Service | Workshops |
Training and Support Request a Service | Service - Consulting | The Core provides two distinct complimentary services to all researchers at Brown. Appointment Based – A team of experienced computational biologists and biostatisticians are on-hand to help investigators design experiments. Weekly Consulting Sessions – The Core offers two hours *walk-in Consulting* sessions for all researchers to discuss any immediate issues in data analysis including trouble-shooting code, help with statistical analysis and discussion of options for bioinformatic analysis. |
Training and Support | Service -Talent Development | Student worker/interns, Guidance and mentoring |
Training and Support Outreach | Service - Outreach | CBC hosts workshops, publishes tutorials on computing tools used by bioinformaticians, and provides analysis support to the Brown community. |
Contact: Patrycja Dubielecka-Szczerba, PhD
Affiliated Centers: Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Training and Technical Assistance | Service | Advise investigators with experimental design, implementation and data analysis. Provide support for grant submissions. |
Contact: Suzanne Araujo
Location: Dept. of Emergency Medicine Administration 55 Claverick St., Suite 100 »See on the MapAffiliated Centers: Department of Emergency Medicine
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Emergency Medicine Research Resource Department of Emergency Medicine Research | Clinical Research Resources, Emergency Medicine Resources | The research program in the Department of Emergency Medicine at Rhode Island, Hasbro Children's, The Miriam, and Newport Hospital was established by UEMF to support investigator-initiated research and pharmaceutical, biologic and biomedical device trials. |
Affiliated Centers: Carney Institute for Brain Science, COBRE Center for Central Nervous System Function
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Experimental Design | Clinical Research Resources, Behavior and Neuroimaging | |
Multilevel and Hierarchical Modeling | Clinical Research Resources, Behavior and Neuroimaging | |
Machine Learning | Clinical Research Resources, Behavior and Neuroimaging | |
Feature Extraction | Clinical Research Resources, Behavior and Neuroimaging | |
Effective and Functional Connectivity | Clinical Research Resources, Behavior and Neuroimaging | |
Spatial-Temporal Modeling | Clinical Research Resources, Behavior and Neuroimaging | |
Time Series Modeling | Clinical Research Resources, Behavior and Neuroimaging | |
General Linear Model (GLM) and Linear Model (LM) | Clinical Research Resources, Behavior and Neuroimaging | |
Analysis of Variance (ANOVA) | Clinical Research Resources, Behavior and Neuroimaging | |
Regression for High Dimensional Data | Clinical Research Resources, Behavior and Neuroimaging | |
Network Analysis | Clinical Research Resources, Behavior and Neuroimaging | |
Causal Interference | Clinical Research Resources, Behavior and Neuroimaging |
Contact: Glenn A. Tung, MD
Location: Gerry House »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Diagnostic Imaging Research Resources | Clinical Trials Support, Diagnostic Imaging | The Division of Imaging Research has successfully completed both federally-funded and industry-sponsored research trials. The Division has participated in cancer imaging trials that include screening studies and studies looking at the efficacy of various imaging modalities.The Division has participated in studies with pharmaceutical companies on phase I, II, and III trials. These studies include both diagnostic and cancer treatment drugs. We have also worked with various device manufacturers that are seeking pre-market and post-market Food and Drug Administration approval for medical devices. In addition, the Division has participated in several blood biomarker studies. |
Contact: Jorge Albina, MD
Location: Nursing Arts Bldg, Room 213 »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Surgical Research Resources | Clinical Research Resources, Surgical | Department of Surgery's 15 separate divisions (including the Division of Surgical Research), each with its own specific research focus to improve understanding of diseases and evaluate new methods of treatment for injuries and illness. |
Contact: Katherine Patenaude
Location: BioMedical Center Building »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Drosophila Media Preparation | Service | The Brown Fly Facility is dedicated to providing investigators with high quality media for Drosophila research. The media kitchen is equipped with a food service quality steam kettle fitted with stirring unit, a Steris autoclave and a Lancer Washer fitted with custom racks for glass vials. Media is dispensed using Filamatic and Materflex/ Digistalic pumps. In the centralized kitchen, a standard cornmeal, sucrose, yeast medium is prepared and dispensed into different sized culture vessels. Media is prepared in a steam-jacketed food kettle and pumped into trays of glass vials (10ml), plastic vials (10ml) or into plastic bottles (30ml) depending on research needs. Media is prepared according to a strict protocol that ensures consistency in diet and the absence of any bacterial, fungal or insect contamination. Researchers using glass vials return them to the facility where they are autoclaved, washed, and filled again. |
Contact: Shengliang Zhang, PhD
Affiliated Centers: Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Training and Technical Assistance | Service | Advise interested investigators on cancer drug screens, cell-based assay development, assay optimization, and use of various chemical libraries/FDA-approved drugs to support research in the area of drug discovery and development. Advise on target validation, and interface with medicinal chemistry. Provide technical support for screening implementation, library plating, high-throughput robotic screening, and advice on prioritization of hits. Provide support for grant submissions. |
Contact: Joseph S Boesenberg
Location: Geo-Chem Building »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Analyzer - Electron Microprobe Contact: Stephen Parman | Cameca SX100 Electron Microprobe Analyzer | The Cameca SX-100 electron microprobe is equipped with 5 wavelength dispersive spectrometers (WDS) and a Rontec energy dispersive spectrometer (EDS).The WDS spectrometers each contain two or four diffracting crystals and presently include LTAP, TAP (2), LPET (2), PET, LLIF (2), LIF, LPCO, PC1 and PC2. The last three crystals are used to measure the light elements (boron to sodium). The absolute detection limits for the instrument are approximately 50-200 ppm, depending on the element. The EDS spectrometer is capable of detecting all elements above sodium (Na). X-ray element maps can easily be acquired on the microprobe. Using 512x512 pixel maps, up to nine element maps (5 elements on WDS, 4 with EDS), plus a backscattered electron (BSE) image, can be obtained simultaneously. Maximum resolution on any one map is one micron per pixel. Utilizing the coordinate system, maps of entire thin sections can be generated. |
Contact: Anthony McCormick
Location: Room 020D, Engineering Research Center Building »See on the MapAffiliated Centers: Institute for Molecular and Nanoscale Innovation (IMNI)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Microscope - Focused Ion Beam Electron (FIB) | Thermo/FEI Helios Dual Beam Focused Ion Beam Electron Microscope (FIB) with an Omniprobe nanomanipulator and autoTEM sample preparation | The FIB is fully equipped for (near) simultaneous ion/electron beam imaging and patterning of specimens. A Pt metal deposition source is available for ion (or electron) beam assisted deposition of conducting lines. A second source is available to enhance the carbon removal rate. An Omniprobe AutoProbe 200.2 allows the physical manipulation of samples with nanometer precision and is used along with Pt metal deposition and standard FIB trenching to allow the selection and removal of electron transparent TEM samples from specific microstructural features. A NPGS pattern generation system (plus beam blanker and external scan interface) controls the electron beam for high resolution, interlaced pattern generation used in the FIB fabrication of nanostructures. Three dimensional crystallographic data can be generated from specimens using the fully automated EBSD system (Oxford HKL&EBS-3). The microscope is also equipped with an EDS detector for elemental analysis. An electron flood gun can be used with the ion beam to image/etch nonconductive samples. A low temperature holder is available for beam sensitive samples. |
Microscope - Scanning Electron (SEM) | LEO 1530 High Resolution Scanning Electron Microscope (HRSEM) | The LEO 1530 VP ultra-high resolution field emitter SEM that allows for a resolution of 1 nm at a voltage of 20 kV in high vacuum and 2 nm at 30 kV in the variable pressure mode. It is fully equipped with EDS for chemical mapping and includes a Debbem tensile test stage 5kn. The instrument is equipped with Nabity pattern generating software a high speed beam blanker and is set-up for high resolution electron-beam lithography. The LEO 1530 VP is capable of a resolution of 2.1 nm at very low electron energies (1 kV) which is of great use for beam-sensitive materials like polymers and insulating surfaces. Also very useful for insulating samples is the variable operating pressure mode which allows insulating materials to be imaged without coating the surface. |
Microscope - Transmission Electron (TEM) | FEI CM20 TEM | The FEI CM20 is available for applications that require high tilt, moderate resolution (0.23 nm). This 200 kV analytical TEM allows the large specimen tilts needed for dislocation characterization and weak-beam imaging applications. It is equipped with a low background double tilt holder and a liquid nitrogen temperature holder. Compositional analysis is performed on this instrument using energy dispersive x-ray spectroscopy. Images are recorded using a large field of view, side mounted, digital image acquisition system. |
Microscope - Scanning Transmission Electron Microscope -S(TEM) | JEOL 2100F - S (TEM) | The 2100F is a 200 kV, field emission source, high-resolution/analytical S(TEM) capable of 0.10 nm lattice resolution. It is primarily used for obtaining lattice images or when chemical or crystallographic information is required from laterally small areas (1-10 nm). The instrument is equipped with an x-ray spectrometer capable of light element detection, a Gatan image filter (GIF) for element and phase analyses and enegy filtered imaging, a high tilt holder for electron tomography and a high-resolution CCD camera system for digital image acquisition and processing. A low background double-tilt holder for chemical analysis by EDS, a standard double tilt holder, a heating holder capable of 1000C, and a heating straining holder are available. Probes as small as 1 nm in diameter are accessible for micro-diffraction experiments. STEM mode for EDS line and area scans, bright and dark field STEM detectors, and high angle annular dark field is capable in STEM mode. |
Spectrometer - ThermoElectron K-Alpha XPS | Thermo/FEI K-Alpha X-Ray Photoelectron Spectrometer | This equipment is used to study the surface composition of materials using photoelectrons generated by 30 kV monochromated Aluminum K-Alpha x-rays hitting the sample. It is equipped with an Argon sputter gun for surface cleaning and depth profiling. There is a tilt and rotate holder. There is a transfer holder so samples can be transferred to the XPS with exposure to atmosphere. |
Microscope - Quattro S-E(SEM) | Thermo/FEI Quattro S-E(SEM) | The Quattro is an environmental SEM which means that the sample chamber can be set to a (relatively) high pressure for water containing samples. This SEM has EDS (X-ray detection) and EBSD (electron backscatter). The Quattro S is a field emission scanning electron microscope capable of generating and collecting all available information from any type of sample material. It provides the most versatile high-resolution low-vacuum FEG SEM with extended low-vacuum capabilities and the most versatile high resolution SEM for characterization, prototyping and in situ analysis. The features include three vacuum modes enabling investigation of conductive, non-conductive and high-vacuum incompatible materials such as High-vacuum mode (<6*10-4 Pa) for imaging and microanalysis of conductive and/or conventionally prepared specimens; Low-vacuum mode (10 to 130 Pa) for imaging and microanalysis of non-conductive specimens without preparation; and ESEM™ mode (10 to 4000 Pa) for high-vacuum incompatible specimens which are impossible to investigate with traditional EM methods. The system is equipped with a 5-axes motorized x-y-z-tilt-rotate stage,for Sample navigation. |
Sample Preparation | Electron Microscope Facility Sample Preperation Area | Tools available in the EMF sample preparation area include a jet polisher, polishing benches, dimpler and high and low speed diamond saws.The sample prep area has a carbon thread evaporator and Gold/Palladium sputter coater for making conductive coatings on SEM samples. There is an ion mill (PIPS) for making TEM samples. There is also a plasma cleaner for TEM sample holders and SEM samples. |
Contact: Gregory Jay
Location: Coro WestInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Emergency Medicine Research Laboratory Resources Contact: Francesca Beaudoin | Clinical Trials Support, Emergency Medicine | The research program in the Department of Emergency was established to support investigator-initiated research and pharmaceutical, biologic and biomedical device trials. The program is supported by a Research Program Administrator, two pre-award Research Administrators, a Clinical Research Supervisor, and a staff of Clinical Research Assistants. The department maintains clinical research space within emergency departments as well as fully-equipped basic science laboratories, and has ongoing collaborations with Brown University and other hospital departments.The main focus areas of the Department of Emergency Medicine research program are (1) injury prevention and control, (2) cardiovascular, neurologic, and resuscitation science, (3) pediatric, age, and gender specific care, and (4) healthcare systems science. |
Contact: David Murray, PhD
Location: MacMillan Hall »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Analyzer - Discrete Analyzer | Westco Smartchem 200 | Used to determine Nitrate/Nitrite, Phosphate, Ammonia, Silicate, and other nutrient concentrations in water samples and soil extracts. |
Analyzer - Elemental Analyzer | Thermo Scientific, FlashSmart EA | Analysis of carbon, nitrogen, and sulfur concentration of solid samples |
Analyzer - Inorganic Carbon Analyzer | UIC, INC Inorganic Carbon Analyzer | Measures total inorganic carbon by automated acidification and coulometric detection in a wide variety of sample matrices. Solid samples ranging from low ppm to 100% inorganic carbon can be analyzed with this system. |
Analyzer - Mercury Analyzer | Milestone DMA-80 Direct Mercury Analyzer | Determines mercury content of solid and liquid samples. |
Analyzer - Water Isotope | Picarro L1102-I | Measures delta deuterium/hydrogen (D/H) ratio and delta 18O/16O in liquid water |
Sample Preparation - Freeze Dry System | Labconco FreeZone 6 Liter | For removing water and other solvents from frozen samples by sublimation. |
Liquid Chromatography System | Dionex DX500 | Ion chromatography analysis of anions and cations in marine and freshwater samples |
Sample Preparation - Microwave Digestion System | Milestone Ultrawave | Used to digest solid samples (soils, sediments, rocks, plants, tissues), for elemental analysis. |
Spectrometer - Atomic Absorption Spectrometer-Graphite Furnace (GFAAS) | Perkin Elmer AAnalyst 600 Graphite Furnace | This spectrometer is useful for measuring trace levels of metals in water and soil. |
Spectrometer - Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES) | Thermo Scientific iCAP 7400 DUO ICP-OES | Analysis of most elements with atomic weights above 10. |
X-Ray Fluorescence - Handheld | Innov-X Systems Alpha 4000 Handheld | Non-destructive elemental analysis on a variety sample types for concentrations of some metals ranging from about 20 ppm to 10%. |
X-Ray Fluorescence - Handheld | Olympus Delta Professional Handheld | Non-destructive elemental analysis on a variety sample types for concentrations of elements greater than 10 ppm. |
Contact: Kevin Carlson
Location: Room 602, BioMedical Center Building »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Fluorescence Activated Cell Sorter (FACS) | Becton Dickinson (BD) Biosciences FACS Aria III | Cell counting, sorting, biomarker detection. The FACSAria has five air-cooled lasers at 351nm, 488nm, 561nm, 633nm, and 407nm allowing multicolor analysis of up to 20 parameters. It can sort 1 to 4 populations simultaneously and is equipped with an Automated Cell Deposition Unit, an Aerosol Management System and a refrigeration system. It can accept various sample input tubes including 1 mL microtubes, 12 x 75-mm test tubes, and 15 mL tubes into the sample and collection chambers. |
Fluorescence Acticated Cell Sorter (FACS) | Becton Dickinson (BD) Biosciences FACS Celesta | Cell counting, biomarker detection. The FACSCelesta has three air-cooled lasers at 488nm, 561nm and 407nm allowing multicolor analysis of up to 15 parameters that has an attached high throughput system (HTS) that allows users to analyze samples directly from a 96 well plate. |
Contact: Mark Dooner
Location: Coro West Building, Suite 5.08A, »See on the MapAffiliated Centers: COBRE Center for Stem Cells and Aging
