A directory of core research facilities, services, and instrumentation in Rhode Island

Core Facilities

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Advance-CTR

(last updated 2017-12-07 11:02:34)
»See Advance-CTR website for more details

Contact: Jim Padbury

Location: Advance-CTR Headquarters  »See on the Map

Affiliated Centers: Advance-CTR (Clinical Translational Research)

Instrument/ServiceManufacturer/DescriptionFunction
Advance-CTR Administration
Contact: Helen Leffers
Request Research Services
Clinical Research Service, Advance-CTR Service CoordinationAdvance-CTR works to support researchers at the state level by developing the infrastructure and resources investigators need to conduct clinical and translational research in Rhode Island. Through its interdisciplinary and inter-institutional model, Advance-CTR funds and supports research across the translational science spectrum, including basic science, clinical, and public health efforts. Ultimately, Advance-CTR seeks to connect researchers and support institutions in Rhode Island in order to advance clinical and translational research that improves public health in the state.
Biostatistical Consulting, Epidemiology & Clinical Research Design Services
Contact: Heather Fournier
Request Research Services
Clinical Research Service, Advance-CTR A team of experienced statisticians and methodological experts are on-hand to help investigators prepare their proposals pre-award, and plan their projects upon receipt of funding. Pre-award services include, positioning of specific aims and hypotheses, measure selection, power analysis and data analysis planning. Post-award services include decision support services, data acquisition and management and consultations to assess the impact of potential design changes on final statistical influence. Data analysis and results interpretation services include implementing data analysis plans, statistical analysis consultations, selecting and accessing statistical analysis software, and coaching to best utilize statistical analysis software. Manuscript and grant proposal writing services include assistance with write-ups, data visualizations, integration of interpretations in the broader context of the project, and addressing comments from peer reviewers
Clinical Research Resources and Facilites
Contact: Heather Fournier
Request Research Services
Clinical Research Service, Advance-CTR The Clinical Research Resources and Facilities Core is based at the Lifespan Clinical Research Center. Clinical Research Support is offered to Rhode Island investigators by highly trained research staff including clinical research coordinators, registered nurses, a medical technologist, and a phlebotomist. Investigators seeking Advance-CTR services have access to regulatory support, subject recruitment, space and support for the conduct for study visits, specimen collection and biobanking.
Biomedical Informatics Services
Contact: Heather Fournier
Request Research Services
Clinical Research Service, Advance-CTR Researchers may request, access, and use data available through the Unified Research data Sharing Access (URSA) infrastructure. The data include information originating from electronic health data systems at Lifespan, Care New England, and the Rhode Island Quality Institute, as well as from publicly accessible biological and health data sets. 
Psychometric Services
Contact: Heather Fournier
Request Research Services
Clinical Research Service, Advance-CTRThis service includes assistance with survey design, original measure development, exploratory dimensional analysis, confirmatory factor analysis, and reliability and validity analysis.
Qualitative Methods Services
Contact: Heather Fournier
Request Research Services
Clinical Research Service, Advance-CTRThis service provides qualitative and mixed methods and data analysis design research support. Qualitative and mixed methods support includes; study design and preparation, original measure development, coaching on qualitative methods design decisions (focus groups, interviews, cognitive interviews), NVivo qualitative software training, help with grant writing of qualitative methods and analysis sections, manuscript and grant proposal review, post interview/focus group debriefing. Data analysis design support includes applied thematic analysis and framework matrix analysis.

Alzheimer's Disease and Memory Disorders Center

(last updated 2017-12-08 11:05:39)
»See Alzheimer's Disease and Memory Disorders Center website for more details

Contact: Brian Ott

Location: Rhode Island Hospital, Ambulatory Patient Center (APC Building)  »See on the Map

Affiliated Centers: Alzheimer's Disease & Memory Disorders Center

Instrument/ServiceManufacturer/DescriptionFunction
Alzheimer's Disease & Memory Disorders Center
Contact: Alzheimer's Disease and Memory Disorders Center
Clinical Research Resources, Alzheimer'sThe Rhode Island Hospital’s Alzheimer's Disease and Memory Disorders Center (ADMDC) provides a comprehensive and integrated program of research and education focused on brain aging and dementia. The ADMDC participates in multicenter clinical trials of investigational drugs to prevent or treat the symptoms of Alzheimer’s Disease and is a primary site for studies sponsored by the Alzheimer's Disease Cooperative Study, funded by the National Institutes of Health, and the Alzheimer's Therapeutic Research Institute. Investigator-initiated studies are an important component of the ADMDC’s research activities; the Center is currently conducting innovative clinical trials for cognitively impaired older drivers and mind-body intervention, as well as studies of the roles of neuroimaging, biologic, and cognitive biomarkers in understanding the preclinical and prodromal stages of Alzheimer's disease. A major thrust of current and future dementia research is primary and secondary prevention. The ADMDC is the primary site for the Rhode Island Alzheimer Prevention Registry, a statewide project that enrolls individuals interested in Alzheimer’s disease prevention trials. To further research into the pathology of Alzheimer’s disease and related dementias, the Center supports the brain donation program at the Brown Brain Tissue Resource Center and operates the Biospecimen Bank, a repository for blood and cerebrospinal fluid specimens stored for future collaborative translational research projects. Intra- and inter-institutional research collaborations are a vital part of the ADMDC’s work. The Center hosts a monthly research seminar co-sponsored by the Norman Prince Neurosciences Institute, which provides a forum for aging and dementia researchers to discuss current research and plan future projects.

Benedum Stable Isotope Facility

(last updated 2016-06-16 10:29:30)

Contact: Steven Clemens

Location: Geological Sciences  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Mass Spectrometer, Isotope RatioThermoFisher (Finnigan) MAT 252 dual inlet Isotope Ratio Mass Spectrometer with automated sample reaction device for up to 48 samples and with Kiel III Carbonate interface.Instrument primarily dedicated to the measurement of the stable isotopes of carbon and oxygen on inorganic carbonates. The facility accommodates projects both internal and external to Brown including analysis of terrestrial and marine material. The vast majority of samples analyzed are funded through external grants but I also facilitate a significant number of small unfunded, exploratory, analyses to help construct proof-of-concept data sets in preparation for proposals.

BioBank, BrainTissue

(last updated 2017-12-08 09:37:57)
»See BioBank, BrainTissue website for more details

Contact: Ed Stopa

Location: Rhode Island Hospital Ambulatory Patient Center (APC) 12  »See on the Map

Affiliated Centers: Alzheimer's Disease & Memory Disorders Center

Instrument/ServiceManufacturer/DescriptionFunction
Brain Tissue Resource CenterClinical Research Resources, Brain Tissues A brain tissue resource center (BTRC) (often referred to as a brain bank) is a collection of human tissue specimens from the nervous system: the brain, spinal cord, muscle and peripheral nerves. The facility is engaged in a variety of functions; rapid specimen transport, tissue processing, state-of-the-art preservation methods and database management. A variety of experts, research doctors, neuropathologists and laboratory specialists, plan and manage the BTRC. Strict protocol is imposed on outside vendors whenever their services are required, particularly with respect to rapid specimen transport.

BioBank, Rhode Island

(last updated 2017-12-08 16:32:17)
»See BioBank, Rhode Island website for more details

Contact: Garrett Sullivan

Location: BioMedical Center Building  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Bioinformatics Analysis - FreezerworksSoftware: Freezerworks version 2015Ascent Sample management software
Biospecimen BankingService Service to store biospecimens at -80 degrees, 4 degrees and in liquid nitrogen. All equipment is connected to back-up generator power and monitored 24/7 by a Rees alarm system.
Biospecimen Banking - Freezer - Liquid NitrogenTaylor Wharton LABS 40K Liquid Nitrogen Storage System(2) Liquid nitrogen biospecimen storage system. Holds up to 40,000 1ml samples
Biospecimen Banking - Freezer - -80 degreesThermo Scientific HERAfreezer 24 cu. Ft. -80 degree freezer(3) Biospecimen Storage at -80 degrees. Holds up to 50,000 1ml samples
Biospecimen Banking - RefrigeratorLABREPCO FUTURA Platinum Series 52 cu. ft. glass door refrigerator(3) Biospecimen Storage Refrigerators at 4 degrees. 4 degree hinged glass door refrigerator
Robotic Workstation - Sample PreparationQiagen QiaCubeDNA, RNA or Protein Purification

Bioengineering Core

(last updated 2017-11-27 14:01:49)
»See Bioengineering Core website for more details

Contact: Braden Fleming, PhD

Location: CORO Center West, Suite 404  »See on the Map

Affiliated Centers: COBRE Center for Skeletal Health and Repair

Instrument/ServiceManufacturer/DescriptionFunction
Testing SystemsBose Corp Biaxial ELF 3200 material test system Force Testers (Tension, Compression, Pull Testers). The ELF 3200 Series perform basic materials tests including axial, axial/torsion, fretting, biaxial, and planar biaxial fatigue tests.
Testing SystemsInstron Electropuls E1000All-Electric Dynamic Test Instrument designed for dynamic and static testing on a wide range of materials and components.
Testing SystemsInstron 8521SAxial-Torsional Fatigue Testing System
Testing SystemsMTS Bionix Electromechanical Torsion SystemTorsion Test System
Testing SystemsMTS 810 Material Test SystemMaterial Test System
MicroscopeAsylum Research MFP-3D-BIOatomic force microscope
MicroscopeNikon TiU inverted microscopeInverted Microscope
Imaging System - CameraQualisys Oqus 5-SeriesThe Oqus cameras are designed to capture accurate mocap data with very low latency and works with both passive and active markers.
Analyzer - MotionNorthern Digital Optotrak SystemTrack and analyze kinetics and dynamic motion in real-time
Analysis System - Force PlateTekscan Force Plate WalkwayLow profile floor walkway system that captures multiple sequential foot strikes of animals.
Analyzer - PressureTekscan I-scanPressure Mapping System
Mapping SystemFuji Film Prescale Pressuregraph (FPD-901E)Pressure Distribution Mapping System
PendulumCustom Active pendulum (small animal joint)System to induce frictional wear in arthrodial joints
PendulumCustom Passive pendulums (small and large animal joints)System to measure the whole joint coefficient of friction
Loading DeviceCustom Biaxial Loading DeviceTissue Engineering
Tissue Engineering SystemICCT Technologies Bio-Stretch Uniaxial SystemMechanical Stretching for Tissue Engineering
Analysis System - GaitTekscan High Resolution Walkway (HRV6)Modular pressure measurement platform for gait analysis.
Testing EquipmentKUKA KR6 700 SIXX6 DOF joint motion testing

Bioinformatics Core

(last updated 2017-03-08 09:24:04)
»See Bioinformatics Core website for more details

Contact: Christopher Hemme, PhD

Location: Pharmacy Building  »See on the Map

Affiliated Centers: RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
Bioinformatics Analysis
Contact: Christopher Hemme
Service We provide bioinformatics consultation and services to the Rhode Island INBRE community and to the general scientific community of Rhode Island. Our bioinformatics services include standard sequence analysis pipelines as well as 3D vidualization and printing of macromolecules in conjunction with the 3D Visualization Laboratory at URI. We also provide bioinformatics training both individually and in structured workshops.

Biostatistics Core at Rhode Island Hospital

(last updated 2017-06-13 15:50:40)
»See Biostatistics Core at Rhode Island Hospital website for more details

Contact: Jason Machan, PhD 

Location: Coro West  »See on the Map

Affiliated Centers: Clinical Reseach Center

Instrument/ServiceManufacturer/DescriptionFunction
Technical Assistance - Biostatistical Consulting
Contact: Jason Machan, PhD 
ServiceThe Biostatistics Core at Rhode Island Hospital offers centralized biostatistics consultation services to Clinical Research Center investigators, providing or steering investigators to a broad array of resources during all phases of research. During planning, the core can provide high quality trial design, including final sculpting of specific aims and hypotheses, measure selection, power analysis, data analysis planning, and grant/proposal preparation. At the beginning of a trial, the core can assist in construction of REDCap data collection tools, databases, and data management protocols, and provide help with special technology needs, such as purchasing non-standard equipment. Throughout the trial, the core can provide decision support, assessing the impact of potential design additions or changes on final statistical inference. It can serve on or help find individuals to serve on the trial’s data and safety monitoring board (DSMB). At the conclusion of the trial, the core can assist with implementation of the data analysis plan, either by providing access to contemporary statistical analysis software and coaching, or by conducting analyses for or with investigators. During reporting/publication preparation, the core can assist in write-up, data visualization, and integration of interpretations in the broader context of the project, and help address comments from peer reviewers.

Bradley Hasbro Children's Research Center Resources

(last updated 2017-12-07 15:04:36)
»See Bradley Hasbro Children's Research Center Resources website for more details

Contact: Gregory K. Fritz, MD

Location: Bradley Hospital  »See on the Map

Affiliated Centers: Bradley Hasbro Children's Research Center

Instrument/ServiceManufacturer/DescriptionFunction
Child Development and Mental Health Research
Contact: Gregory K. Fritz, MD
Child Development and Mental Health Research
Clinical Research Resources, Child DevelopmentThe Bradley Hasbro Children's Research Center (BHCRC) encompasses a broad spectrum of research programs that share a commitment to studying the impact of psychological factors on the growth and development of children and their families. BHCRC investigators are exploring new insights into the genetic roots of autism; finding pediatric bio-behavioral markers of bipolar disorder; creating effective therapies for OCD; devising effective prevention strategies for adolescent sexual risk behaviors and obesity; and much more. Areas of interest include child and adolescent psychiatric disorders, forensic issues and juvenile justice, pediatric behavioral health, biological basis of psychiatric disorders, prevention and early intervention, and health services research.
Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program
Contact: Daniel Dickstein, MD
Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program
Clinical Research Service, Pediatric ImagingThe goal of the Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program is to identify biological and behavioral markers of psychiatric illness in children and adolescents in order to improve diagnosis, treatment, and prevention of these conditions.
Rhode Island Consortium for Autism Research & Treatment (RI-CART)
Contact: RICART
RI-CART Website
Clinical Research Resources, AutismThe Rhode Island Consortium for Autism Research & Treatment (RI-CART) is working to improve the lives of Rhode Islanders with autism spectrum disorder and related neurodevelopmental disorders by promoting collaborative, cutting-edge research, improving health care and support services, and providing data-driven education and advocacy. We’re a community of families and individuals, researchers, clinicians, educators, and local agencies focused on both today’s and future generations.
Sleep Research Lab
Contact: Mary A. Carskadon, MD
Sleep Research Lab Website
Clinical Research Resources, SleepSleep for Science is a program of research focusing on understanding how sleep patterns are shaped and how they affect other activities, functions, and biological processes. Our research is chiefly about sleep patterns and processes in young humans – children, teens, and young adults.
Developmental Disorders Genetics Research
Contact: Eric Morrow
DDGRP Website
Clinical Research Resources, Developmental GeneticsThe Developmental Disorders Genetics Research Program was established in the fall of 2009 by Brown University to facilitate advances in translational research concerned with the genetics of developmental disorders. 

Brown University Herbarium

(last updated 2016-06-16 10:29:30)
»See Brown University Herbarium website for more details

Contact: Tim Whitfeld

Location: Biomed Center  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
HerbariumDried and pressed plant specimens mounted on sheets of archival paper. Plant data.The collection includes around 100,000 plant specimens and is an important depository of Rhode Island and New England collections. It is also rich in western and southern North American plants and includes special sets of historically valuable specimens from 19th and early 20th century western US expeditions. Among other important collections, the herbarium also includes a full set of Charles Wright's Cuban plants (1856-1867) and a unique and classic collection of Carex

Brown University Oncology Group (BRUOG)

(last updated 2017-12-08 09:40:58)
»See Brown University Oncology Group (BRUOG) website for more details

Contact: Howard Safran, MD

Location: 233 Richmond Street, Providence, RI 02903  »See on the Map

Affiliated Centers: Brown University Oncology Research Group (BrUOG)

Instrument/ServiceManufacturer/DescriptionFunction
Brown University Oncology Group (BRUOG)
Contact: Kayla Rosati, EdM, CCRP
Clinical Trials Support, Oncology ResearchThe Brown University Oncology Research Group (BrUOG) mission is to improve cancer care through the implementation of innovative, multidisciplinary cancer clinical trials. BrUOG provides the infrastructure for the efficient development and implementation of these trials, which are created by Brown University faculty. BrUOG’s administrators and physicians provide support for the initial study concept and validation of trial design, and are responsible for trial administration, safety monitoring, data analysis, and the presentation and publication of findings. The trials sponsored by BrUOG investigate novel, cutting-edge applications of chemotherapy, biologic agents and other cancer treatments. Clinical trials are available for a broad range of disorders in hematology/oncology and these include treatment for cancers of the breast, brain, lung, gastrointestinal tract, skin, and prostate as well as trials in leukemia and lymphoma.

Bryant Unistructure Science Spaces

(last updated 2016-06-16 10:29:30)

Contact: Dan McNally

Location: Unistructure  »See on the Map

Affiliated Centers: RI-NSF EPSCoR , RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
Gas Chromatograph - Mass Spectrometer (GC - MS)
Contact: Julia Crowley-Parmentier
Agilent Technologies 7890A GC and 5975C MSDAnalyze for volatile organics; pyrolysis; MSD and FID
Sample Preparation - Sample Concentrator, Purge & Trap
Contact: Julia Crowley-Parmentier
Teledyne Tekmar velocity XPT sample concentrator and AQUATek 70 vial autosamplerAnalyze for highly volatile organics; accessory for the GC-MS
High Performance Liquid Chromatography (HPLC)
Contact: Julia Crowley-Parmentier
ShumatzuAnalyze for non-volatile organics
Spectrometer
Contact: Julia Crowley-Parmentier
Agilent Technologies 7700 series Inductive Coupling Plasma Mass Spectrometer( ICP-MS) with ASX-500 series autosamplerAnalyze for trace elements
Sample Preparation - Chromatography - Solvent Extractor
Contact: Julia Crowley-Parmentier
Dionex ASE 350 Accelerated Solvent Extractor (ASE)Accelerated extractions
Worstation - Concentrator
Contact: Julia Crowley-Parmentier
Caliper LifeSciences Turbo Vap LV Concentration WorkstationConcentrator
Sample Preparation - Freeze Dry System
Contact: Julia Crowley-Parmentier
Labconco FreeZone 4.5Freeze dryer
Spectrophotometer
Contact: Julia Crowley-Parmentier
Shimadzu UV 2600UV/Vis spectrophotometer for quantifying concentrations
SpectrophotometerThermo Scientific AquaMate PlusUV/Vis spectrophotometer for quantifying concentrations
Microscope - Electron
Contact: Julia Crowley-Parmentier
JEOL JSM 6010LA Scanning Electron Microscope (SEM)Scanning electron microscope with EDS
Sample Preparation - Critical Point Dryer
Contact: Julia Crowley-Parmentier
Tousimis Sandri-PVT-3D Critical Point Dryer (CPD)Maintain structural integrity for soft tissue use of the SEM
Sample Preparation - Sputter Coater System
Contact: Julia Crowley-Parmentier
Denton Vacuum Desk V gold sputter coater and carbon coaterCoat non-conducting samples with gold or carbon for use on the SEM
Microscope
Contact: Julia Crowley-Parmentier
Zeiss A1 AXIO Polarized Light Microscope and Q imaging RETIGA 400R ImagerRecordable polarized light imaging
Microscope
Contact: Julia Crowley-Parmentier
Zeiss Axiovert 40CFL Inverted MicroscopeRecordable inverted microscopy
Microscope
Contact: Julia Crowley-Parmentier
Zeiss Primo Star with AxioCamRecordable imaging
Workstation - Anaerobic Chamber
Contact: Julia Crowley-Parmentier
Microbiology International Whitley DG250 Anaerobic WorkstationSimulate anoxic environments for anaerobic work
Workstation - Anaerobic Chamber
Contact: Julia Crowley-Parmentier
MBRAUN Labstar Anaerobic Glovebox Workstationsimulate anoxic environments for anaerobic work
PCR Thermal Cycler
Contact: Julia Crowley-Parmentier
Bio-Rad PCR Thermocycler C1000 Touch; Fraction Collector model 2110DNA amplifier
Biological Safety Cabinet
Contact: Julia Crowley-Parmentier
LABGARD ES class II, type A2 Biological Safety CabinetMaintain sterility and contain infectious work
Biospecimen Banking - Freezer
Contact: Julia Crowley-Parmentier
Thermo Scientific Isotemp Basic U86-13A41 minus 70 degree freezerLong term storage of biological specimens

Cancer Institute at Lifespan

(last updated 2017-12-08 09:43:33)
»See Cancer Institute at Lifespan website for more details

Contact: Howard Safran, MD

Location: Rhode Island Hospital Ambulatory Patient Center (APC Building)  »See on the Map

Affiliated Centers: Lifespan Cancer Institute

Instrument/ServiceManufacturer/DescriptionFunction
Clinical Trials Support, Cancer ResearchClinicalTranslational Research ResourcesThe Lifespan Cancer Institute at Rhode Island, The Miriam, and Newport hospitals is an active clinical trials site, committed to providing patients with the latest protocols.Our patients have access to groundbreaking new immunotherapies and other new and emerging cancer treatments at various stages of diagnosis and across many cancer types. Cancer treatments include the latest chemotherapy, biologic agents, radiation oncology, surgery, and image-guided procedures. Many of these are not available elsewhere in New England. The Dana-Farber Cancer Institute and the Lifespan Cancer Institute have created a strategic alliance to advance cancer treatment and research.

Cardiovascular Research Institute Resources

(last updated 2017-12-08 11:06:48)
»See Cardiovascular Research Institute Resources website for more detailsLocation: Zecchino Pavilion  »See on the Map

Affiliated Centers: Cardiovascular Research Institute

Instrument/ServiceManufacturer/DescriptionFunction
Cardiovascular Research Center (CVRC)
Contact: Gideon Koren
Cardiovascular Research Website
Clinical Research Resources, CardiovascularThe mission of the CVRC is to unravel fundamental mechanisms of heart disease and to discover novel cardiac therapies. The research focus of CVRC investigators is on the molecular mechanisms of rhythm disorders of the heart (cardiac arrhythmias), sudden cardiac arrest, heart enlargement (hypertrophy) and heart failure. CVRC facilities include a sophisticated invasive animal catheterization and electrophysiology laboratory, and a brand new state-of-the-art research facility that is used for the studying of genetically modified mouse and rabbit models of cardiac diseases. These studies include cellular electrophysiology, optical mapping, single cell analyses of calcium transients and contractility, sophisticated imaging tools, as well as biochemical, molecular and cell biological experimental approaches. An important goal of the CVRC is to enhance and promote education and training in molecular cardiology and life sciences.
Cardiovascular Institute’s (CVI) Clinical and Translational Research Center (CTRC)
Contact: Gaurav Choudhary
Cardiovascular Research Institute Website
Clinical Research Resources, CardiovascularThe mission of the Cardiovascular Institute’s Clinical and Translational Research Center (CVI-CTRC) is to enhance, support and facilitate the conduct of high quality clinical and translational research in cardiovascular diseases by investigators at Lifespan. In partnership with Lifespan Office of Research Administration, CVI-CTRC will provide the following services to our investigators: assistance with investigator-initiated research grant preparation; contract and budget initiation; negotiation and execution for industry sponsored trials and subcontracts; assistance with IRB including initial application, continuing review and amendments; coordinating logistics of protocol implementation; assistance with screening and recruitment; regulatory documentation collection and submission; providing access to lab processing, freezers and exam and conference area; nursing and research assistant staff to collect biopecimens, perform exams and follow up; data entry, creating and maintaining source documents and maintaining regulatory binder(s); database searches for retrospective trials; and setting up databases using Redcap.
Vascular Research Center
Contact: Efaza Siddiqui
Cardiovascular Research Institute Website
Clinical Research Resources, VascularThe Vascular Disease Research Center at Rhode Island Hospital develops clinical trials and basic science research, and has a demonstrated track record in obtaining funding for these initiatives from the federal government through the National Institutes of Health (NIH). The center also coordinates a number of Food and Drug Administration (FDA). We can help investigators seeking to develop ideas in the vascular disease arena into fundable grant applications, either formally with center involvement or informally. We also can serve in this capacity for the medical device or drug industry, helping to plan and execute all aspects of FDA studies. Our mission is to advance scientific understanding and improve public health by developing and performing pivotal clinical and basic scientific research in peripheral vascular disease.

