A directory of core research facilities, services, and instrumentation in Rhode Island

Core Facilities Categories

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Behavioral Phenotyping

Brown University
FacilityInstrument/Service/Resource Unit
Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping

Service
A high-throughput behavioral testing facility that integrates high-level computer vision, computer learning, and custom built hardware solutions with behavioral testing to automate tracking, cataloging, and analysis of both home cage behavior and standard rodent testing paradigms to characterize preclinical models of disorders, test novel pharmacological and genetic rescue strategies in rodent models.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - 4x Operant Chambers

Med Associates Operant Chambers
Can be used to train mice on operant tasks (equipped with water dipper system) for reinforcement learning, as well as grid floor and speaker system for fear conditioning experiments

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - 2x Open Field

Service
Fabricated in house; Used to monitor activity in novel settings and to assay anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - 3-chamber Social Preference

Service
Fabricated in house; Used to assess a mouse preference for being in close proximity to another mouse.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Barnes Maze

Service
Fabricated in house; Used to assess spatial learning and memory in rodent models.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Cold Swim Stress

Service
Fabricated in house; Used to monitor anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Cylinder Test

Service
Fabricated in house; Used to assess motor coordination and balance

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Early Life Drug Exposure

Service
Fabricated in house; Used to assess the impact of pharmacological agents on cognitive, motor, and effective development.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Early Life Stress (Maternal Bedding Restriction)

Service
Fabricated in house; Used to induce later development of anxiety and depressive-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Early Life Stress (Variable shock)

Service
Fabricated in house; Used to assess elevated levels of anxiety and depressive-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Elevated Zero Maze

Service
Fabricated in house; Used to monitor rodent anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Estrous Cycling (Vaginal Cytology)

Service
Fabricated in house; Used to assess stage of estrous cycle of rodent models.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Exercise Induced Anorexia

Service
Fabricated in house; Use of running and food restriction to induce lower levels of body fat and food consumption

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Five Lane Forced Treadmill

Columbus Instruments Treadmill
Used to induce exercise stress to assess motor fatigue and locomotor abilities.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Five Lane Rotarod

Med Associates Rotarod
Used to assess motor pattern learning and coordination.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Flurothyl Induced Seizures

Service
Fabricated in house; Used to assess monitored induction of tonic and clonic seizures

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Forced Swim

Service
Fabricated in house; Used to assess depressive-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Formalin Test (Pain)

Service
Fabricated in house; Used to assess chronic pain

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Grip Strength Meter

Columbus Instruments Strength Meter
Used to assess grip strength

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Hargreaves Method to Assess Allodinia

IITC
Used to assess thermal sensitivity and efficacy of analgesics to decease pain sensitivity

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Homecage Monitoring

Service
Fabricated in house; Used for long term monitoring of home-cage activity of mice. Can provide longitudinal data regarding (eating, resting, grooming, drinking, walking, climbing, rearing, and micro-movements). Will be used as a proxy for other more acute tests.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Homecage Wheel Running

Lafayette Instruments Wheel Running
Used to assess general levels of locomotor activity and as a proxy to measure changes in circadian rhythms.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Hot Plate Analgesia Meter

Basille Analgesia Meter
Used to assess thermal sensitivity.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Light /Dark Box

Service
Fabricated in house; Used to assess anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Marble Burying

Service
Fabricated in house; Used to assess anxiety-like behavior and OCD-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Maternal Deprivation

Service
Fabricated in house; Used to assess anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Maternal Separation

Service
Fabricated in house; Used to assess anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Morris Water Maze

Service
Fabricated in house; Used to assess spatial learning and memory

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Non-invasive Blood Pressure Monitoring

Columbus Instruments
Tail cuff and apparatus for repeated measurement of blood pressure in mice.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Novel Object Identity

Service
Fabricated in house; Used to assess working memory

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Novel Object Location

Service
Fabricated in house; Used to assess spatial learning and memory

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Novelty Induced Hypophagia

Service
Fabricated in house; Used to assess anxiety-like behavior and translational efficacy of antidepressants and anxiolytic drugs.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Novelty Suppressed Feeding

Service
Fabricated in house; Used to assess anxiety-like behavior and translational efficacy of antidepressants and anxiolytic drugs.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Olfactory Cross-habituation

Service
Fabricated in house; Used to assess olfactory acuity.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Olfactory Perceptual Learning

Service
Fabricated in house; Used to assess ability to learn to discriminate closely related odor pairs.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Predator Odor Stress

Service
Fabricated in house; Used to assess anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Resident Intruder Aggression

Service
Fabricated in house; Used to assess propensity for aggressive behavior.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Restraint Stress

Service
Fabricated in house; Used to assess hippocampal atrophy and increased anxiety and depressive-like behavior.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Righting Reflex

Service
Fabricated in house; Used to assess coordination and ability to right from a prone position.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Shock Threshold

Service
Fabricated in house; Used to assess changes in pain sensitivity

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Single Lane Rotarod

Service
Fabricated in house; Used to assess motor pattern learning and coordination.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Social Defeat Stress

Service
Fabricated in house; Used to assess anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Social Disruption Stress

Service
Fabricated in house; Used to assess anxiety-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Social Odor Discrimination

Service
Fabricated in house; Used to assess ability to detect and discriminate between odorants of conspecifics.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Sucrose Preference

Service
Fabricated in house; Used to asses depressive-like behavior (anhedonia).

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Tail Suspension

Service
Fabricated in house; Method to assess depressive-like behavior

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Visual Cliff

Service
Fabricated in house; Used to assess depth perception and avoidance learning during visual development.

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - von Frey Filaments

Bioseb
Used to assess tactile sensitivity

Rodent Behavioral Phenotyping Facility

Contact: Kevin Bath, PhD

Behavioral Phenotyping - Wire-hang

Service
Fabricated in house; Used to assess animals strength and endurance.

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Multiplex Facility

Contact: Suzanne de la Monte

Behavioral Phenotyping - Four Lane Rotarod

Emitter-Columbus Rotamex 5 Controller
Used to assess motor coordination and balance

Multiplex Facility

Contact: Suzanne de la Monte

Behavioral Phenotyping - Morris Water Maze

Fabricated in house
Opaque white pool with platform for behavioral swim test.

The Providence VA Medical Center
FacilityInstrument/Service/Resource Unit
Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Behavioral Phenotyping - Eye Tracking System

Tobii
Used to track eye movement

Biomechanics

Brown University
FacilityInstrument/Service/Resource Unit
X-ray Reconstruction of Moving Morphology Facility (XROMM)

Contact: Beth Brainerd, PhD

Imaging System - Computed Tomography (CT) Scanner

Animage Fidex Veterinary
Veterinary CT Scanner designed for animals in the size range from rats to dogs. In vivo scanning of anesthetized animals is possible.

X-ray Reconstruction of Moving Morphology Facility (XROMM)

Contact: Beth Brainerd, PhD

Imaging System - Videoradiography Room

Imaging Systems and Services
Custom designed biplanar videoradiography system for XROMM studies of human and animal subjects.

X-ray Reconstruction of Moving Morphology Facility (XROMM)

Contact: Beth Brainerd, PhD

Imaging system X-Ray Fluoroscopes

Radiological Imaging Mobile C-Arm X-ray
Two retrofitted with 30-cm image intensifiers and high-speed video cameras for measuring accurate 3D skeletal kinematics of small to medium-sized animals.

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Bioengineering Core

Contact: Braden Fleming, PhD

Analysis System - Force Plate

Tekscan Force Plate Walkway
Low profile floor walkway system that captures multiple sequential foot strikes of animals.

Bioengineering Core

Contact: Braden Fleming, PhD

Analysis System - Gait

Tekscan High Resolution Walkway (HRV6)
Modular pressure measurement platform for gait analysis.

Bioengineering Core

Contact: Braden Fleming, PhD

Analyzer - Motion

Northern Digital Optotrak System
Track and analyze kinetics and dynamic motion in real-time

Bioengineering Core

Contact: Braden Fleming, PhD

Analyzer - Pressure

Tekscan I-scan
Pressure Mapping System

Bioengineering Core

Contact: Braden Fleming, PhD

Loading Device

Custom Biaxial Loading Device
Tissue Engineering

Bioengineering Core

Contact: Braden Fleming, PhD

Mapping System

Fuji Film Prescale Pressuregraph (FPD-901E)
Pressure Distribution Mapping System

Bioengineering Core

Contact: Braden Fleming, PhD

Pendulum

Custom Active pendulum (small animal joint)
System to induce frictional wear in arthrodial joints

Bioengineering Core

Contact: Braden Fleming, PhD

Pendulum

Custom Passive pendulums (small and large animal joints)
System to measure the whole joint coefficient of friction

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Equipment

KUKA KR6 700 SIXX
6 DOF joint motion testing

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

Bose Corp Biaxial ELF 3200 material test system
Force Testers (Tension, Compression, Pull Testers). The ELF 3200 Series perform basic materials tests including axial, axial/torsion, fretting, biaxial, and planar biaxial fatigue tests.