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Fluorescence Activated Cell Sorter (FACS) | BD Biosciences LSRII Analyzer/Flow Cytometer | Digital, 4 laser (355nm, 405nm, 488nm and 635nm) flow cytometric analysis system with 10 fluorescent channels plus 2 scatter channels. BD FACSDiva software with digital compensation and ModFit software for cell cycle analysis. |
Analyzer - nanoparticle counter | Nanosight Nanoparticle Counter | Examines size, size distribution and concentration. Fluorescent adapter for extracellular vesicles (EVs) surface receptor studies. Able to control for microvesicle number in experiments, and possibly identify subpopulations of EVs based on surface receptors Particles are illuminated using a laser through a prism, and light scatter is captured on a CCD camera. Nanoparticle tracking analysis (NTA) – direct and real-time visualization and analysis of nanoparticles in liquids, and calculate the size, size distribution and concentration of the particles. Brownian motion of nanoparticles is analyzed using the Stokes-Einstein equation. |
Fluorescence Activated Cell Sorter (FACS) | BD Biosciences Influx Cell Sorter | 5 laser system (355nm, 405nm, 488nm, 561nm and 638nm) for simultaneous detection of up to 14 parameters. Sorts up to 4 different cell populations. Capable of single cell deposition into many different sized culture plates (96 or 384 well plates, etc). Equipped with a small particle objective for FSC size determination down to 0.5 micrometers. Enclosed in a biosafety hood. The sorter separates particles on the detection of fluorescent markers on particles such as cells, chromosomes, bacteria or nuclei. Then the collected cells are suitable for downstream analysis either in molecular applications like protein assays and PCR, or used in viable assays such as tissue culture or injected into in vivo models. Generated data may also be used to determine percentages of interrogated populations. The sorter can separate populations into tubes (1.5ml, 4ml, 15ml, 50ml), multi-well plates (6, 24, 48, 96, 384), or directly onto microscope slides. |
Training and Technical Assistance | Service |
Contact: Janet Atoyan
Location: 352 Center for Biotechnology & Life Sciences »See on the MapAffiliated Centers: RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Bioanalyzer | Agilent Bioanalyzer 2100 | Provides fast and automated separation, sizing and quantification of DNA, RNA and proteins by miniaturized Lab-on-a-Chip electrophoresis |
Bioinformatics Analysis - DNA Sequence and Protein Analysis | Software: DNAStar Lasergene Core Suite | Comprehensive suite of software modules for DNA, RNA, and protein sequence analysis |
Bioinformatics Analysis - Next Generation DNA Sequence Assembly | Software: CLCbio Genomics Workbench | Software for analyzing, comparing, and visualizing Next Generation Sequencing data |
Centrifuge | Beckman Coulter Allegra 25R Refrigerated Centrifuge | Centrifuge for pelleting cells, tissues and macromolecules |
Centrifuge | Thermo Savant DNA110 SpeedVac Vacuum Centrifuge | Centrifugal concentration system for drying low-volume ethanol or isopropanol precipitates of DNA and RNA |
Disrupter | Covaris S220 High Performance Ultrasonicator | Automated acoustic disruption and homogenization of cells and tissue samples using focused ultrasonic energy at 500 KHz. Performs DNA Shearing |
DNA Sequencer | Applied Biosystems 3130xl & 3500xl Genetic Analyzers | DNA Sanger Sequencing & Fragment Analysis: Fluorescence-based instruments utilizing capillary electrophoresis for DNA sequencing and fragment analysis |
DNA Sequencer | Illumina MiSeq DNA NextGen Sequencing | Performs clonal amplification, genomic DNA sequencing, and data analysis with base calling, alignment, variant calling, and reporting |
Electrophoresis System | Sage Science BluePippin DNA Electrophoresis System | A preparative electrophoresis platform that separates and extracts DNA fragments using pre-cast gel cassettes |
Fluorometer | Invitrogen Qubit | Fluorometer that uses fluorescent dyes bound to specific molecules to quantify DNA, RNA and proteins |
Imaging System - Camera | Zeiss AxioCam HRc high-resolution imaging systems | A digital Zeiss AxioCam HRc high-resolution camera and for laser scanning microscopy with a Zeiss LSM 700 confocal module. For use on the AxioImager upright light microscope |
Sample Preparation - Library Preparation System | IntegenX Apollo 324 System NextGen Sequencing (NGS) Library Preparation System | Automated liquid handling instrument dedicated to the preparation of sample libraries for Next Generation Sequencing |
Microscope | Zeiss AxioImager M2 Upright Light Microscope | For use with the AxioImager upright light microscope equipped for digital image acquisition with a Zeiss AxioCam HRc high-resolution camera and for laser scanning microscopy with a Zeiss LSM 700 confocal module |
PCR Thermal Cycler | Roche LC480 qPCR Systems | 2 Quantitative PCR (qPCR) instruments. Used for highly accurate qualitative and quantitative detection of nucleic acids and gene expression. |
PCR Thermal Cycler | Eppendorf Mastercycler ep Gradient S and MJ Research PTC-100 | (3) Thermal cyclers in 96-well format; peltier elements control the temperature of the block for PCR chemistry |
Workstation - PCR | AirClean Systems 600 PCR Workstation | Combination workstation provides an ISO 5 (FS209E) Class 100 clean air environment and UV light sterilization |
Robotic Workstation - Automated Pipetting | Eppendorf epMotion 5075 VAC Pipetting Workstation | Automated pipetting workstation enables fast and reproducible liquid handling for a variety of applications |
Robotic Workstation - Sample Preparation | QIAGEN QIAcube Spin Column Robot | Automated protocols for purification of plasmid DNA, genomic DNA, RNA, viral nucleic acids, and proteins |
Spectrophotometer | Thermo Scientific NanoDrop 8000 | Spectrophotometer that accurately measures up to eight individual 1-2 microliter samples simultaneously |
Contact: Christoph Schorl, PhD
Location: Room 109, Laboratories for Molecular Medicine »See on the MapAffiliated Centers: Center for Genomics and Proteomics (CGP), COBRE Center for Signaling Networks at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Bioanalyzer | Agilent Bioanalyzer 2100 | Microfluidics-based platform for sizing, quantification and quality control of DNA, RNA. |
Analyzer - Fragment | Advanced Analytical, Fragment Analyzer | Capillary Electrophoresis - Analyze DNA fragments for Next-Gen Sequencing, genotyping, checking RNA quality and quantity, and working with microsatellite simple sequence repeats (SSRs). |
Cell Counter | Life Technologies Automated Countess Cell Counter | Measure cell count and viability (live, dead, and total cells) using the standard trypan blue technique. |
Centrifuge | Sorvall Legend T Benchtop | Low to medium speed centrifugation |
Centrifuge - Ultra | Beckman Coulter Optima Max UltraCentrifuge | High speed centrifugation with MLA130, TLA110 & TLA100 Rotors |
Disrupter | Covaris S220 High Performance Ultrasonicator | DNA, RNA, and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization |
Imaging System | LiCor Odyssey Clx Infrared | Western blot analysis, EMSA, protein arrays, In-Cell Western Assays, On-Cell Westerns, in vivo imaging, Coomassie gel documentation, DNA gel documentation, and tissue section analysis. |
Microarray Platform | Affymetrix Gene Chip Instrument System | A fully integrated platform for Affymetrix microarrays |
Microarray Scanner | Molecular Devices GenePix Scanner 4000B | Two color microarray scanner |
PCR Thermal Cycler | Applied Biosystems ViiA 7 Real-Time PCR System | Medium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput |
PCR Thermal Cycler | Applied Biosystems ViiA 7 Real-Time PCR System | Medium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput |
Spectrophotometer | Thermo Scientific Nanodrop One | A microvolume spectrophotometer for measuring DNA and RNA. |
Technical Assistance - Affmetrix Microarray | Service | Service to provide Affymetrix gene expression array service |
Technical Assistance - NGS Library Quality Control | Service | Analysis of library size distribution and qPCR quantification |
Analyzer - nCounter Systems | NanoString - nCounter Sprint Profiler | Molecular barcoding technology for RNA, DNA, and protein profiling applications. Digitally examine multiple pathways in a single tube in an extraction-free workflow. Included nSolver Analysis Software. Compatible with FFPE tissue. Highly multiplexed analysis of many functional pathways such as among others cancer, inflammation, cell death and custom designed expression analysis. Operated as fee for service. |
Imager and Microplate Reader | BioTek Cytation 5 Cell Imaging Multi-Mode Reader | UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence. Cell migration and invasion assays, Live cell imaging, Multi-mode reader applications, Immunofluorescence, Phenotypic assays, Histology |
PCR Thermal Cycler - Digital | Bio-Rad QX200 Droplet Digital (ddPCR) PCR System | Provides absolute quantification of target DNA or RNA molecules for EvaGreen or probe-based digital PCR applications. |
DNA Sequencer | Illumina - NextSeq550 | The NextSeq550 Next Generation Sequencing system is a high throughput bench top sequencer that provides accurate fast sequencing data, and by employing flexible run configurations it can be easily adopted to a researcher’s needs depending on their required read length and sequencing depth. Reagents are available in a mid-output and a high output mode resulting in maximum cluster numbers of 400 million (high output) and 130 million (mid output) clusters (reads). |
Microplate Reader | BioTek Synergy H1 Hybrid Multimode (H1MM) Microplate Reader | UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence. Cell based assays, Biomarker assays, Micro-volume analysis of nucleic acid and protein, Kinetic assays. |
Contact: John McGeary, PhD
Location: Research Building 32, Room 146 »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Autoclave | Tuttnauer | Equipment: consumable sterilization |
Bioanalyzer | Agilent Bioanalyzer | DNA size & quantification (quality check for downstream analyses, i.e. next gen sequencing) |
Analyzer - Genetic | Applied Biosystems 3500 Genetic Analyzer | Capillary Electrophoresis - Analyze fragment length polymorphisms (96 format) (2) |
Centrifuge | Eppendorf Refrigerated Centrifuge | Alcohol precipitation |
Centrifuge | Eppendorf | For centrifuging 96/384 plates |
DNA Sequencer | Ion Torrent/Life Technologies Personal Genome Machine | Next Generation Sequencer |
Mass Spectrometer | Sequenom | high throughput SNP genotyping, epigenetics |
Microarray Scanner | Illumina HiScan | Whole-genome genotyping, gene expression analysis, methylation analysis |
Microplate Reader | BioTek | DNA quantification |
Microplate Reader | Fluidigm End Point Reader | High throughput SNP genotyping |
PCR Thermal Cycler | Applied Biosystems | 384 well DNA amplification for downstream analysis (i.e. sequenom processes) (2 units) |
PCR Thermal Cycler | Applied Biosystems | 96 well DNA amplification for downstream analysis (i.e. fragment length polymorphisms)(2 units) |
Robotic Workstation - DNA Extraction | Chemagen/Perkin Elmer Magnetic Separation Module | DNA extraction from blood & saliva |
Robotic Workstation - Liquid Handler | Sequenom Liquid Handler | Transfers PCR chemistries to samples (96/384 format) |
Robotic Workstation - Liquid Handler | Sequenom Nanodispenser | Dispenses PCR product to Sequenom chip |
Robotic Workstation - Sample Preparation | Iontorrent/Life Technologies Enrichment System | Simplifies the workflows for the Ion PGM system by providing an automated solution for scalable and reproducible template preparation. |
Robotic Workstation - Sample Processing | Thermo Scientific Cap-it-All | Caps tubes to the optimal torque to maintain sample integrity and provide a hands free method to capping and decapping tubes quickly and easily. |
Robotic Workstation -Liquid Handler | Beckman Coulter Lab Automation Workstation | Automated liquid handler |
Spectrophotometer | Thermo Scientific NanoDrop | DNA quantification |
DNA Sequencer Contact: Kayla Dwyer | Qiagen Pyromark Q96 ID | Quantitative analysis of genetic/epigenetic DNA modifications using Pyrosequencing technology |
PCR Thermal Cycler | Applied Biosystems Real Time PCR Quant Studio 12K Flex | Analyze single nucleotide polymorphisms (single locus) (96/384 format) |
Robotic Workstation-Sample Preparation | Tecan Freedom Evo | Simplifies the workflows for the Illumina HiScan system by providing an automated solution for scalable and reproducible sample preparation. |
Contact: Ryan Institute
Location: 130 Flagg Road »See on the MapAffiliated Centers: George and Anne Ryan Institute for Neuroscience
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Neurodegenerative Disorders Research | Clinical Research Resources, Neurodegenerative Disorders | The George & Anne Ryan Institute for Neuroscience is dedicated to finding treatments and cures for neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. |
Contact: Clinton Chichester III, Ph.D.
Location: URI, Avedisian Hall »See on the MapAffiliated Centers: College of Pharmacy, University of Rhode Island
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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current Good Manufacturing Practice (cGMP) Facility | Service | Rapid expansion in the markets for biologics and small molecule pharmaceutical products has created a critical demand for skilled professionals (from equipment operators to advanced technical and quality assurance personnel) and additional infrastructure to support drug development and manufacturing. The current Good Manufacturing Practice (cGMP) Facility at the University of Rhode Island (URI) offers a state-of-the-art training, development and manufacturing facility for GMP production of solid oral dosage forms. |
GMP manufacturing | Clinical Research Service, GMP manufacturing | Assisting academic, government and industry partners with the manufacture of solid dose forms for veterinary and human use |
GMP analytical testing | Clinical Research Service, GMP analytical | Providing pharmaceutical testing services including turn-key stability studies |
Education | Clinical Research Service, GMP education | Providing GMP industrial experience in drug manufacturing and analytical testing for students in various related undergraduate, graduate and adult education programs, as well as industry-specific training in collaboration with pharmaceutical and biotechnology firms. |
Contact: Geetha Gopalakrishnan, MD
Location: 245 Chapman Street, Providence, RI 02905 »See on the MapAffiliated Centers: Hallett Center for Diabetes and Endocrinology
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Clinical Research Resources, Diabetes Diabetes Services | Clinical Research Resources, Diabetes | The Center for Diabetes and Endocrinology conducts basic and clinical research. Active research programs in the Center are focused on women's health topics such as osteoporosis; the pathogenesis of obesity, the integrated physiology of the adipocyte hormone leptin, other neuropeptide hormones, and nutrient sensors actions in controlling food intake and their dysfunction in the obese state; and obesity-related insulin resistance and type 2 diabetes. |
Contact: Phyllis Dennery
Location: Brown University’s School of Public Health »See on the MapAffiliated Centers: Hassenfeld Child Health Innovation Institute
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Hassenfeld Research Institute Contact: Phyllis Dennery Hassenfeld Research Institute Website | Clinical Research Resources, Pediatrics | The work of the Hassenfeld Child Health Innovation Institute will contribute to our understanding of the genetic, prenatal, and early life factors associated with health problems of children, and will develop effective new strategies for prevention and treatment. These strategies will involve careful coordination of medical care, social services, and public health interventions. The research findings and lessons learned in Rhode Island will have broad applicability to other settings in the United States and internationally, amplifying the Institute's ability to improve population health, enhance family life, and help children thrive in school and in their future lives. |
Informatics, Geographical Information Systems (GIS) Contact: Lynn Carlson Geographical Information Systems (GIS) Website | Clinical Research Service, GIS Informatics | The Hassenfeld Core Research and Evaluation Unit will geocode, map, and analyze hospital and other health data for research and evaluation. This will include mapping all emergency department visits and inpatient stays, to first identify “hot spots” in Rhode Island where children disproportionately suffer from health issues, and then help shape interventions to address these disparities. In addition to mining hospital data systems, core researchers will also build the capacity for enrolling families in research and intervention projects at Hasbro Children’s Hospital and affiliated sites. |
Clinical Trials Enrollment, Prospective Birth Cohort Prospective Birth Cohort Website | Clinical Trials Support, Pediatrics | The prospective birth cohort study will include enrolling families, collecting key information about prenatal exposures, initial health status assessments of the newborn, and annual follow up assessments. The prospective birth cohort study will provide critical information on early determinants of child health and will provide a framework for assessing the impact of innovative approaches to improve the health of families. |
Contact: Jennifer Tidey, Ph.D.