CCRI Biology Labs

(last updated 2016-06-16 10:29:30)

Contact: David Vito

Location: Warwick, RI  »See on the Map

Affiliated Centers: RI-NSF EPSCoR

Instrument/ServiceManufacturer/DescriptionFunction
AutoclaveConsolidated Stills & Sterilizers 24D36Sterilization. Chamber size is 24inch x36inch, Volume 9.4 cu. Ft
Balance - AnalyticalOrion Analytical Balance Weight determination with capacity of 60g.
Balance - Top LoadingEK-I Compact Balance Weight determination (2 units)
IncubatorFisher Scientific Isotemp Digital & Analog Dry Bath IncubatorProvide controlled dry heat environment for clinical & general chemistry applications
Electrophoresis SystemBio-Rad Mini-Protean Tetra Cell, Vertical protein electrophoresis gel boxesRunning Protein or DNA polyacrylamide gels
MicroscopeLieder MI-500 Series Compound Inverted MicroscopeTissue Culture
pH MeterThermo Scientific Orion 2-Star Bench Top pH MeterGeneral purpose measurements
Western Blotting System, Semi-Dry Shelton Scientific Semi-Dry Blotting SystemTransfer of protein, RNA & DNA gels to a solid membrane support for visualization, 24cmx30cm.
SpectrophotometerThermo Scientific Genesis 20 Visible SpectrophotometerUV spectrophotometer for quantifying concentrations
Imaging System - Gel Imager - TransilluminatorFOTODYNE Foto Phoresis UV TransilluminatorImaging-protein gel analysis, GFP Analysis
Incubator - ShakerLab Companion IS-971 Floor Model Incubator Shaker Growing of bacteria, 250 L chamber
Biological Safety CabinetNuAire Class II Type A2Maintain sterility and contain infectious work

Cell Analysis and Sorting Core

(last updated 2016-06-16 10:29:30)
»See Cell Analysis and Sorting Core website for more details

Contact: Loren Fast, PhD

Location: 80 Washington Street (Shepard Bldg)  »See on the Map

Affiliated Centers: Institute for Immunology and Informatics, COBRE Immune-Based Interventions Against Infectious Diseases

Instrument/ServiceManufacturer/DescriptionFunction
Flow Cytometer
Contact: Alan Rothman
Miltenyi MACSQuant-10 Analytical Flow CytometerAnalytical flow cytometry- 3 lasers, 10 parameters (8 colors, FSC, SSC)
Imaging System - Plate Reader
Contact: Alan Rothman
Biotek Cytation 3Imaging plate reader; 5 colors (brightfield, GFP, RFP, DAPI, Cy5); 10x, 20x, 60x objectives
Microscope
Contact: Alan Rothman
Life Technologies Evos FL, Fluorescence MicroscopeFluorescence microscope; 4 colors (GFP, RFP, DAPI, Cy5); 10x, 40x, 100x objectives
Cell Sorter - Magnetic
Contact: Alan Rothman
Miltenyi AutoMACSAutomated cell sorter for cell suspensions labeled with magnetic beads.
Microplate Reader
Contact: Alan Rothman
Perkin-Elmer EnvisionMultimodal plate reader- absorbance, luminescence, fluorescence, time-resolved fluorescence, AlphaScreen
Flow Cytometer
Contact: Alan Rothman
BD LSRIIAnalytical flow cytometric analysis; 4 lasers (blue (2), violet (4), red (3) and yellow green (5)) which allows for analysis of up to 14 different fluors (# listed in parentheses for each laser)

Cell Isolation & Organ Function Core

(last updated 2016-06-16 10:29:30)
»See Cell Isolation & Organ Function Core website for more details

Contact: Elizabeth Harrington

Location: The Providence VA Medical Center  »See on the Map

Affiliated Centers: Ocean State Research Institute, COBRE CardioPulmonary Vascular Biology

Instrument/ServiceManufacturer/DescriptionFunction
Analyzer - Cell MetabolismSeahorse Biosciences - XF Extracellular Flux AnalyzerXF instruments analyze mitochondrial respiration and glycolysis in live cells, generating data in just minutes. XF Technology uses solid-state sensors to simultaneously measure both oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in every well. All platforms support injection of up to 4 unique compounds per well.
Analyzer - Electrical Cell Impedance Sensing (ECIS) equipmentApplied BioPhysics, Model 100Measures cell impedance using altering currents across cell monolayers and measuring the change in electrical potential. Impedance is calculated using Ohm's law.
Analyzer - Electrical Cell Impedance Sensing (ECIS) equipmentApplied BioPhysics, Model ECIS Z ThetaMeasures cell impedance using altering currents across cell monolayers and measuring the change in electrical potential. Impedance is calculated using Ohm's law.
Imaging System - Slide ScannerAperio ScanScope CS Digital Slide Scanner CSBrightfield 5 slide scanner with two workstations with Aperio brightfield imaging analysis software.
Imaging System - Slide ScannerAperio Scan Scope FL Fluorescent Digital Slide Scanner5 slide scanner with Indica Labs fluorescence imaging analysis software.
Flow CytometerMiltenyi MACSQuant Analyzer 7 The MACSQuant Analyzer is a powerful benchtop flow cytometer for highly sensitive, multiparameter cell analysis. MACSQuant Analyzers offer fully automated instrument setup via pre-set calibration and compensation programs. Automated startup, shutdown, and cleaning cycles make for hassle-free instrument housekeeping. The MACSQuantify™ Software provides a powerful and easy-to-use user interface for instrument control, data acquisition, and fully automated analysis.
EvaporatorBuchi RotaVapor R215 EvaporatorRotary evaporator for removing solvents.
Ventilator - MechanicalSCIREQ FlexiventContains a computer-controlled precision piston pump that can intersperse mechanical ventilation with a variety of volume and pressure controlled maneuvers to obtain accurate, reproducible measurement of respiratory mechanics for pulmonary research.
Imaging System - EchocardiographVisualSonics, Vevo 2100 Imaging SystemA high-frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode. The Vevo 2100 Imaging System enables in vivo visualization, assessment, and measurement of anatomical structures and hemodynamic function in longitudinal imaging studies for small animal phenotyping.
Channel Cycling Metabolic SystemFor rodent cardiopulmonary exercise Testing OmniTech ElectronicsModel #80 AP4RAT AccuPacer 4 Channel Rat Treadmill and #75 MS8 8

Center for AIDS Research (CFAR) - Providence/Boston

(last updated 2017-12-08 14:23:17)
»See Center for AIDS Research (CFAR) - Providence/Boston website for more details

Contact: Susan Cu-Uvin, MD

Location: The Miriam Hospital, CFAR Building, Room 134  »See on the Map

Affiliated Centers: Center for AIDS Research (CFAR) - Providence/Boston

Instrument/ServiceManufacturer/DescriptionFunction
BioBehavioral Research Support, HIV
Contact: Larry K. Brown MD (Core Director)
BioBehavioral Sciences Webpage
Clinical Research Service, HIV ResearchThe BioBehavioral Sciences Core (BBSC) supports innovative, integrated medical/behavioral research to improve the HIV treatment cascade and HIV prevention among vulnerable populations including justice-involved individuals, women, youth, and persons living in hyperepidemic resource-limited settings.
Biostatistics, HIV Research
Contact: Joseph Hogan, ScD
Biostatistics Webpage
Clinical Research Service, HIV ResearchThe Biostatistics Core ensures that all research undertaken by Center for AIDS Research (CFAR) investigators uses optimal methods for study design and analysis; to develop innovative new approaches that address existing gaps in methodology; to expand the number of quantitative researchers engaging in HIV research; and to ensure, through collaboration, training and mentoring, that CFAR researchers have a strong base of knowledge about principles related to study design, data analysis, and interpretation.
Substance Use Research Core
Contact: Christopher Kahler PhD
Substance Use Research Core Webpage
Clinical Research Service, HIV ResearchThe Substance Use Research Core (SURC) offers services and expertise on the methods needed to conduct effective Substance Use (SU)/HIV research. Services will be directed at: 1)hypothesis generation, 2) assessment, 3) intervention development, and 4) ethical considerations of SU research. The SURC offers expertise in innovative methods for assessing and analyzing SU, and developing and implementing interventions to address alcohol, tobacco, and other drug use.
Administration - CFAR
Contact: Vicki C. Godleski 
Administrative Core Webpage
Clinical Research Service, CFAR Coordinating CenterThe CFAR Administrative Core has built an HIV infrastructure across the partner institutions and provides oversight of the entire CFAR community with responsibility for sound management, organizational structure, appropriate resource allocation, evaluation and the promotion of inter/multi-disciplinary translational HIV research. Through efficient communication to CFAR membership, the Core manages a highly interactive and collaborative scientific environment across geographically dispersed settings in domestic, national and international sites.
Basic and Translational Sciences
Contact: Rami Kantor, MD
Basic and Translational Sciences Webpage
Clinical Research Service, HIV ResearchThe Basic and Translational Sciences Core builds and supports collaborative research and synergy between basic, translational clinical and behavioral investigators as well as other multidisciplinary scientists, by providing laboratory, consultation and mentoring services. Services include; Viral load measurement, STI testing, Genital tract specific assays, Biologic specimens collection techniques, HIV-1 and 2 drug resistance assays, Identification of HIV dependency factors (HDF), Cell culture, Viral stocks, Immune activation, Laboratory Consulting, Training and Mentoring.

Center for Computation and Visualization

(last updated 2016-06-16 10:29:30)
»See Center for Computation and Visualization website for more details

Contact: Gurcharan Khanna

Location: Center for Computation and Visualization  »See on the Map

Affiliated Centers: Center for Computation and Visualization, RI-NSF EPSCoR

Instrument/ServiceManufacturer/DescriptionFunction
High Performance Computing ClusterVarious including IBM idataPlex High Performance Computing ClusterHPC cycles, software development, storage, backups, high speed network hub, visualization, virtual reality, data management, server colocation, scientific support

Center for International Health Research

(last updated 2017-12-08 09:46:37)
»See Center for International Health Research website for more details

Contact: Jake Kurtis

Location: 55 Claverick Street Providence, RI 02903  »See on the Map

Affiliated Centers: Center for International Health Research

Instrument/ServiceManufacturer/DescriptionFunction
Center for International Health Research
Contact: Danielle Barbery
Clinical Research Resources, Tropical Infectious DiseasesThe Center's mission is to address these urgent global health challenges, the Center for International Health Research (CIHR) at Rhode Island Hospital was founded. The center's mission is to understand the pathogenesis of tropical infectious diseases, specifically malaria and schistosomiasis, and to harness this knowledge to design improved treatments and vaccines. ChildrenTo combat these infections, the center is engaged in studies integrating community-based epidemiologic studies in endemic countries with laboratory-based, basic science investigations. The center's research approach is rooted in the belief that the discoveries of tomorrow will come at the intersection of field and lab science.

Center for Neurorestoration and Neurotechnology (CfNN) Resources

(last updated 2017-12-07 15:05:08)
»See Center for Neurorestoration and Neurotechnology (CfNN) Resources website for more details

Contact: Leigh Hochberg

Location: The Providence VA Medical Center  »See on the Map

Affiliated Centers: Center for Neurorestoration and Neurotechnology (CfNN)

Instrument/ServiceManufacturer/DescriptionFunction
Center for Neurorestoration and Neurotechnology (CfNN)
Contact: Leigh Hochberg
Center for Neurorestoration and Neurotechnology (CfNN) Resources Website
Clinical Research Resources, Neurorestoration and NeurotechnologyThe Center for Neurorestoration and Neurotechnology (CfNN) is a collaboration between the Providence VA Medical Center, Brown University, Butler Hospital, Lifespan, and Massachusetts General Hospital. CfNN unifies distinguished researchers and clinicians to advance and translate neurotechnology to restore lost function. Through its three focus areas and three support cores, CfNN seeks to develop, test and implement new therapies and technologies that restore function for Veterans with disorders affecting the nervous system.
Gait and Motion Analysis, Virtual Reality, Human Movement and Rehabilitation
Contact: Susan D’Andrea, PhD
Gait and Motion Analysis Laboratory Website
Clinical Research Resources, Musculoskeletal RehabilitationThe Virtual Reality and Motion Analysis Rehabilitation Laboratory is a fully functional research lab focusing on rehabilitation of the musculoskeletal system. The science of motion is studied through computerized animation with an infrared camera system, electromyography, metabolic assessments and virtual reality. The universal theme throughout the lab is the use technology to analyze human movement, quantify improvements and drive the decision making process for design and treatment. Instrumentation includes a 14-camera Qualisys motion capture system, 2 AMTI force plates, a 16 Delsys wireless EMG system, a Cosmed K24b Metabolic testing unit, a custom-designed virtual reality display, a standard treadmill and a customized dual-track, actuated treadmill, software to support the biomechanical analyses of human motion.
Neurotechnology: Clinical Study Assessment, Outcome Measurement and Implementation Service
Contact: Marguerite Bowker BSN, RN, CIP
Assessment, Outcome Measurement and Implementation Service Website
Clinical Trials Support, CfNN Neurotechnology and NeurorestorationThe Assessment, Outcome Measurement, and Implementation service oversees research related procedures in support of Center for Neurorestoration and Neurotechnology (CfNN) PIs and Project Coordinators, and facilitates the continuity of care and access to care for CfNN’s complex study participants. The core assists with developing protocol related documents (e.g. case report forms, manual of operations etc.), evaluates and helps prepare IRB submission documents, research study protocols, checks training compliance, develops and reviews data entry processes, advises on selection of reliable and valid assessment instruments and outcome measures, and assists in identifying personnel to analyze research outcomes. The Core provides expertise in development and implementation of standardized protocols for data collection, and assists in training research staff to insure uniformity and fidelity to testing and intervention procedures. Core resources include neuropsychological assessments, clinical trials/multisite study management, regulatory assistance (device, intellectual property, technology transfer), statistics and a research assistant/research coordinator pool
Neurotechnology: Recording, Decoding and Computational Neuroscience Service
Contact: Stephanie Jones, PhD
Recording, Decoding, and Computational Neuroscience Website
Clinical Research Service, CfNN Computational NeuroscienceThe Recording, Decoding and Computational Neuroscience core helps VA affiliated researchers deepen their understanding of how device-based neurotherapies act on brain circuits and networks by providing expertise in statistical and computational neuroscience methods. We advise on computational neuroscience methods to reveal mechanisms of action of both invasive and noninvasive brain stimulation therapies, and on decoding strategies to reveal computational functions of neural circuits. To this end, we are developing a software tool that will allow researchers and clinicians to interpret the circuit mechanisms underlying human electroencephalography (EEG) brain signals and the impact of brain stimulation on these signals. We have also created an open-source flexible cost platform for EEG data acquisition and analysis whose development specs are available to the greater neuroscience community. Instruments include a unique computational model of neocortical function, EEG, and somatosensory stimulus probe devices (for touch (in-house), thermal pain, Medoc).
Neurotechnology: Neuromodulation and Neuroimaging Service
Contact: Jerome Sanes, PhD
Neuromodulation and Imaging Website
Clinical Research Service, CfNN Neuromodulation and NeuroimagingThe CfNN Neuromodulation and Neuroimaging Core supports Center projects that use MRI technology, including functional MRI and structural MRI and non-invasive brain stimulation (transcranial magnetic stimulation and transcranial direct and alternating current stimulation) for research with human participants. Core facility users must have a VA appointment or a collaborative agreement with a VA employee. Instrumentation includes a 3T Verio MRI System (Siemens), BOLD Screen (Cambridge Research Systems), Transcranial magnetic and electrical stimulation devices (Magstim, Neuronetics, neuroConn, Soterix, and Neuroelectrics), Brainsight neuronavigation software (Rogue Resolutions).

Center for Primary Care and Prevention

(last updated 2017-12-08 09:52:20)
»See Center for Primary Care and Prevention website for more details

Contact: Chuck Eaton

Location: Memorial Hospital of Rhode Island  »See on the Map

Affiliated Centers: Center for Primary Care and Prevention

Instrument/ServiceManufacturer/DescriptionFunction
Center for Primary Care and PreventionClinical Research Resources, Primary CareThe Brown University Center for Primary Care and Prevention was established to improve the health of individuals and communities by promoting research, enriching knowledge, and improving practice in primary care and prevention. The mission of the Center is to (1) promote interdisciplinary research in community, public health, and clinical aspects of primary care medicine, (2) stimulate innovations in the primary care education for medical students, residents and fellows; and (3) provide technical assistance to private foundations, state and federal agencies on matters of health policy, and to international organizations on matters regarding the development of primary care systems in other countries.

Center for Prisoner Health and Human Rights

(last updated 2017-12-08 09:54:47)
»See Center for Prisoner Health and Human Rights website for more details

Contact: Alexandria Macmadu, MSc

Location: The Miriam Hospital  »See on the Map

Affiliated Centers: Center for Prisoner Health and Human Rights

Instrument/ServiceManufacturer/DescriptionFunction
Center for Prisoner Heath and Human RightsClinical Research Resources, Prisoner HealthThe Center for Prisoner Health and Human Rights seeks to advance the health and human rights of criminal justice-involved populations, among which minority populations are disproportionately represented. The Center aims to achieve its goal through research, education, and advocacy. The Center identifies, initiates, and supports projects that respond to the epidemic of incarceration and recidivism in the criminal justice system and the associated complex public health crisis, among other things. Extensive and fruitful clinical, behavioral, and social research has been carried out within the prison and jail setting by Brown University investigators. The Center supports investigators by connecting them with undergraduate- and graduate-level research assistants, and participates in dissemination activities.

Center for the Study of Children at Risk

(last updated 2017-12-08 09:56:55)
»See Center for the Study of Children at Risk website for more details

Contact: Barry Lester

Location: 50 Holden Street, Providence, RI  »See on the Map

Affiliated Centers: Center for the Study of Children at Risk

Instrument/ServiceManufacturer/DescriptionFunction
Center for the Study of Children at RiskClinical Research Resources, Child Development The mission of the Center for the Study of Children at Risk is to stimulate outstanding interdisciplinary research, education, and clinical services on the biological and social factors that determine the developmental outcome of at-risk children. Our objective is to nurture, promote and coordinate research, training, education, and clinical service in child development and developmental psychopathology. Our group is interdisciplinary spanning the disciplines of developmental and clinical psychology, pediatrics, psychiatry, nursing, occupational therapy, social work, substance abuse and public health. We are excited by the translational work that occurs at the boundaries where disciplines intersect leading to new science and the handshaking between science and clinical practice. Current research at the Center includes studies of children with various risk factors including prenatal drug exposure, autism, prematurity, and maternal depression. We also study epigenetic mechanisms that affect outcome in children at risk.

Center of Innovation in Long Term Services and Supports (LTSS COIN)

(last updated 2017-12-08 09:59:12)
»See Center of Innovation in Long Term Services and Supports (LTSS COIN) website for more details

Contact: James Rudolph

Location: The Providence VA Medical Center  »See on the Map

Affiliated Centers: Center of Innovation in Long Term Services and Supports (LTSS COIN)

Instrument/ServiceManufacturer/DescriptionFunction
Center of Innovation in Long Term Services and Supports (LTSS COIN)
Contact: Debra D'Allesandro
Clinical Research Resources, Veteran PopulationThe Center of Innovation in Long Term Services and Supports (LTSS-COIN) is an emerging health services research center with a focus on aging and other vulnerable Veteran populations. The Center includes an analytic core dedicated to Health Services Research in Long Term Supports. LTSS-COIN Research Concentrations include (1) Quality of Care in Nursing Homes and Home and Community Based Services, (2) High Risk Veteran Populations (Palliative Care, Dialysis, and Cognitive Impairment) (3)Policy and Economic Analysis of Long - Term Care Programs, (4) Antimicrobial Stewardship Research in the Long-Term Care Community, (5) Mental Health and Homelessness Research.

Centers for Behavioral and Preventive Medicine (CBPM)

(last updated 2017-12-08 09:27:13)
»See Centers for Behavioral and Preventive Medicine (CBPM) website for more details

Contact: behavioralmed@lifespan.org

Location: Coro West, Suite 309  »See on the Map

Affiliated Centers: Centers for Behavioral and Preventive Medicine (CBPM)

Instrument/ServiceManufacturer/DescriptionFunction
Behavioral and Preventive Medicine (CBPM) Resources
Contact: Michael Carey, PhD
Clinical Research Resources, Behavioral MedicineThe Centers for Behavioral and Preventive Medicine (CBPM) research scientists and their teams work to discover new and improved health promotion and disease management approach, focusing on the role of human behavior in health and disease. The Centers' research draws upon the social and behavioral sciences as well as biomedical and public health sciences to address the leading lifestyle causes of disease burden and death. The research portfolio includes both primary prevention (e.g., tobacco cessation, weight management, physical activity) and chronic disease management. The Center develops, implements, and evaluates interventions to reduce health risks, promotes active participation in medical care, and enhances quality of life. The Center works with healthy volunteers as well as people living with a chronic illness or condition, such as cancer, heart disease, diabetes, or HIV.

Centralized Research Core Facility

(last updated 2016-06-29 15:13:03)
»See Centralized Research Core Facility website for more details

Contact: Al Bach

Location: Pharmacy Rm 405  »See on the Map

Affiliated Centers: RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
Analyzer - Live CellRoche xCELLigence Real-Time Cell Analysis SystemLabel free live cell analyzer
Biological Safety CabinetNuAire, Laminar Flow HoodCell culture facility
Cell CounterNexcellom Cellometer Vision Cell CounterAutomated cell counter
CentrifugeBeckman Avante High Speed CentrifugeHigh speed centrifuge
CentrifugeThermo MultiFuge Centrifuge table-topCentrifuge
Centrifuge - UltraBeckman Coulter Optima Ultra centrifuge
Centrifuge - UltraSorvall Micro Ultra CentrifugeUltra centrifuge
EvaporatorBuchi RotaVap SystemRotary evaporator
Fluorescence Activated Cell Sorter (FACS)Becton Dickinson (BD) Biosciences FACS Verse Flow cytometerFACS
Electrophoresis System - Gel ElectrophoresisAgilent Offgel Fractionator 3100Liquid phase Isoelectric Focusing (IEF) System
Electrophoresis System - Gel ElectrophoresisBio-Rad 2D Gel SystemTwo Dimensional (2D) Gel Electrophoresis
Electrophoresis System - Gel ElectrophoresisBio-Rad PAGE Electrophoresis SystemOne Dimensional (1D) Gel Electrophoresis
High Performance Liquid Chromatography - Ultra High (UHPLC)Hitachi UPLC SystemUPLC
Liquid ChromatographGE AKTA Fast Protein Liquid Chromatograph (FPLC)FPLC
High Performance Liquid Chromatography (HPLC)Hitachi Analytical HPLCHPLC
High Performance Liquid Chromatography (HPLC)Hitachi Prep-HPLC SystemHPLC
ChromatographyTeledyne-ISCO CombiFlash SystemFlash Chromatography
Imaging System - Gel Imager GE Imagescanner II Gel imager
Imaging System - Gel Imager GE Typhoon FLA 9000 Multimode ImagerGel imager
Imaging System - Gel Imager Li-Cor Odyssey IR ImagerIR gel imager
Liquid Chromatography - Mass Spectrometer (LC - MS) AB SCIEX TripleTOF 4600 and Shimadzu Prominence UFLC sytemESI-TOF MS
Mass SpectrometerShimazu Axima MALDI-TOF MS/MSMALDI MS
Mass SpectrometerThermo iCAPQ-a ICP-MSElemental Analyzer
Microplate ReaderBMG LabTech Microplate ReaderFluorescence/UV/VIS
Microplate ReaderMolecular Devices SpectraMax M2 Fluorescence/UV/VIS
Microplate ReaderPromega GlowMax SystemChemiluminescence
MicroscopeNikon Eclipse E600 Upright MicroscopeMicroscope
MicroscopeNikon TE2000E /C2 Inverted Confocal Confocal Microscope
PCR Thermal CyclerApplied Biosystems/Life Technologies ABI Vii7- RT-PCRRT-PCR
PCR Thermal CyclerEppendorf Mastercycler PCRPCR
Protein SequencerShimadzu PPSQ-31A protein sequencerN-terminal protein sequencer
Robotic Workstation - Liquid HandlerBioTek Precision XS Sample ProcessorSample processor
Robotic Workstation - RNA/DNAFuji Film DNA/RNA Isolation SystemDNA/RNA isolation
Radiometric Detectors - Scintillation CounterPerkinElmer Microbeta1450 Scintillation CounterScintillation counter
Radiometric Detectors - Scintillation CounterPerkinElmer Wizard 1470 Gamma CounterGamma counter
SpectrometerPerkinElmer Luminescence Spectrometer LS55Fluorescence
SpectrophotometerJasco J-1100 Circular Dichroism (CD) SpectrophotometerCD
SpectrometerThermo Nicolet 380 Fourier Transformed Infrared Spectrometer (FT-IR)FT-IR
SpectrophotometerBeckman UV/VIS DU800UV/VIS
ChromatographyMetrohm Ion Chromatography 940 VarioIon Chromatography
SpectrophotometerThermo Scientific NanoDropUV/VIS
Electroporation System - Transfection PlatformLonza Nucleofactor SystemHigh-throughput transfection
Water Purification System - Deionized (DI)Millipore Milli-Q Water SystemDI water System
Western Blotting System Bio-Rad Turbo Trans Blot system Western Blotting
Western Blotting System Life Technologies BenchPro Western SystemWestern Blotting processor
Western Blotting System Protein Simple Simon WesternLiquid phase Western Blotting
Synthesizer, DNA/RNAMerMade-4 Oligonucleotide synthesizerDNA/RNA Synthesizer
High Performance Liquid Chromatography (HPLC)Shimadzu Nexera-i HPLC systemHPLC
MicroscopeEVOS FL Auto Cell Imaging SystemMicroscope
SpectrometerJasco Digital Polarimeter P2000Polarimeter

Clinical Pharmacokinetics Research Laboratory

(last updated 2017-12-07 15:09:06)
»See Clinical Pharmacokinetics Research Laboratory website for more details

Contact: Fatemeh Akhlaghi

Location: Laboratory 490, Avedisian Hall  »See on the Map

Affiliated Centers: College of Pharmacy, University of Rhode Island

Instrument/ServiceManufacturer/DescriptionFunction
Pharmacokinetics Consultation
Contact: Fatemeh Akhlaghi
Clinical Research Resources, PharmakokineticsThe laboratory is capable of providing support for the design and implementation of pre-clinical and clinical pharmacokinetics studies as well as design and conduct of ancillary in vitro studies (protein binding and microsomal incubations to characterize phase 1 or 2 metabolism). With extensive background in pharmacokinetics modeling and simulation using NONMEM, WinNonlin and Simcyp softwares, the laboratory can provide a valuable resource for on-going or completed clinical studies. Additional data analysis capabilities includes in-vitro in-vivo correlation (IVIVC) and bioequivalence analysis.
Pharmacokinetics, Bioanalytical support
Contact: Fatemeh Akhlaghi
Clinical Research Resources, PharmakokineticsThe Clinical Pharmacokinetics Research Laboratory is equipped with two UPLC-MS/MS and one quadrupole-time-of-flight mass spectrometer (ESI-QTOFMS) systems capable of measuring the concentration of small molecule xenobiotics and their metabolites as well as endogenous or therapeutic peptides and proteins. To date, this laboratory has developed various assays for the quantification of up to 60 different compounds and validated these assays according to guidelines by the Food and Drug Administration of the United States. The laboratory is proficient in providing analytical support for on-going pre-clinical and clinical studies and during different stages of a drug development project.