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

Instron 8521S
Axial-Torsional Fatigue Testing System

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

Instron Electropuls E1000
All-Electric Dynamic Test Instrument designed for dynamic and static testing on a wide range of materials and components.

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

MTS 810 Material Test System
Material Test System

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

MTS Bionix Electromechanical Torsion System
Torsion Test System

Bioengineering Core

Contact: Braden Fleming, PhD

Tissue Engineering System

ICCT Technologies Bio-Stretch Uniaxial System
Mechanical Stretching for Tissue Engineering

Botany

Brown University
FacilityInstrument/Service/Resource Unit
Plant Environmental Center

Contact: Fred Jackson

Greenhouse, Plant Environmental Center

Plant environmental center with seven separate, computer controlled rooms where conditions like lighting, temperature, and humidity can be fine tuned; an additional 17 controlled plant growth environments provided by growth chambers (15) and walk-in growth rooms (2)
A plant environmental center with a suite of supporting facilities, including a classroom, a "headhouse" for potting and other prep work,and growth chambers for plants.

Brown University Herbarium

Contact: Tim Whitfeld

Herbarium

Dried and pressed plant specimens mounted on sheets of archival paper. Plant data.
The collection includes around 100,000 plant specimens and is an important depository of Rhode Island and New England collections. It is also rich in western and southern North American plants and includes special sets of historically valuable specimens from 19th and early 20th century western US expeditions. Among other important collections, the herbarium also includes a full set of Charles Wright's Cuban plants (1856-1867) and a unique and classic collection of Carex

Providence College
FacilityInstrument/Service/Resource Unit
PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Environmental Chamber

Percival Scientific
1 unit

PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Environmental Chamber

Percival Scientific, AR-22L Growth Chamber
For Arabidopsis

Chemistry

Bryant University
FacilityInstrument/Service/Resource Unit
Bryant Unistructure Science Spaces

Contact: Dan McNally

Spectrometer

Agilent Technologies 7700 series Inductive Coupling Plasma Mass Spectrometer( ICP-MS) with ASX-500 series autosampler
Analyze for trace elements

Bryant Unistructure Science Spaces

Contact: Dan McNally

Sample Preparation - Chromatography - Solvent Extractor

Dionex ASE 350 Accelerated Solvent Extractor (ASE)
Accelerated extractions

Bryant Unistructure Science Spaces

Contact: Dan McNally

Sample Preparation - Sample Concentrator, Purge & Trap

Teledyne Tekmar velocity XPT sample concentrator and AQUATek 70 vial autosampler
Analyze for highly volatile organics; accessory for the GC-MS

Bryant Unistructure Science Spaces

Contact: Dan McNally

High Performance Liquid Chromatography (HPLC)

Shumatzu
Analyze for non-volatile organics

Bryant Unistructure Science Spaces

Contact: Dan McNally

Gas Chromatograph - Mass Spectrometer (GC - MS)

Agilent Technologies 7890A GC and 5975C MSD
Analyze for volatile organics; pyrolysis; MSD and FID

Bryant Unistructure Science Spaces

Contact: Dan McNally

Worstation - Concentrator

Caliper LifeSciences Turbo Vap LV Concentration Workstation
Concentrator

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Chemical Hood

Thermo Scientific Hamilton SafeAire II
Chemical hood and ultra-high vacuum system for organic synthesis

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Evaporator

Buchi R-124 Rotavapor
Rotary evaporator comes complete with a 45 degree water condenser and a 1L condensing and evaporating flask.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Sample Preparation - Circulator

VWR Recirculating Chiller, Model 1160A
Stable cooling for many common heat removal applications such as rotary evaporators and vacuum systems (-10 to 40C).

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

High Performance Liquid Chromatography (HPLC)

Agilent Technologies, 1260 Infinity HPLC system
A maximum pressure of 600 bar to utilize smaller particle size columns for higher resolution and faster separations.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Sample Preparation - Freeze Dry System

Labconco FreeZone Plus 2.5L Cascade Benchtop Lyophilizer
This system is for light sample loads with low eutectic points. It can remove up to 1.8L of water in 24hrs and holds 2.5L of ice before defrosting is required.

Roger Williams University
FacilityInstrument/Service/Resource Unit
RWU Lab Spaces

Contact: Nancy Breen

Gas Chromatograph - Mass Spectrometer (GC - MS)

Agilent 5890 Gas Chromatograph - Mass Spectrometer (GC - MS) wth Mass Selective Detetor (MSD)
GC MS for teaching and research

RWU Lab Spaces

Contact: Nancy Breen

High Performance Liquid Chromatography (HPLC)

Waters 2695 High Performance Liquid Chromatograph-MS / ZQ Micromass Mass Spectrometer
LC - MS for teaching and research

RWU Lab Spaces

Contact: Nancy Breen

Gas Chromatograph

Agilent 7890 Gas Chromatography with DB-23 column
GC for fatty acid analysis

Clinical Translational Research Resources

Brown University
FacilityInstrument/Service/Resource Unit
Advance-CTR

Contact: Heather Fournier

Biostatistical Consulting, Epidemiology & Clinical Research Design Services

Clinical Research Service, Advance-CTR
A team of experienced statisticians and methodological experts are on-hand to help investigators prepare their proposals pre-award, and plan their projects upon receipt of funding. Pre-award services include, positioning of specific aims and hypotheses, measure selection, power analysis and data analysis planning. Post-award services include decision support services, data acquisition and management and consultations to assess the impact of potential design changes on final statistical influence. Data analysis and results interpretation services include implementing data analysis plans, statistical analysis consultations, selecting and accessing statistical analysis software, and coaching to best utilize statistical analysis software. Manuscript and grant proposal writing services include assistance with write-ups, data visualizations, integration of interpretations in the broader context of the project, and addressing comments from peer reviewers

Advance-CTR

Contact: Heather Fournier

Clinical Research Resources and Facilities

Clinical Research Service, Advance-CTR
The Clinical Research Resources and Facilities Core is based at the Lifespan Clinical Research Center. Clinical Research Support is offered to Rhode Island investigators by highly trained research staff including clinical research coordinators, registered nurses, a medical technologist, and a phlebotomist. Investigators seeking Advance-CTR services have access to regulatory support, subject recruitment, space and support for the conduct for study visits, specimen collection and biobanking.

Advance-CTR

Contact: Heather Fournier

Biomedical Informatics Services

Clinical Research Service, Advance-CTR
Researchers may request, access, and use data available through the Unified Research data Sharing Access (URSA) infrastructure. The data include information originating from electronic health data systems at Lifespan, Care New England, and the Rhode Island Quality Institute, as well as from publicly accessible biological and health data sets. 

Advance-CTR

Contact: Heather Fournier

Advance-CTR Administration

Clinical Research Service, Advance-CTR Service Coordination
Advance-CTR works to support researchers at the state level by developing the infrastructure and resources investigators need to conduct clinical and translational research in Rhode Island. Through its interdisciplinary and inter-institutional model, Advance-CTR funds and supports research across the translational science spectrum, including basic science, clinical, and public health efforts. Ultimately, Advance-CTR seeks to connect researchers and support institutions in Rhode Island in order to advance clinical and translational research that improves public health in the state.

IDeA COBRE Center for Central Nervous System Function

Contact: Jerome Sanes

IDeA COBRE Center for Central Nervous System Function

Clinical Research Resources, Nervous System
Purposeful human behavior requires attention, decisions and action, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing.  Behavioral and brain mechanisms of attention, including vigilance, orienting and perceptual and action selection, are key gateways into high-level function. Thus, in a general and even specific sense, attention, decision making and the ensuing actions define human mental activities. Deficits in these functions are common in both neurological and psychiatric disorders and can result in a wide range of higher-order behavioral deficits. This COBRE Center at Brown University that will investigate the mechanisms of higher-brain function, with a focus on attention, decision making and action and disorders that modify these key systems, using a combination of genetic, behavior, and systems neuroscience approaches. 

IDeA COBRE: Center for Computational Biology of Human Disease

Contact: Patricia Werner

IDeA COBRE: Center for Computational Biology of Human Disease

Clinical Research Resources, Computational
The COBRE Center for Computational Biology of Human Disease provides cmputationjal support for COBRE-funded Investigators engaged in genomics-enabled research. In the future we plan to expand these services to the broader Biomedical community with co-funding from Investigator-initiated grants. By building a collaborative Center of empirical and computational scientists, we advance new discoveries, algorithms, and genomic screening approaches with direct relevance to several human diseases.  This is consistent with NIH's mission of supporting bioinformatics and computational biology to advance all areas of biomedicine.