Location: Brown University School of Public Health »See on the MapAffiliated Centers: COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE) website for more details | Clinical Research Resources, Addiction & Disease | Established in 2019, the Center for Addiction and Disease Risk Exacerbation (CADRE), is a federally funded NIH Center of Biomedical Research Excellence (COBRE). Through its affiliation with the Center for Alcohol and Addiction Studies at the Brown University School of Public Health, CADRE will investigate mechanisms whereby substance use impacts disease, using a combination of behavioral and physiological laboratory-based approaches across several substances of abuse. |
Analyzer - Automated Immunoassay System | ProteinSimple - Ella Next Generation ELISA system | Ella's combination of performance and workflow brings your immunoassays to the next level. In just 90 minutes you get highly reproducible validated assay data with no manual steps. The assay performance behind that data includes sub-picogram level sensitivity, 4+ logs of dynamic range and reproducibility that rivals the best laboratory automation. All in a compact package that doesn't break your budget or your lab bench. |
Contact: Susan A. Johnson
Location: The Miriam HospitalAffiliated Centers: COBRE Center for Antimicrobial Resistance and Therapeutic Discovery (CARTD)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE Center for Antimicrobial Resistance and Therapeutic Discovery (CARTD) Contact: Susan Johnson (CARTD) | Clinical Research Resources, Antimicrobial Resistance | The principal objective of Phase I COBRE application is to build a unique, multidisciplinary center to study mechanisms of antimicrobial resistance and develop therapeutic countermeasures. The long-term goal of the Center for Antimicrobial Resistance and Therapeutic Discovery (CARTD) at The Miriam Hospital is to develop new therapies for infections caused by drug-resistant pathogens. This goal will be attained through short-term objectives of developing a new generation of junior investigators. |
Contact: Chris Marshall
Location: Coro West »See on the MapAffiliated Centers: COBRE Center for Cancer Research and Development at Rhode Island Hospital, Orthopedics Institute
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE for Center for Cancer Research Development Contact: Christopher Marshall | Clinical Research Resources, Cancer | The mission of COBRE Center for Cancer Research Development at Rhode Island Hospital is to create, interpret and apply new knowledge based on original, collaborative, multidisciplinary laboratory studies of the cellular and molecular pathways leading to carcinoma. Such knowledge will be generated in an environment that fosters career development of promising junior investigators and employs cutting-edge methodology and applications to further our understanding of the cancer process. Basic knowledge gained will be used to design and implement novel diagnostic and treatment protocols to benefit the hospital's patients and the community at large. |
Contact: Jerome Sanes
Location: Brown University, 2 Stimson Avenue »See on the MapAffiliated Centers: Carney Institute for Brain Science, COBRE Center for Central Nervous System Function
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE Center for Central Nervous System Function Contact: John Davenport | Clinical Research Resources, Nervous System | Purposeful human behavior requires attention, decisions and action, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing. Behavioral and brain mechanisms of attention, including vigilance, orienting and perceptual and action selection, are key gateways into high-level function. Thus, in a general and even specific sense, attention, decision making and the ensuing actions define human mental activities. Deficits in these functions are common in both neurological and psychiatric disorders and can result in a wide range of higher-order behavioral deficits. This COBRE Center at Brown University that will investigate the mechanisms of higher-brain function, with a focus on attention, decision making and action and disorders that modify these key systems, using a combination of genetic, behavior, and systems neuroscience approaches. |
Contact: Ashok Ragavendran
Location: 80 Waterman Street Providence, RI 02912 »See on the MapAffiliated Centers: Data Science Practice
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE: Center for Computational Biology of Human Disease Contact: Tricia Werner | Clinical Research Resources, Computational | The COBRE Center for Computational Biology of Human Disease provides cmputationjal support for COBRE-funded Investigators engaged in genomics-enabled research. In the future we plan to expand these services to the broader Biomedical community with co-funding from Investigator-initiated grants. By building a collaborative Center of empirical and computational scientists, we advance new discoveries, algorithms, and genomic screening approaches with direct relevance to several human diseases. This is consistent with NIH's mission of supporting bioinformatics and computational biology to advance all areas of biomedicine. |
Contact: Kristen Fortin-Ashburne, MBA
Location: Annex W327 »See on the MapAffiliated Centers: COBRE Center for Neuromodulation (CCN)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Neuroimaging and Neuromodulation Core (NNC) | The Neuroimaging and Neuromodulation Core (NNC) facilitates the research goals of COBRE Project Leaders and pilot grant investigators, and benefits the broader neuromodulation research community by providing expert support, training, assistance, and advice to its constituents in the practical aspects of implementation, data collection, and project management related to neuroimaging and neurostimulation methods. The NCC addresses a critical need, namely, to provide Project Leaders with unique resources, skills, and support for using the best methods and practices surrounding neuroimaging and neuromodulation in clinical neuropsychiatric populations. The NNC provides key services for research projects and creates an enduring resource that offers neuromodulation researchers a series of educational seminars, hands-on workshops and customized training opportunities, high-level consultative and medical input, and use of a specialty research facility at Butler Hospital with lab space, equipment, and medical support. | |
Design and Analysis Core | Quantitative Sciences Program of the Departments of Psychiatry and Neurology at the Alpert Medical School of Brown University and the Norman Prince Neurosciences Institute. | |
IDeA COBRE Center for Neuromodulation (CCN) | Clinical Research Resources, Neuromodulation | The COBRE Center for Neuromodulation (CCN) at Butler Hospital includes multidisciplinary clinical neuromodulation research activities, all of which involve brain stimulation and readouts of circuit activity in clinical or clinically-relevant populations. We have selected projects and project leaders lending themselves to close scientific collaboration and technical links mentoring mechanisms to facilitate their growth towards independent scientific careers, and propose a platform for interchange of scientific insights and technical skills. We also include a robust pilot project award program to meet the need for a sustainable pipeline of researchers in clinical neuromodulation. The Butler COBRE Center for Neuromodulation (CCN) focuses on neuropsychiatric illness including impulsivity, post-traumatic stress disorder and obsessive-compulsive disorder, among other illnesses, by seeking to understand and test methods to change the functioning of the brain circuits underlying pathology. |
Contact: Susan F McNamara, MS, CCRP
Location: The Providence VA Medical Center »See on the MapAffiliated Centers: Ocean State Research Institute, COBRE Center for CardioPulmonary Vascular Biology
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Analyzer - Cell Metabolism | Seahorse Biosciences - XF Extracellular Flux Analyzer | XF instruments analyze mitochondrial respiration and glycolysis in live cells, generating data in just minutes. XF Technology uses solid-state sensors to simultaneously measure both oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in every well. All platforms support injection of up to 4 unique compounds per well. |
Sensing equipment - Electrical Cell Impedance Sensing (ECIS) | Applied BioPhysics, Model 100 and Model ECIS Z Theta | Measures cell impedance using altering currents across cell monolayers and measuring the change in electrical potential. Impedance is calculated using Ohm's law. |
Behavioral Phenotyping - Hypoxia Chamber | BioSpherix Rodent Hypoxia Chamber | The A-Chamber works with a large range of BioSpherix Ltd. gas controllers. These controllers continuously monitor atmospheric condition, ensuring humane conditions as well as experimental integrity for Hypoxia studies. |
Imaging System - Slide Scanner | Aperio ScanScope CS Digital Slide Scanner CS | Brightfield 5 slide scanner with two workstations with Aperio brightfield imaging analysis software. |
Imaging System - Slide Scanner | Aperio Scan Scope FL Fluorescent Digital Slide Scanner | 5 slide scanner with Indica Labs fluorescence imaging analysis software. |
Flow Cytometer - Magnetic-Activated Cell Sorter (MACS) | Miltenyi MACSQuant Analyzer 7 Flow Cytometer | The MACSQuant Analyzer is a powerful benchtop flow cytometer for highly sensitive, multiparameter cell analysis. MACSQuant Analyzers offer fully automated instrument setup via pre-set calibration and compensation programs. Automated startup, shutdown, and cleaning cycles make for hassle-free instrument housekeeping. The MACSQuantify Software provides a powerful and easy-to-use user interface for instrument control, data acquisition, and fully automated analysis. |
Evaporator | Buchi RotaVapor R215 Evaporator | Rotary evaporator for removing solvents. |
Imaging System - Echocardiograph | VisualSonics, Vevo 2100 Imaging System | A high-frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode. The Vevo 2100 Imaging System enables in vivo visualization, assessment, and measurement of anatomical structures and hemodynamic function in longitudinal imaging studies for small animal and zebrafish phenotyping. |
Channel Cycling Metabolic System | OmniTech ElectronicsModel #80 AP4RAT AccuPacer 4 Channel Rat Treadmill and #75 MS8 8 | For rodent cardiopulmonary exercise testing |
Microscope | Nikon Ni-E upright research microscope | Capture both phase, DIC, brightfield and fluorescence images at high magnification with enhanced features such as Z-stack imaging and multi-channel |
Spectrophotometer | NanoDrop | Measures the concentration of peptides, DNA and RNA, purified protein, nanoparticles, perform protein assays and optical density measurements |
Ventilator - Mechanical | SCIREQ FlexiVent | Contains a computer-controlled precision piston pump that can intersperse mechanical ventilation with a variety of volume and pressure controlled maneuvers to obtain accurate, reproducible measurement of respiratory mechanics for pulmonary research. |
Microplate Reader | Biotek Cytation 5 microplate reader | Imaging plate reader; 5 colors (brightfield, GFP, RFP, DAPI, Cy5) 4x, 10x, 20x objectives. |
Imaging system - Laser Doppler | Moor instruments, laser Doppler imaging system | Laser Doppler Imaging examines blood flow non-invasively. Used to examine blow flow in capillary beds in response to pulmonary hypertension, exercise, and/or ischemia/reperfusion. |
Contact: Megan Boudreau
Location: Kilguss Research Institute »See on the MapAffiliated Centers: Kilguss Research Institute
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE for Perinatal Biology Contact: Megan Boudreau | Clinical Research Resources, Perinatal | The scientific aims of this COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. |
Contact: Megan Boudreau
Location: Kilguss Research Institute »See on the MapAffiliated Centers: COBRE for Reproductive Health, Kilguss Research Institute
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE for Reproductive Health Contact: Megan Boudreau | Clinical Research Resources, Reproductive Health | The response to women’s reproductive health requires a broad and balanced research strategy aimed at expanding knowledge and technology in reproductive medicine. The overarching research goals of this COBRE includes the use of well-defined pre-clinical and human models to understand mechanisms mediating preeclampsia, gestational diabetes and prematurity, identification of functional predictive biomarkers, and application of contemporary computational approaches to enhance our understanding of the networks and pathways underlying these devastating pregnancy complications. |
Contact: Rachel Alberg
Location: Coro West »See on the MapAffiliated Centers: COBRE Center for Skeletal Health and Repair
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE for Skeletal Health and Repair Contact: Rachel Alberg | Clinical Research Resources, Skeletal | The COBRE for Skeletal Health and Repair at Rhode Island Hospital enables clinicians, scientists, engineers and biologists to work side-by-side on multidisciplinary research, helping to better understand cartilage and joint health mechanisms and develop strategies for the prevention and treatment of skeletal joint diseases. |
Contact: Lisa Frade
Location: Coro West »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE for Stem Cells and Aging Contact: Lisa Frade | Clinical Research Resources, Stem Cells and Aging | This COBRE supports research in the area of stem cell biology and focuses on neural and hematopoietic stem cells, their microenvironments and the impact of aging, fibrosis, and senescence on their regulation and evolution to diseases of the central nervous system and bone marrow. Promising applications for the research include regeneration and repair for the treatment of leukemia, lymphomas, various neurodegenerative disorders and different aspects of aging. |
Contact: Barbara Muhitch
Location: University of Rhode Island Feinstein Campus »See on the MapAffiliated Centers: Institute for Immunology and Informatics (iCubed)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE Immune-Based Interventions Against Infectious Diseases Contact: Barbara Muhitch | Clinical Research Resources, Infectious Disease | Infectious diseases continue to represent major causes of death and disease worldwide. Our Center of Biomedical Research Excellence (COBRE) seeks to address the challenge of new and emerging infectious diseases by advancing the development of a multidisciplinary and trans-institutional research program in infectious diseases immunology. The unifying scientific theme of this COBRE is translational research at the interface of the pathogen and host. This COBRE is a partnership between the Institute for Immunology and Informatics (iCubed) at the University of Rhode Island’s Providence campus and the Center for International Health Research (CIHR) at Rhode Island Hospital. |
Contact: Gayle Fraser
Location: Lifespan - Rhode Island HospitalAffiliated Centers: COBRE on Opioids and Overdose
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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IDeA COBRE on Opioids and Overdose | Clinical Research Resources, Opioids and Overdose | The COBRE aims to develop and sustain a vibrant interdisciplinary center of research excellence on opioids and overdose. The COBRE will support the selection, mentorship, and career development of junior investigators performing research in the area of opioids and overdose. The Center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is of critical public health importance. |
Contact: Laura Bellavia
Location: Pharmacy Building »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Rhode Island IDeA Network of Biomedical Research Excellence Contact: Laura Bellavia | Clinical Research Resources, Biomedical | RI-INBRE is based out of the University of Rhode Island and is housed at the College of Pharmacy. The statewide network objective is to support and develop talented individuals, committed to research careers in Rhode Island, and to build the biomedical research capacity of Rhode Island institutions. The eight participating research institutions are the University of Rhode Island, Brown University, Bryant University, Community College of Rhode Island, Providence College, Rhode Island College, Roger Williams University, and Salve Regina University. The research foci of the RI-INBRE are: cancer, neuroscience, and environmental health science. |
Contact: Arunasalam Navaraj, PhD
Affiliated Centers: Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Training and Technical Assistance | Service | Advise investigators with experimental design for in vivo imaging applications, provide access to instrumentation and training. Assist investigators with in vivo mouse, organ or cellular imaging, probe selection, antibody labeling, image analysis and presentation. Provide support for grant submissions. |
Contact: Pamela Poethke, RN
Location: Fain Building »See on the MapAffiliated Centers: AIDS/HIV Immunology Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Infectious Diseases Clinical Research Resources Contact: Karen Tashima | Clinical Trials Support, HIV and HCV | The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel. The unit conducts trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C. Other studies offered through our clinical trials unit include pharmaceutical studies to treat hepatitis C, prevent C. difficile infection, and test new methods of diagnosing HIV infection. |
Contact: Barbara Muhitch
Location: Shepard Building, 3rd Floor »See on the MapAffiliated Centers: Institute for Immunology and Informatics (iCubed)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Immunology and Informatics Resources | Clinical Research Resources, Immunology and Informatics | iCubed’s research focuses on creating new and safer vaccines. We also explore new methods of predicting and treating adverse immune responses. iCubed supports a wide variety of training efforts that provide opportunities to advance women and students in science which include unique technology toolkits and hands-on laboratory experiences. |
Contact: Michael Packer
Location: Institute for Molecular & Nanoscale Innovation (IMNI), Room 220, Prince Lab »See on the MapAffiliated Centers: Institute for Molecular and Nanoscale Innovation (IMNI)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Fabrication - Machine Shop | Service that provides machine shop capabilities | The Joint Engineering Physics Instrument Shop (JEPIS) is a specialized service center providing assistance in the development of experimental instruments, research projects and instructional classes. The JEPIS services are offered to faculty, students and staff on the Brown University campus, and is also available to outside academic/hospital users. JEPIS offers all of the basic machine shop capabilities, including Wire EDM and Rapid Prototype printing. JEPIS also offers CNC design consultation, hands on training and instruction through non-credit basic machine shop course and an advanced course geared toward Graduate Students. The Student Shop provides students with a strong base for their experimental studies. The JEPIS staff is available to give general advice and assistance to the Brown Students and Staff in the finding of sources for the materials and devices they require for their projects or instructional classes. Access to the facility is on a user fee basis of an hourly fee for labor plus materials. |
Contact: Anuja Mathew, Ph.D
Affiliated Centers: COBRE Immune-Based Interventions Against Infectious Diseases, Institute for Immunology and Informatics (iCubed)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Contact: Robbert Creton, PhD
Location: Room 121, Sidney Frank Hall »See on the MapAffiliated Centers: Center for Genomics and Proteomics (CGP), RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Analysis - Software | Software: Amira 2019 | Software for image analysis and 3D visualization |
Sample Preparation - Critical Point Dryer | Ladd Research Industries | Removes liquid from biological specimens for SEM |
Sample Preparation - Glow Discharge Unit | Emitech K100X | Adds a charge to make TEM samples hydrophilic |
Microscope - Multiphoton | Olympus FV-1000-MPE Multiphoton Laser Scanning Microscope | Deep optical sectioning of fluorescently labeled samples with SIM photoactivation |
Microscope - Fluorescence | Zeiss Axiovert 200M Fluorescence | Imaging of samples labeled with fluorescent indicators |
Microscope - Fluorescence | Zeiss Axiovert 200M Fluorescence | Imaging of samples labeled with fluorescent indicators |
Microscope - Confocal | Olympus FV3000 Confocal Microscope | Optical sectioning of samples labeled with fluorescent indicators. Equipped with a resonant scanner for fast optical sectioning |
Microscope - Confocal | Zeiss LSM 710 Confocal | Optical sectioning of samples labeled with fluorescent indicators |
Microscope - Fluorescence | Zeiss Lumar Stereo Fluorescence | Imaging of samples labeled with fluorescent indicators |
Microscope - Electron | Thermo Apreo VS Scanning Electron Microscope (SEM) for serial block-face imaging | Equipped for standard scanning electron microscopy as well as serial-block face imaging. The automated system is capable of imaging large z-stacks at isotropic 10x10x10 nm resolution. The series of images can be processed for 3D reconstruction of cells and tissues, with sufficient resolution to identify small vesicles, organelles and neural connections. |
Microscope - Electron | Philips 410 Transmission Electron Microscope (TEM) | Transmission electron microscopy with Advanced Microscopy Techniques (AMT) Camera Accessory |
Microtome | Reichert Ultramicrotome | Ultrathin sectioning for light microscopy and transmission electron microscopy |
Microtome Diamond Knife Set | Diatome DKS | Used on Reichert microtome to cut ultrathin sections for TEM |
Sample Preparation - Sputter Coater System | Emitech K550 | Covers an EM specimen with a thin layer of conducting material |
Training and Technical Assistance - Bioimaging | Service | Service to provide Bioimaging technical assistance and training |
Microscope - Confocal | Zeiss LSM 800 Confocal | Optical sectioning of samples labeled with fluorescent indicators |
High-Content Screening System Contact: Samantha Madnick Opera Phenix High-Content Screening System Website | PerkinElmer Opera Phenix High Content Screening System | Microscope designed for high-throughput 3D imaging of fluorescent samples in microplates. |
Microscope - Fluorescence | Nikon Ti2-E Fluorescence Microscope for high-content imaging | The Nikon Ti2-E fluorecence microscope is a high-content imaging system, based on an inverted microscope and equipped for imaging standard slides, culture dishes, and microplates (e.g. 96-well plates). The microscope includes 'Perfect Focus' for autofocus applications, a Photometrics Prime 95B sCMOS camera for imaging fluorescence, a 16 megapixel Nikon DS-Ri2 color camera for imaging histology slides, a motorized stage and NIS-Elements High Content (HC) software for multiwell plate acquisition. |
Microscope - Confocal | Zeiss LSM 880 Confocal | Optical sectioning of samples labeled with fluorescent indicators |
Microscope - Slide Scanner | Olympus VS200 | Automated slide scanner for imaging fluorescence and brightfield (e.g. H&E slides). |
Contact: Olin Liang, Ph.D.