Clinical Research and Development Service

(last updated 2017-12-08 10:01:14)
»See Clinical Research and Development Service website for more details

Contact: Gaurav Choudhary

Location: The Providence VA Medical Center  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Clinical Research and Development Service ResourcesClinical Research Resources, Veteran PopulationThe VA Research's fundamental mission is to advance the healthcare of Veterans. The Providence VA Medical Center has a large funded research and development program, including studies in Rehabilitation Medicine, Cardiology, Mental Health, Neuroscience, Substance Abuse, Health Services & Economics, and Pulmonary Disease. These studies enhance our ability to provide state-of-the-art techniques and treatments to our patients. At the same time, the research program helps Providence VAMC recruit and retain the highest quality health care professionals who treat our Veterans in the VA Clinics on a daily basis.

Clinical Translational Research Center (CTRC) - Lifespan

(last updated 2017-12-08 14:44:38)
»See Clinical Translational Research Center (CTRC) - Lifespan website for more details

Contact: Bharat Ramratnam

Location: Coro Center West  »See on the Map

Affiliated Centers: Cardiovascular Research Institute

Instrument/ServiceManufacturer/DescriptionFunction
Clinical Research Center Resources
Contact: Andrew Schumacher
Clinical Trials Support, Coordinating CenterIn partnership with Lifespan Office of Research Administration, the Clinical Translational Research Center (CTRC) will provide the following services to our investigators: assistance with investigator-initiated research grant preparation; contract and budget initiation; negotiation and execution for industry sponsored trials and subcontracts; assistance with IRB including initial application, continuing review and amendments; coordinating logistics of protocol implementation; assistance with screening and recruitment; regulatory documentation collection and submission; providing access to lab processing, freezers and exam and conference area; nursing and research assistant staff to collect biopecimens, perform exams and follow up; data entry, creating and maintaining source documents and maintaining regulatory binder(s); database searches for retrospective trials; and setting up databases using Redcap.

Computational Biology Core

(last updated 2017-08-04 08:08:58)
»See Computational Biology Core website for more details

Contact: Ashok Ragavendran

Affiliated Centers: COBRE Center for Computational Biology of Human Disease

Instrument/ServiceManufacturer/DescriptionFunction

Core Research Laboratories - Rhode Island Hospital

(last updated 2017-12-08 14:50:25)
»See Core Research Laboratories - Rhode Island Hospital website for more details

Contact: Suzanne de la Monte

Location: The Coro West Building  »See on the Map

Affiliated Centers: COBRE Center for Cancer Research and Development at Rhode Island Hospital

Instrument/ServiceManufacturer/DescriptionFunction
Cryostat
Contact: Paul Monfils
Reichert-Jung Cryocut 1800Frozen tissue sectioning (used with Superfrost/Plus microscope slides (approximately 4-10 microns).
Fluorescence Activated Cell Sorter (FACS)
Contact: Paul Monfils
Becton Dickinson (BD) Biosciences FACS Vantage Flow CytometerHigh-speed cell sorter. Two lasers analyze cells on 8 parameters. Side/ forward light scatter. 6 different fluorescent color detection. Simultaneously sort up to four populations of cells. Sort 1+ cell type(s) into 6, 24, and 96 well tissue culture plates.
Fluorescence Activated Cell Sorter (FACS)
Contact: Paul Monfils
Becton Dickinson (BD) Biosciences FACSort Flow CytometerAnalytical flow cytometer. Two lasers analyze cells on 6 parameters. Side/ forward light scatter. 4 different fluorescent color detection.
Histology/Tissue Processing - Biosafety Cabinet
Contact: Paul Monfils
Laminar Flow Hood Filter capable of removing 99.97% of particles greater than 0.3 microns.
Histology/Tissue Processing - Knife Sharpener
Contact: Paul Monfils
Hecker Instruments, Inc. Knife SharpenerUsed to sharpen microtome/cryostat knife.
Histology/Tissue Processing - Microwave Oven
Contact: Paul Monfils
Sharp Microwave OvenTissue microwave fixation.
Histology/Tissue Processing - Oven
Contact: Paul Monfils
Fisher Scientific OvenUsed to melt paraffin from paraffin- embedded sections.
Histology/Tissue Processing - Paraffin Embedding Workstation
Contact: Paul Monfils
Miles Scientific Tissue-Tek IIIParaffin embedding sample station (tissue, bone, cell pellet, etc.).
Histology/Tissue Processing - Tissue Processor
Contact: Paul Monfils
Miles Scientific Tissue-Tek-VIP Tissue ProcessorAutomated sample processing (tissue, bone, cell pellet, etc.) for paraffin embedding purposes.
Hybridization Oven
Contact: Carol Ayala
Panomics-Luminex Hybridization ovenHorizontal air flow oven for optimal temperature uniformity.
Imaging System - Camera
Contact: Ginny Hovnesian
Diagnostics SPOT 110-2 Digital Camera Digital Imaging of samples.
Imaging System - Camera
Contact: Ginny Hovnesian
Olympus SPOT IDEA 3.0 MP Digital Camera Digital Imaging of samples. 1.3, 3.0, 5.0 megapixel available. Vivid colors, 12-bit image capture, high-speed readout, external trigger output, USB 2.0 interface for universal connections.
Imaging System - Camera
Contact: Ginny Hovnesian
SPOT RT3 Slider -43C F-MT Digital Camera Attached to Nikon TE-800. Digital Imaging of samples. Ideal for brightfield color imaging, fluorescence microscopy, FISH, GFP imaging, immuno- fluorescence, 3D convolution. CCD cooled to -43.3. 1.92 MP. 1-16x. 14-bit x 20MHz capture, 40MHz live mode, interline progressive scan, FireWire interface.
Imaging System - Dark Room
Contact: Paul Monfils
Dark Room Related equipment eg., automatic processors, dryers, et alSample photo development.
Imaging System - Photo Enlarger
Contact: Carol Ayala
Durst Laborator 1200 Photographic Enlarger Sample digital imaging using high performance enlarger.
Microscope
Contact: Carol Ayala
Bausch Lomb StereomicrosopesVisualization with incident light illumination.
Microscope
Contact: Ginny Hovnesian
NIKON E-800 Fluorescent /Brightfield MicroscopeFluorescence/Brightfield- micro- scope slides only. CFI60 optical system. 0.5x magnification with 50mm field of view. Can be coupled with 2x projection lens to permit macrophotography at 1:1 magnification. Tube lens focal length of 200mm. 10 types of condensers available.
Microscope
Contact: Ginny Hovnesian
Nikon TE 200 Inverted Fluorescent/Brightfield MicroscopeFluorescence/Brightfield Microscope- petri dish/microscope slides on cell/slice culture etc. Phase contrast and fluorescence.
Microscope
Contact: Paul Monfils
Olympus BHTU Upright Light MicroscopeLight Microscope for viewing tissue or cell samples on microscope slides. 45mm parfocal distance system, corrected for a mechanical tube length of 160mm. Two types of standard objectives, D Achromats and D Plan Achromats, magnifications of 4x, 10x, 20x, 40x, 100x. FN20. Equipped for epifluorescence microscopy.
Microscope
Contact: Paul Monfils
Olympus IMT-2 Inverted Light MicroscopeLight Microscope use to view cell/slice/tissue culture samples (microscope slide or petri dish). Inverted research microscope equipped with phase contrast optics.
Microscope
Contact: Carol Ayala
Zeiss S-16 Light MicroscopeLight Microscope used to view 1 micron sectioned resin-embedded samples.
MicroscopeNIKON C1Si Spectral Live Cell Confocal Inverted Microscope System For use with microscope slide. Four diode lasers that excite at 402, 488, 561, & 638 and has spectral capabilities. Suitable for tissue, live cell imaging, time events, FRAP, FRET, deconvolutions, colocalization analysis and 3D reconstructions.
Microscope - Electron
Contact: Carol Ayala
Morgagni 268 Fully Digitized Transmission Electron Microscope (TEM)Ultrastructural analysis (tissue, cells) on stained ultra-thin sections contrasted with uranyl acetate and lead citrate. Examined with Morgagni 268 transmission electron microscope that is fully digitized, high performance, 100 kv, and images collected with an AMT Advantage 542 CCD camera system.
Microtome
Contact: Carol Ayala
Bausch Lomb UltramicrotomeSectioning resin-embedded tissue; micron-nm thickness.
Microtome
Contact: Paul Monfils
Reichert-Jung MicrotomeParaffin embedded tissue sectioning (approximately 2-20 microns).
Vibratome
Contact: Carol Ayala
Bausch Lomb VibratomesSectioning agarose-embedded tissue.
Vibratome
Contact: Paul Monfils
Vibratome 3000 Sectioning SystemFresh tissue sectioning. Thickness: 3- 20 microns.

Diagnostic Imaging Research

(last updated 2017-12-08 10:08:24)
»See Diagnostic Imaging Research website for more details

Contact: Glenn A. Tung, MD

Location: Gerry House  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Diagnostic Imaging Research ResourcesClinical Trials Support, Diagnostic ImagingThe Division of Imaging Research has successfully completed both federally-funded and industry-sponsored research trials. The Division has participated in cancer imaging trials that include screening studies and studies looking at the efficacy of various imaging modalities.The Division has participated in studies with pharmaceutical companies on phase I, II, and III trials. These studies include both diagnostic and cancer treatment drugs. We have also worked with various device manufacturers that are seeking pre-market and post-market Food and Drug Administration approval for medical devices. In addition, the Division has participated in several blood biomarker studies.

Division of Surgical Research at Rhode Island Hospital

(last updated 2017-12-08 10:20:40)
»See Division of Surgical Research at Rhode Island Hospital website for more details

Contact: Jorge Albina, MD

Location: Nursing Arts Bldg, Room 213  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Surgical Research ResourcesClinical Research Resources, SurgicalDepartment of Surgery's 15 separate divisions (including the Division of Surgical Research), each with its own specific research focus to improve understanding of diseases and evaluate new methods of treatment for injuries and illness.  

Electron Microprobe Facility

(last updated 2016-06-16 10:29:30)
»See Electron Microprobe Facility website for more details

Contact: Joseph S Boesenberg

Location: Geo-Chem Building  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Analyzer - Electron Microprobe
Contact: Stephen Parman
Cameca SX100 Electron Microprobe Analyzer The Cameca SX-100 electron microprobe is equipped with 5 wavelength dispersive spectrometers (WDS) and a Rontec energy dispersive spectrometer (EDS).The WDS spectrometers each contain two or four diffracting crystals and presently include LTAP, TAP (2), LPET (2), PET, LLIF (2), LIF, LPCO, PC1 and PC2. The last three crystals are used to measure the light elements (boron to sodium). The absolute detection limits for the instrument are approximately 50-200 ppm, depending on the element. The EDS spectrometer is capable of detecting all elements above sodium (Na). X-ray element maps can easily be acquired on the microprobe. Using 512x512 pixel maps, up to nine element maps (5 elements on WDS, 4 with EDS), plus a backscattered electron (BSE) image, can be obtained simultaneously. Maximum resolution on any one map is one micron per pixel. Utilizing the coordinate system, maps of entire thin sections can be generated.

Emergency Medicine Research Laboratory

(last updated 2017-12-08 10:09:55)
»See Emergency Medicine Research Laboratory website for more details

Contact: Gregory Jay

Location: Coro West
Instrument/ServiceManufacturer/DescriptionFunction
Emergency Medicine Research Laboratory Resources
Contact: Francesca Beaudoin
Clinical Trials Support, Emergency MedicineThe research program in the Department of Emergency was established to support investigator-initiated research and pharmaceutical, biologic and biomedical device trials. The program is supported by a Research Program Administrator, two pre-award Research Administrators, a Clinical Research Supervisor, and a staff of Clinical Research Assistants. The department maintains clinical research space within emergency departments as well as fully-equipped basic science laboratories, and has ongoing collaborations with Brown University and other hospital departments.The main focus areas of the Department of Emergency Medicine research program are (1) injury prevention and control, (2) cardiovascular, neurologic, and resuscitation science, (3) pediatric, age, and gender specific care, and (4) healthcare systems science.

Environmental Chemistry Facility

(last updated 2016-06-16 10:29:30)
»See Environmental Chemistry Facility website for more details

Contact: David Murray, PhD

Location: MacMillan Hall  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Analyzer - Discrete AnalyzerWestco Smartchem 200Used to determine Nitrate/Nitrite, Phosphate, Ammonia, Silicate, and other nutrient concentrations in water samples and soil extracts.
Analyzer - Elemental AnalyzerCE Elantech, Carbon-Nitrogen NC2100Analysis of carbon, nitrogen, and sulfur concentration of solid samples
Analyzer - Inorganic Carbon AnalyzerUIC, INC Inorganic Carbon AnalyzerMeasures total inorganic carbon by automated acidification and coulometric detection in a wide variety of sample matrices. Solid samples ranging from low ppm to 100% inorganic carbon can be analyzed with this system.
Analyzer - Mercury AnalyzerMilestone DMA-80 Direct Mercury Analyzer Determines mercury content of solid and liquid samples.
Analyzer - Water Isotope Picarro L1102-I Measures delta deuterium/hydrogen (D/H) ratio and delta 18O/16O in liquid water
Sample Preparation - Freeze Dry SystemLabconco FreeZone 6 Liter For removing water and other solvents from frozen samples by sublimation.
Liquid Chromatography SystemDionex DX500Ion chromatography analysis of ions in marine and freshwater samples
Sample Preparation - Microwave Digestion SystemMilestone UltrawaveUsed to digest solid samples (soils, sediments, rocks, plants, tissues), for elemental analysis.
Spectrometer - Atomic Absorption Spectrometer-Graphite Furnace (GFAAS)Perkin Elmer AAnalyst 600 Graphite Furnace This spectrometer is useful for measuring trace levels of metals in water and soil.
Spectrometer - Atomic Emission Spectrometer (AES)Jobin Yvon JY2000 Ultrace Inductively coupled plasma atomic emission spectrometer (ICP-AES) Analysis of most elements with atomic weights above 10.
X-Ray Fluorescence - HandheldInnov-X Systems Alpha 4000 Handheld Non-destructive elemental analysis on a variety sample types for concentrations of some metals ranging from about 20 ppm to 10%.
X-Ray Fluorescence - HandheldOlympus Delta Professional HandheldNon-destructive elemental analysis on a variety sample types for concentrations of elements greater than 10 ppm.

Flow Cytometry and Sorting Facility

(last updated 2017-02-20 12:05:03)
»See Flow Cytometry and Sorting Facility website for more details

Contact: Kevin Carlson

Location: Room 602, BioMedical Center Building  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Fluorescence Activated Cell Sorter (FACS)Becton Dickinson (BD) Biosciences FACS Aria IIICell counting, sorting, biomarker detection. The FACSAria has four air-cooled lasers at 488nm, 561nm, 633nm, and 407nm allowing multicolor analysis of up to 19 parameters. It can sort 1 to 4 populations simultaneously and is equipped with an Automated Cell Deposition Unit, an Aerosol Management System and a refrigeration system. It can accept various sample input tubes including 1 mL microtubes, 12 x 75-mm test tubes, and 15 mL tubes into the sample and collection chambers.

Genomics & Sequencing Center

(last updated 2017-06-20 08:27:28)
»See Genomics & Sequencing Center website for more details

Contact: Janet Atoyan

Location: 352 Center for Biotechnology & Life Sciences  »See on the Map

Affiliated Centers: RI-NSF EPSCoR

Instrument/ServiceManufacturer/DescriptionFunction
BioanalyzerAgilent Bioanalyzer 2100Provides fast and automated separation, sizing and quantification of DNA, RNA and proteins by miniaturized Lab-on-a-Chip electrophoresis
Bioinformatics Analysis - DNA Sequence and Protein AnalysisSoftware: DNAStar Lasergene Core SuiteComprehensive suite of software modules for DNA, RNA, and protein sequence analysis
Bioinformatics Analysis - Next Generation DNA Sequence AssemblySoftware: CLCbio Genomics Workbench Software for analyzing, comparing, and visualizing Next Generation Sequencing data
CentrifugeBeckman Coulter Allegra 25R Refrigerated CentrifugeCentrifuge for pelleting cells, tissues and macromolecules
CentrifugeThermo Savant DNA110 SpeedVac Vacuum CentrifugeCentrifugal concentration system for drying low-volume ethanol or isopropanol precipitates of DNA and RNA
CryostatVibratome 5000 Advanced CryostatPerforms histological sectioning of unfixed frozen cells and tissues.
DisrupterCovaris S220 High Performance UltrasonicatorAutomated acoustic disruption and homogenization of cells and tissue samples using focused ultrasonic energy at 500 KHz. Performs DNA Shearing
DisrupterQIAGEN TissueLyserProvides rapid and efficient disruption of cells and tissues
DNA SequencerApplied Biosystems 3130xl & 3500xl Genetic AnalyzersDNA Sanger Sequencing & Fragment Analysis: Fluorescence-based instruments utilizing capillary electrophoresis for DNA sequencing and fragment analysis
DNA SequencerIllumina MiSeq DNA NextGen SequencingPerforms clonal amplification, genomic DNA sequencing, and data analysis with base calling, alignment, variant calling, and reporting
Electrophoresis SystemSage Science BluePippin DNA Electrophoresis SystemA preparative electrophoresis platform that separates and extracts DNA fragments using pre-cast gel cassettes
FluorometerInvitrogen QubitFluorometer that uses fluorescent dyes bound to specific molecules to quantify DNA, RNA and proteins
Imaging System - CameraZeiss AxioCam HRc high-resolution imaging systemsA digital Zeiss AxioCam HRc high-resolution camera and for laser scanning microscopy with a Zeiss LSM 700 confocal module. For use on the AxioImager upright light microscope
Sample Preparation - Library Preparation SystemIntegenX Apollo 324 System NextGen Sequencing (NGS) Library Preparation SystemAutomated liquid handling instrument dedicated to the preparation of sample libraries for Next Generation Sequencing
Microarray PlatformBioLog OmniLog Phenotype Microarray System Plate Incubator/ReaderUses Phenotype Microarrays in microtiter plates to test for unique phenotypes or cell functions
Microscope Zeiss AxioImager M2 Upright Light MicroscopeFor use with the AxioImager upright light microscope equipped for digital image acquisition with a Zeiss AxioCam HRc high-resolution camera and for laser scanning microscopy with a Zeiss LSM 700 confocal module
PCR Thermal CyclerAgilent Mx3005P and Roche LC480 qPCR Systems3 Quantitative PCR (qPCR) instruments. Used for highly accurate qualitative and quantitative detection of nucleic acids and gene expression .
PCR Thermal CyclerEppendorf Mastercycler ep Gradient S and MJ Research PTC-100(3) Thermal cyclers in 96-well format; peltier elements control the temperature of the block for PCR chemistry
Workstation - PCR AirClean Systems 600 PCR WorkstationCombination workstation provides an ISO 5 (FS209E) Class 100 clean air environment and UV light sterilization
Robotic Workstation - Automated Pipetting Eppendorf epMotion 5075 VAC Pipetting WorkstationAutomated pipetting workstation enables fast and reproducible liquid handling for a variety of applications
Robotic Workstation - Sample PreparationQIAGEN QIAcube Spin Column RobotAutomated protocols for purification of plasmid DNA, genomic DNA, RNA, viral nucleic acids, and proteins
SpectrophotometerThermo Scientific NanoDrop 8000Spectrophotometer that accurately measures up to eight individual 1-2 microliter samples simultaneously

Genomics Facility

(last updated 2017-02-20 11:57:26)
»See Genomics Facility website for more details

Contact: Christoph Schorl, PhD

Location: Room 109, Laboratories for Molecular Medicine  »See on the Map

Affiliated Centers: Center for Genomics and Proteomics (CGP), COBRE Center for Signaling Networks at Brown University

Instrument/ServiceManufacturer/DescriptionFunction
BioanalyzerAgilent Bioanalyzer 2100Microfluidics-based platform for sizing, quantification and quality control of DNA, RNA, proteins and cells
Analyzer - Fragment Advanced Analytical, Fragment AnalyzerCapillary Electrophoresis - Analyze DNA fragments for Next-Gen Sequencing, genotyping, checking RNA quality and quantity, and working with microsatellite simple sequence repeats (SSRs).
Cell CounterLife Technologies Automated Countess Cell CounterMeasure cell count and viability (live, dead, and total cells) using the standard trypan blue technique.
CentrifugeSorvall Legend T BenchtopLow to medium speed centrifugation
Centrifuge - UltraBeckman Coulter Optima Max High speed centrifugation with MLA130, TLA110 & TLA100 Rotors
DisrupterCovaris S220 High Performance UltrasonicatorDNA, RNA, and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization
Fluorescence Activated Cell Sorter (FACS)Becton Dickinson (BD) Biosciences FACS Calibur Flow cytometry cell analysis and cell sorting
Hybridization Oven Agilent G2534A Microarray hybridization oven
Imaging SystemLiCor Odyssey Clx InfraredWestern blot analysis, EMSA, protein arrays, In-Cell Western Assays, On-Cell Westerns, in vivo imaging, Coomassie gel documentation, DNA gel documentation, and tissue section analysis.
Imaging System Molecular Dynamics Typhoon 9410 Imaging system for gel sandwiches agarose and polyacrylamide gels membranes, microplates and microarrays.
Microarray PlatformAffymetrix Gene Chip Instrument SystemA fully integrated platform for Affymetrix microarrays
Microarray ScannerMolecular Devices GenePix Scanner 4000BTwo color microarray scanner
Microplate ReaderMolecular Devices Spectra Max M5Detects UV-Visible Absorbance (Abs), Fluorescence Intensity (FI), Time-Resolved Fluorescence (TRF), Fluorescence Polarization (FP), Glow Luminescence (Lumi)
PCR Thermal CyclerApplied Biosystems ViiA 7 Real-Time PCR SystemMedium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput
PCR Thermal CyclerApplied Biosystems ViiA 7 Real-Time PCR SystemMedium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput
SpectrophotometerThermo Scientific Nanodrop One A microvolume spectrophotometer for measuring DNA, RNA, and protein.
Technical Assistance - Affmetrix MicroarrayServiceService to provide Affymetrix gene expression array service
Technical Assistance - NGS Library Quality ControlServiceAnalysis of library size distribution and qPCR quantification
Microplate Reader BioTek Cytation 3 Cell Imaging Multi-Mode ReaderUV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence
PCR Thermal Cycler - DigitalQX200 Droplet Digital (ddPCR) PCR SystemThe QX200 Droplet Digital PCR (ddPCR™) System provides absolute quantification of target DNA or RNA molecules for EvaGreen or probe-based digital PCR applications.