Center for the Study of Children at Risk

Contact: Barry Lester

Center for the Study of Children at Risk

Clinical Research Resources, Child Development
The mission of the Center for the Study of Children at Risk is to stimulate outstanding interdisciplinary research, education, and clinical services on the biological and social factors that determine the developmental outcome of at-risk children. Our objective is to nurture, promote and coordinate research, training, education, and clinical service in child development and developmental psychopathology. Our group is interdisciplinary spanning the disciplines of developmental and clinical psychology, pediatrics, psychiatry, nursing, occupational therapy, social work, substance abuse and public health. We are excited by the translational work that occurs at the boundaries where disciplines intersect leading to new science and the handshaking between science and clinical practice. Current research at the Center includes studies of children with various risk factors including prenatal drug exposure, autism, prematurity, and maternal depression. We also study epigenetic mechanisms that affect outcome in children at risk.

Center for Primary Care and Prevention

Contact: Chuck Eaton

Center for Primary Care and Prevention

Clinical Research Resources, Primary Care
The Brown University Center for Primary Care and Prevention was established to improve the health of individuals and communities by promoting research, enriching knowledge, and improving practice in primary care and prevention. The mission of the Center is to (1) promote interdisciplinary research in community, public health, and clinical aspects of primary care medicine, (2) stimulate innovations in the primary care education for medical students, residents and fellows; and (3) provide technical assistance to private foundations, state and federal agencies on matters of health policy, and to international organizations on matters regarding the development of primary care systems in other countries.

Norman Prince Neurosciences Institute Resources

Contact: Suzanne De La Monte

Quantitative Sciences Program

Clinical Research Resources, Quantitative Sciences
The quantitative sciences program (QSP) provides training in the form of formal workshops, seminars and individual mentoring in the areas of quantitative methodology, including research and experimental design, survey and sampling methods, basic and advanced multivariate data analysis.

Norman Prince Neurosciences Institute Resources

Contact: Suzanne De La Monte

Hospital-Imaging Research and Education Service (HI-RES)

Clinical Research Resources, Imaging
HI-RES has two image analysis and education centers, one at Rhode Island Hospital and the other at Butler Hospital. The Rhode Island Hospital site features advanced computing for image analysis, an image processing server, conference room and three offices. The Butler Hospital site consists of two room that house eight computers equipped for image analysis. HI-RES also utilizes Brown University’s high performance computing center (HPC).

Norman Prince Neurosciences Institute Resources

Contact: Suzanne De La Monte

Cellular and Molecular Neuroscience Core Resources

Clinical Research Resources, Neuroscience
Core laboratory resources are available to Norman Prince Neurological Institute and Brown Institute of Brain Science clinical and translational research scientists.

Hassenfeld Child Health Innovation Institute Resources

Contact: Phyllis Dennery

Clinical Trials Enrollment, Prospective Birth Cohort

Clinical Trials Support, Pediatrics
The prospective birth cohort study will include enrolling families, collecting key information about prenatal exposures, initial health status assessments of the newborn, and annual follow up assessments. The prospective birth cohort study will provide critical information on early determinants of child health and will provide a framework for assessing the impact of innovative approaches to improve the health of families.

Hassenfeld Child Health Innovation Institute Resources

Contact: Phyllis Dennery

Informatics, Geographical Information Systems (GIS)

Clinical Research Service, GIS Informatics
The Hassenfeld Core Research and Evaluation Unit will geocode, map, and analyze hospital and other health data for research and evaluation. This will include mapping all emergency department visits and inpatient stays, to first identify “hot spots” in Rhode Island where children disproportionately suffer from health issues, and then help shape interventions to address these disparities. In addition to mining hospital data systems, core researchers will also build the capacity for enrolling families in research and intervention projects at Hasbro Children’s Hospital and affiliated sites.

Hassenfeld Child Health Innovation Institute Resources

Contact: Phyllis Dennery

Hassenfeld Research Institute

Clinical Research Resources, Pediatrics
The work of the Hassenfeld Child Health Innovation Institute will contribute to our understanding of the genetic, prenatal, and early life factors associated with health problems of children, and will develop effective new strategies for prevention and treatment. These strategies will involve careful coordination of medical care, social services, and public health interventions. The research findings and lessons learned in Rhode Island will have broad applicability to other settings in the United States and internationally, amplifying the Institute's ability to improve population health, enhance family life, and help children thrive in school and in their future lives.

Advance-CTR

Contact: Heather Fournier

Qualitative Methods Services

Clinical Research Service, Advance-CTR
This service provides qualitative and mixed methods and data analysis design research support. Qualitative and mixed methods support includes; study design and preparation, original measure development, coaching on qualitative methods design decisions (focus groups, interviews, cognitive interviews), NVivo qualitative software training, help with grant writing of qualitative methods and analysis sections, manuscript and grant proposal review, post interview/focus group debriefing. Data analysis design support includes applied thematic analysis and framework matrix analysis.

Advance-CTR

Contact: Heather Fournier

Psychometric Services

Clinical Research Service, Advance-CTR
This service includes assistance with survey design, original measure development, exploratory dimensional analysis, confirmatory factor analysis, and reliability and validity analysis.

Brown University Oncology Group (BRUOG)

Contact: Howard Safran, MD

Brown University Oncology Group (BRUOG)

Clinical Trials Support, Oncology Research
The Brown University Oncology Research Group (BrUOG) mission is to improve cancer care through the implementation of innovative, multidisciplinary cancer clinical trials. BrUOG provides the infrastructure for the efficient development and implementation of these trials, which are created by Brown University faculty. BrUOG’s administrators and physicians provide support for the initial study concept and validation of trial design, and are responsible for trial administration, safety monitoring, data analysis, and the presentation and publication of findings. The trials sponsored by BrUOG investigate novel, cutting-edge applications of chemotherapy, biologic agents and other cancer treatments. Clinical trials are available for a broad range of disorders in hematology/oncology and these include treatment for cancers of the breast, brain, lung, gastrointestinal tract, skin, and prostate as well as trials in leukemia and lymphoma.

Hallett Center for Diabetes and Endocrinology

Clinical Research Resources, Diabetes

Clinical Research Resources, Diabetes
The Center for Diabetes and Endocrinology conducts basic and clinical research. Active research programs in the Center are focused on women's health topics such as osteoporosis; the pathogenesis of obesity, the integrated physiology of the adipocyte hormone leptin, other neuropeptide hormones, and nutrient sensors actions in controlling food intake and their dysfunction in the obese state; and obesity-related insulin resistance and type 2 diabetes.

Care New England - Women and Infants Hospital
FacilityInstrument/Service/Resource Unit
Neonatal Research Network NICHD

Contact: Abbot Laptook

Neonatal Research Network of the NICHD

Clinical Trials Support, Neonatal Research
The NICHD Neonatal Research Network (NRN) was established to undertake multicenter clinical studies to investigate the safety and efficacy of treatment and management strategies to improve the outcome of sick newborns. By providing large populations through a network of centers using common protocols, questions could be answered more rapidly than by individual centers acting alone. The NRN structure promotes randomized controlled trials with short (during the hospitalization) and/or long term (neurodevelopmental) outcome. The NRN at Women and Infants Hospital studies evidence-based practice in neonatology through collaborative research performed in academic perinatal centers. The Center has played a leadership role in studies such as hypothermia for perinatal hypoxic ischemic encephalopathy, a high-impact report in the New England Journal of Medicine which has changed care nationally. The Center has played a leadership role in studies such as hypothermia for perinatal hypoxic ischemic encephalopathy. Follow up programs exist in participating Centers to evaluate the long term neuro-developmental outcome of extremely low birth weight infants.

Maternal-Fetal Medicine Units Network of the NICHD

Contact: Dwight Rouse

Maternal-Fetal Medicine Units Network of the NICHD

Clinical Trials Support, Maternal-Fetal Medicine Clinical Trials Recruitment
Maternal Fetal Medicine Units Network conducts studies of pregnancy, maternal, fetal and infant health. The NICHD Eunice Kennedy Shriver Maternal Fetal Medicine Units (MFMU) Network is a consortium of 12 premier clinical centers across the U.S. whose charge is to investigate problems in clinical obstetrics by conducting multi-institutional clinical trials and observational studies. The Network conducts large randomized clinical trials aimed at improving outcomes for pregnant women and their offspring. With 140,000 births spread among its 12 centers, the Network is able to perform trials of sufficient size to reach definitive conclusions that result in health-improving practice changes locally, nationally and internationally. The 16 associated research nurses are experienced and expert in the identification, recruitment, retention, and follow-up of eligible research patients.