Location: CORO West Research Building, Suite 5.17J »See on the MapAffiliated Centers: COBRE Center for Stem Cells and Aging, Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Lentivirus-mediated Stable Gene Over-expression in Cells | Service | |
Lentivirus-mediated CRISPR/Cas9 Gene Knock-out in Cells | Service | |
Site-directed Mutagenesis | Service | |
Virus Packaging | Service | |
COVID-19 Pseudovirus design and production | Service | |
COVID-19 Pseudovirus cell entry assays | Service | |
SARS-CoV-2 spike and human ACE2 constructs | Service |
Contact: Gwen Lariviere
Location: West River Center 2nd Floor, Suite 1-G »See on the MapAffiliated Centers: Lifestyle Medicine Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Lifestyle Medicine Resource Lifespan Lifestyle Medicine Center | Clinical Research Resources, Lifestyle Medicine | Lifestyle Medicine focuses on four areas: Physical activity Nutrition Substance use Stress management |
Contact: Michael Worden, PhD
Location: Sidney Frank Hall »See on the MapAffiliated Centers: Carney Institute for Brain Science
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Imaging System - Magnetic Resonance Imaging (MRI) Scanner | Siemens 3 Tesla Prisma fit | Brain structure and function in normal and clinical populations as well as studies of other body systems, non-invasive animal imaging and materials science. |
Contact: Alexander Margulis, PhD
Location: 241 Francis Avenue »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Laboratory and office space Mansfield Bio-Incubator 2020 Rates | Mansfield Bio-Incubator | Mansfield Bio-Incubator is a non-profit organization whose mission is to facilitate and assist the creation, growth, and success of the next generation of biotech companies. Our incubator assists these companies and nurtures entrepreneurial and economic development in the community by maintaining affordable lab and office space, services, training, mentoring, and a network of professional advisors. Shared and private office and lab space are available, with additional space coming online in 2021. More information on the membership rates can be found here. https://www.bioinc.org/membership-rates-2 |
Chemical Hood | Labconco Protector Premier Fume Hood | Suitable for providing personal protection needed for general chemistry applications involving fumes and vapors. |
Biological Safety Cabinet | Labconco Purifier Logic Series Biological Safety Cabinet | Provide personnel, product and environmental protection from hazardous particulates and agents that require biosafety level 1 or 2 containment. |
Incubators (2) | VWR Symphony CO2 incubator | CO2 incubators designed to maintain adequate interior moisture to prevent the drying out of cultures. |
PCR Thermal Cycler | Illumina Eco real-time PCR system | The Eco Real-Time PCR System offers life science researchers a full-featured real-time PCR system at an attractive price. Its features include: Four-color multiplexing High Resolution Melt (HRM) Fast PCR cycling: 40-cycle PCR in 40 minutes User-friendly, MIQE-compliant software. |
Mass Spectrometer | Agilent LC/MSD VL mass spectrometer | The Agilent 1100 Series LC/MSD offers you the sensitivity, selectivity, and depth of molecular information inherent in mass spectrometry—in a package that is rugged, reliable, and surprisingly easy to learn, operate, and maintain |
Plate Reader - Fuorescence | Fluoroskan Ascent | Measures sample fluorescence Excitation wavelengths 320-700 nm, emission 360-700 nm |
High Performance Liquid Chromatography (HPLC) | Agilent 1100 HPLC system | |
Freezer | NuAire -85C Ultralow Temp Freezer | Sample storage |
Freezer | Kenmore -20C Freezer | Sample storage |
Refrigerator | 4C Glass Door | Sample storage |
Luminometer | Digene DML 2000 luminometer | The DML 2000 instrument is a luminometer that automates amplified chemiluminescent signal detection and results reporting for Hybrid Capture 2 (HC2) assays, |
Contact: Dawn Outram
Location: Aquarium Building »See on the MapAffiliated Centers: RI-NSF EPSCoR , Graduate School of Oceanography
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Analyzer - Dissolved Gas | Bay Instruments Membrane Inlet Mass Spectrometer- Dissolved Gas Analyzer | Mass Spectrometer: Quantifies dissolved gases |
Analyzer - Multiparameter Water Analyzer | YSI Professional Plus Hand Held Multiparameter Water Meter | Measures temperature, salinity, dissolved oxygen (DO), and pH |
Analyzer - Nutrient | Lachat QuickChem 8500 Flow Injection Nutrient Auto Analyzer | Measures dissolved nutrients in water, Ammonia, Phosphate, Nitrite, Nitrate, and Silicate |
Aquatic Culture - Algae and Live Feed Room Contact: Ed Baker | Various manufacturers | K-walls, small rearing tanks for live feed, flowing seawater and freshwater |
Aquatic Culture - Phytoplankton Culture Wheels Contact: Ed Baker | Various manufacturers | Motorized and water driven, clear plexiglass, ambient and experimental temperature control, can accommodate culture bottles of differing sizes (1-3L) |
Aquatic System - Dechlorination System - Freshwater Contact: Ed Baker | Various manufacturers | 2 Freshwater dechlorination tanks |
Disrupter | Biospec Mini Bead Beater | Shakes tubes with beads to disrupt cells, DNA , RNA |
Disrupter | Branson Digital Ultasonic Liquid Sonifier | Disrupts cells |
Environmental Chamber Contact: Ed Baker | EnvironAir Environmental Chamber | 100 sq ft Temperature control, Two range 4-24 C, Two range -4-24 C (to simulate polar conditions), On generator back up and emergency monitoring systems. (4 Units) |
Aquatic System - Flowing Seawater System Contact: Ed Baker | Various manufacturers | Raw-Ambient temperature and Filtered- Chilled, Heated, Ambient. UV treated, air supply, emergency monitoring systems |
Fluorescence Activated Cell Sorter (FACS) | Becton Dickinson (BD) Biosciences Influx Flow Cytometer and Cell Sorter | Measures light scatter and fluorescence of cells. Sorts cells based on measured properties. |
Fluorometer | Satlantic Fluorescence Induction Relaxation Fluorometer (FIRE) | Measures variable fluorescence in phytoplankton |
Fluorometer | Turner Designs 10-AU (Chlorophyll) Field Fluorometer | Measures extracted or in vivo chlorophyll fluorescence of samples, Field-portable, can be set up for continuous-flow monitoring or discrete sample analyses |
Fluorometer | Life Technologies Qubit Fluorometer | Quantifies DNA, RNA, and protein |
Biospecimen Banking - Freezer - Walk-in Contact: Ed Baker | -20 C Walk-In Freezer | 185 sq ft Long term storage, On generator back up and emergency monitoring systems |
Homogenizer | Polytron Homogenizer PT-10-35-GT | Breaks down plant and animal tissue for analysis, and performs homogenization, dispersion, mixing, and prepares emulsions |
Cell Counter | Sizing and counting of particles suspended in liquid samples | Beckman Coulter Multisizer 4 |
Imaging System - Camera | Allied Digital Stingray Firewire Microscope Camera | Captures video and still images (C-mount) |
Analyzer - Fluid Particle Counter and Imager | Fluid Imaging Technologies FlowCam | Imaging Particle Analysis: counts and records images of particles in liquid samples |
Incubator | Percival Incubator/Growth Chamber | Temperature and light controlled incubator for environmental applications |
Microplate Reader | Molecular Devices Spectramax M5 | Measures Fluorescence Intensity, Absorbance, Time Resolved Fluorescence, Fluorescence Polarization and Luminescence in cuvettes and multiple sized microplates. |
Microscope | Nikon inverted Microscope | Microscopy: Works with Stingray Camera |
Microscope | Olympus SZX16 Stereo Microscope | Microscopy. Works with Stingray Camera |
PCR Thermal Cycler | Eppendorf Master Cycler Pro | Replicates DNA |
PCR Thermal Cycler | Stratagene QPCR Mx3000P | Analysis of gene expression, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Quantitative PCR Filters- FAM/Syber Green, Rox, Hex, CY3, CY5 |
Photoperiod controller Contact: Ed Baker | Various manufacturers | Wattstopper controller(Blount), Various individual timers |
Pier Access Contact: Ed Baker | Access to Graduate School of Oceanography pier | Access to pier for deployment, collection, testing. Water depths 18-15 feet to intertidal zone |
Radiometer | Biospherical Instruments Quantum Scalar Laboratory (QSL) Radiometer - PAR Light Meter | Measures Photosynthetically Active Radiation (PAR) |
Incubator - Shaker | Thermo Max-Q Orbital Shaker Table | Orbital shaker with 18x24 in platform and variety of clamps |
Incubator - Shaker | Thermo Max Q Incubated Shaker | Heated incubated shaker |
Spectrometer | Ocean Optics Jaz Spectrometer | Optical sensing instrumentation that measures light wavelengths. Its unique features and expandable platform makes it uniquely suited for field applications, remote sensing, process flow and quality assurance. |
Spectrophotometer | Thermo Scientific NanoDrop 1000 | Microvolume UV-Vis spectrophotometer that quantifies DNA, RNA, and protein from small 1-2 microliter sample size |
Aquatic System - Laminar Flow Tank Contact: Ed Baker | Laminar Flow Tank | 1000 gal, Seawater or Freshwater, Multiple speeds with precision control. Experimental chamber visable from 5 sides |
Aquatic System - Mesocosm Tank Contact: Ed Baker | Various manufacturers | 10, 5 ft deep outdoor mesocosms, with available raw ambient seawater flow |
Vacuum Manifold Contact: Rodrigue Spinette | Vacuum Filter Manifold | Allows for filtration of 5 ports simultaneously, 25 and 47 mm filter cups available |
Worksation - Marine General Wet Lab Contact: Ed Baker | Various manufacturers | 3 Buildings, 7,000 sq ft indoor, and nearly unlimited outdoor space, Multiple insulated tank sizes, various sized aquaria, possible to perform simultaneous replicates |
Workstation - Marine Pathology and Transgenics Laboratory and Systems Contact: Ed Baker | Various manufacturers | Ozone treated effluent and separate effluent drain |
Microscope | Nikon Eclipse Ni epifluorescence microscope | Epifluorescence and phase microscopy with digital camera system |
Gas Chromatograph - Mass Spectrometer (GC - MS) Contact: David Adelman | Agilent Technologies 7890B/5977A GC/MSD | Identifies and enumerates chemical constituents of samples |
Imaging System - Gel Imager | Fluorescence gel imaging system | Carestream Molecular Imaging Gel Logic 212 Pro |
Contact: Soumen Mallick
Location: GeoChemistry, GC040 »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Mass Spectrometer Contact: Alberto Saal | Thermo Scientific Multi-collector inductively coupled plasma mass spectrometer, ICP-MS, Neptune Plus | This is a multi-collector ICP-MS equipped with nine Faraday cups and eight ion counters, which allows us to monitor multiple masses simultaneously providing precise isotope ratio measurement. |
Mass Spectrometer Contact: Alberto Saal | Thermo Scientific Quadrupole inductively coupled plasma mass spectrometer, ICP-MS, X-series-2 | This is a single collector ICP-MS that allows us to measure precise elemental composition at sub-ppb level concentration. |
Analyzer - Laser Ablation Contact: Alberto Saal | Photon-machines Analyte G2, 193 nm excimer laser ablation | This 193 nm wave-length excimer laser allows us to perform in-situ analysis on a solid sample with a beam diameter as small as 3µm. To determine the elemental abundances the laser is coupled with the single collector inductively coupled plasma mass spectrometer ICPMS and to determine the isotope ratios the laser is coupled with multi collector ICPMS. |
Clean lab, Trace metal free Contact: Alberto Saal | Pico Trace | This Clean Lab is equipped with Millipore water filtration system that provides greater than 18MΩ Milli-Q water. The working stations in this Clean Lab meet ISO class 4 standard (equivalent to FS class 10) allowing us to perform ultra-low blank chemical analysis. |
Contact: Tun-Li Shen, PhD
Location: MacMillan Hall »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Gas Chromatograph - Mass Spectrometer (GC - MS) | Hewlett-Packard (Agilent) GCD 1800C | This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 450 Da). |
Liquid Chromatography - Mass Spectrometer (LC - MS) | Agilent 6530 Mass TOF | This system consist of Agilent 1260 infinite HPLC and Agilent 1260 infinite nanoglow LC/chipcube nanoelectrospray MS interface, and 6530 Accurate Mass Q-TOF mass spectrometer . This instrument can detect and identify compounds in amounts smaller than two trillionths of a gram (2 picograms), making the Agilent 6530 a powerful tool for food safety, toxicology and other measurements where minute amounts of compounds must be identified. |
Mass Spectrometer | JEOL JMS-600H double focusing magnetic sector | The JMS-600H is a compact double-focusing, high-resolution, magnetic sector mass spectrometer. This instrument is equipped with electron impact ionization (EI), Chemical Ionization (CI), and fast atom bombardment ionization (FAB) for characterization of synthetic organic, inorganic, and biological molecules. This instrument is also used for routine exact mass measurement of organic molecules. |
Mass Spectrometer | Thermo LXQ linear ion trap with Surveyor HPLC system | The LXQ has capabilities similar to the conventional 3D ion trap such as LCQ Deca. It is based on linear ion trap technology that has faster cycle time. It is capable of data-dependent LC/MSn analysis. |
Mass Spectrometer | Thermo LCQ Deca XP Max ion trap with Shimadzu HPLC system | The LCQ Deca XP Max is equipped with electrospray (ESI) and APCI ionization sources. It is capable of mass analysis of a broad range of molecules that are relatively polar, nonvolatile and thermally labile. This instrument is used for routine molecular weight determination of compounds from organic, inorganic, natural products, small proteins and peptides, and oligonucleotides. |
Mass Spectrometer | Bruker Autoflex Speed Linear (L) Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometer (MALDI-TOF MS). | The Bruker autoflex Speed is a linear time-of-flight (TOF) mass spectrometer equipped with a matrix-assisted laser desorption ionization (MALDI) ion source. This instrument is routinely used for analysis of organic molecules, natural products, and macromolecules, including recombinant proteins, oligonucleotides, polysaccharides and synthetic polymers. |
Gas Chromatograph - Mass Spectrometer (GC - MS) | Agilent 5977A GC/MSD System | This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 1050 Da). |
Contact: Dwight Rouse
Location: 100 Dudley Street, Providence, RI »See on the MapAffiliated Centers: Maternal-Fetal Medicine Units Network of the NICHD
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Maternal-Fetal Medicine Units Network of the NICHD Contact: Donna Allard | Clinical Trials Support, Maternal-Fetal Medicine Clinical Trials Recruitment | Maternal Fetal Medicine Units Network conducts studies of pregnancy, maternal, fetal and infant health. The NICHD Eunice Kennedy Shriver Maternal Fetal Medicine Units (MFMU) Network is a consortium of 12 premier clinical centers across the U.S. whose charge is to investigate problems in clinical obstetrics by conducting multi-institutional clinical trials and observational studies. The Network conducts large randomized clinical trials aimed at improving outcomes for pregnant women and their offspring. With 140,000 births spread among its 12 centers, the Network is able to perform trials of sufficient size to reach definitive conclusions that result in health-improving practice changes locally, nationally and internationally. The 16 associated research nurses are experienced and expert in the identification, recruitment, retention, and follow-up of eligible research patients. |
Contact: Sunil Shaw, PhD
Location: Kilguss Research Institute »See on the MapAffiliated Centers: COBRE Center for Perinatal Biology at Women and Infants Hospital
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Fluorescence Activated Cell Sorter (FACS) | Thermo Scientific Attune NXT | Analytical flow cytometer: 4 lasers, 14 colors, with 96 well plate handler capability |
Microscope - Spinning disk Contact: Sunil Shaw | Andor CSU-W1 spinning disk confocal system | The Spinning disk confocal microscope is a Nikon Ti-E (inverted) with Perfect Focus and motorized stage, with an Andor Zyla 4.2 plus SCMOS camera, an Andor CSU-W1 spinning disk with 405, 488 and 561 nm laser lines, as well as a SpectraX LED widefield light source and controlled by NIS-Elements software. This system is suitable for fast confocal imaging and live cell imaging, with low phototoxicity and long term focus stability. A stage incubator with CO2 and temperature control is available for maintenance of physiological conditions during live cell imaging. |
Fluorescence Activated Cell Sorter (FACS) | Becton Dickinson (BD) Biosciences FACSCanto | Analytical Flow Cytometer: 2 lasers, 6 colors |
Imaging System - Gel Imager | Bio-Rad Chemidoc XRS | The ChemiDoc XRS+ system is based on CCD high-resolution, high-sensitivity detection technology and modular options to accommodate a wide range of samples and support multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. The system is controlled by Image Lab software to optimize imager performance for fast, integrated, and automated image capture and analysis of various samples. |
Imaging System - Gel Imager | Bio-Rad Molecular Imager FX system | Imager with 50 micron resolution and a 5 order of magnitude linear dynamic range for fluorescence and radioisotopic imaging. You can also image and accurately quantitate chemiluminescent samples. |
Cell Sorter - Magnetic | Miltenyi AutoMACS Magnetic cell sorter | Automated cell sorter, for separating cell suspensions labeled with magnetic beads |
Microplate Reader | Molecular Devices Spectramax Gemini EM Fluorescence Microplate Reader | Enables top and bottom reading of microplates over a greater range of fluorescence intensities all without the use of filters. |
Microplate Reader | Perkin Elmer TopCount NXT Microplate Scintillation and Luminescence Counter | TopCount NXT analyzes two, six, or twelve samples at a time, and counts samples in 24-, 96-, and 384-well microplates, as well as microcentrifuge tubes. It can count gammas, betas, or luminescent samples. |
Microscope | Leica MZ FLIII Stereo Fluorescent dissection microscope | Dissection microscope with Leica color camera DC300F. |
Microscope | Nikon 80i Upright Fluorescence Microscope | Upright microscope with color CCD camera Spot Insight 2 |
Microscope | Nikon TE2000E Inverted fluorescence, | A live cell imaging microscope, with cooled CCD camera Roper CoolSnap HQ |
Microscope | Zeiss AxioImager M2 Upright Microscope, | Upright microscope with color CCD camera AxioCam MRC. |
Microscope | Nikon TE2000E Inverted fluorescence, | A Multicolor fluorescence widefield microscope, with stage incubator, specialized in live cell imaging |
PCR Thermal Cycler | Applied Biosystems ABI 7500 | 96-well quantitative PCR |
Spectrophotometer | Bio-Rad smartspec | 90-260 V, UV/visible benchtop spectrophotometer for nucleic acid and protein quantitation, wavelength range 200–800 nm, built-in thermal printer |
Spectrophotometer | Thermo Scientific NanoDrop 2000 | A full spectral microvolume UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein. |
Suspension Array System | Bio-Rad BioPlex 200 | Detection and quantification of multiple analytes (proteins and peptides, or nucleic acids) in a single sample volume. |
Cryostat | Frozen tissue sections | Thermo Shandon Cryotome E |
Microtome | Paraffin embedded tissue sections | Thermo Shandon Finesse ME |
Histology/Tissue Processing - Paraffin Embedding Workstation | Tissue processing | Thermo Shandon Histocenter 2 |
Centrifuge - Cyto | Thin layer preparation from cell suspensions | Thermo Scientific Cytospin 4 Cytocentrifuge |
Analyzer - Nanoparticle counter Contact: Sunil Shaw | Malvern Nanosight NS300 | Analysis of size distribution and concentration of nanoparticles from 10nm to 2000nm in diameter. A 532nm green laser also allows the detection of red fluorescent particles. A syringe pump allows sample analysis under constant flow, increasing reliability and reproducibility of data. |