Genomics Laboratory - Providence VA Medical Center

(last updated 2017-12-08 14:24:51)
»See Genomics Laboratory - Providence VA Medical Center website for more details

Contact: John McGeary, PhD

Location: Research Building 32, Room 146  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
AutoclaveTuttnauer Equipment: consumable sterilization
Behavioral Phenotyping - Eye Tracking SystemTobiiUsed to track eye movement
Bioanalyzer Agilent BioanalyzerDNA size & quantification (quality check for downstream analyses, i.e. next gen sequencing)
Analyzer - GeneticApplied Biosystems 3500 Genetic AnalyzerCapillary Electrophoresis - Analyze fragment length polymorphisms (96 format) (2),
CentrifugeEppendorf Refrigerated Centrifuge Alcohol precipitation
Centrifuge EppendorfFor centrifuging 96/384 plates
DNA SequencerIon Torrent/Life Technologies Personal Genome MachineNext Generation Sequencer
Mass Spectrometer Sequenomhigh throughput SNP genotyping, epigenetics
Microarray ScannerIllumina HiScanWhole-genome genotyping, gene expression analysis, methylation analysis
Microplate ReaderBioTekDNA quantification
Microplate ReaderFluidigm End Point Reader High throughput SNP genotyping
PCR Thermal CyclerApplied Biosystems384 well DNA amplification for downstream analysis (i.e. sequenom processes) (2 units)
PCR Thermal CyclerApplied Biosystems96 well DNA amplification for downstream analysis (i.e. fragment length polymorphisms)(2 units)
PCR Thermal CyclerApplied Biosystems Real Time PCRAnalyze single nucleotide polymorphisms (single locus)
PCR Thermal CyclerApplied Biosystems Real Time PCRAnalyze single nucleotide polymorphisms (single locus)
Robotic Workstation - DNA ExtractionChemagen/Perkin Elmer Magnetic Separation ModuleDNA extraction from blood & saliva
Robotic Workstation - Liquid HandlerSequenom Liquid Handler Transfers PCR chemistries to samples (96/384 format)
Robotic Workstation - Liquid HandlerSequenom NanodispenserDispenses PCR product to Sequenom chip
Robotic Workstation - Sample PreparationIontorrent/Life Technologies Enrichment SystemSimplifies the workflows for the Ion PGM system by providing an automated solution for scalable and reproducible template preparation.
Robotic Workstation - Sample PreparationIontorrent/Life Technologies One TouchSimplifies the workflows for the Ion PGM system by providing an automated solution for scalable and reproducible template preparation.
Robotic Workstation - Sample ProcessingThermo Scientific Cap-it-AllCaps tubes to the optimal torque to maintain sample integrity and provide a hands free method to capping and decapping tubes quickly and easily.
Robotic Workstation -Liquid HandlerBeckman Coulter Lab Automation WorkstationAutomated liquid handler
SpectrophotometerThermo Scientific NanoDropDNA quantification
DNA Sequencer
Contact: Kayla Dwyer
Qiagen Pyromark Q96 IDQuantitative analysis of genetic/epigenetic DNA modifications using Pyrosequencing technology
PCR Thermal CyclerApplied Biosystems Real Time PCR Quant Studio 12K FlexAnalyze single nucleotide polymorphisms (single locus) (96/384 format)
Robotic Workstation-Sample PreparationTecan Freedom EvoSimplifies the workflows for the Illumina HiScan system by providing an automated solution for scalable and reproducible sample preparation.

Good Manufacturing Practice Facility-current (cGMP)

(last updated 2017-12-08 14:37:07)
»See Good Manufacturing Practice Facility-current (cGMP) website for more details

Contact: Clinton Chichester III, Ph.D.

Location: URI, Avedisian Hall  »See on the Map

Affiliated Centers: College of Pharmacy, University of Rhode Island

Instrument/ServiceManufacturer/DescriptionFunction
current Good Manufacturing Practice (cGMP) FacilityServiceRapid expansion in the markets for biologics and small molecule pharmaceutical products has created a critical demand for skilled professionals (from equipment operators to advanced technical and quality assurance personnel) and additional infrastructure to support drug development and manufacturing.  The current Good Manufacturing Practice (cGMP) Facility at the University of Rhode Island (URI) offers a state-of-the-art training, development and manufacturing facility for GMP production of solid oral dosage forms.  
GMP manufacturingClinical Research Service, GMP manufacturingAssisting academic, government and industry partners with the manufacture of solid dose forms for veterinary and human use
GMP analytical testingClinical Research Service, GMP analyticialProviding pharmaceutical testing services including turn-key stability studies
EducationClinical Research Service, GMP educationProviding GMP industrial experience in drug manufacturing and analytical testing for students in various related undergraduate, graduate and adult education programs, as well as industry-specific training in collaboration with pharmaceutical and biotechnology firms.

Hassenfeld Child Health Innovation Institute Resources

(last updated 2017-12-08 11:07:24)
»See Hassenfeld Child Health Innovation Institute Resources website for more details

Contact: Phyllis Dennery

Location: Brown University’s School of Public Health  »See on the Map

Affiliated Centers: Hassenfeld Child Health Innovation Institute

Instrument/ServiceManufacturer/DescriptionFunction
Hassenfeld Research Institute
Contact: Phyllis Dennery
Hassenfeld Research Institute Website
Clinical Research Resources, PediatricsThe work of the Hassenfeld Child Health Innovation Institute will contribute to our understanding of the genetic, prenatal, and early life factors associated with health problems of children, and will develop effective new strategies for prevention and treatment. These strategies will involve careful coordination of medical care, social services, and public health interventions. The research findings and lessons learned in Rhode Island will have broad applicability to other settings in the United States and internationally, amplifying the Institute's ability to improve population health, enhance family life, and help children thrive in school and in their future lives.
Informatics, Geographical Information Systems (GIS)
Contact: Lynn Carlson
Geographical Information Systems (GIS) Website
Clinical Research Service, GIS InformaticsThe Hassenfeld Core Research and Evaluation Unit will geocode, map, and analyze hospital and other health data for research and evaluation. This will include mapping all emergency department visits and inpatient stays, to first identify “hot spots” in Rhode Island where children disproportionately suffer from health issues, and then help shape interventions to address these disparities. In addition to mining hospital data systems, core researchers will also build the capacity for enrolling families in research and intervention projects at Hasbro Children’s Hospital and affiliated sites.
Clinical Trials Enrollment, Prospective Birth Cohort
Prospective Birth Cohort Website
Clinical Trials Support, PediatricsThe prospective birth cohort study will include enrolling families, collecting key information about prenatal exposures, initial health status assessments of the newborn, and annual follow up assessments. The prospective birth cohort study will provide critical information on early determinants of child health and will provide a framework for assessing the impact of innovative approaches to improve the health of families.

HIV Therapeutic and Vaccine Clinical Trials Program - The Miriam Hospital

(last updated 2017-12-08 14:48:52)
»See HIV Therapeutic and Vaccine Clinical Trials Program - The Miriam Hospital website for more details

Contact: Pamela Poethke, RN

Location: Fain Building  »See on the Map

Affiliated Centers: AIDS/HIV Immunology Center

Instrument/ServiceManufacturer/DescriptionFunction
Infectious Diseases Clinical Research Resources
Contact: Karen Tashima
Clinical Trials Support, HIV and HCVThe Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel. The unit conducts trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C. Other studies offered through our clinical trials unit include pharmaceutical studies to treat hepatitis C, prevent C. difficile infection, and test new methods of diagnosing HIV infection.

IDeA COBRE Center for Central Nervous System Function

(last updated 2017-12-08 10:34:57)
»See IDeA COBRE Center for Central Nervous System Function website for more details

Contact: Jerome Sanes

Location: Brown University, 2 Stimson Avenue  »See on the Map

Affiliated Centers: Brown Institute for Brain Science (BIBS)

Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE Center for Central Nervous System Function
Contact: John Davenport
Clinical Research Resources, Nervous SystemPurposeful human behavior requires attention, decisions and action, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing.  Behavioral and brain mechanisms of attention, including vigilance, orienting and perceptual and action selection, are key gateways into high-level function. Thus, in a general and even specific sense, attention, decision making and the ensuing actions define human mental activities. Deficits in these functions are common in both neurological and psychiatric disorders and can result in a wide range of higher-order behavioral deficits. This COBRE Center at Brown University that will investigate the mechanisms of higher-brain function, with a focus on attention, decision making and action and disorders that modify these key systems, using a combination of genetic, behavior, and systems neuroscience approaches. 

IDeA COBRE for Center for Cancer Research Development

(last updated 2017-12-08 10:38:06)
»See IDeA COBRE for Center for Cancer Research Development website for more details

Contact: Bharat Ramratnam

Location: Coro West  »See on the Map

Affiliated Centers: Orthopedics Institute

Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE for Center for Cancer Research Development
Contact: Christopher Marshall
Clinical Research Resources, CancerThe mission of COBRE Center for Cancer Research Development at Rhode Island Hospital is to create, interpret and apply new knowledge based on original, collaborative, multidisciplinary laboratory studies of the cellular and molecular pathways leading to carcinoma. Such knowledge will be generated in an environment that fosters career development of promising junior investigators and employs cutting-edge methodology and applications to further our understanding of the cancer process. Basic knowledge gained will be used to design and implement novel diagnostic and treatment protocols to benefit the hospital's patients and the community at large.

IDeA COBRE for Endothelial Injury and Repair: Cardiopulmonary Vascular Biology

(last updated 2017-12-08 10:39:59)
»See IDeA COBRE for Endothelial Injury and Repair: Cardiopulmonary Vascular Biology website for more details

Contact: Sharon Rounds

Location: Providence VA Medical Center Building 35  »See on the Map

Affiliated Centers: Ocean State Research Institute

Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE for Endothelial Injury and Repair: Cardiopulmonary Vascular Biology
Contact: Susan McNamara
Clinical Research Resources, Cardiopulmonary VascularThe overall objective of the CardioPulmonary Vascular Biology COBRE is to bring together a group of investigators in the fields of pulmonary and cardiovascular diseases in a unique trans-disciplinary approach to improve understanding of the pathogenesis and treatment of vascular pathobiology in lung and heart diseases. 

IDeA COBRE for Perinatal Biology

(last updated 2017-12-08 10:41:27)
»See IDeA COBRE for Perinatal Biology website for more details

Contact: Sunil Shaw

Location: Kilguss Research Institute  »See on the Map

Affiliated Centers: Kilguss Research Institute

Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE for Perinatal Biology
Contact: Megan Boudreau
Clinical Research Resources, PerinatalThe scientific aims of this COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. 

IDeA COBRE for Reproductive Health

(last updated 2017-12-08 16:32:03)

Contact: Surendra Sharma

Location: Kilguss Research Institute  »See on the Map

Affiliated Centers: Kilguss Research Institute

Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE for Reproductive Health
Contact: Megan Boudreau
Clinical Research Resources, Reproductive HealthThe response to women’s reproductive health requires a broad and balanced research strategy aimed at expanding knowledge and technology in reproductive medicine. The overarching research goals of this COBRE includes the use of well-defined pre-clinical and human models to understand mechanisms mediating preeclampsia, gestational diabetes and prematurity, identification of functional predictive biomarkers, and application of contemporary computational approaches to enhance our understanding of the networks and pathways underlying these devastating pregnancy complications.

IDeA COBRE for Skeletal Health and Repair

(last updated 2017-12-08 10:47:48)
»See IDeA COBRE for Skeletal Health and Repair website for more details

Contact: Qian Chen

Location: Coro West  »See on the Map

Affiliated Centers: COBRE Center for Skeletal Health and Repair

Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE for Skeletal Health and Repair
Contact: Rachel Alberg
Clinical Research Resources, SkeletalThe COBRE for Skeletal Health and Repair at Rhode Island Hospital enables clinicians, scientists, engineers and biologists to work side-by-side on multidisciplinary research, helping to better understand cartilage and joint health mechanisms and develop strategies for the prevention and treatment of skeletal joint diseases.

IDeA COBRE for Stem Cells and Aging

(last updated 2017-12-08 10:51:34)
»See IDeA COBRE for Stem Cells and Aging website for more details

Contact: Peter Quesenberry

Location: Coro West  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE for Stem Cells and Aging
Contact: Lisa Frade
Clinical Research Resources, Stem Cells and AgingThis COBRE supports research in the area of stem cell biology and focuses on neural and hematopoietic stem cells, their microenvironments and the impact of aging, fibrosis, and senescence on their regulation and evolution to diseases of the central nervous system and bone marrow. Promising applications for the research include regeneration and repair for the treatment of leukemia, lymphomas, various neurodegenerative disorders and different aspects of aging.

IDeA COBRE Immune-Based Interventions Against Infectious Diseases

(last updated 2017-12-08 10:53:29)
»See IDeA COBRE Immune-Based Interventions Against Infectious Diseases website for more details

Contact: Alan Rothman

Location: University of Rhode Island Feinstein Campus  »See on the Map

Affiliated Centers: Institute for Immunology and Informatics

Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE Immune-Based Interventions Against Infectious Diseases
Contact: Barbara Muhitch
Clinical Research Resources, Infectious DiseaseInfectious diseases continue to represent major causes of death and disease worldwide. Our Center of Biomedical Research Excellence (COBRE) seeks to address the challenge of new and emerging infectious diseases by advancing the development of a multidisciplinary and trans-institutional research program in infectious diseases immunology. The unifying scientific theme of this COBRE is translational research at the interface of the pathogen and host. This COBRE is a partnership between the Institute for Immunology and Informatics (iCubed) at the University of Rhode Island’s Providence campus and the Center for International Health Research (CIHR) at Rhode Island Hospital.

IDeA COBRE: Center for Computational Biology of Human Disease

(last updated 2017-12-08 10:55:51)
»See IDeA COBRE: Center for Computational Biology of Human Disease website for more details

Contact: David Rand

Location: 80 Waterman Street Providence, RI 02912  »See on the Map

Affiliated Centers: Data Science Practice

Instrument/ServiceManufacturer/DescriptionFunction
IDeA COBRE: Center for Computational Biology of Human Disease
Contact: Tricia Werner
Clinical Research Resources, Computational The COBRE Center for Computational Biology of Human Disease embraces the age of genomics medicine from an explicitly data-driven, computational perspective.  By building a collaborative Center of empirical and computational scientists, we advance new discoveries, algorithms, and genomic screening approaches with direct relevance to several human diseases.  This is consistent with NIH's mission of supporting bioinformatics and computational biology to advance all areas of biomedicine.

IDeA INBRE Rhode Island Network for Excellence in Biomedical Research

(last updated 2017-12-08 10:57:58)
»See IDeA INBRE Rhode Island Network for Excellence in Biomedical Research website for more details

Contact: Bonsup Cho

Location: Pharmacy Building  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
IDeA INBRE Rhode Island Network for Excellence in Biomedical Research
Contact: Laura Arrighi
Clinical Research Resources, BiomedicalRI-INBRE is based out of the University of Rhode Island and is housed at the College of Pharmacy. The statewide network objective is to support and develop talented individuals, committed to research careers in Rhode Island, and to build the biomedical research capacity of Rhode Island institutions. The seven participating research institutions are the University of Rhode Island, Brown University, Bryant University, Providence College, Rhode Island College, Roger Williams University, and Salve Regina University. The Community College of Rhode Island serves an outreach institution for the network. The research foci of the RI-INBRE are: cancer, neuroscience, and molecular toxicology.

Leduc Bioimaging Facility

(last updated 2017-02-20 12:03:46)
»See Leduc Bioimaging Facility website for more details

Contact: Robbert Creton, PhD

Location: Room 121, Sidney Frank Hall  »See on the Map

Affiliated Centers: Center for Genomics and Proteomics (CGP)

Instrument/ServiceManufacturer/DescriptionFunction
Bioinformatics Analysis - Molecular Devices, MetaMorph Software: Molecular Devices, MetaMorph Software for microscopy automation & image analysis
Sample Preparation - Critical Point DryerLadd Research IndustriesRemoves liquid from biological specimens for SEM
Sample Preparation - Glow Discharge UnitEmitech K100XAdds a charge to make TEM samples hydrophilic
MicroscopeOlympus MultiPhoton Laser Scanning Deep optical sectioning of fluorescently labeled samples with SIM photoactivation
MicroscopeZeiss Axiovert 200M FluorescenceImaging of samples labeled with fluorescent indicators
MicroscopeZeiss Axiovert 200M FluorescenceImaging of samples labeled with fluorescent indicators
MicroscopeZeiss LSM 510 Meta ConfocalOptical sectioning of samples labeled with fluorescent indicators
MicroscopeZeiss LSM 710 ConfocalOptical sectioning of samples labeled with fluorescent indicators
MicroscopeZeiss Lumar Stereo FluorescenceImaging of samples labeled with fluorescent indicators
Microscope - ElectronHitachi S-2700 Scanning Electron Microscope (SEM) Transmission electron microscopy with PCI Digital Imaging Accessory
Microscope - ElectronPhilips 410 Transmission Electron Microscope (TEM) Scanning electron microscopy with AMT Camera Accessory
MicrotomeReichert UltramicrotomeUltrathin sectioning for TEM
Microtome Diamond Knife SetDiatome DKSUsed on Reichert microtome to cut ultrathin sections for TEM
Sample Preparation - Sputter Coater SystemEmitech K550Covers an EM specimen with a thin layer of conducting material
Technical Assistance - BioimagingServiceService to provide Bioimaging Technical Assistance
Technical Assistance - Bioimaging TrainingService Service to provide Bioimaging Training
MicroscopeZeiss LSM 800 Confocal Optical sectioning of samples labeled with fluorescent indicators

Magnetic Resonance Imaging Facility

(last updated 2016-06-16 10:29:30)
»See Magnetic Resonance Imaging Facility website for more details

Contact: Michael Worden, PhD

Location: Sidney Frank Hall  »See on the Map

Affiliated Centers: Brown Institute for Brain Science (BIBS)

Instrument/ServiceManufacturer/DescriptionFunction
Imaging System - Magnetic Resonance Imaging (MRI) ScannerSiemens 3 Tesla Prisma fitBrain structure and function in normal and clinical populations as well as studies of other body systems, non-invasive animal imaging and materials science.

Marine Science Research Facility

(last updated 2016-06-16 10:29:30)
»See Marine Science Research Facility website for more details

Contact: Rodrique Spinette

Location: Aquarium Building  »See on the Map

Affiliated Centers: RI-NSF EPSCoR , Graduate School of Oceanography

Instrument/ServiceManufacturer/DescriptionFunction
Analyzer - Dissolved Gas Bay Instruments Membrane Inlet Mass Spectrometer- Dissolved Gas AnalyzerMass Spectrometer: Quantifies dissolved gases
Analyzer - Multiparameter Water AnalyzerYSI Professional Plus Hand Held Multiparameter Water Meter Measures temperature, salinity, dissolved oxygen (DO), and pH
Analyzer - NutrientLachat QuickChem 8500 Flow Injection Nutrient Auto AnalyzerMeasures dissolved nutrients in water, Ammonia, Phosphate, Nitrite, Nitrate, and Silicate
Aquatic Culture - Algae and Live Feed Room
Contact: Ed Baker
Various manufacturersK-walls, small rearing tanks for live feed, flowing seawater and freshwater
Aquatic Culture - Phytoplankton Culture Wheels
Contact: Ed Baker
Various manufacturersMotorized and water driven, clear plexiglass, ambient and experimental temperature control, can accommodate culture bottles of differing sizes (1-3L)
Aquatic System - Dechlorination System - Freshwater
Contact: Ed Baker
Various manufacturers2 Freshwater dechlorination tanks
DisrupterBiospec Mini Bead BeaterShakes tubes with beads to disrupt cells, DNA , RNA
DisrupterBranson Digital Ultasonic Liquid SonifierDisrupts cells
Environmental Chamber
Contact: Ed Baker
EnvironAir Environmental Chamber100 sq ft Temperature control, Two range 4-24 C, Two range -4-24 C (to simulate polar conditions), On generator back up and emergency monitoring systems. (4 Units)
Aquatic System - Flowing Seawater System
Contact: Ed Baker
Various manufacturersRaw-Ambient temperature and Filtered- Chilled, Heated, Ambient. UV treated, air supply, emergency monitoring systems
Fluorescence Activated Cell Sorter (FACS)Becton Dickinson (BD) Biosciences Influx Flow Cytometer and Cell SorterMeasures light scatter and fluorescence of cells. Sorts cells based on measured properties.
FluorometerSatlantic Fluorescence Induction Relaxation Fluorometer (FIRE)Measures variable fluorescence in phytoplankton
FluorometerTurner Designs 10-AU (Chlorophyll) Field Fluorometer Measures extracted or in vivo chlorophyll fluorescence of samples, Field-portable, can be set up for continuous-flow monitoring or discrete sample analyses
FluorometerLife Technologies Qubit FluorometerQuantifies DNA, RNA, and protein
Biospecimen Banking - Freezer - Walk-in
Contact: Ed Baker
-20 C Walk-In Freezer185 sq ft Long term storage, On generator back up and emergency monitoring systems
HomogenizerPolytron Homogenizer PT-10-35-GT Breaks down plant and animal tissue for analysis, and performs homogenization, dispersion, mixing, and prepares emulsions
Cell CounterSizing and counting of particles suspended in liquid samplesBeckman Coulter Multisizer 4
Imaging System - CameraAllied Digital Stingray Firewire Microscope Camera Captures video and still images (C-mount)
Analyzer - Fluid Particle Counter and ImagerFluid Imaging Technologies FlowCam Imaging Particle Analysis: counts and records images of particles in liquid samples
IncubatorPercival Incubator/Growth ChamberTemperature and light controlled incubator for environmental applications
Microplate ReaderMolecular Devices Spectramax M5 Measures Fluorescence Intensity, Absorbance, Time Resolved Fluorescence, Fluorescence Polarization and Luminescence in cuvettes and multiple sized microplates.
MicroscopeNikon inverted MicroscopeMicroscopy: Works with Stingray Camera
MicroscopeOlympus SZX16 Stereo MicroscopeMicroscopy. Works with Stingray Camera
PCR Thermal CyclerEppendorf Master Cycler Pro Replicates DNA
PCR Thermal CyclerStratagene QPCR Mx3000PAnalysis of gene expression, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Quantitative PCR Filters- FAM/Syber Green, Rox, Hex, CY3, CY5
Photoperiod controller
Contact: Ed Baker
Various manufacturersWattstopper controller(Blount), Various individual timers
Pier Access
Contact: Ed Baker
Access to Graduate School of Oceanography pierAccess to pier for deployment, collection, testing. Water depths 18-15 feet to intertidal zone
Radiometer Biospherical Instruments Quantum Scalar Laboratory (QSL) Radiometer - PAR Light Meter Measures Photosynthetically Active Radiation (PAR)
Incubator - ShakerThermo Max-Q Orbital Shaker Table Orbital shaker with 18x24 in platform and variety of clamps
Incubator - ShakerThermo Max Q Incubated ShakerHeated incubated shaker
SpectrometerOcean Optics Jaz SpectrometerOptical sensing instrumentation that measures light wavelengths. Its unique features and expandable platform makes it uniquely suited for field applications, remote sensing, process flow and quality assurance.
SpectrophotometerThermo Scientific NanoDrop 1000Microvolume UV-Vis spectrophotometer that quantifies DNA, RNA, and protein from small 1-2 microliter sample size
Aquatic System - Laminar Flow Tank
Contact: Ed Baker
Laminar Flow Tank1000 gal, Seawater or Freshwater, Multiple speeds with precision control. Experimental chamber visable from 5 sides
Aquatic System - Mesocosm Tank
Contact: Ed Baker
Various manufacturers10, 5 ft deep outdoor mesocosms, with available raw ambient seawater flow
Vacuum Manifold
Contact: Rodrigue Spinette
Vacuum Filter Manifold Allows for filtration of 5 ports simultaneously, 25 and 47 mm filter cups available
Worksation - Marine General Wet Lab
Contact: Ed Baker
Various manufacturers3 Buildings, 7,000 sq ft indoor, and nearly unlimited outdoor space, Multiple insulated tank sizes, various sized aquaria, possible to perform simultaneous replicates
Workstation - Marine Pathology and Transgenics Laboratory and Systems
Contact: Ed Baker
Various manufacturersOzone treated effluent and separate effluent drain
MicroscopeEpifluorescence and phase microscopy with digital camera systemNikon Eclipse Ni epifluorescence microscope
Gas Chromatograph - Mass Spectrometer (GC - MS)
Contact: David Adelman
Agilent Technologies 7890B/5977A GC/MSDIdentifies and enumerates chemical constituents of samples
Imaging System - Gel Imager Fluorescence gel imaging systemCarestream Molecular Imaging Gel Logic 212 Pro
Cell CounterSizing and counting of particles suspended in liquid samplesBeckman Coulter Multisizer 4
MicroscopeEpifluorescence and phase microscopy with digital camera systemNikon Eclipse Ni epifluorescence microscope
Imaging System - Gel Imager Fluorescence gel imaging systemCarestream Molecular Imaging Gel Logic 212 Pro