IDeA COBRE for Reproductive Health

Contact: Megan Boudreau

IDeA COBRE for Reproductive Health

Clinical Research Resources, Reproductive Health
The response to women’s reproductive health requires a broad and balanced research strategy aimed at expanding knowledge and technology in reproductive medicine. The overarching research goals of this COBRE includes the use of well-defined pre-clinical and human models to understand mechanisms mediating preeclampsia, gestational diabetes and prematurity, identification of functional predictive biomarkers, and application of contemporary computational approaches to enhance our understanding of the networks and pathways underlying these devastating pregnancy complications.

IDeA COBRE for Perinatal Biology

Contact: Megan Boudreau

IDeA COBRE for Perinatal Biology

Clinical Research Resources, Perinatal
The scientific aims of this COBRE have been to increase our understanding of reproductive biology and cardiopulmonary development, to enhance our understanding of perinatal diseases, like preeclampsia and preterm birth, and to develop new opportunities for novel therapeutic strategies. 

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Biological Safety Cabinet

Labconco Purifier Logic Series Biological Safety Cabinet
Provide personnel, product and environmental protection from hazardous particulates and agents that require biosafety level 1 or 2 containment.

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Laboratory and office space

Mansfield Bio-Incubator
Mansfield Bio-Incubator is a non-profit organization whose mission is to facilitate and assist the creation, growth, and success of the next generation of biotech companies. Our incubator assists these companies and nurtures entrepreneurial and economic development in the community by maintaining affordable lab and office space, services, training, mentoring, and a network of professional advisors. We provide entrepreneurs, innovative life-sciences start-ups, students and faculty of Massachusetts colleges and vocational schools with the space and resources they need to test out, challenge, and nurture early ideas and will teach students the skills for successful career in the biotech industry.

Lifespan - Bradley Hospital
FacilityInstrument/Service/Resource Unit
Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Child Development and Mental Health Research

Clinical Research Resources, Child Development
The Bradley Hasbro Children's Research Center (BHCRC) encompasses a broad spectrum of research programs that share a commitment to studying the impact of psychological factors on the growth and development of children and their families. BHCRC investigators are exploring new insights into the genetic roots of autism; finding pediatric bio-behavioral markers of bipolar disorder; creating effective therapies for OCD; devising effective prevention strategies for adolescent sexual risk behaviors and obesity; and much more. Areas of interest include child and adolescent psychiatric disorders, forensic issues and juvenile justice, pediatric behavioral health, biological basis of psychiatric disorders, prevention and early intervention, and health services research.

Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program

Clinical Research Service, Pediatric Imaging
The goal of the Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program is to identify biological and behavioral markers of psychiatric illness in children and adolescents in order to improve diagnosis, treatment, and prevention of these conditions.

Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Rhode Island Consortium for Autism Research & Treatment (RI-CART)

Clinical Research Resources, Autism
The Rhode Island Consortium for Autism Research & Treatment (RI-CART) is working to improve the lives of Rhode Islanders with autism spectrum disorder and related neurodevelopmental disorders by promoting collaborative, cutting-edge research, improving health care and support services, and providing data-driven education and advocacy. We’re a community of families and individuals, researchers, clinicians, educators, and local agencies focused on both today’s and future generations.

Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Sleep Research Lab

Clinical Research Resources, Sleep
Sleep for Science is a program of research focusing on understanding how sleep patterns are shaped and how they affect other activities, functions, and biological processes. Our research is chiefly about sleep patterns and processes in young humans – children, teens, and young adults.

Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Developmental Disorders Genetics Research

Clinical Research Resources, Developmental Genetics
The Developmental Disorders Genetics Research Program was established in the fall of 2009 by Brown University to facilitate advances in translational research concerned with the genetics of developmental disorders. 

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Cardiovascular Institute Research Resources

Vascular Disease Research Center

Clinical Research Resources, Vascular
The Vascular Disease Research Center at Rhode Island Hospital develops clinical trials and basic science research, and has a demonstrated track record in obtaining funding for these initiatives from the federal government through the National Institutes of Health (NIH). The center also coordinates a number of Food and Drug Administration (FDA). We can help investigators seeking to develop ideas in the vascular disease arena into fundable grant applications, either formally with center involvement or informally. We also can serve in this capacity for the medical device or drug industry, helping to plan and execute all aspects of FDA studies. Our mission is to advance scientific understanding and improve public health by developing and performing pivotal clinical and basic scientific research in peripheral vascular disease.

Cardiovascular Institute Research Resources

Cardiovascular Research Center (CVRC)

Clinical Research Resources, Cardiovascular
The mission of the CVRC is to unravel fundamental mechanisms of heart disease and to discover novel cardiac therapies. The research focus of CVRC investigators is on the molecular mechanisms of rhythm disorders of the heart (cardiac arrhythmias), sudden cardiac arrest, heart enlargement (hypertrophy) and heart failure. CVRC facilities include a sophisticated invasive animal catheterization and electrophysiology laboratory, and a brand new state-of-the-art research facility that is used for the studying of genetically modified mouse and rabbit models of cardiac diseases. These studies include cellular electrophysiology, optical mapping, single cell analyses of calcium transients and contractility, sophisticated imaging tools, as well as biochemical, molecular and cell biological experimental approaches. An important goal of the CVRC is to enhance and promote education and training in molecular cardiology and life sciences.

IDeA COBRE for Skeletal Health and Repair

Contact: Rachel Alberg

IDeA COBRE for Skeletal Health and Repair

Clinical Research Resources, Skeletal
The COBRE for Skeletal Health and Repair at Rhode Island Hospital enables clinicians, scientists, engineers and biologists to work side-by-side on multidisciplinary research, helping to better understand cartilage and joint health mechanisms and develop strategies for the prevention and treatment of skeletal joint diseases.

Ocean State Clinical Coordinating Center

Contact: Mitchell Levy

Ocean State Clinical Coordinating Center

Clinical Trials Support, Critical Care and Sepsis Research
Our expertise is in clinical trial designs investigating novel agents for treatment of sepsis. Our physicians have extensive backgrounds in pulmonary, critical care medicine and infectious diseases. The Ocean State Clinical Coordinating Center (OSCCC) staff can collaborate with a sponsor on protocol design with an eye to its practical application. Services include protocol design assistance, patient enrollment/site selection, site education and study start-up, subject adjudication, consulting.

Emergency Medicine Research Laboratory

Contact: Gregory Jay

Emergency Medicine Research Laboratory Resources

Clinical Trials Support, Emergency Medicine
The research program in the Department of Emergency was established to support investigator-initiated research and pharmaceutical, biologic and biomedical device trials. The program is supported by a Research Program Administrator, two pre-award Research Administrators, a Clinical Research Supervisor, and a staff of Clinical Research Assistants. The department maintains clinical research space within emergency departments as well as fully-equipped basic science laboratories, and has ongoing collaborations with Brown University and other hospital departments.The main focus areas of the Department of Emergency Medicine research program are (1) injury prevention and control, (2) cardiovascular, neurologic, and resuscitation science, (3) pediatric, age, and gender specific care, and (4) healthcare systems science.

Weight Control and Diabetes Research Center

Contact: Rena Wing

Weight Control and Diabetes Research Center

Clinical Research Resources, Weight Control
The primary objective of our Center is to foster a multidisciplinary approach to research in the field of obesity prevention and treatment. Through our program of scientific research we seek to: (1) Expand our knowledge of the causes and consequences of obesity, (2) Develop innovative and effective treatments for weight loss and weight maintenance, (3) Offer quality obesity treatment to the community through ongoing clinical trials, (4) Provide advanced training for interns and postdoctoral fellows interested in obesity research.

Division of Surgical Research at Rhode Island Hospital

Contact: Jorge Albina, MD

Surgical Research Resources

Clinical Research Resources, Surgical
Department of Surgery's 15 separate divisions (including the Division of Surgical Research), each with its own specific research focus to improve understanding of diseases and evaluate new methods of treatment for injuries and illness.  

Cancer Institute at Lifespan

Contact: Howard Safran, MD

Clinical Trials Support, Cancer Research

Clinical Research Resources
The Lifespan Cancer Institute at Rhode Island, The Miriam, and Newport hospitals is an active clinical trials site, committed to providing patients with the latest protocols.Our patients have access to groundbreaking new immunotherapies and other new and emerging cancer treatments at various stages of diagnosis and across many cancer types. Cancer treatments include the latest chemotherapy, biologic agents, radiation oncology, surgery, and image-guided procedures. Many of these are not available elsewhere in New England. The Dana-Farber Cancer Institute and the Lifespan Cancer Institute have created a strategic alliance to advance cancer treatment and research.