Imaging System - Gel Imager | Bio-Rad Chemidoc MP | The ChemiDoc MP system is based on CCD high-resolution, high-sensitivity detection technology and modular options to accommodate a wide range of samples and support multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. The system is controlled by Image Lab software to optimize imager performance for fast, integrated, and automated image capture and analysis of various samples. |
Cell Counter | Nexcelom Cellometer | The Auto T4 is a PC-based instrument for one-step 4x bright field image capture and analysis. This state-of-the-art cell counter performs count, size, and Trypan Blue viability analyses that are 10x faster and more accurate than manual counting. This instrument is ideal for cell lines and purified primary cells, including MCF-7 breast cancer cells, PC3 prostate cancer cells, and 1600 other cell types, due to its advanced software that assesses clumpy cells and omits debris |
Single Cell Analysis for RNAseq | 1Cell Bio InDrop | The InDrop enables single cell encapsulation, barcoading of cDNA, preparation of a sequencing librrary, and informatics. |
Contact: Qian Chen
Location: The Coro West Building »See on the MapAffiliated Centers: COBRE Center for Skeletal Health and Repair, Orthopedics Institute
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
---|---|---|
Microplate Reader Contact: Cherie Charbonneau | Molecular Devices SpectraMax M2e plate reader | Features top and bottom read capability for absorbance, fluoresence, luminescence, and time-resolved fluorescence. |
Hybridization Oven Contact: Cherie Charbonneau | Fisher Scientific Isotemp hybridization chamber | Temperature range of +7C to 85C. Includes a rotisserie. |
Incubator - Shaker Contact: Cherie Charbonneau | Lab Companion SI-600 Incubated Shaker | Bacterial culture shaker with a temperature of ambient to +60C. |
Luminometer Contact: Cherie Charbonneau | Promega Glomax 20/20 luminometer with printer | Ultrasensitive luminescence detection in a single microcentrifuge tube (1.5ml) format. |
PCR Thermal Cycler Contact: Cherie Charbonneau | Bioer Life ECO thermal cycler | This thermal cycler has a 96 well format with a 2C/sec ramp rate. |
PCR Thermal Cycler Contact: Cherie Charbonneau | Applied Biosystems ProFlex thermal cycler | This thermal cycler has a 3x32 well format that allows for 3 separate programs to be run. The ramp rate is 6C/sec. |
PCR Thermal Cycler Contact: Cherie Charbonneau | Applied Biosystems Veriti thermal cycler | This thermal cycler has a 96 well format with 3.9C/sec ramp rate. |
Imaging System Contact: Cherie Charbonneau | LI-COR Odyssey Classic Infared Imaging system | This near-infared fluorescent detector can be used for quantitative western blots, gel shift assays, coomassie stains, tissue section and small animal imaging. |
Imaging System - Gel Imager Contact: Cherie Charbonneau | UVP GelCam 310 Bioimaging digital gel documentation system | High resolution 2.0 GelCam 310 CCD with manual zoom lens for fluorscent and colorimetric gel imaging. EtBr filter included. |
PCR Thermal Cycler Contact: Cherie Charbonneau | MJ Opticon 2 real-time PCR system. | This 96-well system accepts low-profile tubes or plates. There are two fluorophore channels with emission spectra in the 523-543 nm range and 540-700nm. |
Incubator Contact: Cherie Charbonneau | (4) NuAire IR water-jacketed CO2 incubators (NU-8500) | This incubator provides an optimal in-vitro growth environment for both cell and tissue culture while minimizing dessication through a closed loop HEPA filtration system. |
Biological Safety Cabinet Contact: Cherie Charbonneau | (4) NuAire Bio Safety Cabinets (Class II, Type A/B3) | These biological safety cabinets reduce exposure to airborne biological or particulate chemical agents in low to moderate risk-hazard research and/or drug preparations. |
Centrifuge Contact: Cherie Charbonneau | Sorvall Legend X1R centrifuge | Process samples for diverse laboratory applications with rotors for 1.5ml eppendorf tubes, 15, and 50ml conical tubes. Refrigerated with a max speed of 152000 rpm. |
Autoclave Contact: Cherie Charbonneau | Amerex HVE-50 top loading autoclave sterilizer | This is a 50L, self-contained, portable, top-loading autoclave with auto-exhaust and warming cycles. |
Microscope Contact: Cherie Charbonneau | Nikon Eclipse TS-100F Inverted Microscope | This phase contrast microscope used for tissue culture is also equipped with FITC and TRITC filters to capture fluorescent images in SPOT imaging software. |
Microscope Contact: Cherie Charbonneau | Nikon Eclipse 90i Upright Research Microscope | This microscope is equipped with two cameras (color and monochromatic) and is ideal for brightfield and/or epi-fluorescent images of whole tissues etc with 4x, 10x, 20x and 40x dry objectives. The filter cubes available are DAPI, FITC, and TRITC. |
Fluorescence Activated Cell Sorter (FACS) Contact: Cherie Charbonneau | Becton Dickinson - Accuri Flow Cytometer | This system is equipped with a blue and red laser, two light scatter detectors, and fluorescence detectors with optical filters optimized for FITC, PE, PerCP, and APC. The user does not need to adjust detector voltages and there is a wide dynamic range of digitally collected data (7.2 decades). |
Bioanalyzer Contact: Cherie Charbonneau | Invitrogen Luminex 200 with xMap technology | This is a versatile, efficient standard in multiplexing with the ability to use magnetic or polystyrene beads on up to 100 targets/sample. |
pH Meter Contact: Cherie Charbonneau | Orion pH meter 920 | pH range of -2 to 19.99 and oxygen range of -2 to 19.99ppm. Autocalibration buffers of 4.01, 7, and 10.01. |
pH meter Contact: Cherie Charbonneau | Hanna Instruments 2209 | This pH meter features manual pH calibration and temperature compensation. |
Microtome Contact: Cherie Charbonneau | Thermo Scientific Shandon Finesse 325 manual microtome | With a lightly balanced flywheel it is ideal for routine paraffin sectioning. |
Sample Preparation - Cutter Contact: Cherie Charbonneau | Buehler-Isomet Cutter | The IsoMet Low Speed Cutter is a precision sectioning saw designed for cutting various types of materials with minimal deformation. Its low kerf loss capability and great versatility in holding all types of sample shapes and configurations, gives today's laboratory a precision sectioning tool capable of cutting viturally any material including brittle or ductile metals, composites, cements, laminates, plastics, electronic devices and biomaterials. The Cutter is equipped with a diamond studded carborundum wheel and Buehler Ecomet 4 grinder/polisher with Automet 2 powerhead. |
Imaging System Contact: Cherie Charbonneau | PerkinElmer FMT 4000 Fluorescence Tomography System. | The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. The system comes with four excitation laser channels (635, 680, 750, and 790 nm) and is useful for a range of applications including oncology, inflammation, and cardiovascular disease. It is ideal for researchers who are well-versed in 3D fluorescence tomography and require the widest range of in vivo applications and imaging agents. |
Imaging System Contact: Cherie Charbonneau | Faxitorn Pre-clinical imaging system | Ultra-high resolution x-ray imaging is an important tool in investigating�a variety of disease states. From metastatic cancer to arthritis and�osteoporosis, small animal models are commonly used. Both in vivo and�ex vivo planar imaging is used to screen, track, and evaluate structural�changes in these studies. Cabinet x-ray systems allow researchers to�take images directly in the vivarium to protect the integrity of the colony. �These planar imaging systems are less expensive, subject animals to�lower doses, and provide faster results than microCT systems. |
Incubator Contact: Cherie Charbonneau | GQF 1502 Sportsman egg incubator | This is a complete incubator and hatching system with 3 automatically turned racks. It has an accurate digital thermostat with LCD of humidity and temperature. |
Homogenizer Contact: Cherie Charbonneau | Fisher Scientific, Powergen 125 Tissue Homogenizer | Process volumes from 0.03 to 100mL. Variable speed control to 30,000rpm for efficient cell disruption. Disposable plastic generators eliminate sample cross-contamination. Flat-bottom stainless-steel generators process liquid or soft tissues. |
Microscope Contact: Cherie Charbonneau | Olympus SZ61 Zoom Stereomicroscope | Greenough design with two optical paths inclined at an inward angle. Magnification range 0.67X to 4.5X; zoom ratio 6.7:1; FN 22. Working distance of 100mm; observation tube angle 45 degrees; right and left eyepiece tubes interlocked; interpupillary distance adjustment 50-76mm; forward positioned zoom adjustment knobs with zoom magnification graduations. With 0.5x cmount for documentation. |
Chemical Hood Contact: Cherie Charbonneau | Thermo Scientific Hamilton SafeAire II | Chemical hood and ultra-high vacuum system for organic synthesis |
Evaporator Contact: Cherie Charbonneau | Buchi R-124 Rotavapor | Rotary evaporator comes complete with a 45 degree water condenser and a 1L condensing and evaporating flask. |
Sample Preparation - Circulator Contact: Cherie Charbonneau | VWR Recirculating Chiller, Model 1160A | Stable cooling for many common heat removal applications such as rotary evaporators and vacuum systems (-10 to 40C). |
High Performance Liquid Chromatography (HPLC) Contact: Cherie Charbonneau | Agilent Technologies, 1260 Infinity HPLC system | A maximum pressure of 600 bar to utilize smaller particle size columns for higher resolution and faster separations. |
Disrupter Contact: Cherie Charbonneau | Qsonica 700W sonicator with 5.5" cup horn | This sonicator has full amplitude control from 1-100%. |
Imaging System Contact: Cherie Charbonneau | Xtreme back illuminated 4MP with x-ray for small animal imaging | High sensitivity luminescence, fluorescence, radioisotopic, and radiographic imaging for up to 5 mice at a time. Isofluarne and temperature controlled chamber for the mice. |
PCR Thermal Cycler - Digital Contact: Cherie Charbonneau | RainDrop Digital PCR by RainDance | The RainDrop is composed of a Source instrument that can generate 10million droplets/sample and the Sense instrument, which can detect whether the PCR reactions are positive or negative for your fluorophore. Multiplexing is possible for the 8 samples that are run at a time on the microfluidics chip. |
PCR Thermal Cycler Contact: Cherie Charbonneau | BioRad CFX96 Real-Time PCR system | This real-time PCR instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format. |
Spectrophotometer Contact: Cherie Charbonneau | Thermo Scientific NanoDrop 2000c | This is a full spectrum, UV-Vis spectrophotometer used to quantify and assess the purity of DNA, RNA, protein, and more at sample volumes as low as 0.5ul. |
Bioreactor Contact: Cherie Charbonneau | Flexcell FX5000 Tension System | This is a computer-regulated bioreactor that uses vacuum pressure to apply either cyclic or static strain to cells cultured on flexible-bottomed culture plates. |
Sample Preparation - Freeze Dry System Contact: Cherie Charbonneau | Labconco FreeZone Plus 2.5L Cascade Benchtop Lyophilizer | This system is for light sample loads with low eutectic points. It can remove up to 1.8L of water in 24hrs and holds 2.5L of ice before defrosting is required. |
Contact: Giovanni Carderon
Location: Laboratories for Molecular Medicine, Room 539 »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Histology/Tissue Processing - Tissue Sample Processing and Embedding | Service | Paraffin Processing and Embedding- automated and manual, Plastic Processing and Embedding, TEM and SEM Processing and Embedding, Frozen Tissue-Embedding in OCT Block, Sample Preparation for Serial Blockface Imaging |
Histology/Tissue Processing - Sectioning | Service | Paraffin sectioning, plastic sectioning, Frozen/Cryostat prep and sectioning, TEM ultrathin sectioning, Vibratome, Serial and Step sectioning |
Paraffin Embedding Workstation | Leica EG1150C Paraffin Embedding Center | Paraffin embedding |
Microtome | Leica RM2265 Automated Microtome | Paraffin and plastic sectioning |
Cryostat | Leica CM3050S Cryostat | Sectioning of fixed and unfixed frozen samples |
Vibratome | Leica VT 1000S Vibratome | Sectioning of fixed samples |
Biospecimen Banking - Freezer | Revco -80 degree C Freezer | Temporary Sample storage |
Microscope | Nikon Eclipse 50i light microscope | Collaborative analyses of histological slides and digital imaging capability |
Histology/Tissue Processing - Staining | Service | Hematoxylin and Eosin (H&E), Periodic Acid Schiff (PAS), Masson's Trichrome, Special Stains |
Histology/Tissue Processing - Immunolabelling | Service | Immunohistochemistry, Immunocytochemistry, Immunofluoresence, Immunogold, TUNEL Assay |
Contact: Jinping Luo, PhD
Location: Laboratories for Molecular Medicine »See on the MapAffiliated Centers: COBRE Center for Signaling Networks at Brown University, Center for Genomics and Proteomics (CGP)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Biological Safety Cabinet | NuAire Safety Cabinets Class 2 Type A/B3 | Transgenics and gene targeting safety cabinets (2 units) |
Centrifuge | Thermo IEC Centra CL3R Refrigerated Centrifuge | Transgenics and gene targeting refrigerated centrifuge |
Electroporation System | Bio-Rad Gene Pulsar II | Transgenics and gene targeting electroporation system |
Biospecimen Banking - Freezer | Custom BioGenic Systems Liquid Nitrogen (LN2) Freezer | Transgenics and gene targeting liquid nitrogen freezer |
Biospecimen Banking - Freezer | Thermo Fisher Scientific -80 C | Transgenics and gene targeting -80 C freezer |
Biospecimen Banking - Freezer | Frigidaire -20 C Freezer | Transgenics and gene targeting freezer |
Transgenics and Gene Targeting - ES Cell Gene Targeting System | Service | Gene targeting services through transfection and microinjection of murine embryonic stem (ES) cells to produce germline knockout (KO) or knockin (KI) mice. |
Incubator | NuAire CO2 water jacketed Incubators | Transgenics and gene targeting incubators (3 units) |
Cell Manipulator - Microinjection system | Eppendorf FemtoJet Microinjection System | Transgenics and gene targeting pronuclear injection system |
Micromanipulator | Eppendorf Transferman NK 2 Micromanipulators | Transgenics and gene targeting micromanipulators (2 units) |
Microscope | Nikon Eclipse TE200 Inverted Microscope | Transgenics and gene targeting microinjection microscope |
Microscope | Nikon Eclipse TS100 (cell culture scope) | Transgenics and gene targeting cell culture scope |
Microscope | Nikon SMZ1500 Zoom Stereomicroscopes | Transgenics and gene targeting dissecting microscopes (2 units) |
Microscope | Nikon SMZ800 Zoom Stereomicroscopes | Transgenics and gene targeting surgical microscope |
Transgenics and Gene Targeting - CRISPR/Cas9 Design and Reagent Preparation | Service | Service to provide consultation, design a CRISPR model, synthesize sgRNAs and prepare microinjection mix |
Transgenics and Gene Targeting - CRISPR/Cas9 Donor Construction/Preparation | Service | Service to construct a donor DNA for a CRISPR model.Knock-In (KI, >80bp), Knock-Out (KO), Conditional Knock-Out (cKO - two steps), Point Mutation (PM) |
Transgenics and Gene Targeting - Transgenesis by Random Integrations | Service | Service to provide custom services related to microinjection, ES cell culture, mouse surgery, or mouse reproduction. The core facility will provide services and/or training related to our capabilities that are not specifically covered by our service list. These services are available for an hourly fee. Examples include: production of MEFs (murine embryonic fibroblasts), polar body biopsy, reproductive surgery, blastomere injection, frozen embryo shipment, training |
Transgenics and Gene Targeting - Mouse Line Recovery from Cryopreservation | Service | Service to thaw and implant previously cryopreserved mouse embryos From frozen embryos or frozen sperm. |
Transgenics and Gene Targeting - Cryopreserved Mouse Embryo Storage | Service | Service to store cryopreserved mouse embryos in liquid nitrogen (LN2) |
Transgenics and Gene Targeting - Derivation of Mouse Embryonic Stem (ES) cell lines | Service | Service to produce embryonic stem (ES) cells from an existing mouse line key words: murine embryonic stem cells |
Transgenics and Gene Targeting - Chimeric Mouse Production | Service | Service to produce chimeric mice for analysis through microinjection of murine embryonic stem (ES) cells into blastocyst stage embryos. |
Transgenics and Gene Targeting - Mouse Colony Expansion | Service | Service to use superovulation and surgical implantation to produce large cohorts of age matched mice for experimentation or to quickly expand a mouse colony |
Transgenics and Gene Targeting - Mouse Embryo Cryopreservation | Service | Service to cryopreserve valuable mouse lines for storage or shipment to other investigators. Heterozygous embryos or Homozygous embryos |
Transgenics and Gene Targeting - Mouse In vitro Fertilization (IVF) | Service | Service to perform in vitro fertilization of mouse embryos using fresh or frozen sperm. |
Transgenics and Gene Targeting - Rederivation of Mouse Lines | Service | Service to rederive mouse lines obtained from a source other than a Brown University approved vendor. Rederived mouse lines may be housed in any campus mouse facility. |
Transgenics and Gene Targeting - Embryo Microinjection/Electroporation | Service | Service to perform pronuclear microinjection of 0.5 dpc mouse embryos to produce transgenic or CRISPR founders on an FVB/N or C57/BL6 background. Custom backgrounds also available. |
Transgenics and Gene Targeting - CRISPR/Cas9 Genotyping | Service | Service to genotype founders and G1 progeny from a CRISPR project |
Transgenics and Gene Targeting - CRISPR/Cas9 Germline Transmission | Service | Service to subclone and sequence a PCR amplicon from founders of a CRISPR project |
Transgenics and Gene Targeting - Germline Transmission | Service | Service to breed chimera from mouse ES cell injection or founders from a CRISPR project with WT mice for germline transmission |
Transgenics and Gene Targeting - Sperm Cryopreservation | Service | Service to cryopreserve sperm from males provided by investigators |
Biospecimen Banking - Freezer | SP Scientific, Bio-cool IV40A | Embryo cryopreservation at a controlled slow rate |
Microinjection system | Prime Tech, Piezo Drive PMM4G | Intracytoplasmic sperm injection |
Contact: Michael Jibitsky
Location: Room 010, Engineering Research Center Building »See on the MapAffiliated Centers: Institute for Molecular and Nanoscale Innovation (IMNI)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Deposition System - Thin Film Deposition | Angstrom - Multi-Target Sputtering System | This system accommodates four 3-inch sputtering sources and a variety of PVD processes (RF and DC). The temperature of the substrate can be increased up to 800˚C. |
Chemical Hood | Wet chemistry workbenches equipped with fume hoods for lithography | The Microelectronics Facility has a number of wet chemistry workbenches equipped with fume hoods for chemical processing (cleaning, wet etching, electroplating, anodization, etc) employed in the fabrication of semiconductor and nanomaterials devices. These hoods also house spinners for applying photoresist for lithography and other polymers. |
Lithography - Mask Aligner | Karl Suss MJB3 UV300 Mask Aligner for Lithography | The Karl Suss MJB3 UV300 3-inch mask aligner is designed for high-resolution photolithography, with a 350 W mercury lamp and Suss diffraction-reducing exposure optics. The primary exposure wavelengths of 365 or 403 nm lead to roughly 1 µm minimum feature size. For smaller feature sizes, electron-beam lithography is available in the Electron Microscope Facility. |