Mass Spectrometer Analytical Facility

(last updated 2017-12-08 14:42:50)
»See Mass Spectrometer Analytical Facility website for more details

Contact: Soumen Mallick

Location: GeoChemistry, GC040  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Mass Spectrometer
Contact: Alberto Saal
Thermo Scientific Multi-collector inductively coupled plasma mass spectrometer, ICP-MS, Neptune PlusThis is a multi-collector ICP-MS equipped with nine Faraday cups and eight ion counters, which allows us to monitor multiple masses simultaneously providing precise isotope ratio measurement.
Mass Spectrometer
Contact: Alberto Saal
Thermo Scientific Quadrupole inductively coupled plasma mass spectrometer, ICP-MS, X-series-2This is a single collector ICP-MS that allows us to measure precise elemental composition at sub-ppb level concentration.
Analyzer - Laser Ablation
Contact: Alberto Saal
Photon-machines Analyte G2, 193 nm excimer laser ablationThis 193 nm wave-length excimer laser allows us to perform in-situ analysis on a solid sample with a beam diameter as small as 3µm. To determine the elemental abundances the laser is coupled with the single collector inductively coupled plasma mass spectrometer ICPMS and to determine the isotope ratios the laser is coupled with multi collector ICPMS.
Clean lab, Trace metal free
Contact: Alberto Saal
Pico Trace This Clean Lab is equipped with Millipore water filtration system that provides greater than 18MΩ Milli-Q water. The working stations in this Clean Lab meet ISO class 4 standard (equivalent to FS class 10) allowing us to perform ultra-low blank chemical analysis.

Mass Spectrometry Facility

(last updated 2016-06-16 10:29:30)
»See Mass Spectrometry Facility website for more details

Contact: Tun-Li Shen, PhD

Location: MacMillan Hall  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Gas Chromatograph - Mass Spectrometer (GC - MS)Hewlett-Packard (Agilent) GCD 1800C This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 450 Da).
Liquid Chromatography - Mass Spectrometer (LC - MS) Agilent 6530 Mass TOF This system consist of Agilent 1260 infinite HPLC and Agilent 1260 infinite nanoglow LC/chipcube nanoelectrospray MS interface, and 6530 Accurate Mass Q-TOF mass spectrometer . This instrument can detect and identify compounds in amounts smaller than two trillionths of a gram (2 picograms), making the Agilent 6530 a powerful tool for food safety, toxicology and other measurements where minute amounts of compounds must be identified.
Mass SpectrometerJEOL JMS-600H double focusing magnetic sector The JMS-600H is a compact double-focusing, high-resolution, magnetic sector mass spectrometer. This instrument is equipped with electron impact ionization (EI), Chemical Ionization (CI), and fast atom bombardment ionization (FAB) for characterization of synthetic organic, inorganic, and biological molecules. This instrument is also used for routine exact mass measurement of organic molecules.
Mass SpectrometerThermo LXQ linear ion trap with Surveyor HPLC systemThe LXQ has capabilities similar to the conventional 3D ion trap such as LCQ Deca. It is based on linear ion trap technology that has faster cycle time. It is capable of data-dependent LC/MSn analysis.
Mass Spectrometer Thermo LCQ Deca XP Max ion trap with Shimadzu HPLC systemThe LCQ Deca XP Max is equipped with electrospray (ESI) and APCI ionization sources. It is capable of mass analysis of a broad range of molecules that are relatively polar, nonvolatile and thermally labile. This instrument is used for routine molecular weight determination of compounds from organic, inorganic, natural products, small proteins and peptides, and oligonucleotides.
Mass SpectrometerBruker Autoflex Speed Linear (L) Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometer (MALDI-TOF MS).The Bruker autoflex Speed is a linear time-of-flight (TOF) mass spectrometer equipped with a matrix-assisted laser desorption ionization (MALDI) ion source. This instrument is routinely used for analysis of organic molecules, natural products, and macromolecules, including recombinant proteins, oligonucleotides, polysaccharides and synthetic polymers.
Gas Chromatograph - Mass Spectrometer (GC - MS)Agilent 5977A GC/MSD SystemThis system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 1050 Da).

Maternal-Fetal Medicine Units Network of the NICHD

(last updated 2017-12-08 10:13:46)
»See Maternal-Fetal Medicine Units Network of the NICHD website for more details

Contact: Dwight Rouse

Location: 100 Dudley Street, Providence, RI  »See on the Map

Affiliated Centers: Maternal-Fetal Medicine Units Network of the NICHD

Instrument/ServiceManufacturer/DescriptionFunction
Maternal-Fetal Medicine Units Network of the NICHD
Contact: Donna Allard
Clinical Trials Support, Maternal-Fetal Medicine Clinical Trials RecruitmentMaternal Fetal Medicine Units Network conducts studies of pregnancy, maternal, fetal and infant health. The NICHD Eunice Kennedy Shriver Maternal Fetal Medicine Units (MFMU) Network is a consortium of 12 premier clinical centers across the U.S. whose charge is to investigate problems in clinical obstetrics by conducting multi-institutional clinical trials and observational studies. The Network conducts large randomized clinical trials aimed at improving outcomes for pregnant women and their offspring. With 140,000 births spread among its 12 centers, the Network is able to perform trials of sufficient size to reach definitive conclusions that result in health-improving practice changes locally, nationally and internationally. The 16 associated research nurses are experienced and expert in the identification, recruitment, retention, and follow-up of eligible research patients.

Media Prep Kitchen

(last updated 2016-06-16 10:29:30)
»See Media Prep Kitchen website for more details

Contact: Kristi Wharton

Location: BioMedical Center Building  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Drosophila Media PreparationServiceThe Brown Fly Facility is dedicated to providing investigators with high quality media for Drosophila research. The media kitchen is equipped with a food service quality steam kettle fitted with stirring unit, a Steris autoclave and a Lancer Washer fitted with custom racks for glass vials. Media is dispensed using Filamatic and Materflex/ Digistalic pumps. In the centralized kitchen, a standard cornmeal, sucrose, yeast medium is prepared and dispensed into different sized culture vessels.  Media is prepared in a steam-jacketed food kettle and pumped into trays of glass vials (10ml), plastic vials (10ml) or into plastic bottles (30ml) depending on research needs. Media is prepared according to a strict protocol that ensures consistency in diet and the absence of any bacterial, fungal or insect contamination. Researchers using glass vials return them to the facility where they are autoclaved, washed, and filled again.

Molecular Biology and Imaging Core

(last updated 2017-08-09 09:43:52)
»See Molecular Biology and Imaging Core website for more details

Contact: Sunil Shaw PhD

Location: Kilguss Research Institute  »See on the Map

Affiliated Centers: COBRE Center for Perinatal Biology at Women and Infants Hospital

Instrument/ServiceManufacturer/DescriptionFunction
Fluorescence Activated Cell Sorter (FACS)Thermo Scientific Attune NXTAnalytical flow cytometer: 3 lasers, 11 colors, with 96 well plate handler capability
Microscope
Contact:
Andor CSU-W1 spinning disk confocal systemThe Spinning disk confocal microscope is a Nikon Ti-E (inverted) with Perfect Focus and motorized stage, with an Andor Zyla 4.2 plus SCMOS camera, an Andor CSU-W1 spinning disk with 405, 488 and 561 nm laser lines, as well as a SpectraX LED widefield light source and controlled by NIS-Elements software. This system is suitable for fast confocal imaging and live cell imaging, with low phototoxicity and long term focus stability. A stage incubator with CO2 and temperature control is available for maintenance of physiological conditions during  live cell imaging.
Fluorescence Activated Cell Sorter (FACS)Becton Dickinson (BD) Biosciences FACSCantoAnalytical Flow Cytometer: 2 lasers, 6 colors
Imaging System - Gel Imager Bio-Rad Chemidoc XRS The ChemiDoc XRS+ system is based on CCD high-resolution, high-sensitivity detection technology and modular options to accommodate a wide range of samples and support multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. The system is controlled by Image Lab software to optimize imager performance for fast, integrated, and automated image capture and analysis of various samples.
Imaging System - Gel Imager Bio-Rad Molecular Imager FX systemImager with 50 micron resolution and a 5 order of magnitude linear dynamic range for fluorescence and radioisotopic imaging. You can also image and accurately quantitate chemiluminescent samples.
Cell Sorter - MagneticMiltenyi AutoMACS Magnetic cell sorterAutomated cell sorter, for separating cell suspensions labeled with magnetic beads
Microplate Reader Molecular Devices Spectramax Gemini EM Fluorescence Microplate ReaderEnables top and bottom reading of microplates over a greater range of fluorescence intensitiesall without the use of filters.
Microplate Reader Perkin Elmer TopCount NXT Microplate Scintillation and Luminescence CounterTopCount NXT analyzes two, six, or twelve samples at a time, and counts samples in 24-, 96-, and 384-well microplates, as well as microcentrifuge tubes. It can count gammas, betas, or luminescent samples.
MicroscopeLeica MZ FLIII Stereo Fluorescent dissection microscope Dissection microscope with Leica color camera DC300F.
MicroscopeNikon 80i Upright Fluorescence MicroscopeUpright microscope with color CCD camera Spot Insight 2
MicroscopeNikon TE2000E Inverted fluorescence, A live cell imaging microscope, with cooled CCD camera Roper CoolSnap HQ
MicroscopeZeiss AxioImager M2 Upright Microscope,Upright microscope with color CCD camera AxioCam MRC.
MicroscopeNikon TE2000E Inverted fluorescence,A Multicolor fluorescence widefield microscope, with stage incubator, specialized in live cell imaging
PCR Thermal CyclerApplied Biosystems ABI 750096-well quantitative PCR
SpectrophotometerBio-Rad smartspec 90-260 V, UV/visible benchtop spectrophotometer for nucleic acid and protein quantitation, wavelength range 200800 nm, built-in thermal printer
SpectrophotometerThermo Scientific NanoDrop 2000 A full spectral microvolume UV-Vis analysis spectrophotometer for measuring DNA, RNA, andprotein.
Suspension Array SystemBio-Rad BioPlex 200 Detection and quantification of multiple analytes (proteins and peptides, or nucleic acids) in a single sample volume.
CryostatFrozen tissue sectionsThermo Shandon Cryotome E
MicrotomeParaffin embedded tissue sectionsThermo Shandon Finesse ME
Histology/Tissue Processing - Paraffin Embedding WorkstationTissue processingThermo Shandon Histocenter 2
Centrifuge - CytoThin layer preparation from cell suspensionsThermo Scientific Cytospin 4 Cytocentrifuge
Analyzer - Nanoparticle counter
Contact:
Malvern Nanosight NS300Analysis of size distribution and concentration of nanoparticles from 10nm to 2000nm in diameter. A 532nm green laser also allows the detection of red fluorescent particles. A syringe pump allows sample analysis under constant flow, increasing reliability and reproducibility of data.
Imaging System - Gel Imager Bio-Rad Chemidoc MPThe ChemiDoc MP system is based on CCD high-resolution, high-sensitivity detection technology and modular options to accommodate a wide range of samples and support multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. The system is controlled by Image Lab software to optimize imager performance for fast, integrated, and automated image capture and analysis of various samples.
Cell CounterNexcelom CellometerThe Auto T4 is a PC-based instrument for one-step 4x bright field image capture and analysis. This state-of-the-art cell counter performs count, size, and Trypan Blue viability analyses that are 10x faster and more accurate than manual counting. This instrument is ideal for cell lines and purified primary cells, including MCF-7 breast cancer cells, PC3 prostate cancer cells, and 1600 other cell types, due to its advanced software that assesses clumpy cells and omits debris

Molecular Biology and Nanomedicine Facility

(last updated 2016-06-16 10:29:30)
»See Molecular Biology and Nanomedicine Facility website for more details

Contact: Qian Chen

Location: The Coro West Building  »See on the Map

Affiliated Centers: COBRE Center for Skeletal Health and Repair, Orthopedics Institute

Instrument/ServiceManufacturer/DescriptionFunction
Microplate Reader
Contact: Cherie Charbonneau
Molecular Devices SpectraMax M2e plate readerFeatures top and bottom read capability for absorbance, fluoresence, luminescence, and time-resolved fluorescence.
Hybridization Oven
Contact: Cherie Charbonneau
Fisher Scientific Isotemp hybridization chamber Temperature range of +7C to 85C. Includes a rotisserie.
Incubator - Shaker
Contact: Cherie Charbonneau
Lab Companion SI-600 Incubated ShakerBacterial culture shaker with a temperature of ambient to +60C.
Luminometer
Contact: Cherie Charbonneau
Promega Glomax 20/20 luminometer with printerUltrasensitive luminescence detection in a single microcentrifuge tube (1.5ml) format.
PCR Thermal Cycler
Contact: Cherie Charbonneau
Bioer Life ECO thermal cyclerThis thermal cycler has a 96 well format with a 2C/sec ramp rate.
PCR Thermal Cycler
Contact: Cherie Charbonneau
Applied Biosystems ProFlex thermal cyclerThis thermal cycler has a 3x32 well format that allows for 3 separate programs to be run. The ramp rate is 6C/sec.
PCR Thermal Cycler
Contact: Cherie Charbonneau
Applied Biosystems Veriti thermal cyclerThis thermal cycler has a 96 well format with 3.9C/sec ramp rate.
Imaging System
Contact: Cherie Charbonneau
LI-COR Odyssey Classic Infared Imaging systemThis near-infared fluorescent detector can be used for quantitative western blots, gel shift assays, coomassie stains, tissue section and small animal imaging.
Imaging System - Gel Imager
Contact: Cherie Charbonneau
UVP GelCam 310 Bioimaging digital gel documentation systemHigh resolution 2.0 GelCam 310 CCD with manual zoom lens for fluorscent and colorimetric gel imaging. EtBr filter included.
PCR Thermal Cycler
Contact: Cherie Charbonneau
MJ Opticon 2 real-time PCR system.This 96-well system accepts low-profile tubes or plates. There are two fluorophore channels with emission spectra in the 523-543 nm range and 540-700nm.
Incubator
Contact: Cherie Charbonneau
(4) NuAire IR water-jacketed CO2 incubators (NU-8500)This incubator provides an optimal in-vitro growth environment for both cell and tissue culture while minimizing dessication through a closed loop HEPA filtration system.
Biological Safety Cabinet
Contact: Cherie Charbonneau
(4) NuAire Bio Safety Cabinets (Class II, Type A/B3)These biological safety cabinets reduce exposure to airborne biological or particulate chemical agents in low to moderate risk-hazard research and/or drug preparations.
Centrifuge
Contact: Cherie Charbonneau
Sorvall Legend X1R centrifugeProcess samples for diverse laboratory applications with rotors for 1.5ml eppendorf tubes, 15, and 50ml conical tubes. Refrigerated with a max speed of 152000 rpm.
Autoclave
Contact: Cherie Charbonneau
Amerex HVE-50 top loading autoclave sterilizerThis is a 50L, self-contained, portable, top-loading autoclave with auto-exhaust and warming cycles.
Microscope
Contact: Cherie Charbonneau
Nikon Eclipse TS-100F Inverted MicroscopeThis phase contrast microscope used for tissue culture is also equipped with FITC and TRITC filters to capture fluorescent images in SPOT imaging software.
Microscope
Contact: Cherie Charbonneau
Nikon Eclipse 90i Upright Research MicroscopeThis microscope is equipped with two cameras (color and monochromatic) and is ideal for brightfield and/or epi-fluorescent images of whole tissues etc with 4x, 10x, 20x and 40x dry objectives. The filter cubes available are DAPI, FITC, and TRITC.
Flow Cytometer
Contact: Cherie Charbonneau
Becton Dickinson - AccuriThis system is equipped with a blue and red laser, two light scatter detectors, and fluorescence detectors with optical filters optimized for FITC, PE, PerCP, and APC. The user does not need to adjust detector voltages and there is a wide dynamic range of digitally collected data (7.2 decades).
Bioanalyzer
Contact: Cherie Charbonneau
Invitrogen Luminex 200 with xMap technology This is a versatile, efficient standard in multiplexing with the ability to use magnetic or polystyrene beads on up to 100 targets/sample.
pH Meter
Contact: Cherie Charbonneau
Orion pH meter 920pH range of -2 to 19.99 and oxygen range of -2 to 19.99ppm. Autocalibration buffers of 4.01, 7, and 10.01.
pH meter
Contact: Cherie Charbonneau
Hanna Instruments 2209This pH meter features manual pH calibration and temperature compensation.
Microtome
Contact: Cherie Charbonneau
Thermo Scientific Shandon Finesse 325 manual microtomeWith a lightly balanced flywheel it is ideal for routine paraffin sectioning.
Sample Preparation - Cutter
Contact: Cherie Charbonneau
Buehler-Isomet CutterThe IsoMet Low Speed Cutter is a precision sectioning saw designed for cutting various types of materials with minimal deformation. Its low kerf loss capability and great versatility in holding all types of sample shapes and configurations, gives today's laboratory a precision sectioning tool capable of cutting viturally any material including brittle or ductile metals, composites, cements, laminates, plastics, electronic devices and biomaterials. The Cutter is equipped with a diamond studded carborundum wheel and Buehler Ecomet 4 grinder/polisher with Automet 2 powerhead.
Imaging System
Contact: Cherie Charbonneau
PerkinElmer FMT 4000 Fluorescence Tomography System.The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. The system comes with four excitation laser channels (635, 680, 750, and 790 nm) and is useful for a range of applications including oncology, inflammation, and cardiovascular disease. It is ideal for researchers who are well-versed in 3D fluorescence tomography and require the widest range of in vivo applications and imaging agents.
Imaging System
Contact: Cherie Charbonneau
Faxitorn Pre-clinical imaging systemUltra-high resolution x-ray imaging is an important tool in investigating�a variety of disease states. From metastatic cancer to arthritis and�osteoporosis, small animal models are commonly used. Both in vivo and�ex vivo planar imaging is used to screen, track, and evaluate structural�changes in these studies. Cabinet x-ray systems allow researchers to�take images directly in the vivarium to protect the integrity of the colony. �These planar imaging systems are less expensive, subject animals to�lower doses, and provide faster results than microCT systems.
Incubator
Contact: Cherie Charbonneau
GQF 1502 Sportsman egg incubatorThis is a complete incubator and hatching system with 3 automatically turned racks. It has an accurate digital thermostat with LCD of humidity and temperature.
Homogenizer
Contact: Cherie Charbonneau
Fisher Scientific, Powergen 125 Tissue HomogenizerProcess volumes from 0.03 to 100mL. Variable speed control to 30,000rpm for efficient cell disruption. Disposable plastic generators eliminate sample cross-contamination. Flat-bottom stainless-steel generators process liquid or soft tissues.
Microscope
Contact: Cherie Charbonneau
Olympus SZ61 Zoom StereomicroscopeGreenough design with two optical paths inclined at an inward angle. Magnification range 0.67X to 4.5X; zoom ratio 6.7:1; FN 22. Working distance of 100mm; observation tube angle 45 degrees; right and left eyepiece tubes interlocked; interpupillary distance adjustment 50-76mm; forward positioned zoom adjustment knobs with zoom magnification graduations. With 0.5x cmount for documentation.
Fume Hood
Contact: Cherie Charbonneau
Thermo Scientific Hamilton SafeAire IIChemical hood and ultra-high vacuum system for organic synthesis
Evaporator
Contact: Cherie Charbonneau
Buchi R-124 RotavaporRotary evaporator comes complete with a 45 degree water condenser and a 1L condensing and evaporating flask.
Sample Preparation - Circulator
Contact: Cherie Charbonneau
VWR Recirculating Chiller, Model 1160AStable cooling for many common heat removal applications such as rotary evaporators and vacuum systems (-10 to 40C).
High Performance Liquid Chromatography (HPLC)
Contact: Cherie Charbonneau
Agilent Technologies, 1260 Infinity HPLC systemA maximum pressure of 600 bar to utilize smaller particle size columns for higher resolution and faster separations.
Disrupter
Contact: Cherie Charbonneau
Qsonica 700W sonicator with 5.5" cup hornThis sonicator has full amplitude control from 1-100%.
Imaging System
Contact: Cherie Charbonneau
Xtreme back illuminated 4MP with x-ray for small animal imaging High sensitivity luminescence, fluorescence, radioisotopic, and radiographic imaging for up to 5 mice at a time. Isofluarne and temperature controlled chamber for the mice.
PCR Thermal Cycler, Digital
Contact: Cherie Charbonneau
RainDrop Digital PCR by RainDanceThe RainDrop is composed of a Source instrument that can generate 10million droplets/sample and the Sense instrument, which can detect whether the PCR reactions are positive or negative for your fluorophore. Multiplexing is possible for the 8 samples that are run at a time on the microfluidics chip.
PCR Thermal Cycler
Contact: Cherie Charbonneau
BioRad CFX96 Real-Time PCR systemThis real-time PCR instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format.
Spectrophotometer
Contact: Cherie Charbonneau
Thermo Scientific NanoDrop 2000cThis is a full spectrum, UV-Vis spectrophotometer used to quantify and assess the purity of DNA, RNA, protein, and more at sample volumes as low as 0.5ul.
Bioreactor
Contact: Cherie Charbonneau
Flexcell FX5000 Tension SystemThis is a computer-regulated bioreactor that uses vacuum pressure to apply either cyclic or static strain to cells cultured on flexible-bottomed culture plates.
Sample Preparation - Freeze Dry System
Contact: Cherie Charbonneau
Labconco FreeZone Plus 2.5L Cascade Benchtop LyophilizerThis system is for light sample loads with low eutectic points. It can remove up to 1.8L of water in 24hrs and holds 2.5L of ice before defrosting is required.