IDeA COBRE for Stem Cells and Aging

Contact: Lisa Frade

IDeA COBRE for Stem Cells and Aging

Clinical Research Resources, Stem Cells and Aging
This COBRE supports research in the area of stem cell biology and focuses on neural and hematopoietic stem cells, their microenvironments and the impact of aging, fibrosis, and senescence on their regulation and evolution to diseases of the central nervous system and bone marrow. Promising applications for the research include regeneration and repair for the treatment of leukemia, lymphomas, various neurodegenerative disorders and different aspects of aging.

Diagnostic Imaging Research

Contact: Glenn A. Tung, MD

Diagnostic Imaging Research Resources

Clinical Trials Support, Diagnostic Imaging
The Division of Imaging Research has successfully completed both federally-funded and industry-sponsored research trials. The Division has participated in cancer imaging trials that include screening studies and studies looking at the efficacy of various imaging modalities.The Division has participated in studies with pharmaceutical companies on phase I, II, and III trials. These studies include both diagnostic and cancer treatment drugs. We have also worked with various device manufacturers that are seeking pre-market and post-market Food and Drug Administration approval for medical devices. In addition, the Division has participated in several blood biomarker studies.

Clinical Research Center - Lifespan

Contact: Andrew Schumacher

Clinical Research Center Resources

Clinical Trials Support, Coordinating Center
In partnership with Lifespan Office of Research Administration, the Clinical Translational Research Center (CTRC) will provide the following services to our investigators: assistance with investigator-initiated research grant preparation; contract and budget initiation; negotiation and execution for industry sponsored trials and subcontracts; assistance with IRB including initial application, continuing review and amendments; coordinating logistics of protocol implementation; assistance with screening and recruitment; regulatory documentation collection and submission; providing access to lab processing, freezers and exam and conference area; nursing and research assistant staff to collect biopecimens, perform exams and follow up; data entry, creating and maintaining source documents and maintaining regulatory binder(s); database searches for retrospective trials; and setting up databases using Redcap.

Orthopaedic Surgery Research Laboratories

Contact: Roy Aaron

Orthopaedic Surgery Research Laboratories

Clinical Research Resources, Orthopaedics
The Orthopaedic Research Labs at Rhode Island Hospital exist to expand the basic science of orthopaedics, improve understanding of orthopaedic diseases, and evaluate new methods of treatment for orthopaedic injuries and illnesses. Research projects are generated from the interests of the research staff, orthopaedic physicians, and residents. Research topics range from collagen breakdown products to joint kinematics to new biomimetic surfaces for implants. Research resources include bioengineering, skeletal biology, nanotechnology, oncology, trauma, cartilage, spine, and anatomy and arthroskills facilities.

Center for International Health Research

Contact: Jake Kurtis

Center for International Health Research

Clinical Research Resources, Tropical Infectious Diseases
The Center's mission is to address these urgent global health challenges, the Center for International Health Research (CIHR) at Rhode Island Hospital was founded. The center's mission is to understand the pathogenesis of tropical infectious diseases, specifically malaria and schistosomiasis, and to harness this knowledge to design improved treatments and vaccines. ChildrenTo combat these infections, the center is engaged in studies integrating community-based epidemiologic studies in endemic countries with laboratory-based, basic science investigations. The center's research approach is rooted in the belief that the discoveries of tomorrow will come at the intersection of field and lab science.

Centers for Behavioral and Preventive Medicine (CBPM)

Contact: behavioralmed@lifespan.org

Behavioral and Preventive Medicine (CBPM) Resources

Clinical Research Resources, Behavioral Medicine
The Centers for Behavioral and Preventive Medicine (CBPM) research scientists and their teams work to discover new and improved health promotion and disease management approach, focusing on the role of human behavior in health and disease. The Centers' research draws upon the social and behavioral sciences as well as biomedical and public health sciences to address the leading lifestyle causes of disease burden and death. The research portfolio includes both primary prevention (e.g., tobacco cessation, weight management, physical activity) and chronic disease management. The Center develops, implements, and evaluates interventions to reduce health risks, promotes active participation in medical care, and enhances quality of life. The Center works with healthy volunteers as well as people living with a chronic illness or condition, such as cancer, heart disease, diabetes, or HIV.

Alzheimer's Disease and Memory Disorders Center

Contact: Brian Ott

Alzheimer's Disease & Memory Disorders Center

Clinical Research Resources, Alzheimer's
The Rhode Island Hospital’s Alzheimer's Disease and Memory Disorders Center (ADMDC) provides a comprehensive and integrated program of research and education focused on brain aging and dementia. The ADMDC participates in multicenter clinical trials of investigational drugs to prevent or treat the symptoms of Alzheimer’s Disease and is a primary site for studies sponsored by the Alzheimer's Disease Cooperative Study, funded by the National Institutes of Health, and the Alzheimer's Therapeutic Research Institute. Investigator-initiated studies are an important component of the ADMDC’s research activities; the Center is currently conducting innovative clinical trials for cognitively impaired older drivers and mind-body intervention, as well as studies of the roles of neuroimaging, biologic, and cognitive biomarkers in understanding the preclinical and prodromal stages of Alzheimer's disease. A major thrust of current and future dementia research is primary and secondary prevention. The ADMDC is the primary site for the Rhode Island Alzheimer Prevention Registry, a statewide project that enrolls individuals interested in Alzheimer’s disease prevention trials. To further research into the pathology of Alzheimer’s disease and related dementias, the Center supports the brain donation program at the Brown Brain Tissue Resource Center and operates the Biospecimen Bank, a repository for blood and cerebrospinal fluid specimens stored for future collaborative translational research projects. Intra- and inter-institutional research collaborations are a vital part of the ADMDC’s work. The Center hosts a monthly research seminar co-sponsored by the Norman Prince Neurosciences Institute, which provides a forum for aging and dementia researchers to discuss current research and plan future projects.

IDeA COBRE Center for Cancer Research Development at Rhode Island Hospital

Contact: Chris Marshall

IDeA COBRE for Center for Cancer Research Development

Clinical Research Resources, Cancer
The mission of COBRE Center for Cancer Research Development at Rhode Island Hospital is to create, interpret and apply new knowledge based on original, collaborative, multidisciplinary laboratory studies of the cellular and molecular pathways leading to carcinoma. Such knowledge will be generated in an environment that fosters career development of promising junior investigators and employs cutting-edge methodology and applications to further our understanding of the cancer process. Basic knowledge gained will be used to design and implement novel diagnostic and treatment protocols to benefit the hospital's patients and the community at large.

BioBank, BrainTissue

Contact: Ed Stopa

Brain Tissue Resource Center

Clinical Research Resources, Brain Tissues
A brain tissue resource center (BTRC) (often referred to as a brain bank) is a collection of human tissue specimens from the nervous system: the brain, spinal cord, muscle and peripheral nerves. The facility is engaged in a variety of functions; rapid specimen transport, tissue processing, state-of-the-art preservation methods and database management. A variety of experts, research doctors, neuropathologists and laboratory specialists, plan and manage the BTRC. Strict protocol is imposed on outside vendors whenever their services are required, particularly with respect to rapid specimen transport.

Clinical Translational Research Center (CTRC) - Lifespan

Contact: Gaurav Choudhary, MD

Cardiovascular Institute’s (CVI) Clinical and Translational Research Center (CTRC)

Clinical Research Resources, Cardiovascular
The mission of the Cardiovascular Institute’s Clinical and Translational Research Center (CVI-CTRC) is to enhance, support and facilitate the conduct of high quality clinical and translational research in cardiovascular diseases by investigators at Lifespan. In partnership with Lifespan Office of Research Administration, CVI-CTRC will provide the following services to our investigators: assistance with investigator-initiated research grant preparation; contract and budget initiation; negotiation and execution for industry sponsored trials and subcontracts; assistance with IRB including initial application, continuing review and amendments; coordinating logistics of protocol implementation; assistance with screening and recruitment; regulatory documentation collection and submission; providing access to lab processing, freezers and exam and conference area; nursing and research assistant staff to collect biopecimens, perform exams and follow up; data entry, creating and maintaining source documents and maintaining regulatory binder(s); database searches for retrospective trials; and setting up databases using Redcap.