Lithography - Maskless Aligner | Heidleberg MLA 150 Maskless Aligner | MLA150 Maskless Aligner is a high-speed, direct-write, optical lithography system to fabricate nano- and micro-patterned materials and surfaces at low-cost and over large areas. The instrument comprises two laser illumination modules, optical systems to steer the laser beams and control exposure, integrated cameras for high-accuracy alignment to pre-existing structures, automated translation stage, real-time pneumatic autofocus, and a class 10 climate controlled chamber to achieve photo-lithographically defined structures with feature size ≤1μm. |
Lithography - Flexible Mylar-Mask | Newport-Oriel flexible Mylar-Mask Lithography System | Newport-Oriel flexible Mylar-Mask Lithography System is designed for printing from flexible Mylar masks onto substrates as large as 4” x 4” square or 5” diameter. It is capable of printing 5-micron features with placement and alignment to approximately 2 microns with appropriate alignment marks. |
Evaporator - Thin Film Deposition | Electron Beam Evaporator | This system deposits thin films of inorganic materials, usually metals, from a four-pocket electron-beam source inside a high vacuum (cryopumped) chamber. Deposition rates of up to 0.1 micron/minute are possible for some materials. This system can easily accomodate relatively large, 3-D objects and has substrate heating to 300 C for flat substrates. Restrictions on what materials may be evaporated are somewhat less stringent than for our other evaporators. |
Lithography - Imprinter | NIL Technology Nano Imprinter | The Nano Imprinter system offers thermal and UV nanoimprint and imprinting in vacuum if needed. The system transfers the patterns, usually nanohole or nanopillar arrays, from a silicon stamp to a nanoimprint-polymer-coated substrate by applying heat and pressure. |
Evaporator - Thin Film Deposition | Angstrom Organic Evaporator | The Angstrom Resitive-heated Evaporator is a thermal evaporator coupled with a nitrogen glove box. It is for depositing thin organic and inorganic films when either the deposition material or the substrate is adversely affected by moisture or oxygen. Samples and/or evaporants are loaded from a nitrogen glove box maintained at under 10 ppm of oxygen and under 1 ppm of water vapor. |
Deposition System - Thin Film Deposition | Cambridge NanoTech Atomic Layer Deposition System | The Cambridge NanoTech Fiji F200 series Atomic Layer Deposition System is a modular medium to high-vacuum ALD system that accommodates a wide range of deposition modes. This tool is currently configured with precursors for metallic and oxide layers of Hafnium, Aluminum, and Tungsten. |
Deposition System - Thin Film Deposition | Plasmatherm Model 790, Fluorine Chemistry Reactive Ion Etching Plasma Enhanced Chemical Vapor Deposition System (RIE PECVD) | The PlasmaTherm Model 790 RIE-PECVD system has a computer-controlled single-wafer turbopumped chamber that provides reactive ion etching (RIE) and plasma-enhanced chemical vapor deposition (PECVD) capabilities. RIE is accomplished using fluorine-chemistry gases (CF4, CBrF3, CHF3, SF6, etc.) with up to 500 W RF power. PECVD capability provides low-temperature (up to 350 C) SiO2 and Si3N4 deposition from silane chemistry. |
Profilometer - Characterization | DekTak3 Profilometer | The DekTak3 is a computer-controlled surface profile measuring system, which accurately measures step heights from below 50 A to over 50 µm by moving a diamond-tipped stylus over the surface. Equipped with video camera and surface profile analysis software. |
Furnace | Annealing and Drive-in Heat Treatment | Two quartz tube furnaces with flexible oxidizing or reducing (forming gas) environments at temperatures from 700˚C to 1100˚C. One is available for general purpose annealing and the other is reserved for silicon device processing. |
Furnace | Dopant | Furnaces for doping Si wafers (up to 2 inch) n or p type using phosphorus (from POCl3) or boron (from BBr3) at high temperatures. |
Deposition System - Thin Film Deposition | Lesker Lab 18 thin film deposition system | The Lab-18 thin film deposition system is a combined electron-beam evaporator and RF sputtering Physical Vapor Deposition (PVD) system that makes high quality, research-grade metallic, semiconducting, and dielectric thin films. The Lab 18 includes a four-pocket electron beam evaporator as well as two 2” magnetron sputter sources. Two mass flow regulated gas lines provide for control of chamber pressure and gas composition for reactive sputtering. |
Plasma Etching System | Inductively Coupled Plasma RIE System | The SPTS LPX is an inductively-coupled plasma (ICP) reactive-ion etcher (RIE). It can etch high-aspect ratio structures in a wide range of materials, including silicon, silicon dioxide, and silicon nitride. This system is configured with a range of gases for reactive- and physical-ion etching, including SF6, C4F8, CF4, O2, and Ar. The LPX-ICP system is equipped with a single-wafer load-lock transfer arm for 100mm wafers; smaller wafers and small pieces may be processed on the system using a carrier wafer. |
Characterization - Thin Film Deposition | JA Woollam, M-2000 Ellipsometer Variable Angle Research Grade | The JA Woollam, M-2000 Variable Angle Research Grade ellipsometer measures angle- and wavelength-dependent reflectivity and transmissivity data over a wide spectral range (from ultraviolet to near-infrared) that is analyzed to directly to determine optical properties of single- and multi-layer films (e.g., their thickness and complex wavelength-dependent refractive index), which provide insight into their underlying chemical, electronic, and mechanical properties. |
Furnace | Wet and Dry Oxididation | Quartz tube furnace for thermal oxide growth on silicon by a chemical reaction between the silicon and either dry oxygen or water vapor at atmospheric pressure. The typical temperature range for the oxidation of silicon for wafer fabrication 750˚C to 1100˚C. The tubes accommodate multiple 2 inch wafers. |
Furnace | Low-pressure Chemical Vapor Deposition (LPCVD) for Thin Film Deposition | A furnace used to deposit SiO2, Si3N4 or poly-silicon films onto multiple wafers (up to 2 inch). The deposition is accomplished at 750o C from silane, ammonia, and dichlorosilane at reduced pressure. The dielectric films are of higher quality than those produced by low-temperature PECVD, at the cost of a higher thermal budget. |
Contact: Hector Garces
Location: Institute for Molecular & Nanoscale Innovation (IMNI), Room 104, Prince Lab »See on the MapAffiliated Centers: Institute for Molecular and Nanoscale Innovation (IMNI)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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X-Ray Diffraction System, 2 Dimensional | Bruker, D8, XPS | This Bruker D8 Discover X-ray Diffraction System can be configured with a point and line source x-rays. A Vantec 500 2D area detector or a LinxEye (0D, 1D)detector can be used for the analysis. The system is suitable for texture, stress, and micro-x-ray diffraction as well as for orientation and epitaxy studies. The instrument has in-situ capabilities for studies at low/high temperature and under vacuum to study properties as a function of time, temperature, gas environment or vacuum. A capillary spinner stage is also available for investigations of air sensible materials with the sample prepared in a capillary glass. |
X-Ray Diffration System, High-Resolution | Bruker, D8, XPS | This Bruker D8 Discover X-ray Diffraction System includes a line source configuration system with a LinxEye (0D, 1D) detector and a Scintillator detector. The system is suitable to determine thickness, crystallographic structure and strain in epitaxially thin films as well as high resolution analysis of bulk materials. X-ray reflectometry (XRR), high resolution XRD, grazing incidence diffraction (GI-XRD), in-plane GID (IGID) and reciprocal space mapping (RSM) are some techniques that can be performed with this configuration. High resolution is obtained using parallel beam optics: Goebel mirror, monochromators, soller slits and analyzer crystals. |
Microscope - Atomic Force | Asylum, MFP-3D, AFM | The Asylum MFP-3D Origin atomic force microscope (AFM) is a multi-mode instrument. It is equipped with a closed loop operation in all three axes with high precision, resolution and low noise operation. The closed loop Z scanner eliminates hysteresis. The AFM provides a 90 µm X and Y range (< 0.5nm noise) and 15 µm Z range (Z sensor, 0.25 nm noise) and detector noise <15 pm. It also includes Inverted optical lever design that eliminates interference artifacts and a low-coherence infrared (860 nm) super-luminescent diode (SLD) light source (class 1M). Applications include dual AC resonance tracking (DART), electric force microscopy (EFM), force mapping mode, lateral force microscopy (LFM), magnetic force microscopy (MFM), kelvin probe force microscopy (KPFM), piezo-response force microscopy (PFM), and conductive AFM (C-AFM) with ORCA. |
Microscope - Confocal Raman | Witec, Alpha 300 M+, CRM | The Witec Alpha 300 Confocal Raman Microscope is equipt with different scan modes for local Raman spectra, mapping distribution of phases within a sample and with 3D image generation and depth profile of samples. The depth profiling and 3D imaging capabilities of the Alpha 300 provide the ability to analyze the interior of transparent samples without microtome sectioning or freeze etching. Multi-wavelength coupler for selection of 532 nm or 633 nm wavelength laser sources and a Ray Shield coupler for measurements of Raman spectra at low wave numbers. Fast Raman imaging with integration time in the milliseconds order per spectrum. A heating stage for in-situ measurements in the temperature range 25°C to 1400°C with a thermal stability of ± 0.3°C. |
Spectrometer - Electron Paramagnetic Resonance (EPR) | Bruker, EMX+, EPR | The Bruker EMX Electron Paramagnetic Resonance (EPR) Spectrometer is equipt for the Technique for the direct detection of paramagnetic species. The EMX EPR has a digital resolution of 24 bit center field, a field sweep up to 256,000 points, high-sensitivity resonator with irradiation window, dual channel, simultaneous detection of 1st and 2nd harmonic, and sensitivity S/N up to 2000:1. The system has a helium temperature control system for low temperature measurements in the temperature range 3.8 K (~-269 °C) to 300 K (~27°C). Applications span a wide range of areas an include kinetics of radical reactions, oxidation and reduction process, polymerization reactions, degradation of compounds by light, organometallic compounds and catalysis, free radicals, and antioxidants and radical scavengers. |
Contact: Abbot Laptook
Location: Neonatal Intensive Care Unit »See on the MapAffiliated Centers: Neonatal Research Network
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Neonatal Research Network of the NICHD | Clinical Trials Support, Neonatal Research | The NICHD Neonatal Research Network (NRN) was established to undertake multicenter clinical studies to investigate the safety and efficacy of treatment and management strategies to improve the outcome of sick newborns. By providing large populations through a network of centers using common protocols, questions could be answered more rapidly than by individual centers acting alone. The NRN structure promotes randomized controlled trials with short (during the hospitalization) and/or long term (neurodevelopmental) outcome. The NRN at Women and Infants Hospital studies evidence-based practice in neonatology through collaborative research performed in academic perinatal centers. The Center has played a leadership role in studies such as hypothermia for perinatal hypoxic ischemic encephalopathy, a high-impact report in the New England Journal of Medicine which has changed care nationally. The Center has played a leadership role in studies such as hypothermia for perinatal hypoxic ischemic encephalopathy. Follow up programs exist in participating Centers to evaluate the long term neuro-developmental outcome of extremely low birth weight infants. |
Contact: Russell Hopson, PhD
Location: MacMillan Hall »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Nuclear Magnetic Resonance (NMR) Spectrometer | Bruker 300 Avance | z-BBI probe, (least sensitivte 1H and indirect detection to all broadband nuclei) |
Nuclear Magnetic Resonance (NMR) Spectrometer | Bruker 600 Avance III HD Ascend | z-BBFO probe for all nuclei (most sensitive for all nuclei) |
Nuclear Magnetic Resonance (NMR) Spectrometer | Bruker 400 Avance III Ultra-Shield | z-BBFO probe (2nd most sensitive for 1H and broadband nuclei) - (HR-MAS probe) |
Nuclear Magnetic Resonance (NMR) Spectrometer | Bruker 400 Avance Ultra-Shield | z-BBO (3rd best sensitivity for broadband nuclei) |
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Cellular and Molecular Neuroscience Core Resources Contact: Suzanne De La Monte Cellular and Molecular Neuroscience Core Resources Website | Clinical Research Resources, Neuroscience | Core laboratory resources are available to Norman Prince Neurological Institute and Brown Institute of Brain Science clinical and translational research scientists. |
Hospital-Imaging Research and Education Service (HI-RES) Contact: Daniel Dickstein, MD HI-RES Website | Clinical Research Resources, Imaging | HI-RES has two image analysis and education centers, one at Rhode Island Hospital and the other at Butler Hospital. The Rhode Island Hospital site features advanced computing for image analysis, an image processing server, conference room and three offices. The Butler Hospital site consists of two room that house eight computers equipped for image analysis. HI-RES also utilizes Brown University’s high performance computing center (HPC). |
Quantitative Sciences Program Contact: Rich Jones Quantitative Sciences Website | Clinical Research Resources, Quantitative Sciences | The quantitative sciences program (QSP) provides training in the form of formal workshops, seminars and individual mentoring in the areas of quantitative methodology, including research and experimental design, survey and sampling methods, basic and advanced multivariate data analysis. |
Contact: Mitchell Levy
Location: 1 Virginia Avenue, Suite 105, Providence, RI 02905 »See on the MapAffiliated Centers: Ocean State Clinical Coordinating Center (OSCCC)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Ocean State Clinical Coordinating Center Contact: Jacqueline Robinson | Clinical Trials Support, Critical Care and Sepsis Research | Our expertise is in clinical trial designs investigating novel agents for treatment of sepsis. Our physicians have extensive backgrounds in pulmonary, critical care medicine and infectious diseases. The Ocean State Clinical Coordinating Center (OSCCC) staff can collaborate with a sponsor on protocol design with an eye to its practical application. Services include protocol design assistance, patient enrollment/site selection, site education and study start-up, subject adjudication, consulting. |
Contact: Xiaobing Tian, PhD
Affiliated Centers: Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Training and Technical Assistance | Service | Assist investigators with experimental plans for drug synthesis for lead optimization. Facilitate organic synthesis efforts through interactions with the Department of Chemistry, Industry or other collaborations. Provide support for grant submissions. |
Contact: Lanlan Zhou, MD, PhD
Affiliated Centers: Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Training and Technical Assistance | Service | Advise and assist investigators with the production of organoids to facilitate cancer biology, drug efficacy and toxicity evaluation of therapeutics towards tumor versus normal organoids that express different cancer gene mutants. Provide support for the growth and maintenance of organoid and spheroid cultures including passaging. Maintain a collection of established organoids that can be provided to investigators for research. Develop gene knockout and overexpression matched patient-derived organoids. Assist investigators with planning of drug screens working with the drug discovery capability. Provide support for grant submissions. |
Contact: Roy Aaron
Location: Coro West »See on the MapAffiliated Centers: Orthopaedic Surgery Research Laboratories
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Orthopaedic Surgery Research Laboratories | Clinical Research Resources, Orthopaedics | The Orthopaedic Research Labs at Rhode Island Hospital exist to expand the basic science of orthopaedics, improve understanding of orthopaedic diseases, and evaluate new methods of treatment for orthopaedic injuries and illnesses. Research projects are generated from the interests of the research staff, orthopaedic physicians, and residents. Research topics range from collagen breakdown products to joint kinematics to new biomimetic surfaces for implants. Research resources include bioengineering, skeletal biology, nanotechnology, oncology, trauma, cartilage, spine, and anatomy and arthroskills facilities. |
Contact: Charles Toth
Location: Albertus Magnus Hall »See on the MapAffiliated Centers: RI-NSF EPSCoR , RI-INBRE
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Environmental Chamber Contact: Maia Bailey | Percival Scientific | 1 unit |
Environmental Chamber Contact: Maia Bailey | Percival Scientific, AR-22L Growth Chamber | For Arabidopsis |
Imaging System - Camera Contact: Pat Ewanchuk | Fastec HiSpec1, Low-Light High-Speed Camera | Innovative Low-Light High-Speed Camera. Monochrome with 2GB Memory, C-Mount, includes ImageBLITZ Auto Trigger, Burst Trigger Mode, Multi- Sequence Record Mode (1280 x 1024 at 506fps) 2 Units |
Microscope - Electron Contact: Joe DeGiorgis | Philips EM-300 Transmission Electron Microscope (TEM) | Transmission electron microscopy |
Sample Preparation - Laboratory - Prep Lab Contact: Joe DeGiorgis | Electron Microscopy Prep Lab | Laboratory space for preparing samples for electron microscopy |
Microscope - Electron Contact: Joe DeGiorgis | Amray-1000 Scanning Electron Microscope (SEM) | Scanning Electron Microscope equipped with EDEX for elemental analysis and a digital imaging system, a Zeiss Axiophot equipped for bright field, dark field, DIC and fluorescence microscopy with a digital imaging system |
Microtome Contact: Joe DeGiorgis | Porter-Blum MT-2B Ultramicrotome | Porter-Blum MT-2B UltraMicrotomes, 2 Units |
Aquatic System Contact: Pat Ewanchuk | Aquatic Habitats Glass Tank System and Life Support Controller | Glass tank system and life support controller with low water level protection (18-10 gallon tanks) |
Imaging System - Visualization- Camera lucida Contact: James Waters | Leica Drawing tube | Drawing tube, for MZ and M-series, the object and the drawing surface are visible at the same time, suitable for drawing for left and right handed persons, work is possible in the daylight. Documents and scales can be mirrored-in and photographed along with the object. |
Analyzer - Respiratory physiology Contact: James Waters | LI-COR Biosciences - Li-7000 CO2/H2O | The LI-7000 is a high performance, dual cell, differential gas analyzer. It uses a dichroic beam splitter and two separate detectors to measure infrared absorption by CO2 and H2O in the same gas stream. The LI-7000 is ideally suited for applications that demand high speed, high precision measurements in absolute and/or differential modes, including plant and insect gas exchange using chamber-based methods, atmospheric-surface flux eddy covariance and Bowen ratio techniques, vertical profiling, and general atmospheric monitoring. |
Contact: Charles Toth
Location: Hickey Hall »See on the MapAffiliated Centers: RI-NSF EPSCoR , RI-INBRE
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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DNA Sequencer Contact: Elisabeth Arevalo | ABI Prism 3100 Genetic Analyzer | Used for DNA sequencing and fragment analysis. The ABI PRISM 3100 Genetic Analyzer is an automated capillary electrophoresis system that can separate, detect, and analyze up to 16 capillaries of fluorescently labeled DNA fragments in one run. |