Molecular Characterization Facility

(last updated 2016-06-16 10:29:30)
»See Molecular Characterization Facility website for more details

Contact: Al Bach, Ph.D

Location: Pharmacy Rm 315  »See on the Map

Affiliated Centers: RI-NSF EPSCoR

Instrument/ServiceManufacturer/DescriptionFunction
Nuclear Magnetic Resonance (NMR) SpectrometerAgilent NMRS 500 with OneNMR probeOptimized for small molecule NMR
Nuclear Magnetic Resonance (NMR) Spectrometer
Contact: Dr. Al Bach
Agilent NMRS 500 with OneNMR ProbeNMR Spectroscopy
Nuclear Magnetic Resonance (NMR) Spectrometer
Contact: Dr. Al Bach
Bruker Avance III 300 with BBO probeOptimized for small molecule NMR
Mass Spectrometer
Contact: Dr. Al Bach
ABSciex Qtrap 4500 Triple Quadrapole LC/MSHas Shimadzu HPLC system attached

Molecular Pathology Core - Brown

(last updated 2017-12-08 14:28:45)
»See Molecular Pathology Core - Brown website for more details

Contact: Paula Weston, M.A.

Location: Laboratories for Molecular Medicine, Room 539  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Histology/Tissue Processing - Sample ProcessingServiceParaffin Processing - automated and manual, Placing tissue in cassettes, Glycol Methacrylate Processing, Routine TEM processing, Enhanced contrast TEM, Immunogold labeling
Histology/Tissue Processing - SectioningServiceParaffin sectioning, Glycol sectioning Frozen prep and sectioning, TEM ultrathin sectioning
Histology/Tissue Processing - Tissue ProcessorLeica ASP300 S Automated Tissue ProcessorTissue processing for paraffin embedding
Histology/Tissue Processing - Paraffin embedding WorkstationLeica EG1150C Paraffin Embedding CenterParaffin embedding
MicrotomeMicrom HM 355S Automated MicrotomeParaffin sectioning
MicrotomeLeica RM2265 Automated MicrotomeParaffin and plastic sectioning
CryostatLeica CM3050S CryostatSectioning of fixed and unfixed frozen samples
VibratomeLeica VT 1000S VibratomeSectioning of fixed and unfixed samples
Biospecimen Banking - FreezerRevco -80 degree C FreezerSample storage
MicroscopeNikon Eclipse 50i light microscope with a projectorCollaborative analyses of histological slides and digital imaging capability
Microscope - Laser Capture Microdissection SystemArcturus PixCell IIe Laser Capture MicrodissectionCapture of specific cell types for RNA, DNA and Protein analysis
Imaging System - Slide ScannerAperio ScanScope CS slide scannerThis microscope uses a 20x objective to produce high-resolution digital scans of histological slides.
Histology/Tissue Processing - StainingServiceH&E staining, Cat 1 and 2 staining, PAS staining, Lectin staining, TUNEL staining, Immunohistochemistry (IHC), TEM heavy metal staining

Molecular Pathology Core Laboratory - Rhode Island Hospital

(last updated 2017-12-08 14:29:04)
»See Molecular Pathology Core Laboratory - Rhode Island Hospital website for more details

Contact: Murray Resnick

Location: Aldrich Building , 6th Floor, Rhode Island Hospital Campus  »See on the Map

Affiliated Centers: COBRE Center for Cancer Research and Development at Rhode Island Hospital

Instrument/ServiceManufacturer/DescriptionFunction
BioanalyzerAgilent Bioanalyzer 2100The Agilent 2100 Bioanalyzer system provides sizing, quantitation and quality control of DNA, RNA, proteins and cells on a single platform, providing high quality digital data.
Biological Safety CabinetHEPA filter and NuAire laminar flow hood Filter capable of removing 99.97% of particles greater than 0.3 micronss.
Biospecimen Banking - FreezerThermoForma Freezer - 80 C #8606Sample storage
Biospecimen Banking - FreezerThermoForma Freezer -20 C #3801Sample storage
Biospecimen Banking - FreezerThermoForma Refrigerator #3771Sample storage
Biospecimen Banking - RefrigeratorThermoForma Ultra 932 Lo Freezer -80 C (2) Sample storage
CentrifugeEppendorf 5424 MicrocentrifugeAerosol-tight rotor. Max rcf: 20,238 x g. Automatic lid opening following application sequence. Low access height: 23 cm. Short spin, rpm/rcf setting as required
CentrifugeThermoForma refrigerated MicrocentrifugeWorking temperatures from -5 C to +40 C.
CryostatLeica Cryostat CM1850Frozen Tissue Sectioning. UVC disinfection and AgProtect minimizes contamination risk. Optional section waste and vacuum, disposable blade holder.
Histology/Tissue Processing - BalanceMettler (PB303-S) semimicro balanceMass range of 0.01 mg- 120 g.
Histology/Tissue Processing - HistobathFisher Histobath 134Prevents development of microscopic ice crystals and sample distortion.
Histology/Tissue Processing - Microwave OvenAmana (RFS18MPS) Microwave OvenTissue microwave fixation.
Histology/Tissue Processing - Microwave OvenGE Microwave oven (JE1460BF001)Tissue microwave fixation.
Imaging System - CameraPolaroid camera Instant recording of gels.
Imaging System - Slide ScannerAperio ScanScope Slide Scanner CS2Generates full color, high resolution digital images (cells, tissues and tissue arrays). 5 slide capacity. Image analysis software available. Stored and catalogued in searchable image data base.
IncubatorFisher Scientific Dry Bath IncubatorPrecise temperature control for temperatures up to 130 C. Built in temperature sensing probe for improved temperature accuracy and control.
Microscope - Laser Capture Microdissection SystemArcturus XT Laser Capture Microdissection System Automated IR and UV laser capture. Microdissection and cutting of cells for RNA, DNA and protein isolation. One modular platform with laser capture and cutting. Optional live-cell modules and camera. Any slide type. Wide range of objectives available, 2x-100x dry and 100x oil immersion.
MicroscopeOlympus Fluorescent Microscope BX41Image Pro Imaging Software. Excitation available 330-385nm, 460-490nm, 510-550nm. Magnifications of 20,40, 100, 200 power. Both reflected light and sample fluorescence may be viewed through and recorded at the microscope.
MicroscopeOlympus BX41 General Use MicroscopeOptical system: UIS2. Built in transmitted Koehler illuminator, 6V/30W bulb. Stage height movement by roller guide, stroke per rotation: 36.8mm. Full stroke range: 25mm. FN20, tube inclination 30 degrees. Stage size: 188 x 134 mm.
MicrotomeFinesse 325 Microtome Used to prepare samples for observation under transmitted light or electron radiation. Microtome material varies depending on the specimen being sliced and the desired thickness of the sections cut.
PCR Thermal CyclerBio-Rad C1000 Touch Thermal Cycler The C1000 Touch thermal cycler offers superior performance and a large color touch screen for easy programming. This fully modular platform is able to accommodate different throughput needs with easily interchangeable reaction modules that swap in seconds without tools. Each PCR module has a fully adjustable heated lid that supports a wide range of vessels and sealers, including low-profile and standard-height PCR plates.
pH MeterAccumet pH meter pH meter.
Robotic Workstation - BarcodingVentana Discovery System Automated staining module using bar code technology. Total automation in IHC staining of frozen/ paraffin embedded tissue, FISH and ISH using DNA, RNA or oligonucleotide probes on tissue or microarrays (gene expression).
SpectrophotometerEppendorf BioPhotometer 50 microliter volumes. Automatic calculation of dilution factors. Measures wave lengths: 230, 260, 280, 340, 405, 490, 550, 595, 650 nm. Spectral bandwidth: 5nm at 230-340nm, 7nm at 405-650nm. Photometric random error +/- 0.002A at 0A, +/- 0.005A at 1A.
Suspension Array SystemBeecher Manual Tissue Microarrayer Generates multiple specimen slides that can contain hundreds of individual tissues. Up to 100 tissue cores per paraffin block. Use for same histochemical and molecular detection techniques as with regular sections.
Vacuum OvenNapco Model 5831 vacuum ovenCapacity: 0.45 cu ft. Temp range: 35 C to 200 C. 30-in Hg vacuum capability. Vacuum bleed valves permit pulling of vacuums as high as 30 inches H. Full view observation window with latched door and built in safety to prevent thermal runaway.
WaterbathPolyScience refrigerated/heated (9106) circulating waterbathThese quality baths are ideal for calibration, electrophoresis, rotary evaporation, viscometry, or other applications requiring cooling or heating. Standard Digital Controller Bath features ±0.05°C temperature stability down to -20°C
PCR Thermal CyclerAgilent Mx3005P qPCR SystemAvailable for gene expression analysis, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies.
SpectrophotometerThermo Scientific NanoDrop 2000Wide spectral range (190-840nm) for measuring a variety of samples types. Only requires 0.5 - 2 µL of your sample. Pre-configured methods for DNA, Protein A280, Microarray, Protein and Labels, Pierce 660, Bradford, BCA, and Lowry. No dilutions required, even for highly concentrated samples. Fast measurement time of less than 5 seconds, 10 -15 seconds from sample pipetting to wiping the pedestal clean.
Imaging System- Image Analysis SoftwareMedia Cybernetics Image-Pro PremierAllows processing and analysis of a 2D and 3D (limited) images (brightfield/IHC, fluorescent, other) for qualitative and quantitative in both spatial and frequency domains

Mouse Transgenic and Gene Targeting Facility

(last updated 2017-07-18 08:55:15)
»See Mouse Transgenic and Gene Targeting Facility website for more details

Contact: Youngwook Ahn

Location: Laboratories for Molecular Medicine  »See on the Map

Affiliated Centers: COBRE Center for Signaling Networks at Brown University, Center for Genomics and Proteomics (CGP)

Instrument/ServiceManufacturer/DescriptionFunction
Biological Safety CabinetNuAire Safety Cabinets Class 2 Type A/B3Transgenics and gene targeting safety cabinets (2 units)
CentrifugeThermo IEC Centra CL3R Refrigerated CentrifugeTransgenics and gene targeting refrigerated centrifuge
Electroporation SystemBio-Rad Gene Pulsar IITransgenics and gene targeting electroporation system
Biospecimen Banking - FreezerCustom BioGenic Systems Liquid Nitrogen (LN2) FreezerTransgenics and gene targeting liquid nitrogen freezer
Biospecimen Banking - FreezerThermo Fisher Scientific -80 CTransgenics and gene targeting -80 C freezer
Biospecimen Banking - Freezer Frigidaire -20 C FreezerTransgenics and gene targeting freezer
Transgenics and Gene Targeting - Gene TargetingServiceGene targeting services through transfection and microinjection of murine embryonic stem (ES) cells to produce germline knockout (KO) or knockin (KI) mice
IncubatorNuAire CO2 water jacketed Incubators Transgenics and gene targeting incubators (3 units)
Cell Manipulator - Microinjection systemEppendorf FemtoJet Microinjection SystemTransgenics and gene targeting pronuclear injection system
MicromanipulatorEppendorf Transferman NK 2 MicromanipulatorsTransgenics and gene targeting micromanipulators (2 units)
MicroscopeNikon Eclipse TE200 Inverted MicroscopeTransgenics and gene targeting microinjection microscope
MicroscopeNikon Eclipse TS100 (cell culture scope)Transgenics and gene targeting cell culture scope
MicroscopeNikon SMZ1500 Zoom StereomicroscopesTransgenics and gene targeting dissecting microscopes (2 units)
MicroscopeNikon SMZ800 Zoom StereomicroscopesTransgenics and gene targeting surgical microscope
Transgenics and Gene Targeting - CRISPR Design and Reagent PreparationServiceService to provide consultation, design a CRISPR model, synthesize sgRNAs and prepare microinjection mix
Transgenics and Gene Targeting - CRISPR Donor ConstructionServiceService to construct a donor DNA for a CRISPR model
Transgenics and Gene Targeting - TransgenicsServiceService to provide custom services related to microinjection, ES cell culture, mouse surgery, or mouse reproduction. The core facility will provide services and/or training related to our capabilities that are not specifically covered by our service list. These services are available for an hourly fee. Examples include: production of MEFs (murine embryonic fibroblasts), polar body biopsy, reproductive surgery, blastomere injection, frozen embryo shipment, training
Transgenics and Gene Targeting - Cryopreserved Mouse Embryo RecoveryServiceService to thaw and implant previously cryopreserved mouse embryos
Transgenics and Gene Targeting - Cryopreserved Mouse Embryo StorageServiceService to store cryopreserved mouse embryos in liquid nitrogen (LN2)
Transgenics and Gene Targeting - Derivation of Mouse Embryonic Stem (ES) cell linesServiceService to produce embryonic stem (ES) cells from an existing mouse line key words: murine embryonic stem cells
Transgenics and Gene Targeting - Embryonic Stem (ES) Cell Injection ServiceService to produce chimeric mice for analysis through microinjection of murine embryonic stem (ES) cells into blastocyst stage embryos.
Transgenics and Gene Targeting - Mouse Colony ExpansionServiceService to use superovulation and surgical implantation to produce large cohorts of age matched mice for experimentation or to quickly expand a mouse colony
Transgenics and Gene Targeting - Mouse Embryo Cryopreservation ServiceService to cryopreserve valuable mouse lines for storage or shipment to other investigators.
Transgenics and Gene Targeting - Mouse In vitro Fertilization (IVF) ServiceService to perform in vitro fertilization of mouse embryos
Transgenics and Gene Targeting - Rederivation of Mouse LinesServiceService to rederive mouse lines obtained from a source other than a Brown University approved vendor. Rederived mouse lines may be housed in any campus mouse facility.
Transgenics and Gene Targeting - Transgenic ProductionServiceService to perform pronuclear microinjection of 0.5 dpc mouse embryos to produce transgenic or CRISPR founders on an FVB/N or C57/BL6 background. Custom backgrounds also available.
Water Purification SystemMilli Q Biocel Transgenics and gene targeting water purification
WaterbathThermo Scientific Precision 260 Circulating Waterbath Transgenics and gene targeting circulating waterbath
Transgenics and Gene Targeting - CRISPR GenotypingServiceService to genotype founders and G1 progeny from a CRISPR project
Transgenics and Gene Targeting - CRISPR Founder TA cloning & SequencingServiceService to subclone and sequence a PCR amplicon from founders of a CRISPR project
Transgenics and Gene Targeting - Mating for Germline TransmissionServiceService to breed chimera from mouse ES cell injection or founders from a CRISPR project with WT mice for germline transmission
Transgenics and Gene Targeting - Sperm CryopreservationServiceService to cryopreserve sperm from males provided by investigators

Multiplex Facility

(last updated 2016-06-16 10:29:30)
»See Multiplex Facility website for more details

Contact: Suzanne de la Monte

Location: 55 Claverick Street  »See on the Map

Affiliated Centers: Liver Research Center, Center for International Health Research, Center for International Health Research, Liver Research Center, COBRE Immune-Based Interventions Against Infectious Diseases

Instrument/ServiceManufacturer/DescriptionFunction
Behavioral Phenotyping - Four Lane RotarodEmitter-Columbus Rotamex 5 ControllerUsed to assess motor coordination and balance
Behavioral Phenotyping - Morris Water MazeFabricated in house Opaque white pool with platform for behavioral swim test.
Biospecimen Banking - FreezerHHP Barcoding InstrumentBarcode samples for identification. File Pro software.
CentrifugeBeckman- Coulter Allegra 64R Refrigerated CentrifugeFor use with 50 mL conical tubes.
CryostatLeica CryostatFrozen Tissue Sectioning. UVC disinfection and AgProtect minimizes contamination risk. Optional section waste and vacuum, disposable blade holder.
DisrupterSiegen Tissue LyserDisrupts multiple biological samples through high speed shaking in plastic tubes with steel, tungsten carbide, or glass beads. Up to 48 samples can be processed simultaneously.
Imaging SystemApplied Scientific Instrumentation MS-1000XY stage designed to provide a high resolution, and highly repeatable, means of controlling the X and Y position of a microscope stage
Imaging System - CameraOlympus U-CMAD3 cameraConnected to Olympus Inverted CKX31 Fluorescent Microscope. Digital Imaging of samples. 1.3, 3.0, 5.0 megapixel available. Vivid colors, 12-bit image capture, high-speed readout, external trigger output, USB 2.0 interface for universal connections.
Imaging System - CameraSony 3CCD Exwave HAD Digital CameraConnected to Olympus BX60. Digital Imaging of samples. 1.3, 3.0, 5.0 megapixel available. Vivid colors, 12-bit image capture, high-speed readout, external trigger output, USB 2.0 interface for universal connections.
Imaging System - CameraStereologer 2001/3" type DSP 3-CCD PAL color video camera with improved camera sensitivity (F8 at 2000 lx). Resolution of 800 TVL and a high S/N ratio of 61 dB.
Microplate ReaderMolecular Dynamics M5 SpectracountCross talk (96-well): 3X 10-5, sensitivity: <20 attomol ATP per well, <0.2 firely luciferase per well, spectral range: 380-630 nm.
Microplate ReaderPackard-Perkin Elmer TopcountAnalysis of cell proliferation, receptor binding assays, solid phase RIA/LIA, reporter gene assays, 51Cr release assays, HPLC fraction analysis, scintillation proximity assays, etc.
Microplate ReaderMolecular Devices UV Max Microplate Reader96-wellplate reader. Spectral range: 405-630 nm.
MicroscopeOlympus BX60High-resolution digital pictures using conventional manual filter cubes or more versatile automated filter wheels, and can superimpose multi-color pictures
MicroscopeOlympus Inverted CKX31 Fluorescent MicroscopeInverted microscope with the capability of a fluorescence illuminator for GFP; documentation of images with digital imaging and video monitoring. Use for petri dishes, culture flasks, and multi-well plates.
MicroscopeOlympus Inverted Fluorescent microscopeFN22. 9mm stroke, coaxial coarse and fine focusing knobs. Long working distance universal condenser.
PCR Thermal CyclerRoche Lightcycler 4810Exchangeable 96 or 384 multiwell plate format. Ideal for multiplexing and automated workflows. Provides various methods for gene detection, gene expression analysis, genetic variation analysis and array data validation.
Robotic Workstation - DNA ExtractionQUIAGEN Biorobot EZ1Fully automated purification of genomic DNA from human whole blood and viral nucleic acids from serum or plasma samples.
Robotic Workstation - PipettingEppendorf EpMotion 5070Automated pipetting. Four deck positions can hold tips, reagent reservoirs, single tubes, tube racks, micro-plates, or PCR plates with up to 384 wells. Suited for serial dilutions, reagent distribution, transfer from tubes to plates and normalization.
Robotic Workstation - PipettingTecan Genesis 200 RobotAutomated robot for pipetting tasks. Two arms- the LiHa (liquid handler) and the RoMa (robot manipulator). LiHa- conductivity-sensing 8-channel pipetting arm dispenses volumes of 5-1000 L; RoMa- manipulating arm picks up and moves objects on the workstation.
SpectrophotometerThermo Scientific NanoDrop 2000Measures DNA, RNA, and protein concentrations, and purity (A260/A280 ratio). Conc. range= 2 ng/microliter-15,000 ng/microliter; Min Sample size = 0.5 microliter.
Suspension Array SystemLuminex MagpixReads magnetic bead-based immunoassays. Automated reading of 96-well plates (~60 min/plate). Multiplex analysis of up to 50 biomolecules in a single sample.
Suspension Array SystemBio-Rad BioPlex 100Automated reading of 96-well plates, up to 9,600 data points in about 35 min. Multiplex analysis of up to 100 biomolecules in a single sample via suspension array.
Suspension Array SystemBio-Rad Vacuum manifoldVacuum purification platform for single 96-well plates or individual luer-ended spin columns. Compatible with Bio-Plex 200 suspension array system.

Neonatal Research Network NICHD

(last updated 2017-12-08 10:15:15)
»See Neonatal Research Network NICHD website for more details

Contact: Abbot Laptook

Location: Neonatal Intensive Care Unit  »See on the Map

Affiliated Centers: Neonatal Research Network

Instrument/ServiceManufacturer/DescriptionFunction
Neonatal Research Network of the NICHDClinical Trials Support, Neonatal Research The NICHD Neonatal Research Network (NRN) was established to undertake multicenter clinical studies to investigate the safety and efficacy of treatment and management strategies to improve the outcome of sick newborns. By providing large populations through a network of centers using common protocols, questions could be answered more rapidly than by individual centers acting alone. The NRN structure promotes randomized controlled trials with short (during the hospitalization) and/or long term (neurodevelopmental) outcome. The NRN at Women and Infants Hospital studies evidence-based practice in neonatology through collaborative research performed in academic perinatal centers. The Center has played a leadership role in studies such as hypothermia for perinatal hypoxic ischemic encephalopathy, a high-impact report in the New England Journal of Medicine which has changed care nationally. The Center has played a leadership role in studies such as hypothermia for perinatal hypoxic ischemic encephalopathy. Follow up programs exist in participating Centers to evaluate the long term neuro-developmental outcome of extremely low birth weight infants.

NMR Facility

(last updated 2016-06-16 10:29:30)
»See NMR Facility website for more details

Contact: Russell Hopson, PhD

Location: MacMillan Hall  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Nuclear Magnetic Resonance (NMR) SpectrometerBruker 300 Avance z-BBI probe, (least sensitivte 1H and indirect detection to all broadband nuclei)
Nuclear Magnetic Resonance (NMR) SpectrometerBruker 600 Avance III HD Ascendz-BBFO probe for all nuclei (most sensitive for all nuclei)
Nuclear Magnetic Resonance (NMR) SpectrometerBruker 400 Avance III Ultra-Shield z-BBFO (2nd most sensitive for 1H and broadband nuclei)
Nuclear Magnetic Resonance (NMR) SpectrometerBruker 400 Avance Ultra-Shield z-BBO (3rd best sensitivity for broadband nuclei)

Norman Prince Neurosciences Institute Resources

(last updated 2017-12-07 15:10:17)
»See Norman Prince Neurosciences Institute Resources website for more details

Contact: Suzanne De La Monte

Location: Rhode Island Hospital  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Cellular and Molecular Neuroscience Core Resources
Contact: Suzanne De La Monte
Cellular and Molecular Neuroscience Core Resources Website
Clinical Research Resources, NeuroscienceCore laboratory resources are available to Norman Prince Neurological Institute and Brown Institute of Brain Science clinical and translational research scientists.
Hospital-Imaging Research and Education Service (HI-RES)
Contact: Daniel Dickstein, MD
HI-RES Website
Clinical Research Resources, Imaging HI-RES has two image analysis and education centers, one at Rhode Island Hospital and the other at Butler Hospital. The Rhode Island Hospital site features advanced computing for image analysis, an image processing server, conference room and three offices. The Butler Hospital site consists of two room that house eight computers equipped for image analysis. HI-RES also utilizes Brown University’s high performance computing center (HPC).
Quantitative Sciences Program
Contact: Rich Jones
Quantitative Sciences Website
Clinical Research Resources, Quantitative SciencesThe quantitative sciences program (QSP) provides training in the form of formal workshops, seminars and individual mentoring in the areas of quantitative methodology, including research and experimental design, survey and sampling methods, basic and advanced multivariate data analysis.

Ocean State Clinical Coordinating Center

(last updated 2017-12-08 10:16:44)
»See Ocean State Clinical Coordinating Center website for more details

Contact: Mitchell Levy

Location: 1 Virginia Avenue, Suite 105, Providence, RI 02905  »See on the Map

Affiliated Centers: Ocean State Clinical Coordinating Center (OSCCC)

Instrument/ServiceManufacturer/DescriptionFunction
Ocean State Clinical Coordinating Center
Contact: Jacqueline Robinson
Clinical Trials Support, Critical Care and Sepsis ResearchOur expertise is in clinical trial designs investigating novel agents for treatment of sepsis. Our physicians have extensive backgrounds in pulmonary, critical care medicine and infectious diseases. The Ocean State Clinical Coordinating Center (OSCCC) staff can collaborate with a sponsor on protocol design with an eye to its practical application. Services include protocol design assistance, patient enrollment/site selection, site education and study start-up, subject adjudication, consulting.

Orthopaedic Surgery Research Laboratories

(last updated 2017-12-08 10:18:42)
»See Orthopaedic Surgery Research Laboratories website for more details

Contact: Roy Aaron

Location: Coro West  »See on the Map

Affiliated Centers: Orthopaedic Surgery Research Laboratories

Instrument/ServiceManufacturer/DescriptionFunction
Orthopaedic Surgery Research LaboratoriesClinical Research Resources, OrthopaedicsThe Orthopaedic Research Labs at Rhode Island Hospital exist to expand the basic science of orthopaedics, improve understanding of orthopaedic diseases, and evaluate new methods of treatment for orthopaedic injuries and illnesses. Research projects are generated from the interests of the research staff, orthopaedic physicians, and residents. Research topics range from collagen breakdown products to joint kinematics to new biomimetic surfaces for implants. Research resources include bioengineering, skeletal biology, nanotechnology, oncology, trauma, cartilage, spine, and anatomy and arthroskills facilities.