Lifespan-The Miriam Hospital
FacilityInstrument/Service/Resource Unit
Center for AIDS Research (CFAR) - Providence/Boston

Contact: Susan Cu-Uvin, MD

Basic and Translational Sciences

Clinical Research Service, HIV Research
The Basic and Translational Sciences Core builds and supports collaborative research and synergy between basic, translational clinical and behavioral investigators as well as other multidisciplinary scientists, by providing laboratory, consultation and mentoring services. Services include; Viral load measurement, STI testing, Genital tract specific assays, Biologic specimens collection techniques, HIV-1 and 2 drug resistance assays, Identification of HIV dependency factors (HDF), Cell culture, Viral stocks, Immune activation, Laboratory Consulting, Training and Mentoring.

HIV Therapeutic and Vaccine Clinical Trials Program - The Miriam Hospital

Contact: Pamela Poethke, RN

Infectious Diseases Clinical Research Resources

Clinical Trials Support, HIV and HCV
The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel. The unit conducts trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C. Other studies offered through our clinical trials unit include pharmaceutical studies to treat hepatitis C, prevent C. difficile infection, and test new methods of diagnosing HIV infection.

Center for Prisoner Health and Human Rights

Contact: Alexandria Macmadu, MSc

Center for Prisoner Health and Human Rights

Clinical Research Resources, Prisoner Health
The Center for Prisoner Health and Human Rights seeks to advance the health and human rights of criminal justice-involved populations, among which minority populations are disproportionately represented. The Center aims to achieve its goal through research, education, and advocacy. The Center identifies, initiates, and supports projects that respond to the epidemic of incarceration and recidivism in the criminal justice system and the associated complex public health crisis, among other things. Extensive and fruitful clinical, behavioral, and social research has been carried out within the prison and jail setting by Brown University investigators. The Center supports investigators by connecting them with undergraduate- and graduate-level research assistants, and participates in dissemination activities.

Center for AIDS Research (CFAR) - Providence/Boston

Contact: Susan Cu-Uvin, MD

BioBehavioral Research Support, HIV

Clinical Research Service, HIV Research
The BioBehavioral Sciences Core (BBSC) supports innovative, integrated medical/behavioral research to improve the HIV treatment cascade and HIV prevention among vulnerable populations including justice-involved individuals, women, youth, and persons living in hyperepidemic resource-limited settings.

Center for AIDS Research (CFAR) - Providence/Boston

Contact: Susan Cu-Uvin, MD

Administration - CFAR

Clinical Research Service, CFAR Coordinating Center
The CFAR Administrative Core has built an HIV infrastructure across the partner institutions and provides oversight of the entire CFAR community with responsibility for sound management, organizational structure, appropriate resource allocation, evaluation and the promotion of inter/multi-disciplinary translational HIV research. Through efficient communication to CFAR membership, the Core manages a highly interactive and collaborative scientific environment across geographically dispersed settings in domestic, national and international sites.

Center for AIDS Research (CFAR) - Providence/Boston

Contact: Susan Cu-Uvin, MD

Substance Use Research Core

Clinical Research Service, HIV Research
The Substance Use Research Core (SURC) offers services and expertise on the methods needed to conduct effective Substance Use (SU)/HIV research. Services will be directed at: 1)hypothesis generation, 2) assessment, 3) intervention development, and 4) ethical considerations of SU research. The SURC offers expertise in innovative methods for assessing and analyzing SU, and developing and implementing interventions to address alcohol, tobacco, and other drug use.

Center for AIDS Research (CFAR) - Providence/Boston

Contact: Susan Cu-Uvin, MD

Biostatistics, HIV Research

Clinical Research Service, HIV Research
The Biostatistics Core ensures that all research undertaken by Center for AIDS Research (CFAR) investigators uses optimal methods for study design and analysis; to develop innovative new approaches that address existing gaps in methodology; to expand the number of quantitative researchers engaging in HIV research; and to ensure, through collaboration, training and mentoring, that CFAR researchers have a strong base of knowledge about principles related to study design, data analysis, and interpretation.

The Providence VA Medical Center
FacilityInstrument/Service/Resource Unit
Center for Neurorestoration and Neurotechnology (CfNN) Resources

Contact: Leigh Hochberg

Center for Neurorestoration and Neurotechnology (CfNN)

Clinical Research Resources, Neurorestoration and Neurotechnology
The Center for Neurorestoration and Neurotechnology (CfNN) is a collaboration between the Providence VA Medical Center, Brown University, Butler Hospital, Lifespan, and Massachusetts General Hospital. CfNN unifies distinguished researchers and clinicians to advance and translate neurotechnology to restore lost function. Through its three focus areas and three support cores, CfNN seeks to develop, test and implement new therapies and technologies that restore function for Veterans with disorders affecting the nervous system.

Clinical Research and Development Service

Contact: Gaurav Choudhary

Clinical Research and Development Service Resources

Clinical Research Resources, Veteran Population
The VA Research's fundamental mission is to advance the healthcare of Veterans. The Providence VA Medical Center has a large funded research and development program, including studies in Rehabilitation Medicine, Cardiology, Mental Health, Neuroscience, Substance Abuse, Health Services & Economics, and Pulmonary Disease. These studies enhance our ability to provide state-of-the-art techniques and treatments to our patients. At the same time, the research program helps Providence VAMC recruit and retain the highest quality health care professionals who treat our Veterans in the VA Clinics on a daily basis.

Center of Innovation in Long Term Services and Supports (LTSS COIN)

Contact: James Rudolph

Center of Innovation in Long Term Services and Supports (LTSS COIN)

Clinical Research Resources, Veteran Population
The Center of Innovation in Long Term Services and Supports (LTSS-COIN) is an emerging health services research center with a focus on aging and other vulnerable Veteran populations. The Center includes an analytic core dedicated to Health Services Research in Long Term Supports. LTSS-COIN Research Concentrations include (1) Quality of Care in Nursing Homes and Home and Community Based Services, (2) High Risk Veteran Populations (Palliative Care, Dialysis, and Cognitive Impairment) (3)Policy and Economic Analysis of Long - Term Care Programs, (4) Antimicrobial Stewardship Research in the Long-Term Care Community, (5) Mental Health and Homelessness Research.

Center for Neurorestoration and Neurotechnology (CfNN) Resources

Contact: Leigh Hochberg

Neurotechnology: Neuromodulation and Neuroimaging Service

Clinical Research Service, CfNN Neuromodulation and Neuroimaging
The CfNN Neuromodulation and Neuroimaging Core supports Center projects that use MRI technology, including functional MRI and structural MRI and non-invasive brain stimulation (transcranial magnetic stimulation and transcranial direct and alternating current stimulation) for research with human participants. Core facility users must have a VA appointment or a collaborative agreement with a VA employee. Instrumentation includes a 3T Verio MRI System (Siemens), BOLD Screen (Cambridge Research Systems), Transcranial magnetic and electrical stimulation devices (Magstim, Neuronetics, neuroConn, Soterix, and Neuroelectrics), Brainsight neuronavigation software (Rogue Resolutions).

Center for Neurorestoration and Neurotechnology (CfNN) Resources

Contact: Leigh Hochberg

Neurotechnology: Recording, Decoding and Computational Neuroscience Service

Clinical Research Service, CfNN Computational Neuroscience
The Recording, Decoding and Computational Neuroscience core helps VA affiliated researchers deepen their understanding of how device-based neurotherapies act on brain circuits and networks by providing expertise in statistical and computational neuroscience methods. We advise on computational neuroscience methods to reveal mechanisms of action of both invasive and noninvasive brain stimulation therapies, and on decoding strategies to reveal computational functions of neural circuits. To this end, we are developing a software tool that will allow researchers and clinicians to interpret the circuit mechanisms underlying human electroencephalography (EEG) brain signals and the impact of brain stimulation on these signals. We have also created an open-source flexible cost platform for EEG data acquisition and analysis whose development specs are available to the greater neuroscience community. Instruments include a unique computational model of neocortical function, EEG, and somatosensory stimulus probe devices (for touch (in-house), thermal pain, Medoc).