PCR Thermal Cycler Contact: Charles Toth | Stratagene Mx3000p Real-time PCR Thermal Cycler | This instrument is available for gene expression analysis, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Agilent's qPCR software, MxPro, provides users with an intuitive interface, quick experiment design, powerful data analysis and easy report generation. |
Fluorescence Activated Cell Sorter (FACS) Contact: Charles Toth | Flow Cytometer- Accuri C6 | The BD Accuri C6 is a personal flow cytometer that is easy to use, simple to maintain, and affordable. |
Cold Room Contact: Charles Toth | Walk-In Cold Room | |
Analyzer - Cell Metabolism Contact: Marla Tipping | Seahorse Biosciencies, XFe Extracellular Flux Analyzers, XFe96 | Platform for metabolic assays that simultaneously measures the two major energy producing pathways of the cell - mitochondrial respiration and glycolysis - in a microplate, in real-time. |
Laboratory - Tissue Culture Contact: Charles Toth | Tissue Culture Laboratory | Space and instrumentation for tissue culture preparation |
Imaging System - Gel Imager Contact: Yinsheng Wan | Licor Odyssey IR (Infrared) Imaging System | Instrumentation for quantitating western blots. |
Fluorescence Activated Cell Sorter (FACS) Contact: Nicanor Austriaco | Cellometer Vision Image Cytometry | The Vision CBA System combines the simplicity of image cytometry with the power of flow analysis software to offer user-friendly cell-based assays |
Spectrophotometer Contact: Charles Toth | Thermo Scientific NanoDrop | UV/VIS |
Contact: Charles Toth
Location: Sowa Hal »See on the MapAffiliated Centers: RI-NSF EPSCoR , RI-INBRE
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Microscope Contact: Joe DeGiorgis | Zeiss LMS 700 Flexible Confocal Microscope | Performs fluorescence measurements, creates optical sections of samples and combines them into 3D image stacks. |
Contact: Fred Jackson
Location: Building for Environmental Research and Teaching »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Greenhouse, Plant Environmental Center Contact: Chris Claussen | Plant environmental center with seven separate, computer controlled rooms where conditions like lighting, temperature, and humidity can be fine tuned; an additional 17 controlled plant growth environments provided by growth chambers (15) and walk-in growth rooms (2) | A plant environmental center with a suite of supporting facilities, including a classroom, a "headhouse" for potting and other prep work,and growth chambers for plants. |
Contact: Phyllis Dennery, MD
Location: Hasbro Children's HospitalAffiliated Centers: Environmental influences on Child Health Outcomes (ECHO)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Program for Environmental influences on Child Health Outcomes (ECHO) | Clinical Research Resources, Environmental Influences on Child Health | The ECHO program investigates how exposure to a range of environmental factors in early development — from conception through early childhood — influences the health of children and adolescents. |
Contact: Memory and Aging Program
Location: 345 Blackstone Boulevard ,1st Floor Weld Building »See on the MapAffiliated Centers: Memory and Aging Program
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Memory and Aging Resources Memory and Aging Program Website | Clinical Research Resources, Memory and Aging | The Center has a 25-year history of excellence in clinical care, training, and research. We are dedicated to developing breakthrough treatments that improve quality of life for Alzheimer’s disease. As a worldwide leader in the fight against Alzheimer’s the Center offers cutting-edge research for people with normal memory who may be at risk for dementia and those who are already experiencing memory loss. We are working hand in hand with community groups, health care providers, research organizations, and people like you to find preventative and breakthrough treatments for Alzheimer’s disease. |
Contact: Chris Marshall
Location: The Coro West Building »See on the MapAffiliated Centers: COBRE Center for Cancer Research and Development at Rhode Island Hospital
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Bioanalyzer | Agilent Bioanalyzer 2100 | Microfluidics platform (electrophoresis and flow cytometry) for sizing, quantification, and QC of DNA, RNA, proteins, and cells. Sample size= 1-4 microliters. |
Bioinformatics Analysis - MASCOT | Software: Matrix Science MASCOT Search Engine | Software for MS data analysis through statistical evaluation of matches between observed and projected peptide fragments. |
Bioinformatics Analysis - ProteoIQ | Software: NuSep ProteoIQ Mass Spec Data Analysis | Software for post-analysis of MASCOT results. Protein and peptide probabilities generated and protein relative quantitation is performed by spectral counting. Normalized and with standard deviations. |
Bioinformatics Analysis - Workstation | Hardware: HP HPZ 800 Workstation | Software (2 workstations available) used in conjunction with ProteoIQ, DXMS, MASCOT analysis. |
Imaging System - Gel Imager | Bio-Rad Molecular Imager VersaDoc | Quantitative digital imaging system for single or multi-color images. Includes multiplexed samples (1-D or 2-D gels), chemiluminescent and chemifluorescent blots, and microplates. |
High Performance Liquid Chromatography (HPLC) | Bio-Rad DuoFlow Biologic HPLC | Medium-pressure chromatography system. 100/120 V, F10 workstation, mixer, AVR7-3 valve, UV detector with flow cell and filters. Flow rate= 0.01-10 ml/min. |
High Performance Liquid Chromatography (HPLC) | Transgenomic Wave DHPLC System | Detect mutations/ polymorphisms by Denaturing High Performance Liquid Chromatography (DHPLC). Uses SURVEYOR nuclease cleavage. Identifies single nucleotide polymorphisms (SNPs) or small insertions/ deletions. |
High Performance Liquid Chromatography (HPLC) | Dionex UltiMate3000 Nano HPLC | Single gradient and x2 dual configurations. Eluted directly into MS. Min detection= fmole; Min flow rate= 20 nL/min; Max pressure = 800 bar. |
Liquid Chromatography- Mass Spectrometer (LC-MS) | Thermo Scientific Q Exactive Plus Mass Spectrometer | Benchtop LC-MS/MS. Combination of high-performance quadrupole with high resolution, accurate-mass (HR/AM) Orbitrap. Max resolving power= 140,000; max scan speed= 12Hz, Intra-scan dynamic range > 5000:, Quadrupole mass filter. |
Mass Spectrometer | AB SCIEX QSTAR XL Mass Spectrometer | Identification and analysis of protein structure/conformational change by deuterium exchange mass spectrometry (DXMS). LC/MS/MS- Ionization by MALDI or ESI after HPLC (Dionex) and analyzed by quadrupole and TOF. |
Mass Spectrometer | Brucker UltrafleXtreme: Imaging Mass Spectrometry | MALDI-IMS for tissue imaging, intact proteins analysis, protein spatial distribution, glycoproteomics, or biologics (1-2000 Hz repetition rates) of non-injured vs. injured tissues. MALDI/TOF/TOF analysis for proteomic profiling. Minimum diameter = 10 microns. |
Robotic Workstation - Liquid Handler | Perkin Elmer JANUS Automated Workstation | Automated Sterile Liquid Handler. 2 arm system, with 4- or 8-tip arm plus a 96/384 MDT arm. Arms include 4-tip or 8-tip dispense arms for transfer from tubes to vials to plates. |
Spectrophotometer | Amersham Biosciences UV/Visible Spectrophotometer Ultrospec 1100 | Wavelength range: 200-900 nm. Spectral bandwidth: 5 nm Wavelength accuracy - 2 nm. Wavelength reproducibility: - 0.5 nm. |
Spectrophotometer | Thermo Scientific NanoDrop 2000 | Measures DNA, RNA, and protein concentrations, and purity (A260/A280 ratio). Conc. range= 2 ng/microliter-15,000 ng/microliter; Min Sample size = 0.5 microliter. |
Suspension Array System | Bruker ImagePrep matrix sprayer | Matrix deposition device for MALDI Imaging. Average droplet size ? 20 microns, all droplet dia. are < 50 microns. Lateral resolution of 50 microns in tissue. |
Technical Assistance - 1D SDS PAGE Coomasie | Service | Service to provide 1D gel (SDS-PAGE) Coomasie Staining. |
Technical Assistance - 1D SDS PAGE Silver Stain | Service | Service to provide 1D gel (SDS-PAGE) Silver Stain MS compatible. |
Technical Assistance - Gel Imaging | Service | Service to provide Gel imaging by VersaDoc. |
Technical Assistance - Mass Spectrometry | Service | Service to provide ImagingMass Spectrometry Data Analysis. |
Technical Assistance - Protein Determination | Service | Service to provide Protein Determination (BCA assay). |
Technical Assistance - Protein Extraction | Service | Service to provide ReadyPrep Protein Extraction Kit (Sequential Extraction). |
Technical Assistance - Protein Extraction | Service | Service to provide ReadyPrep Protein Extraction Kit (Total Protein). |
Technical Assistance - Protein In-Gel Digestion | Service | Service to provide In-gel digestion LC/MS analysis and protein database search. |
Technical Assistance - Protein In-Solution Digestion | Service | Service to provide In-solution digestion LC/MS analysis and protein database search. |
Technical Assistance - Protein Quantification | Service | Service to provide Data interpretation and protein quantification. |
Technical Assistance - Protein Sample Clean-up | Service | Service to provide ReadyPrep 2D Cleanup Kit. |
Technical Assistance - Proteomics Project Consultation | Service | Service to provide Project consultation with the Director of Proteomics - Subsequent Consultation |
Technical Assistance - Proteomics Project Consultation | Service | Service to provide Project consultation with the Director of Proteomics - Initial Consultation |
Mass Spectrometer | Thermo Scientific TSQ Quantiva - Triple Quadrupole Mass Spectrometer | Allows identification and absolute quantification of biomarkers, target proteins/peptides with their known post-translational modifications from any biological samples. |
Microplate Reader | GloMax Discover - Multimode Detection System | Multi-mode detection instrument offering flexible use of filters and includes: high-performance, luminescence, fluorescence, UV-Visible absorbance, BRET and FRET, two-color filtered luminescence and kinetic measurement capabilities |
Contact: Mandar T Naik, PhD
Location: 3rd Floor, Laboratories for Molecular Medicine »See on the MapAffiliated Centers: Center for Genomics and Proteomics (CGP), RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Analyzer - Calorimeter | Microcal Isothermal Titration 200 (ITC) | Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules. |
Analyzer - Calorimeter | Microcal VP Differential Scanning (DSC) | Measurement of heat changes that occur in biomolecules during controlled increase or decrease in temperature. |
Fluorometer - Spectrofluorometer | Horiba Jobin Yvon FluoroMax-4 | Fluorescence detection. A heated cell allows temperature studies. |
Spectrometer | JASCO J-815 Circular Dichroism (CD) Spectrometer | Protein folding studies, Protein conformational studies, DNA/RNA interactions, Enzyme kinetics, Purity testing of optically active substances, quantitative analysis of pharmaceuticals, natural products chemistry, biochemistry and macromolecules, rapid scanning (time resolved) experiments. Peltier device for temperature studies. |
Spectrophotometer | Thermo Scientific NanoDrop 8000 | A full spectral microvolume (microliter) UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein of 8 samples simultaneously. |
Technical Assistance | Service | Service to provide Proteomics Technal Assistance |
Contact: Rich Jones, Sc.D.
Affiliated Centers: Department of Psychiatry and Human Behavior (DPHB)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Statistical and Methodological Consulting | Clinical Research Resources, Quantitative Science | The QSP provides statistical consulting to individual research groups. There is no fee for initial consultation and proposal development work (power analysis, analysis plan). Data analysis consultation is fee-based and will be discussed after the initial consultation. |
Current Instructional Programs | Clinical Research Resources, Quantitative Science | The QSP provides training as part of the didactic series for DPHB post-doctoral fellows, and in a number of seminars and workshops. A three-day summer workshop on latent variable modeling (lvmworkshop.org) is included. |
Training Programs In Development | Clinical Research Resources, Quantitative Science | Travelling Office Hours, Introduction to Data Analysis with Latent Variables, Data analysis and workflow using R, Stata and Mplus. |
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Export Controls - Brown Contact: Jules Blyth Brown Export Control Compliance Webpage | Research Compliance, Export Controls | Export Controls regulate the shipment or transfer, by whatever means, of controlled items, software, technology, or services out of the U.S. and also restricts the release of certain information to foreign nationals here in the U.S. |
Biosafety - Lifespan - Rhode Island Hospital and The Miriam Hospital Contact: Jacqueline Poore | Research Compliance, Biosafety | The Biohazards and Laboratory Safety Committee reviews and approves the use of potentially hazardous agents in the laboratory setting. |
IRB - Care New England - Kent Hospital Contact: Donna Coppola | Human Subjects Protection | |
IRB - Care New England - Women and Infants Hospital Contact: Amber Latronica Women & Infants Institutional Review Board Webpage | Human Subjects Protection | Women & Infants Institutional Review Board (IRB) is a committee established to review and approve research involving human subjects. The purpose of the IRB is to protect the rights and welfare of human research subjects and to ensure that all human subject research be conducted in accordance with federal, state, institutional, and ethical guidelines. |
IRB - Lifespan - Rhode Island Hospital and The Miriam Hospital Contact: Janice Muratori | Human Subjects Protection | The Institutional Review Board (IRB) is a committee made up of physicians, scientists and community members who ensure that research involving human research subjects is well planned and ethical. All research that involves human subjects or their identifiable data must be reviewed by the IRB. |
IRB - Care New England - Butler Hospital Contact: Cheryl Cordeiro | Human Subjects Protection | |
IRB - Brown Contact: Sheila Vandal HRPP/IRB Home Page | Human Subjects Protection | The IRB is a diverse body of Brown faculty researchers, physicians, staff and unaffiliated community members appointed by Brown’s Vice President for Research and charged with reviewing human subject research protocols to uphold two broad standards To ensure that participants are not placed at undue risk; and To ensure that participants give informed consent to their participation free of coercion or undue influence To this end, projects that meet the regulatory definition of human subject research must be reviewed and approved by the IRB prior to initiation. |
IRB - The Providence VA Medical Center Contact: Val Micucci | Human Subjects Protection | |
IRB - University of Rhode Island Contact: Heather Paskalides Human Subjects Protection - URI Webpage | Human Subjects Protection | The University of Rhode Island Institutional Review Board (IRB) reviews research projects which involve human subjects to ensure that two broad standards are upheld: first, that subjects are not placed at undue risk; second, that they give uncoerced, informed consent to their participation. |
IACUC - Brown University Contact: Megan Clark Brown IACUC Webpage | Animal Subjects Protection | The ARPP is the administrative office dedicated to facilitating the submission, review and approval of IACUC protocols, supporting the various functions of the IACUC, and providing individual assistance to researchers whenever needed. |
IACUC - Lifespan - Rhode Island Hospital Contact: Jacqueline Poore | Animal Subjects Protection | The Animal Welfare Committee (IACUC) is a committee made up of scientists and community members who ensure that research involving animal subjects is well planned and ethical. |
IACUC - Care New England - Women and Infants Contact: Jacqueline Poore | Animal Subjects Protection | |
IACUC - The Providence VA Medical Center Contact: Tiffany Galligan Providence VA Medical Center IACUC Webpage | Animal Subjects Protection | |
IACUC - University of Rhode Island Contact: Gwen Currier IACUC - URI Webpage | Animal Subjects Protection | The URI Institutional Animal Care and Use Committee (IACUC) is responsible for overseeing the provisions for the care and well -being of animals used for research and educational purposes at the University and serves the public by ensuring compliance with all legal and ethical standards regarding the use of vertebrate animals in research and teaching at URI. |
Biosafety - Brown Contact: Devorah Weiner Institutional Biosafety Committee (IBC) Webpage | Research Compliance, Biosafety | The Institutional Biosafety Committee (IBC) evaluates and provides oversight of the use of biohazardous agents to ensure compliance with appropriate regulations and guidelines and to safeguard the health and safety of Brown University personnel, the community, and the environment. |
Biosafety - University of Rhode Island Contact: Gwen Currier URI Biosafety Committee Webpage | Research Compliance, Biosafety | The Institutional Biosafety Committee (IBC) reviews and approves Biological Research protocols. |
Export Controls - University of Rhode Island Contact: Ross Levine URI Export Controls Webpage | Research Compliance, Export Controls | The Export Controls office ensures that all personnel, including employees, visiting scientists, postdoctoral fellows, students, and other persons retained by or working at or for URI conduct their affairs in accordance with U.S. laws and regulations, including compliance with U.S. export control laws and regulations applicable to its operations. |
Contact: Dr. Irene Andreu, PhD
Location: Fascitelli Center for Advanced Engineering »See on the MapAffiliated Centers: RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Sample Preparation - Sputter Coater System Contact: Irene Andreu | Cressington 7002-8 sputter coater with film thickness monitor | Coat non-conducting samples with gold for use on the SEM, rotating/tilting stage for coating of large specimens. |
X-Ray Diffraction System Contact: Irene Andreu Request a Service | Rigaku Ultima IV multipurpose X-ray diffraction (XRD) system | micro-crystalline diffraction, thin-film diffraction, small angle scattering, and in-plane scattering. |
Microscope - Transmission Electron Microscope Contact: Irene Andreu TEM Request a Service | JEOL JEM-2100 LaB6 Transmission Electron Microscope (TEM) | Transmission electron microscope JEOL JEM 2100 with sub nanometer resolution, cryoTEM (Gatan) and energy dispersive X-ray spectroscopy (Oxford Instruments) |
Microscope - Field Emission-Scanning Electron Microscope (FE-SEM) Contact: Irene Andreu SIGMA VP FE-SEM Request a Service | Zeiss Gemini Sigma VP Field Emission-Scanning Electron Microscope (FE-SEM) | Field emission scanning electron microscope Zeiss Gemini Sigma VP, with cryoSEM (Gatan), energy dispersive X-ray spectroscopy (Oxford Instruments), variable pressure mode, backscattering detector, in lens detector and secondary electron detector |
Microscope - High Content Screening System | Perkin Elmer - Opera Phenix | High Content Screening System: Automated confocal fluorescence microscope designed for high-throughput 3D imaging of fluorescent samples in microplates, live-cell imaging, drug screening, spheroid imaging |
Sample preparation - Plunge freezer Contact: Irene Andreu Vitrobot Mark IV | FEI Vitrobot Mark 2 Plunge Freezer for cryoTEM | Automatic plunge freezer for cryoTEM sample preparation |
Microtome Contact: Irene Andreu | Sorvall MT2-B ultramicrotome | Preparation of biological tissue, cross sections and embedded samples for TEM. |