PC - Albertus Magnus Hall Labs

(last updated 2016-06-16 10:29:30)

Contact: Charles Toth

Location: Albertus Magnus Hall  »See on the Map

Affiliated Centers: RI-NSF EPSCoR , RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
Environmental Chamber
Contact: Maia Bailey
Percival Scientific 1 unit
Environmental Chamber
Contact: Maia Bailey
Percival Scientific, AR-22L Growth ChamberFor Arabidopsis
Imaging System - Camera
Contact: Pat Ewanchuk
Fastec HiSpec1, Low-Light High-Speed CameraInnovative Low-Light High-Speed Camera. Monochrome with 2GB Memory, C-Mount, includes ImageBLITZ Auto Trigger, Burst Trigger Mode, Multi- Sequence Record Mode (1280 x 1024 at 506fps) 2 Units
Microscope - Electron
Contact: Joe DeGiorgis
Philips EM-300 Transmission Electron Microscope (TEM)Transmission electron microscopy
Sample Preparation - Laboratory - Prep Lab
Contact: Joe DeGiorgis
Electron Microscopy Prep LabLaboratory space for preparing samples for electron microscopy
Microscope - Electron
Contact: Joe DeGiorgis
Amray-1000 Scanning Electron Microscope (SEM)Scanning Electron Microscope equipped with EDEX for elemental analysis and a digital imaging system, a Zeiss Axiophot equipped for bright field, dark field, DIC and fluorescence microscopy with a digital imaging system
Microtome
Contact: Joe DeGiorgis
Porter-Blum MT-2B UltramicrotomePorter-Blum MT-2B UltraMicrotomes, 2 Units
Aquatic System
Contact: Pat Ewanchuk
Aquatic Habitats Glass Tank System and Life Support Controller Glass tank system and life support controller with low water level protection (18-10 gallon tanks)
Imaging System - Visualization- Camera lucida
Contact: James Waters
Leica Drawing tubeDrawing tube, for MZ and M-series, the object and the drawing surface are visible at the same time, suitable for drawing for left and right handed persons, work is possible in the daylight. Documents and scales can be mirrored-in and photographed along with the object.
Analyzer - Respiratory physiology
Contact: James Waters
LI-COR Biosciences - Li-7000 CO2/H2OThe LI-7000 is a high performance, dual cell, differential gas analyzer. It uses a dichroic beam splitter and two separate detectors to measure infrared absorption by CO2 and H2O in the same gas stream. The LI-7000 is ideally suited for applications that demand high speed, high precision measurements in absolute and/or differential modes, including plant and insect gas exchange using chamber-based methods, atmospheric-surface flux eddy covariance and Bowen ratio techniques, vertical profiling, and general atmospheric monitoring.

PC - Hickey Hall Labs

(last updated 2016-06-16 10:29:30)

Contact: Charles Toth

Location: Hickey Hall  »See on the Map

Affiliated Centers: RI-NSF EPSCoR , RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
DNA Sequencer
Contact: Elisabeth Arevalo
ABI Prism 3100 Genetic AnalyzerUsed for DNA sequencing and fragment analysis. The ABI PRISM 3100 Genetic Analyzer is an automated capillary electrophoresis system that can separate, detect, and analyze up to 16 capillaries of fluorescently labeled DNA fragments in one run.
PCR Thermal Cycler
Contact: Charles Toth
Stratagene Mx3000p Real-time PCR Thermal CyclerThis instrument is available for gene expression analysis, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Agilent's qPCR software, MxPro, provides users with an intuitive interface, quick experiment design, powerful data analysis and easy report generation.
Fluorescence Activated Cell Sorter (FACS)
Contact: Charles Toth
Flow Cytometer- Accuri C6The BD Accuri C6 is a personal flow cytometer that is easy to use, simple to maintain, and affordable.
Cold Room
Contact: Charles Toth
Walk-In Cold Room
Analyzer - Cell Metabolism
Contact: Marla Tipping
Seahorse Biosciencies, XFe Extracellular Flux Analyzers, XFe96Platform for metabolic assays that simultaneously measures the two major energy producing pathways of the cell - mitochondrial respiration and glycolysis - in a microplate, in real-time.
Laboratory - Tissue Culture
Contact: Charles Toth
Tissue Culture LaboratorySpace and instrumentation for tissue culture preparation
Imaging System - Gel Imager
Contact: Yinsheng Wan
Licor Odyssey IR (Infrared) Imaging SystemInstrumentation for quantitating western blots.
Fluorescence Activated Cell Sorter (FACS)
Contact: Nicanor Austriaco
Cellometer Vision Image CytometryThe Vision CBA System combines the simplicity of image cytometry with the power of flow analysis software to offer user-friendly cell-based assays
Spectrophotometer
Contact: Charles Toth
Thermo Scientific NanoDropUV/VIS

PC - Sowa Hall Labs

(last updated 2016-06-16 10:29:30)

Contact: Charles Toth

Location: Sowa Hal  »See on the Map

Affiliated Centers: RI-NSF EPSCoR , RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
Microscope
Contact: Joe DeGiorgis
Zeiss LMS 700 Flexible Confocal Microscope Performs fluorescence measurements, creates optical sections of samples and combines them into 3D image stacks.

Plant Environmental Center

(last updated 2016-06-16 10:29:30)
»See Plant Environmental Center website for more details

Contact: Fred Jackson

Location: Building for Environmental Research and Teaching  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Greenhouse, Plant Environmental Center
Contact: Chris Claussen
Plant environmental center with seven separate, computer controlled rooms where conditions like lighting, temperature, and humidity can be fine tuned; an additional 17 controlled plant growth environments provided by growth chambers (15) and walk-in growth rooms (2)A plant environmental center with a suite of supporting facilities, including a classroom, a "headhouse" for potting and other prep work,and growth chambers for plants.

Proteomics Facility - Brown

(last updated 2017-12-08 14:29:32)
»See Proteomics Facility - Brown website for more details

Contact: Mandar T Naik, PhD

Location: 3rd Floor, Laboratories for Molecular Medicine  »See on the Map

Affiliated Centers: Center for Genomics and Proteomics (CGP), RI-NSF EPSCoR

Instrument/ServiceManufacturer/DescriptionFunction
Bioinformatics Analysis - Mascot ServerSoftware: Matrix Science Mascot Search EngineSoftware for protein identification, characterization and quantitation (v.2.5)
Bioinformatics Analysis - PEAKS Studio Software: Bioinformatics Solutions Inc. PEAKS Studio Software for de novo sequencing and database searching (v.7.0)
Bioinformatics Analysis - ProSight PC Software: Thermo Scientific ProSight PC Software for Top-Down proteomics analysis (v.2.0)
Bioinformatics Analysis - ProteoIQSoftware: NuSep ProteoIQ Mass Spec Data AnalysisSoftware for mass spectrometry proteomic analysis (v.2.7)
Bioinformatics Analysis - Proteome Discoverer Software: Thermo Scientific Proteome Discoverer Software for database searching and protein quantitation (v.1.4)
Analyzer - CalorimeterMicrocal Isothermal Titration 200 (ITC)Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules.
Analyzer - CalorimeterMicrocal VP Differential Scanning (DSC)Measurement of heat changes that occur in biomolecules during controlled increase or decrease in temperature.
Bioreactor - FermenterInfors MiniforA bench-top (1-5 L) laboratory fermenter and bioreactor for bacteria and yeast.
Fluorometer - SpectrofluorometerHoriba Jobin Yvon FluoroMax-4Fluorescence detection. A heated cell allows temperature studies.
High Performance Liquid Chromatography (HPLC)Agilent 1200 HPLC SystemHigh performance liquid chromatography system with: quaternary pump, thermostatted autosampler, thermostatted fraction collector, and a multi-wavelength UV/Vis detector. It can be used for analytical detection of biomolecules and/or their purification.
Liquid Chromatography SystemGE Healthcare AktaPrime Plus The KTA Prime Plus is a low pressure chromatography system that performs simple purifications of tagged and untagged proteins.
SpectrophotometerJASCO J-815 Circular Dichroism (CD) SpectrometerProtein folding studies, Protein conformational studies, DNA/RNA interactions, Enzyme kinetics, Purity testing of optically active substances, quantitative analysis of pharmaceuticals, natural products chemistry, biochemistry and macromolecules, rapid scanning (time resolved) experiments. Peltier device for temperature studies.
SpectrometerThermo Scientific NanoDrop 8000 A full spectral microvolume (microliter) UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein of 8 samples simultaneously.
Analyzer - Surface Plasmon Resonance (SPR) SensorGE Healthcare Biosciences Biacore X 100Label-free protein interaction analysis provides unique and comprehensive data on the interactions between biomolecules. Performs quantitative kinetic analysis (rate constants), quantitative determination of affinity constants, determination of binding specificity (yes/no), and concentration analysis.
Technical Assistance - Proteomics Project Consultation ServiceService to provide Proteomics Technical Assistance
Technical Assistance - Proteomics TrainingServiceService to provide Proteomics Training
Bioinformatics Analysis - Mascot DistillerSoftware for peptide and protein quantitation (v.2.5.1)Software: Matrix Science Mascot Distiller
Bioinformatics Analysis - ScaffoldSoftware for mass spectrometry proteomic analysis (v.4.3.4)Software: Proteome Software Scaffold Q+S

Proteomics Laboratory - Rhode Island Hospital

(last updated 2017-12-08 14:29:45)
»See Proteomics Laboratory - Rhode Island Hospital website for more details

Contact: Nagib Ahsan, PhD

Location: The Coro West Building  »See on the Map

Affiliated Centers: COBRE Center for Cancer Research and Development at Rhode Island Hospital

Instrument/ServiceManufacturer/DescriptionFunction
BioanalyzerAgilent Bioanalyzer 2100Microfluidics platform (electrophoresis and flow cytometry) for sizing, quantification, and QC of DNA, RNA, proteins, and cells. Sample size= 1-4 microliters.
Bioinformatics Analysis - MASCOTSoftware: Matrix Science MASCOT Search EngineSoftware for MS data analysis through statistical evaluation of matches between observed and projected peptide fragments.
Bioinformatics Analysis - ProteoIQSoftware: NuSep ProteoIQ Mass Spec Data AnalysisSoftware for post-analysis of MASCOT results. Protein and peptide probabilities generated and protein relative quantitation is performed by spectral counting. Normalized and with standard deviations.
Bioinformatics Analysis - WorkstationHardware: HP HPZ 800 Workstation Software (2 workstations available) used in conjunction with ProteoIQ, DXMS, MASCOT analysis.
Imaging System - Gel Imager Bio-Rad Molecular Imager VersaDocQuantitative digital imaging system for single or multi-color images. Includes multiplexed samples (1-D or 2-D gels), chemiluminescent and chemifluorescent blots, and microplates.
High Performance Liquid Chromatography (HPLC)Bio-Rad DuoFlow Biologic HPLCMedium-pressure chromatography system. 100/120 V, F10 workstation, mixer, AVR7-3 valve, UV detector with flow cell and filters. Flow rate= 0.01-10 ml/min.
High Performance Liquid Chromatography (HPLC)Transgenomic Wave DHPLC SystemDetect mutations/ polymorphisms by Denaturing High Performance Liquid Chromatography (DHPLC). Uses SURVEYOR nuclease cleavage. Identifies single nucleotide polymorphisms (SNPs) or small insertions/ deletions.
High Performance Liquid Chromatography (HPLC)Dionex UltiMate3000 Nano HPLCSingle gradient and x2 dual configurations. Eluted directly into MS. Min detection= fmole; Min flow rate= 20 nL/min; Max pressure = 800 bar.
Liquid Chromatography- Mass Spectrometer (LC-MS)Thermo Scientific Q Exactive Plus Mass Spectrometer Benchtop LC-MS/MS. Combination of high-performance quadrupole with high resolution, accurate-mass (HR/AM) Orbitrap. Max resolving power= 140,000; max scan speed= 12Hz, Intra-scan dynamic range > 5000:, Quadrupole mass filter.
Mass SpectrometerAB SCIEX QSTAR XL Mass SpectrometerIdentification and analysis of protein structure/conformational change by deuterium exchange mass spectrometry (DXMS). LC/MS/MS- Ionization by MALDI or ESI after HPLC (Dionex) and analyzed by quadrupole and TOF.
Mass SpectrometerBrucker UltrafleXtreme: Imaging Mass SpectrometryMALDI-IMS for tissue imaging, intact proteins analysis, protein spatial distribution, glycoproteomics, or biologics (1-2000 Hz repetition rates) of non-injured vs. injured tissues. MALDI/TOF/TOF analysis for proteomic profiling. Minimum diameter = 10 microns.
Robotic Workstation - Liquid HandlerPerkin Elmer JANUS Automated Workstation Automated Sterile Liquid Handler. 2 arm system, with 4- or 8-tip arm plus a 96/384 MDT arm. Arms include 4-tip or 8-tip dispense arms for transfer from tubes to vials to plates.
SpectrophotometerAmersham Biosciences UV/Visible Spectrophotometer Ultrospec 1100Wavelength range: 200-900 nm. Spectral bandwidth: 5 nm Wavelength accuracy - 2 nm. Wavelength reproducibility: - 0.5 nm.
SpectrophotometerThermo Scientific NanoDrop 2000Measures DNA, RNA, and protein concentrations, and purity (A260/A280 ratio). Conc. range= 2 ng/microliter-15,000 ng/microliter; Min Sample size = 0.5 microliter.
Suspension Array SystemBruker ImagePrep matrix sprayerMatrix deposition device for MALDI Imaging. Average droplet size ? 20 microns, all droplet dia. are < 50 microns. Lateral resolution of 50 microns in tissue.
Technical Assistance - 1D SDS PAGE CoomasieServiceService to provide 1D gel (SDS-PAGE) Coomasie Staining.
Technical Assistance - 1D SDS PAGE Silver StainServiceService to provide 1D gel (SDS-PAGE) Silver Stain MS compatible.
Technical Assistance - Gel ImagingServiceService to provide Gel imaging by VersaDoc.
Technical Assistance - Mass SpectrometryServiceService to provide Imaging Mass Spectrometry Data Analysis.
Technical Assistance - Protein Determination ServiceService to provide Protein Determination (BCA assay).
Technical Assistance - Protein ExtractionServiceService to provide ReadyPrep Protein Extraction Kit (Sequential Extraction).
Technical Assistance - Protein Extraction ServiceService to provide ReadyPrep Protein Extraction Kit (Total Protein).
Technical Assistance - Protein In-Gel DigestionServiceService to provide In-gel digestion LC/MS analysis and protein database search.
Technical Assistance - Protein In-Solution DigestionServiceService to provide In-solution digestion LC/MS analysis and protein database search.
Technical Assistance - Protein QuantificationServiceService to provide Data interpretation and protein quantification.
Technical Assistance - Protein Sample Clean-up ServiceService to provide ReadyPrep 2D Cleanup Kit.
Technical Assistance - Proteomics Project Consultation ServiceService to provide Project consultation with the Director of Proteomics - Subsequent Consultation
Technical Assistance - Proteomics Project Consultation ServiceService to provide Project consultation with the Director of Proteomics - Initial Consultation
Mass SpectrometerThermo Scientific TSQ Quantiva - Triple Quadrupole Mass SpectrometerAllows identification and absolute quantification of biomarkers, target proteins/peptides with their known post-translational modifications from any biological samples.
Microplate ReaderGloMax Discover - Multimode Detection SystemMulti-mode detection instrument offering flexible use of filters and includes: high-performance, luminescence, fluorescence, UV-Visible absorbance, BRET and FRET, two-color filtered luminescence and kinetic measurement capabilities

Research Integrity and Compliance-Multi-institutions

(last updated 2017-12-12 08:55:08)
»See Research Integrity and Compliance-Multi-institutions website for more details
Instrument/ServiceManufacturer/DescriptionFunction
Export Controls - Brown
Contact: Jules Blyth
Brown Export Control Compliance Webpage
Research Compliance, Export ControlsExport Controls regulate the shipment or transfer, by whatever means, of controlled items, software, technology, or services out of the U.S. and also restricts the release of certain information to foreign nationals here in the U.S.
Biosafety - Lifespan - Rhode Island Hospital and The Miriam Hospital
Contact: Jacqueline Poore
Lifespan Biohazards and Lab Safety Webpage
Research Compliance, BiosafetyThe Biohazards and Laboratory Safety Committee reviews and approves the use of potentially hazardous agents in the laboratory setting.
IRB - Care New England - Kent Hospital
Contact: Alexandra Caffrey Boutros
Human Subjects Protection
IRB - Care New England - Women and Infants Hospital
Contact: Alexandra Caffrey Boutros
Women & Infants Institutional Review Board Webpage
Human Subjects ProtectionWomen & Infants Institutional Review Board (IRB) is a committee established to review and approve research involving human subjects. The purpose of the IRB is to protect the rights and welfare of human research subjects and to ensure that all human subject research be conducted in accordance with federal, state, institutional, and ethical guidelines.
IRB - Lifespan - Rhode Island Hospital and The Miriam Hospital
Contact: Janice Muratori
Institutional Review Board (IRB) Webpage
Human Subjects ProtectionThe Institutional Review Board (IRB) is a committee made up of physicians, scientists and community members who ensure that research involving human research subjects is well planned and ethical. All research that involves human subjects or their identifiable data must be reviewed by the IRB.
IRB - Care New England - Butler Hospital
Contact: Cheryl Cordeiro
Institutional Review Board (IRB) Webpage
Human Subjects Protection
IRB - Brown
Contact: Katharine Menke
HRPP/IRB Home Page
Human Subjects ProtectionThe IRB is a diverse body of Brown faculty researchers, physicians, staff and unaffiliated community members appointed by Brown’s Vice President for Research and charged with reviewing human subject research protocols to uphold two broad standards To ensure that participants are not placed at undue risk; and To ensure that participants give informed consent to their participation free of coercion or undue influence To this end, projects that meet the regulatory definition of human subject research must be reviewed and approved by the IRB prior to initiation.
IRB - The Providence VA Medical Center
Contact: Val Micucci
Providence VA Research and Development Service
Human Subjects Protection
IRB - University of Rhode Island
Contact: Mary Riedford
Human Subjects Protection - URI Webpage
Human Subjects ProtectionThe University of Rhode Island Institutional Review Board (IRB) reviews research projects which involve human subjects to ensure that two broad standards are upheld: first, that subjects are not placed at undue risk; second, that they give uncoerced, informed consent to their participation.
IACUC - Brown University
Contact: Carol Colena
Brown IACUC Webpage
Animal Subjects ProtectionThe ARPP is the administrative office dedicated to facilitating the submission, review and approval of IACUC protocols, supporting the various functions of the IACUC, and providing individual assistance to researchers whenever needed.
IACUC - Lifespan - Rhode Island Hospital
Contact: Jacqueline Poore
Lifespan IACUC Webpage
Animal Subjects ProtectionThe Animal Welfare Committee (IACUC) is a committee made up of scientists and community members who ensure that research involving animal subjects is well planned and ethical.
IACUC - Care New England - Women and Infants
Contact: Jacqueline Poore
Animal Subjects Protection
IACUC - The Providence VA Medical Center
Contact: Tiffany Galligan
Providence VA Medical Center IACUC Webpage
Animal Subjects Protection
IACUC - University of Rhode Island
Contact: Gwen Currier
IACUC - URI Webpage
Animal Subjects ProtectionThe URI Institutional Animal Care and Use Committee (IACUC) is responsible for overseeing the provisions for the care and well -being of animals used for research and educational purposes at the University and serves the public by ensuring compliance with all legal and ethical standards regarding the use of vertebrate animals in research and teaching at URI.
Biosafety - Brown
Contact: Shannon Benjamin
Institutional Biosafety Committee (IBC) Webpage
Research Compliance, BiosafetyThe Institutional Biosafety Committee (IBC) evaluates and provides oversight of the use of biohazardous agents to ensure compliance with appropriate regulations and guidelines and to safeguard the health and safety of Brown University personnel, the community, and the environment.
Biosafety - University of Rhode Island
Contact: Gwen Currier
URI Biosafety Committee Webpage
Research Compliance, BiosafetyThe Institutional Biosafety Committee (IBC) reviews and approves Biological Research protocols.
Export Controls - University of Rhode Island
Contact: Ross Levine
URI Export Controls Webpage
Research Compliance, Export ControlsThe Export Controls office ensures that all personnel, including employees, visiting scientists, postdoctoral fellows, students, and other persons retained by or working at or for URI conduct their affairs in accordance with U.S. laws and regulations, including compliance with U.S. export control laws and regulations applicable to its operations.