Center for Neurorestoration and Neurotechnology (CfNN) Resources

Contact: Leigh Hochberg

Neurotechnology: Clinical Study Assessment, Outcome Measurement and Implementation Service

Clinical Trials Support, CfNN Neurotechnology and Neurorestoration
The Assessment, Outcome Measurement, and Implementation service oversees research related procedures in support of Center for Neurorestoration and Neurotechnology (CfNN) PIs and Project Coordinators, and facilitates the continuity of care and access to care for CfNN’s complex study participants. The core assists with developing protocol related documents (e.g. case report forms, manual of operations etc.), evaluates and helps prepare IRB submission documents, research study protocols, checks training compliance, develops and reviews data entry processes, advises on selection of reliable and valid assessment instruments and outcome measures, and assists in identifying personnel to analyze research outcomes. The Core provides expertise in development and implementation of standardized protocols for data collection, and assists in training research staff to insure uniformity and fidelity to testing and intervention procedures. Core resources include neuropsychological assessments, clinical trials/multisite study management, regulatory assistance (device, intellectual property, technology transfer), statistics and a research assistant/research coordinator pool

Center for Neurorestoration and Neurotechnology (CfNN) Resources

Contact: Leigh Hochberg

Gait and Motion Analysis, Virtual Reality, Human Movement and Rehabilitation

Clinical Research Resources, Musculoskeletal Rehabilitation
The Virtual Reality and Motion Analysis Rehabilitation Laboratory is a fully functional research lab focusing on rehabilitation of the musculoskeletal system. The science of motion is studied through computerized animation with an infrared camera system, electromyography, metabolic assessments and virtual reality. The universal theme throughout the lab is the use technology to analyze human movement, quantify improvements and drive the decision making process for design and treatment. Instrumentation includes a 14-camera Qualisys motion capture system, 2 AMTI force plates, a 16 Delsys wireless EMG system, a Cosmed K24b Metabolic testing unit, a custom-designed virtual reality display, a standard treadmill and a customized dual-track, actuated treadmill, software to support the biomechanical analyses of human motion.

IDeA COBRE for CardioPulmonary Vascular Biology

Contact: Susan McNamara

IDeA COBRE for Endothelial Injury and Repair: Cardiopulmonary Vascular Biology

Clinical Research Resources, Cardiopulmonary Vascular
The overall objective of the CardioPulmonary Vascular Biology COBRE is to bring together a group of investigators in the fields of pulmonary and cardiovascular diseases in a unique trans-disciplinary approach to improve understanding of the pathogenesis and treatment of vascular pathobiology in lung and heart diseases. 

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
IDeA COBRE Immune-Based Interventions Against Infectious Diseases

Contact: Barbara Muhitch

IDeA COBRE Immune-Based Interventions Against Infectious Diseases

Clinical Research Resources, Infectious Disease
Infectious diseases continue to represent major causes of death and disease worldwide. Our Center of Biomedical Research Excellence (COBRE) seeks to address the challenge of new and emerging infectious diseases by advancing the development of a multidisciplinary and trans-institutional research program in infectious diseases immunology. The unifying scientific theme of this COBRE is translational research at the interface of the pathogen and host. This COBRE is a partnership between the Institute for Immunology and Informatics (iCubed) at the University of Rhode Island’s Providence campus and the Center for International Health Research (CIHR) at Rhode Island Hospital.

IDeA INBRE Rhode Island Network for Excellence in Biomedical Research

Contact: Laura Bellavia

IDeA INBRE Rhode Island Network for Excellence in Biomedical Research

Clinical Research Resources, Biomedical
RI-INBRE is based out of the University of Rhode Island and is housed at the College of Pharmacy. The statewide network objective is to support and develop talented individuals, committed to research careers in Rhode Island, and to build the biomedical research capacity of Rhode Island institutions. The seven participating research institutions are the University of Rhode Island, Brown University, Bryant University, Providence College, Rhode Island College, Roger Williams University, and Salve Regina University. The Community College of Rhode Island serves an outreach institution for the network. The research foci of the RI-INBRE are: cancer, neuroscience, and molecular toxicology.

Clinical Pharmacokinetics Research Laboratory

Contact: Fatemeh Akhlaghi

Pharmacokinetics, Bioanalytical support

Clinical Research Resources, Pharmakokinetics
The Clinical Pharmacokinetics Research Laboratory is equipped with two UPLC-MS/MS and one quadrupole-time-of-flight mass spectrometer (ESI-QTOFMS) systems capable of measuring the concentration of small molecule xenobiotics and their metabolites as well as endogenous or therapeutic peptides and proteins. To date, this laboratory has developed various assays for the quantification of up to 60 different compounds and validated these assays according to guidelines by the Food and Drug Administration of the United States. The laboratory is proficient in providing analytical support for on-going pre-clinical and clinical studies and during different stages of a drug development project.

Clinical Pharmacokinetics Research Laboratory

Contact: Fatemeh Akhlaghi

Pharmacokinetics Consultation

Clinical Research Resources, Pharmakokinetics
The laboratory is capable of providing support for the design and implementation of pre-clinical and clinical pharmacokinetics studies as well as design and conduct of ancillary in vitro studies (protein binding and microsomal incubations to characterize phase 1 or 2 metabolism). With extensive background in pharmacokinetics modeling and simulation using NONMEM, WinNonlin and Simcyp softwares, the laboratory can provide a valuable resource for on-going or completed clinical studies. Additional data analysis capabilities includes in-vitro in-vivo correlation (IVIVC) and bioequivalence analysis.

Computation

Brown University
FacilityInstrument/Service/Resource Unit
Center for Computation and Visualization (CCV)

Contact: Linnea Wolfe

High Performance Computing Cluster

Various including IBM idataPlex High Performance Computing Cluster
HPC cycles, software development, storage, backups, high speed network hub, visualization, virtual reality, data management, server colocation, scientific support

DNA Sequencing

Providence College
FacilityInstrument/Service/Resource Unit
PC - Hickey Hall Labs

Contact: Charles Toth

DNA Sequencer

ABI Prism 3100 Genetic Analyzer
Used for DNA sequencing and fragment analysis. The ABI PRISM 3100 Genetic Analyzer is an automated capillary electrophoresis system that can separate, detect, and analyze up to 16 capillaries of fluorescently labeled DNA fragments in one run.

The Providence VA Medical Center
FacilityInstrument/Service/Resource Unit
Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

DNA Sequencer

Ion Torrent/Life Technologies Personal Genome Machine
Next Generation Sequencer

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

DNA Sequencer

Qiagen Pyromark Q96 ID
Quantitative analysis of genetic/epigenetic DNA modifications using Pyrosequencing technology

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Genomics & Sequencing Center

Contact: Janet Atoyan

DNA Sequencer

Applied Biosystems 3130xl & 3500xl Genetic Analyzers
DNA Sanger Sequencing & Fragment Analysis: Fluorescence-based instruments utilizing capillary electrophoresis for DNA sequencing and fragment analysis

Genomics & Sequencing Center

Contact: Janet Atoyan

DNA Sequencer

Illumina MiSeq DNA NextGen Sequencing
Performs clonal amplification, genomic DNA sequencing, and data analysis with base calling, alignment, variant calling, and reporting

Flow Cytometry

Brown University
FacilityInstrument/Service/Resource Unit
Flow Cytometry and Sorting Facility

Contact: Kevin Carlson

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACS Aria III
Cell counting, sorting, biomarker detection. The FACSAria has four air-cooled lasers at 488nm, 561nm, 633nm, and 407nm allowing multicolor analysis of up to 19 parameters. It can sort 1 to 4 populations simultaneously and is equipped with an Automated Cell Deposition Unit, an Aerosol Management System and a refrigeration system. It can accept various sample input tubes including 1 mL microtubes, 12 x 75-mm test tubes, and 15 mL tubes into the sample and collection chambers.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACS Calibur
Flow cytometry cell analysis and cell sorting

Care New England - Women and Infants Hospital
FacilityInstrument/Service/Resource Unit
Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACSCanto
Analytical Flow Cytometer: 2 lasers, 6 colors

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Fluorescence Activated Cell Sorter (FACS)

Thermo Scientific Attune NXT
Analytical flow cytometer: 4 lasers, 14 colors, with 96 well plate handler capability

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Flow Cytometry Core

Flow Cytometry and Cell Sorting
The Flow Cytometry Core facility is dedicated to advancing research projects requiring cell sorting and/or analysis of cell populations by flow cytometry. The core offers training on and access to shared use instrumentation for analytical flow cytometry, services for fluorescence activated cell sorting (FACS) as well as technical consultation and support on experimental design, execution, and data analysis.

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Fluorescence Activated Cell Sorter (FACS) - Portable flow cytometer/cell counter

Orflo / Moxi GO II Next Gen Flow Cytometer
488nm laser (MXG102). Configurable 2 PMT system 525/45nm (e.g. FITC, GFP) and 561nm/LP (PE, PI). Ideal for tissue culture, cell line development, gene delivery, toxicity screening

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACS Vantage Flow Cytometer
High-speed cell sorter. Two lasers analyze cells on 8 parameters. Side/ forward light scatter. 6 different fluorescent color detection. Simultaneously sort up to four populations of cells. Sort 1+ cell type(s) into 6, 24, and 96 well tissue culture plates.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACSort Flow Cytometer
Analytical flow cytometer. Two lasers analyze cells on 6 parameters. Side/ forward light scatter. 4 different fluorescent color detection.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson - Accuri Flow Cytometer
This system is equipped with a blue and red laser, two light scatter detectors, and fluorescence detectors with optical filters optimized for FITC, PE, PerCP, and APC. The user does not need to adjust detector voltages and there is a wide dynamic range of digitally collected data (7.2 decades).