Microscope - Confocal Raman Spectroscopy Contact: Irene Andreu | WITec alpha 300R | Confocal imaging and chemical analysis by Raman spectroscopy up to 100x magnification, 3D chemical imaging, large area imaging, principal component analysis of chemical composition, upright and inverted mode, automated XY stage, 785 and 532 nm excitation lasers |
Microscope - Fourier Transform Infrared Spectroscopy | Shimadzu AIM-9000 with Shimadzu IRTracer100 | FTIR microscope and spectrometer, ATR, liquid and gas cell. |
Sample Preparation - Critical Point Drier | Tousimis Sandri-PVT-3B | Critical point dryer (CPD) Maintain structural integrity for soft tissue use of the SEM. |
Sample Preparation - Automated pipettor | Opentrons OT-2 | Automated sample preparation platform for staining well plates |
Affiliated Centers: Rhode Island Methods To Improve Diagnostic Assessment And Services (MIDAS)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Diagnostic Assessment Resources | Clinical Research Resources, Diagnostic Assessment | The Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project is an ongoing clinical research study involving the integration of research assessment methods into routine clinical practice. |
Contact: Dr. Cameron Goodwin
Location: URI Bay Campus »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
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Reactor, Research and Test Contact: Cameron Goodwin | 2 Mega-Watt, light water cooled, pool type reactor | Neutron and gamma irradiation and experimental set-up, as well as analysis |
Contact: Dr. Rebeka Merson
Location: Fogarty Life Science »See on the MapAffiliated Centers: RI-NSF EPSCoR , RI-INBRE
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Sample Preparation - Knifemaker Contact: Breea Govenar | LKB 7800 Knifemaker | Slide/Sample Preparation |
Microtome Contact: Breea Govenar | Leica RM2165 Motorized Rotary Microtome | Slide/Sample Preparation |
Microtome Contact: Breea Govenar | TBS Microtome plus Cryostat | Slide/Sample Preparation |
Microscope Contact: Breea Govenar | American Optical Series 10 Fluorescence Microstart | Microscopy course |
Microscope Contact: Breea Govenar | Nikon E600 Epifluorescence with DIC/Phase and digital camera | Research |
Microscope Contact: Breea Govenar | Olympus CKS41 Inverted Microscope | Tissue culture general use |
Microscope Contact: Breea Govenar | Olympus Compound Light Microscope | General use |
Microscope Contact: Breea Govenar | Olympus FluoView 1000 Laser Scanning Confocal Microscope | Research and Microscopy course |
Microscope Contact: Breea Govenar | Olympus Inverted Epifluorescence Microscope with digital camera | Tissue culture/Research |
Microscope Contact: Breea Govenar | Zeiss SteREO discovery V8 Microscope with Digital Camera | Research |
Aquatic System - Wet Lab / Aquarium room Contact: Breea Govenar | Aquaria and related equipment | Research |
Autoclave Contact: Breea Govenar | Autoclave | Microbiology/Research |
Biological Safety Cabinet Contact: Breea Govenar | Labconco class II Biological Safety Cabinet | Used for tissue culture |
Biological Safety Cabinet Contact: Breea Govenar | Sterile laminar flow hood | Microbiology prep |
Centrifuge Contact: Breea Govenar | Eppendorf 5810R Refrigerated Centrifuge | Used for tissue culture |
Centrifuge Contact: Breea Govenar | Sorvall Discovery M120SE Mini Ultracentrifuge | Research/Cell fractionation |
Centrifuge Contact: Breea Govenar | Sorvall Superspeed RC2 Centrifuge | General use |
Centrifuge Contact: Breea Govenar | Sorvall Superspeed RC5 Plus Centrifuge | Research |
Centrifuge Contact: Breea Govenar | Thermo IEC Centra CL3R Refrigerated Centrifuge | Genetics and Cell & Molec courses |
Cold Room Contact: Breea Govenar | Walk-In Cold Room | Large cold room for experimentation and storage |
Dishwasher Contact: Breea Govenar | Dishwasher | Microbiology/Research |
Disrupter Contact: Breea Govenar | French Pressure Cell Press | Research |
Disrupter Contact: Breea Govenar | Polytron Tissue Grinder | Slide/Sample Preparation |
Disrupter Contact: Breea Govenar | Sonicator | General use and research |
Disrupter Contact: Breea Govenar | Sonicator with cup | Research and graduate courses |
Electroporation System Contact: Breea Govenar | BioRad Micropulser Electroporator | Research |
Sample Preparation - Freeze Dry System Contact: Breea Govenar | ATMO VAC 5009 freeze dryer | Slide/Sample Preparation |
Biospecimen Banking - Freezer Contact: Breea Govenar | Thermolyne Liquid Nitrogen cryogenic storage system | Cell storage |
Biospecimen Banking - Freezer Contact: Breea Govenar | Ultralow Freezer | Used for freezing biological samples, 6 units |
Imaging System - Gel Imager Contact: Breea Govenar | InGenius Syngene Gel Documentation System | Research |
Ice Machine Contact: Breea Govenar | Ice Machine | General use |
Imaging System - Dark Room Contact: Breea Govenar | Imaging System - Dark Room | Gel imaging and analysis |
Incubator Contact: Breea Govenar | Non CO2 Incubator | Used for tissue culture |
Incubator Contact: Breea Govenar | Thermo CO2 Incubators | Used for tissue culture, 2 units |
Incubator Contact: Breea Govenar | Refrigerated Incubator | Used for tissue culture |
Laboratory - Tissue Culture Contact: Breea Govenar | Tissue Culture Room | A room outfitted with tissue culture instrumentation |
Microplate Reader Contact: Breea Govenar | Lenovo Automated Plate Reader | Research |
Microplate Reader Contact: Breea Govenar | Thermo Labsystems Multiskan MMCC/340 plate reader | Research |
Sample Preparation - Oven Contact: Breea Govenar | Drying Oven | General use |
PCR Thermal Cycler Contact: Breea Govenar | BioRad IQS Real time PCR thermocycler | Research |
PCR Thermal Cycler Contact: Breea Govenar | Eppendorf Gradient Mastercycler | PCR instrumentation, 2 units |
Incubator - Shaker Contact: Breea Govenar | Incubator/Shakers | Multiple units |
Spectrophotometer Contact: Breea Govenar | BioRad SmartSpec Plus | Research |
Spectrophotometer Contact: Breea Govenar | Eppendorf Biophotometer | Gectrophotometerseral use |
Spectrophotometer Contact: Breea Govenar | Spectronic 21 D UV/VIS | Research |
Spectrophotometer Contact: Breea Govenar | Therm Spectronic Genesys UV/VIS Scanning | Research, 6 units |
Spectrophotometer Contact: Breea Govenar | Thermo Scientific NanoDrop ND-1000 | UV/VIS, 2 units |
Water Purification System Contact: Breea Govenar | Barnstead Still Water Purifier | General use for teaching labs |
Water Purification System Contact: Breea Govenar | Millipore DirectQ (X2) | Tissue culture |
Water Purification System Contact: Breea Govenar | Millipore NanoPure Diamond | 2nd floor research use |
Imaging System - X-ray Film Contact: Breea Govenar | X-ray film processor | Blot imaging |
Contact: Neal Overstrom
Location: RISD Auditorium »See on the MapAffiliated Centers: RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Imaging System - Audio|Visual | Kodak zi 10 Video Camera (8 units) | Portable HD pocket camcorder, batteries, adaptor cables, cases, accessories |
Imaging System - Audio|Visual | H4N ZOOM Audio Recorder (5 Units) | High performance portable digital audio recorder, batteries, adaptor cables, cases, accessories |
Imaging System - Audio|Visual | ZOOM Q3 Video Camera (7 Units) | Portable palm camcorder, batteries, adaptor cables, cases, accessories |
Imaging System - Audio|Visual | EPS-SonyPMWEX1R-01 (2 Units) | High performance HD CMOS solid state video camera, batteries, portable hard drive, adaptor cables, cases, studio lighting equipment, accessories |
Contact: Neal Overstrom
Location: Waterman Building »See on the MapAffiliated Centers: RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Aquatic System | Marine Ecological Habitats Closed-System Aquarium | 560 L closed-system recirculating marine holding tanks with temperature control (2 units) |
Microscope | Phenom G2Pro Scanning Electron Microscope (SEM) | Desktop Scanning Electron Microscope with ProSuite tiling and remote access software |
Microscope | Olympus SZX16 Stereomicroscope | Light microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software |
Microscope | Olympus IX51 Inverted Fluorescent/Brightfield Microscope | Fluorescence/brightfield microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software |
Microscope | Olympus CH30 Upright Light Microscope | Upright light microscope with 5 MP Jenoptik digital camera, Canon Vixia HFS20 HD video camera, computer workstation, graphics and imaging software (2 units) |
Microscope | Olympus SZ40 Stereomicroscope | Light microscope with 5 MP Jenoptik digital camera, computer workstation, graphics and imaging software |
Microscope | Olympus SZ30 Stereomicroscope | Light microscope with LED illuminator (24 units) |
GPS Unit | Trimble Geo 7x Subfoot GPS | Survey-grade high resolution handheld GPS unit with sub-foot accuracy |
GPS Unit | Garmin eTrex 30 (10 units) | Mapping grade gps unit for student use |
Imaging System - Videocamera - High Speed | Edgertronic - monochrome | High speed videocamera for capturing slow motion footage. Capable of Resolutions up to 1280x1024, frame rates at lower resolution up to nearly 18,000 fps |
Imaging System - Videocamera - High Speed | Edgertronic - color | High speed videocamera for capturing slow motion footage. Capable of Resolutions up to 1280x1024, frame rates at lower resolution up to nearly 18,000 fps |
Imaging System - Videocamera - High Speed | Phantom Miro M120 | Digital high speed video camera, resolution up to 1920x1080 at 800fps |
Imaging System - 3D Scanner | Artec Spider | High resolution 3D scanner designed specifically for CAD users |
Imaging System - 3D Scanner | Structure Sensor | Scanners (3) for use with iPad Air, capable of 3D scanning objects and entire rooms |
Workstation, Computer Geographic Information System (GIS) | EPC workstations (3) | Computer workstations outfitted with ArcGIS, auto cad and the full adobe creative suite |
Contact: John W. Morgan, Ph.D.
Location: Roger Williams Medical Center »See on the MapAffiliated Centers: Roger Williams Medical Center Core Research Facilities
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Flow Cytometry Core Contact: Flow Cytometry Core Webpage | Flow Cytometry and Cell Sorting | The Flow Cytometry Core facility is dedicated to advancing research projects requiring cell sorting and/or analysis of cell populations by flow cytometry. The core offers training on and access to shared use instrumentation for analytical flow cytometry, services for fluorescence activated cell sorting (FACS) as well as technical consultation and support on experimental design, execution, and data analysis. |
Imaging Core Imaging Core Webpage | Zeiss LSM 700 confocal, Zeiss Axioplan 2 optical, Zeiss Axiovert 200M optical, IVIS Model 100 | The Imaging Core facility provides technical and logistical access for fixed and live cell fluorescence imaging via visual and digital fluorescent microscopes. This core also offers the ability to visualize fluorescent and bioluminescent markers in live animals via an IVIS imager. |
Molecular Core Molecular Core Webpage | Applied Biosystem PRISM 7000 Sequence Detection System, Bio-Rad ChemiDoc Molecular Imager, Bio-Rad CFX96 Touch Real-Time PCR Detection System | The molecular core offers the capability of performing PCR analysis, quantitative real-time PCR analysis, and digital gel documentation. |
Cell Immunotherapy and Gene Therapy (CITGT) Good Manufacturing Practice (GMP) Facility Contact: Steven C. Katz, MD, FACS (GMP) Facility Webpage | Services and Equipment | The Cell Immunotherapy and Gene Therapy GMP facility supports the manufacture of investigational new drug (IND) products for principal investigators under FDA rules and regulations. |
Tissue Bank Core Tissue Bank Core Webpage | Biospecimen Banking - Tissue Banking and Specimen access | The Tissue Repository Core (TRC) is designed to facilitate translational cancer research by procuring and storing diseased and normal control tissues, with the associated clinical data, for RWMC investigators and outside clients. |
Animal Services Core Animal Services Core Webpage | Husbandry, Surgical Procedures and Injections | The Animal Care Facility is fully maintained, certified, and is supervised by a certified veterinarian, and our Office of Research Administration. |
Contact: Nancy Breen
Location: Marine and Natural Sciences »See on the MapAffiliated Centers: RI-NSF EPSCoR , RI-INBRE
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Fluorescence Activated Cell Sorter (FACS) Contact: Marcie Marston | Millipore Guava easyCyte Flow Cytometer | Cell sorting and analysis |
Gas Chromatograph - Mass Spectrometer (GC - MS) Contact: Nancy Breen | Agilent 5890 Gas Chromatograph - Mass Spectrometer (GC - MS) wth Mass Selective Detetor (MSD) | GC MS for teaching and research |
High Performance Liquid Chromatography (HPLC) Contact: Nancy Breen | Waters 2695 High Performance Liquid Chromatograph-MS / ZQ Micromass Mass Spectrometer | LC - MS for teaching and research |
Gas Chromatograph Contact: Nancy Breen | Agilent 7890 Gas Chromatography with DB-23 column | GC for fatty acid analysis |
Contact: Anne Reid
Location: O'Hare Academic Center »See on the MapAffiliated Centers: RI-NSF EPSCoR
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Fluorescence Activated Cell Sorter (FACS) | Millipore Guava EasyCyte 8 Flow Cytometer | Single blue (488 nm), dual blue and red (642 nm), or triple blue, red, and violet (405 nm) excitation lasers provide up to 12 simultaneous detection parameters, including 10 fluorescent colors plus forward and side scatter for size and granularity determination. The guava easyCyte family also meets your sample throughput needs by offering both single sample and multi-sample processing. |
Contact: Vinald Francis
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Illustration, Graphic Design, and Data Displays | Service | BioMedical Communications offers medical and scientific illustration, graphic design, and data displays for use in web, digital, and print media to faculty across the Division of Biology and Medicine. |
Affiliated Centers: The Sexually Transmitted Disease Clinic
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Infectious Diseases Clinical Research | The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel. We conduct trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C. |
Contact: Paul Bertone, PhD
Affiliated Centers: Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Training and Technical Assistance | Service | Advise investigators with experimental design for single cell analysis including implementation of technical plans as well as analysis of results. Advise on single cell genomics, RNA-seq, ChIP-seq and bioinformatic analysis. Provide support for grant submissions. |
Contact: Jennifer Friedman, MD, PhD
Location: 55 Claverick Street »See on the MapAffiliated Centers: Center for International Health Research, COBRE Immune-Based Interventions Against Infectious Diseases
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Technical Assistance - Statistics and Data Management Contact: Sangshin Park, PhD | Service | This Core provides consultation and assistance in managing and analyzing research data, such as the large datasets, and in linking these data with clinical predictors and outcomes collected in the field. The Core also performs more sophisticated data analytic approaches, including hierarchical, repeated measures modeling and Principal Components Analysis. |
Contact: Mandar T Naik, PhD
Location: Laboratories for Molecular Medicine »See on the MapAffiliated Centers: Center for Genomics and Proteomics (CGP)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
---|---|---|
Nuclear Magnetic Resonance (NMR) Spectrometer | Bruker 500 Avance II, with TCI cryoprobe | An NMR spectrometer optimized for studying proteins in solution. This spectrometer is most useful for tracking binding interactions, measuring dynamic properties of proteins, and assigning protein resonances. Capable of using 5 mm and 3 mm tubes. Also suitable for proton NMR of small molecules and natural products. |
Nuclear Magnetic Resonance (NMR) Spectrometer | Bruker 850 MHz Avance III HD, with TCI cryoprobe | An NMR spectrometer optimized for studying proteins in solution. This spectrometer is ideal for determining protein structures and measuring protein dynamics. Its extreme sensitivity allows studies on otherwise intractable samples. Capable of using 5 mm, 3 mm, and shaped NMR tubes. Also suitable for proton NMR of small molecules and natural products |
X-Ray Diffraction System | Rigaku ACTOR robot and Saturn 944 HG CCD | An instrument useful for obtaining X-ray diffraction patterns of proteins and other biomacromolecules under cryogenic or room-temperature conditions. Rapid screening and sorting of up to 80 candidate crystals is possible. |
Nuclear Magnetic Resonance (NMR) Spectrometer | Bruker AVANCE III HD 600 MHz High Performance Digital NMR Spectrometer | Bruker NEO 600 MHz NMR spectrometer for high resolution solution-state protein NMR experiments 4 RF channels, triple-resonance (1H-13C-15N) inverse cryoprobe with cooled 1H, 13C and 15N preamplifiers. |
Contact: Attila Seyhan, PhD
Affiliated Centers: Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Training and Technical Assistance | Service | Advise investigators on study design leading to translational clinical protocols. For prioritized studies, provide assistance with clinical protocol preparation as well as NIH, Industry or Foundation grant submissions to secure funding for the research. |
Contact: Murray Resnick, MD, PhD
Affiliated Centers: Cancer Center at Brown University
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Affiliated Centers: COBRE Immune-Based Interventions Against Infectious Diseases, Institute for Immunology and Informatics (iCubed)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Contact: Lenny Moise, Ph.D.
Affiliated Centers: COBRE Immune-Based Interventions Against Infectious Diseases, Institute for Immunology and Informatics (iCubed)
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
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Contact: Rena Wing
Location: 196 Richmond Street, Providence, RI 02903 »See on the MapAffiliated Centers: Weight Control and Diabetes Research Center
Instrument/Service/Resource Unit | Manufacturer/Description | Function |
---|---|---|
Weight Control and Diabetes Research Center Contact: Ana Almeida | Clinical Research Resources, Weight Control | The primary objective of our Center is to foster a multidisciplinary approach to research in the field of obesity prevention and treatment. Through our program of scientific research we seek to: (1) Expand our knowledge of the causes and consequences of obesity, (2) Develop innovative and effective treatments for weight loss and weight maintenance, (3) Offer quality obesity treatment to the community through ongoing clinical trials, (4) Provide advanced training for interns and postdoctoral fellows interested in obesity research. |
Contact: Beth Brainerd, PhD
Location: BioMedical Center Building »See on the MapInstrument/Service/Resource Unit | Manufacturer/Description | Function |
---|---|---|
Imaging System - Computed Tomography (CT) Scanner | Animage Fidex Veterinary | Veterinary CT Scanner designed for animals in the size range from rats to dogs. In vivo scanning of anesthetized animals is possible. |
Imaging System - Videoradiography Room | Imaging Systems and Services | Custom designed biplanar videoradiography system for XROMM studies of human and animal subjects. |
Imaging system X-Ray Fluoroscopes | Radiological Imaging Mobile C-Arm X-ray | Two retrofitted with 30-cm image intensifiers and high-speed video cameras for measuring accurate 3D skeletal kinematics of small to medium-sized animals. |
Imaging System - MicroComputed Tomography (uCT) Scanner | Bruker BioSpin | SkyScan 1276 in vivo microCT scanner for small animals (mouse to rat size) |