Rhode Island Nuclear Science Center

(last updated 2016-06-16 10:29:30)
»See Rhode Island Nuclear Science Center website for more details

Contact: Dr. Cameron Goodwin

Location: URI Bay Campus  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Reactor, Research and Test
Contact: Cameron Goodwin
2 Mega-Watt, light water cooled, pool type reactorNeutron and gamma irradiation and experimental set-up, as well as analysis

RIC - Fogarty Life Sciences Labs

(last updated 2017-11-14 16:14:08)

Contact: Eric Hall

Location: Fogarty Life Science  »See on the Map

Affiliated Centers: RI-NSF EPSCoR , RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
Sample Preparation - Knifemaker
Contact: Breea Govenar
LKB 7800 KnifemakerSlide/Sample Preparation
Microtome
Contact: Breea Govenar
Leica RM2165 Motorized Rotary MicrotomeSlide/Sample Preparation
Microtome
Contact: Breea Govenar
TBS Microtome plus CryostatSlide/Sample Preparation
Microscope
Contact: Breea Govenar
American Optical Series 10 Fluorescence MicrostartMicroscopy course
Microscope
Contact: Breea Govenar
Nikon E600 Epifluorescence with DIC/Phase and digital cameraResearch
Microscope
Contact: Breea Govenar
Olympus CKS41 Inverted MicroscopeTissue culture general use
Microscope
Contact: Breea Govenar
Olympus Compound Light MicroscopeGeneral use
Microscope
Contact: Breea Govenar
Olympus FluoView 1000 Laser Scanning Confocal MicroscopeResearch and Microscopy course
Microscope
Contact: Breea Govenar
Olympus Inverted Epifluorescence Microscope with digital cameraTissue culture/Research
Microscope
Contact: Breea Govenar
Zeiss SteREO discovery V8 Microscope with Digital CameraResearch
Aquatic System - Wet Lab / Aquarium room
Contact: Breea Govenar
Aquaria and related equipmentResearch
Autoclave
Contact: Breea Govenar
AutoclaveMicrobiology/Research
Biological Safety Cabinet
Contact: Breea Govenar
Labconco class II Biological Safety CabinetUsed for tissue culture
Biological Safety Cabinet
Contact: Breea Govenar
Sterile laminar flow hoodMicrobiology prep
Centrifuge
Contact: Breea Govenar
Eppendorf 5810R Refrigerated CentrifugeUsed for tissue culture
Centrifuge
Contact: Breea Govenar
Sorvall Discovery M120SE Mini UltracentrifugeResearch/Cell fractionation
Centrifuge
Contact: Breea Govenar
Sorvall Superspeed RC2 CentrifugeGeneral use
Centrifuge
Contact: Breea Govenar
Sorvall Superspeed RC5 Plus CentrifugeResearch
Centrifuge
Contact: Breea Govenar
Thermo IEC Centra CL3R Refrigerated CentrifugeGenetics and Cell & Molec courses
Cold Room
Contact: Breea Govenar
Walk-In Cold RoomLarge cold room for experimentation and storage
Dishwasher
Contact: Breea Govenar
DishwasherMicrobiology/Research
Disrupter
Contact: Breea Govenar
French Pressure Cell PressResearch
Disrupter
Contact: Breea Govenar
Polytron Tissue GrinderSlide/Sample Preparation
Disrupter
Contact: Breea Govenar
SonicatorGeneral use and research
Disrupter
Contact: Breea Govenar
Sonicator with cupResearch and graduate courses
Electroporation System
Contact: Breea Govenar
BioRad Micropulser ElectroporatorResearch
Sample Preparation - Freeze Dry System
Contact: Breea Govenar
ATMO VAC 5009 freeze dryerSlide/Sample Preparation
Biospecimen Banking - Freezer
Contact: Breea Govenar
Thermolyne Liquid Nitrogen cryogenic storage systemCell storage
Biospecimen Banking - Freezer
Contact: Breea Govenar
Ultralow FreezerUsed for freezing biological samples, 6 units
Imaging System - Gel Imager
Contact: Breea Govenar
InGenius Syngene Gel Documentation SystemResearch
Ice Machine
Contact: Breea Govenar
Ice MachineGeneral use
Imaging System - Dark Room
Contact: Breea Govenar
Imaging System - Dark RoomGel imaging and analysis
Incubator
Contact: Breea Govenar
Non CO2 IncubatorUsed for tissue culture
Incubator
Contact: Breea Govenar
Thermo CO2 Incubators Used for tissue culture, 2 units
Incubator
Contact: Breea Govenar
Refrigerated IncubatorUsed for tissue culture
Laboratory - Tissue Culture
Contact: Breea Govenar
Tissue Culture RoomA room outfitted with tissue culture instrumentation
Microplate Reader
Contact: Breea Govenar
Lenovo Automated Plate ReaderResearch
Microplate Reader
Contact: Breea Govenar
Thermo Labsystems Multiskan MMCC/340 plate readerResearch
Sample Preparation - Oven
Contact: Breea Govenar
Drying OvenGeneral use
PCR Thermal Cycler
Contact: Breea Govenar
BioRad IQS Real time PCR thermocyclerResearch
PCR Thermal Cycler
Contact: Breea Govenar
Eppendorf Gradient Mastercycler PCR instrumentation, 2 units
Incubator - Shaker
Contact: Breea Govenar
Incubator/ShakersMultiple units
Spectrophotometer
Contact: Breea Govenar
BioRad SmartSpec PlusResearch
Spectrophotometer
Contact: Breea Govenar
Eppendorf BiophotometerGectrophotometerseral use
Spectrophotometer
Contact: Breea Govenar
Spectronic 21 D UV/VISResearch
Spectrophotometer
Contact: Breea Govenar
Therm Spectronic Genesys UV/VIS Scanning Research, 6 units
Spectrophotometer
Contact: Breea Govenar
Thermo Scientific NanoDrop ND-1000 UV/VIS, 2 units
Water Purification System
Contact: Breea Govenar
Barnstead Still Water PurifierGeneral use for teaching labs
Water Purification System
Contact: Breea Govenar
Millipore DirectQ (X2)Tissue culture
Water Purification System
Contact: Breea Govenar
Millipore NanoPure Diamond 2nd floor research use
Imaging System - X-ray Film
Contact: Breea Govenar
X-ray film processorBlot imaging

RISD Media Resources

(last updated 2016-06-16 10:29:30)
»See RISD Media Resources website for more details

Contact: Neal Overstrom

Location: RISD Auditorium  »See on the Map

Affiliated Centers: RI-NSF EPSCoR

Instrument/ServiceManufacturer/DescriptionFunction
Imaging System - Audio|VisualKodak zi 10 Video Camera (8 units)Portable HD pocket camcorder, batteries, adaptor cables, cases, accessories
Imaging System - Audio|VisualH4N ZOOM Audio Recorder (5 Units)High performance portable digital audio recorder, batteries, adaptor cables, cases, accessories
Imaging System - Audio|VisualZOOM Q3 Video Camera (7 Units)Portable palm camcorder, batteries, adaptor cables, cases, accessories
Imaging System - Audio|VisualEPS-SonyPMWEX1R-01 (2 Units)High performance HD CMOS solid state video camera, batteries, portable hard drive, adaptor cables, cases, studio lighting equipment, accessories

RISD Nature Lab

(last updated 2016-06-16 10:29:30)
»See RISD Nature Lab website for more details

Contact: Neal Overstrom

Location: Waterman Building  »See on the Map

Affiliated Centers: RI-NSF EPSCoR

Instrument/ServiceManufacturer/DescriptionFunction
Aquatic SystemMarine Ecological Habitats Closed-System Aquarium560 L closed-system recirculating marine holding tanks with temperature control (2 units)
MicroscopePhenom G2Pro Scanning Electron Microscope (SEM)Desktop Scanning Electron Microscope with ProSuite tiling and remote access software
MicroscopeOlympus SZX16 StereomicroscopeLight microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software
MicroscopeOlympus IX51 Inverted Fluorescent/Brightfield MicroscopeFluorescence/brightfield microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software
MicroscopeOlympus CH30 Upright Light Microscope Upright light microscope with 5 MP Jenoptik digital camera, Canon Vixia HFS20 HD video camera, computer workstation, graphics and imaging software (2 units)
MicroscopeOlympus SZ40 StereomicroscopeLight microscope with 5 MP Jenoptik digital camera, computer workstation, graphics and imaging software
MicroscopeOlympus SZ30 Stereomicroscope Light microscope with LED illuminator (24 units)
GPS UnitTrimble Geo 7x Subfoot GPSSurvey-grade high resolution handheld GPS unit with sub-foot accuracy
GPS UnitGarmin eTrex 30 (10 units)Mapping grade gps unit for student use
Imaging System - Videocamera - High SpeedEdgertronic - monochromeHigh speed videocamera for capturing slow motion footage. Capable of Resolutions up to 1280x1024, frame rates at lower resolution up to nearly 18,000 fps
Imaging System - Videocamera - High SpeedEdgertronic - colorHigh speed videocamera for capturing slow motion footage. Capable of Resolutions up to 1280x1024, frame rates at lower resolution up to nearly 18,000 fps
Imaging System - Videocamera - High SpeedPhantom Miro M120Digital high speed video camera, resolution up to 1920x1080 at 800fps
Imaging System - 3D ScannerArtec SpiderHigh resolution 3D scanner designed specifically for CAD users
Imaging System - 3D ScannerStructure SensorScanners (3) for use with iPad Air, capable of 3D scanning objects and entire rooms
Workstation, Computer Geographic Information System (GIS)EPC workstations (3)Computer workstations outfitted with ArcGIS, auto cad and the full adobe creative suite

Rodent Behavioral Phenotyping Facility

(last updated 2016-06-16 10:29:30)
»See Rodent Behavioral Phenotyping Facility website for more details

Contact: Kevin Bath, PhD

Location: BioMedical Center Building  »See on the Map

Affiliated Centers: Brown Institute for Brain Science (BIBS)

Instrument/ServiceManufacturer/DescriptionFunction
Behavioral PhenotypingService A high-throughput behavioral testing facility that integrates high-level computer vision, computer learning, and custom built hardware solutions with behavioral testing to automate tracking, cataloging, and analysis of both home cage behavior and standard rodent testing paradigms to characterize preclinical models of disorders, test novel pharmacological and genetic rescue strategies in rodent models.
Behavioral Phenotyping - 4x Operant ChambersMed Associates Operant ChambersCan be used to train mice on operant tasks (equipped with water dipper system) for reinforcement learning, as well as grid floor and speaker system for fear conditioning experiments
Behavioral Phenotyping - 2x Open FieldServiceFabricated in house; Used to monitor activity in novel settings and to assay anxiety-like behavior
Behavioral Phenotyping - 3-chamber Social Preference ServiceFabricated in house; Used to assess a mouse preference for being in close proximity to another mouse.
Behavioral Phenotyping - Barnes Maze ServiceFabricated in house; Used to assess spatial learning and memory in rodent models.
Behavioral Phenotyping - Cold Swim StressServiceFabricated in house; Used to monitor anxiety-like behavior
Behavioral Phenotyping - Cylinder TestServiceFabricated in house; Used to assess motor coordination and balance
Behavioral Phenotyping - Early Life Drug Exposure ServiceFabricated in house; Used to assess the impact of pharmacological agents on cognitive, motor, and effective development.
Behavioral Phenotyping - Early Life Stress (Maternal Bedding Restriction)ServiceFabricated in house; Used to induce later development of anxiety and depressive-like behavior
Behavioral Phenotyping - Early Life Stress (Variable shock)ServiceFabricated in house; Used to assess elevated levels of anxiety and depressive-like behavior
Behavioral Phenotyping - Elevated Zero Maze ServiceFabricated in house; Used to monitor rodent anxiety-like behavior
Behavioral Phenotyping - Estrous Cycling (Vaginal Cytology)ServiceFabricated in house; Used to assess stage of estrous cycle of rodent models.
Behavioral Phenotyping - Exercise Induced AnorexiaServiceFabricated in house; Use of running and food restriction to induce lower levels of body fat and food consumption
Behavioral Phenotyping - Five Lane Forced Treadmill Columbus Instruments Treadmill Used to induce exercise stress to assess motor fatigue and locomotor abilities.
Behavioral Phenotyping - Five Lane RotarodMed Associates RotarodUsed to assess motor pattern learning and coordination.
Behavioral Phenotyping - Flurothyl Induced SeizuresServiceFabricated in house; Used to assess monitored induction of tonic and clonic seizures
Behavioral Phenotyping - Forced Swim ServiceFabricated in house; Used to assess depressive-like behavior
Behavioral Phenotyping - Formalin Test (Pain)ServiceFabricated in house; Used to assess chronic pain
Behavioral Phenotyping - Grip Strength MeterColumbus Instruments Strength MeterUsed to assess grip strength
Behavioral Phenotyping - Hargreaves Method to Assess Allodinia IITCUsed to assess thermal sensitivity and efficacy of analgesics to decease pain sensitivity
Behavioral Phenotyping - Homecage MonitoringServiceFabricated in house; Used for long term monitoring of home-cage activity of mice. Can provide longitudinal data regarding (eating, resting, grooming, drinking, walking, climbing, rearing, and micro-movements). Will be used as a proxy for other more acute tests.
Behavioral Phenotyping - Homecage Wheel Running Lafayette Instruments Wheel Running Used to assess general levels of locomotor activity and as a proxy to measure changes in circadian rhythms.
Behavioral Phenotyping - Hot Plate Analgesia MeterBasille Analgesia MeterUsed to assess thermal sensitivity.
Behavioral Phenotyping - Light /Dark BoxService Fabricated in house; Used to assess anxiety-like behavior
Behavioral Phenotyping - Marble BuryingServiceFabricated in house; Used to assess anxiety-like behavior and OCD-like behavior
Behavioral Phenotyping - Maternal DeprivationServiceFabricated in house; Used to assess anxiety-like behavior
Behavioral Phenotyping - Maternal SeparationServiceFabricated in house; Used to assess anxiety-like behavior
Behavioral Phenotyping - Morris Water Maze ServiceFabricated in house; Used to assess spatial learning and memory
Behavioral Phenotyping - Non-invasive Blood Pressure MonitoringColumbus InstrumentsTail cuff and apparatus for repeated measurement of blood pressure in mice.
Behavioral Phenotyping - Novel Object IdentityServiceFabricated in house; Used to assess working memory
Behavioral Phenotyping - Novel Object LocationServiceFabricated in house; Used to assess spatial learning and memory
Behavioral Phenotyping - Novelty Induced HypophagiaServiceFabricated in house; Used to assess anxiety-like behavior and translational efficacy of antidepressants and anxiolytic drugs.
Behavioral Phenotyping - Novelty Suppressed FeedingServiceFabricated in house; Used to assess anxiety-like behavior and translational efficacy of antidepressants and anxiolytic drugs.
Behavioral Phenotyping - Olfactory Cross-habituationServiceFabricated in house; Used to assess olfactory acuity.
Behavioral Phenotyping - Olfactory Perceptual LearningServiceFabricated in house; Used to assess ability to learn to discriminate closely related odor pairs.
Behavioral Phenotyping - Predator Odor StressServiceFabricated in house; Used to assess anxiety-like behavior
Behavioral Phenotyping - Resident Intruder AggressionServiceFabricated in house; Used to assess propensity for aggressive behavior.
Behavioral Phenotyping - Restraint StressServiceFabricated in house; Used to assess hippocampal atrophy and increased anxiety and depressive-like behavior.
Behavioral Phenotyping - Righting ReflexServiceFabricated in house; Used to assess coordination and ability to right from a prone position.
Behavioral Phenotyping - Shock ThresholdServiceFabricated in house; Used to assess changes in pain sensitivity
Behavioral Phenotyping - Single Lane RotarodServiceFabricated in house; Used to assess motor pattern learning and coordination.
Behavioral Phenotyping - Social Defeat StressServiceFabricated in house; Used to assess anxiety-like behavior
Behavioral Phenotyping - Social Disruption StressServiceFabricated in house; Used to assess anxiety-like behavior
Behavioral Phenotyping - Social Odor DiscriminationServiceFabricated in house; Used to assess ability to detect and discriminate between odorants of conspecifics.
Behavioral Phenotyping - Sucrose PreferenceServiceFabricated in house; Used to asses depressive-like behavior (anhedonia).
Behavioral Phenotyping - Tail Suspension ServiceFabricated in house; Method to assess depressive-like behavior
Behavioral Phenotyping - Visual Cliff ServiceFabricated in house; Used to assess depth perception and avoidance learning during visual development.
Behavioral Phenotyping - von Frey FilamentsBiosebUsed to assess tactile sensitivity
Behavioral Phenotyping - Wire-hangServiceFabricated in house; Used to assess animals strength and endurance.

Roger Williams Medical Center Resources

(last updated 2017-12-08 09:01:48)
»See Roger Williams Medical Center Resources website for more details

Contact: John W. Morgan, Ph.D.

Location: Roger Williams Medical Center  »See on the Map

Affiliated Centers: Clinical Reseach Center

Instrument/ServiceManufacturer/DescriptionFunction
Flow Cytometry Core
Flow Cytometry Core Webpage
Flow Cytometry and Cell SortingThe Flow Cytometry Core facility is dedicated to advancing research projects requiring cell sorting and/or analysis of cell populations by flow cytometry. The core offers training on and access to shared use instrumentation for analytical flow cytometry, services for fluorescence activated cell sorting (FACS) as well as technical consultation and support on experimental design, execution, and data analysis.
Imaging Core
http://www.rwmc.org/core-research-facilities/imaging-confocal-visual-fluor-scopes-ivis
Zeiss LSM 700 confocal, Zeiss Axioplan 2 optical, Zeiss Axiovert 200M optical, IVIS Model 100The Imaging Core facility provides technical and logistical access for fixed and live cell fluorescence imaging via visual and digital fluorescent microscopes. This core also offers the ability to visualize fluorescent and bioluminescent markers in live animals via an IVIS imager.
Molecular Core
http://www.rwmc.org/core-research-facilities/molecular-thermal-cycler
Applied Biosystem PRISM 7000 Sequence Detection System, Bio-Rad ChemiDoc Molecular ImagerThe molecular core offers the capability of performing PCR analysis, quantitative real-time PCR analysis, and digital gel documentation. 
Cell Immunotherapy and Gene Therapy (CITGT) Good Manufacturing Practice (GMP) Facility
Contact: Steven C. Katz, MD, FACS
http://www.rwmc.org/core-research-facilities/gmp-facility
Services and EquipmentThe Cell Immunotherapy and Gene Therapy GMP facility supports the manufacture of investigational new drug (IND) products for principal investigators under FDA rules and regulations. 
Tissue Bank Core
http://www.rwmc.org/core-research-facilities/tissue-bank-core-facility
Biospecimen Banking - Tissue Banking and Specimen accessThe Tissue Repository Core (TRC) is designed to facilitate translational cancer research by procuring and storing diseased and normal control tissues, with the associated clinical data, for RWMC investigators and outside clients.
Animal Services Core
http://www.rwmc.org/core-research-facilities/animal-care-facility
Husbandry, Surgical Procedures and InjectionsThe Animal Care Facility is fully maintained, certified, and is supervised by a certified veterinarian, and our Office of Research Administration.

RWU Lab Spaces

(last updated 2016-06-16 10:29:30)

Contact: Nancy Breen

Location: Marine and Natural Sciences  »See on the Map

Affiliated Centers: RI-NSF EPSCoR , RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
Flow Cytometer
Contact: Marcie Marston
Millipore Guava easyCyte Flow CytometerFlow Cytometer
Gas Chromatograph - Mass Spectrometer (GC - MS)
Contact: Nancy Breen
Agilent 5890 Gas Chromatograph - Mass Spectrometer (GC - MS) wth Mass Selective Detetor (MSD)GC MS for teaching and research
High Performance Liquid Chromatography (HPLC)
Contact: Nancy Breen
Waters 2695 High Performance Liquid Chromatograph-MS / ZQ Micromass Mass SpectrometerLC - MS for teaching and research
Gas Chromatograph
Contact: Nancy Breen
Agilent 7890 Gas Chromatography with DB-23 columnGC for fatty acid analysis

Salve Regina Biology and Biomedical Sciences

(last updated 2016-06-16 10:29:30)
»See Salve Regina Biology and Biomedical Sciences website for more details

Contact: John-David Swanson

Location: O'Hare Academic Center  »See on the Map

Affiliated Centers: RI-NSF EPSCoR

Instrument/ServiceManufacturer/DescriptionFunction
Flow CytometerMillipore Guava EasyCyte 8 Flow CytometerSingle blue (488 nm), dual blue and red (642 nm), or triple blue, red, and violet (405 nm) excitation lasers provide up to 12 simultaneous detection parameters, including 10 fluorescent colors plus forward and side scatter for size and granularity determination. The guava easyCyte family also meets your sample throughput needs by offering both single sample and multi-sample processing.

Statistical Consulting Unit (SCU)

(last updated 2017-06-14 10:42:11)
»See Statistical Consulting Unit (SCU) website for more details

Contact: Zheng Zhang

Location: School of Public Health, Department of Biostatistics  »See on the Map

Affiliated Centers: Center for Statistical Sciences

Instrument/ServiceManufacturer/DescriptionFunction
Technical Assistance - Biostatistical Consulting / Statistical Consulting ServiceThe Statistical Consulting Unit (SCU) at the Center for Statistical Sciences(CSS) and Department of Biostatistics is an approved service center located at 121 South Main Street. The mission of the SCU is threefold: to provide collaborative research assistance to faculty, research staff, and students in all departments of Brown University and its affiliated hospitals; to promote the growth of research collaborations between faculty at CSS and other units of the university and its affiliated hospitals; to provide a valuable educational experience to Biostatistics graduate students through training as statistical collaborators. The SCU consists of a faculty director (Dr. Zheng Zhang), faculty consultants from the Department of Biostatistics and Center for Statistical Sciences and student consultants who are enrolled in the graduate programs (MS, AM or PhD) offered by the Department of Biostatistics at Brown University School of Public Health.

Statistics and Data Management Core

(last updated 2016-06-16 10:29:30)
»See Statistics and Data Management Core website for more details

Contact: Jennifer Friedman, MD, PhD

Location: 55 Claverick Street  »See on the Map

Affiliated Centers: Center for International Health Research, COBRE Immune-Based Interventions Against Infectious Diseases

Instrument/ServiceManufacturer/DescriptionFunction
Technical Assistance - Statistics and Data Management
Contact: Sangshin Park, PhD
ServiceThis Core provides consultation and assistance in managing and analyzing research data, such as the large datasets, and in linking these data with clinical predictors and outcomes collected in the field. The Core also performs more sophisticated data analytic approaches, including hierarchical, repeated measures modeling and Principal Components Analysis.

Structural Biology Facility

(last updated 2017-01-26 13:38:54)
»See Structural Biology Facility website for more details

Contact: Mandar T Naik, PhD

Location: Laboratories for Molecular Medicine  »See on the Map

Affiliated Centers: Center for Genomics and Proteomics (CGP)

Instrument/ServiceManufacturer/DescriptionFunction
Nuclear Magnetic Resonance (NMR) SpectrometerBruker 500 Avance II, with TCI cryoprobeAn NMR spectrometer optimized for studying proteins in solution. This spectrometer is most useful for tracking binding interactions, measuring dynamic properties of proteins, and assigning protein resonances. Capable of using 5 mm and 3 mm tubes. Also suitable for proton NMR of small molecules and natural products.
Nuclear Magnetic Resonance (NMR) SpectrometerBruker 850 MHz Avance III HD, with TCI cryoprobeAn NMR spectrometer optimized for studying proteins in solution. This spectrometer is ideal for determining protein structures and measuring protein dynamics. Its extreme sensitivity allows studies on otherwise intractable samples. Capable of using 5 mm, 3 mm, and shaped NMR tubes. Also suitable for proton NMR of small molecules and natural products
X-Ray Diffraction SystemRigaku ACTOR robot and Saturn 944 HG CCDAn instrument useful for obtaining X-ray diffraction patterns of proteins and other biomacromolecules under cryogenic or room-temperature conditions. Rapid screening and sorting of up to 80 candidate crystals is possible.

Three Dimensional (3D) Facility for Biomedical Sciences: Animation, Visualization and Printing

(last updated 2017-12-07 12:49:09)
»See Three Dimensional (3D) Facility for Biomedical Sciences: Animation, Visualization and Printing website for more details

Contact: Bongsup Cho, Professor of Biomedical and Pharmaceutical Sciences

Location: Pharmacy Building  »See on the Map

Affiliated Centers: RI-INBRE

Instrument/ServiceManufacturer/DescriptionFunction
Imaging System - 3D PrinterZ650 3D System/Z-corpProduces realistic color (Powder Based) models without paint to better evaluate the look, feel, and style of product designs. Five print heads provide the widest range of accurate colors, including true black and improved color consistency from part to part. 3D print text labels or images can be directly applied onto printed models.

Tissue Banking Core

(last updated 2016-11-22 14:32:07)
»See Tissue Banking Core website for more details

Contact: Murray Resnick

Location: Aldrich Building , 6th Floor, Rhode Island Hospital Campus  »See on the Map

Affiliated Centers: COBRE Center for Cancer Research and Development at Rhode Island Hospital

Instrument/ServiceManufacturer/DescriptionFunction
Bioinformatics Analysis - DatabaseSoftware: Database developed in Filemaker ProDatabase and tissue inventory management on a Dell computer workstation
Biospecimen Banking - Biosafety CabinetDissecting hoodHood dedicated to sterile tissue cutting with biohazard protection.
Biospecimen Banking - Freezer System Forma 195878 LN2 backup for bank freezersSystems inject liquid LN2 into cabinet when cabinet temperature warms to preset level, adjustable in 1 C increments to -150 C.
Biospecimen Banking - Freezing BathLow temp isopentane bathBath with min. temperature of -160 C by addition of liquid nitrogen to isopentane.
Histology/Tissue Processing - Freezing BathLow temp isopentane bathBath with min. temperature of -160 C by addition of liquid nitrogen to isopentane.

Weight Control and Diabetes Research Center

(last updated 2017-12-08 10:32:24)
»See Weight Control and Diabetes Research Center website for more details

Contact: Rena Wing

Location: 196 Richmond Street, Providence, RI 02903  »See on the Map

Affiliated Centers: Weight Control and Diabetes Research Center

Instrument/ServiceManufacturer/DescriptionFunction
Weight Control and Diabetes Research Center
Contact: Ana Almeida
Clinical Research Resources, Weight ControlThe primary objective of our Center is to foster a multidisciplinary approach to research in the field of obesity prevention and treatment. Through our program of scientific research we seek to: (1) Expand our knowledge of the causes and consequences of obesity, (2) Develop innovative and effective treatments for weight loss and weight maintenance, (3) Offer quality obesity treatment to the community through ongoing clinical trials, (4) Provide advanced training for interns and postdoctoral fellows interested in obesity research.

X-ray Reconstruction of Moving Morphology Facility (XROMM)

(last updated 2016-06-16 10:29:30)
»See X-ray Reconstruction of Moving Morphology Facility (XROMM) website for more details

Contact: Beth Brainerd, PhD

Location: BioMedical Center Building  »See on the Map
Instrument/ServiceManufacturer/DescriptionFunction
Imaging System - Computed Tomography (CT) Scanner Animage Fidex VeterinaryVeterinary CT Scanner designed for animals in the size range from rats to dogs. In vivo scanning of anesthetized animals is possible.
Imaging System - Videoradiography RoomCustom made biplanar3D x-ray motion analysis methods that combine skeletal movement data from in vivo x-ray videos with skeletal morphology from 3D bone scans (e.g. computed tomography (CT) or laser scans).
Imaging system X-Ray FluoroscopesRadiological Imaging Mobile C-Arm X-ray Two retrofitted with 30-cm image intensifiers and high-speed video cameras for measuring accurate 3D skeletal kinematics of small to medium-sized animals.