Flow Cytometry Core - Rhode Island Hospital

Contact: Mark Dooner

Fluorescence Activated Cell Sorter (FACS)

BD Biosciences LSRII Analyzer/Flow Cytometer
Digital, 4 laser (355nm, 405nm, 488nm and 635nm) flow cytometric analysis system with 10 fluorescent channels plus 2 scatter channels. BD FACSDiva software with digital compensation and ModFit software for cell cycle analysis.

Flow Cytometry Core - Rhode Island Hospital

Contact: Mark Dooner

Fluorescence Activated Cell Sorter (FACS)

BD Biosciences Influx Cell Sorter
5 laser system (355nm, 405nm, 488nm, 561nm and 638nm) for simultaneous detection of up to 14 parameters. Sorts up to 4 different cell populations. Capable of single cell deposition into many different sized culture plates (96 or 384 well plates, etc). Equipped with a small particle objective for FSC size determination down to 0.5 micrometers. Enclosed in a biosafety hood. The sorter separates particles on the detection of fluorescent markers on particles such as cells, chromosomes, bacteria or nuclei. Then the collected cells are suitable for downstream analysis either in molecular applications like protein assays and PCR, or used in viable assays such as tissue culture or injected into in vivo models. Generated data may also be used to determine percentages of interrogated populations. The sorter can separate populations into tubes (1.5ml, 4ml, 15ml, 50ml), multi-well plates (6, 24, 48, 96, 384), or directly onto microscope slides.

Flow Cytometry Core - Rhode Island Hospital

Contact: Mark Dooner

Analyzer - nanoparticle counter

Nanosight Nanoparticle Counter
Examines size, size distribution and concentration. Fluorescent adapter for extracellular vesicles (EVs) surface receptor studies. Able to control for microvesicle number in experiments, and possibly identify subpopulations of EVs based on surface receptors Particles are illuminated using a laser through a prism, and light scatter is captured on a CCD camera. Nanoparticle tracking analysis (NTA) – direct and real-time visualization and analysis of nanoparticles in liquids, and calculate the size, size distribution and concentration of the particles. Brownian motion of nanoparticles is analyzed using the Stokes-Einstein equation.

Flow Cytometry Core - Rhode Island Hospital

Contact: Mark Dooner

Training and Technical Assistance

Service

Providence College
FacilityInstrument/Service/Resource Unit
PC - Hickey Hall Labs

Contact: Charles Toth

Fluorescence Activated Cell Sorter (FACS)

Flow Cytometer- Accuri C6
The BD Accuri C6 is a personal flow cytometer that is easy to use, simple to maintain, and affordable.

Roger Williams University
FacilityInstrument/Service/Resource Unit
RWU Lab Spaces

Contact: Nancy Breen

Fluorescence Activated Cell Sorter (FACS)

Millipore Guava easyCyte Flow Cytometer
Cell sorting and analysis

Salve Regina University
FacilityInstrument/Service/Resource Unit
Salve Regina Biology and Biomedical Sciences

Contact: John-David Swanson

Fluorescence Activated Cell Sorter (FACS)

Millipore Guava EasyCyte 8 Flow Cytometer
Single blue (488 nm), dual blue and red (642 nm), or triple blue, red, and violet (405 nm) excitation lasers provide up to 12 simultaneous detection parameters, including 10 fluorescent colors plus forward and side scatter for size and granularity determination. The guava easyCyte family also meets your sample throughput needs by offering both single sample and multi-sample processing.

The Providence VA Medical Center
FacilityInstrument/Service/Resource Unit
Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Magnetic-Activated Cell Sorter (MACS)

Miltenyi MACSQuant Analyzer 7 Flow Cytometer
The MACSQuant Analyzer is a powerful benchtop flow cytometer for highly sensitive, multiparameter cell analysis. MACSQuant Analyzers offer fully automated instrument setup via pre-set calibration and compensation programs. Automated startup, shutdown, and cleaning cycles make for hassle-free instrument housekeeping. The MACSQuantify™ Software provides a powerful and easy-to-use user interface for instrument control, data acquisition, and fully automated analysis.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Marine Science Research Facility

Contact: Rodrique Spinette

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences Influx Flow Cytometer and Cell Sorter
Measures light scatter and fluorescence of cells. Sorts cells based on measured properties.

Centralized Research Core Facility

Contact: Al Bach

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACS Verse Flow cytometer
FACS

Cell Analysis and Sorting Core

Contact: Loren Fast, PhD

Magnetic-Activated Cell Sorter (MACS)

Miltenyi MACSQuant-10 Analytical Flow Cytometer
Analytical flow cytometry- 3 lasers, 10 parameters (8 colors, FSC, SSC)

Cell Analysis and Sorting Core

Contact: Loren Fast, PhD

Magnetic-Activated Cell Sorter (MACS)

Miltenyi AutoMACS
Automated cell sorter for cell suspensions labeled with magnetic beads.

Cell Analysis and Sorting Core

Contact: Loren Fast, PhD

Fluorescence Activated Cell Sorter (FACS)

BD LSRII Flow Cytometer
Analytical flow cytometric analysis; 4 lasers (blue (2), violet (4), red (3) and yellow green (5)) which allows for analysis of up to 14 different fluors (# listed in parentheses for each laser)

Gene Expression Profiling

Brown University
FacilityInstrument/Service/Resource Unit
Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Hybridization Oven

Agilent G2534A
Microarray hybridization oven

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Microarray Platform

Affymetrix Gene Chip Instrument System
A fully integrated platform for Affymetrix microarrays

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Microarray Scanner

Molecular Devices GenePix Scanner 4000B
Two color microarray scanner

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

PCR Thermal Cycler

Bio-Rad C1000 Touch Thermal Cycler
The C1000 Touch thermal cycler offers superior performance and a large color touch screen for easy programming. This fully modular platform is able to accommodate different throughput needs with easily interchangeable reaction modules that swap in seconds without tools. Each PCR module has a fully adjustable heated lid that supports a wide range of vessels and sealers, including low-profile and standard-height PCR plates.

The Providence VA Medical Center
FacilityInstrument/Service/Resource Unit
Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Microarray Scanner

Illumina HiScan
Whole-genome genotyping, gene expression analysis, methylation analysis

GeoChemistry

Brown University
FacilityInstrument/Service/Resource Unit
Mass Spectrometry Facility

Contact: Tun-Li Shen, PhD

Gas Chromatograph - Mass Spectrometer (GC - MS)

Hewlett-Packard (Agilent) GCD 1800C
This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 450 Da).

Mass Spectrometry Facility

Contact: Tun-Li Shen, PhD

Liquid Chromatography - Mass Spectrometer (LC - MS)

Agilent 6530 Mass TOF
This system consist of Agilent 1260 infinite HPLC and Agilent 1260 infinite nanoglow LC/chipcube nanoelectrospray MS interface, and 6530 Accurate Mass Q-TOF mass spectrometer . This instrument can detect and identify compounds in amounts smaller than two trillionths of a gram (2 picograms), making the Agilent 6530 a powerful tool for food safety, toxicology and other measurements where minute amounts of compounds must be identified.

Mass Spectrometry Facility

Contact: Tun-Li Shen, PhD

Mass Spectrometer

JEOL JMS-600H double focusing magnetic sector
The JMS-600H is a compact double-focusing, high-resolution, magnetic sector mass spectrometer. This instrument is equipped with electron impact ionization (EI), Chemical Ionization (CI), and fast atom bombardment ionization (FAB) for characterization of synthetic organic, inorganic, and biological molecules. This instrument is also used for routine exact mass measurement of organic molecules.

Mass Spectrometry Facility

Contact: Tun-Li Shen, PhD

Mass Spectrometer

Thermo LXQ linear ion trap with Surveyor HPLC system
The LXQ has capabilities similar to the conventional 3D ion trap such as LCQ Deca. It is based on linear ion trap technology that has faster cycle time. It is capable of data-dependent LC/MSn analysis.

Mass Spectrometry Facility

Contact: Tun-Li Shen, PhD

Mass Spectrometer

Thermo LCQ Deca XP Max ion trap with Shimadzu HPLC system
The LCQ Deca XP Max is equipped with electrospray (ESI) and APCI ionization sources. It is capable of mass analysis of a broad range of molecules that are relatively polar, nonvolatile and thermally labile. This instrument is used for routine molecular weight determination of compounds from organic, inorganic, natural products, small proteins and peptides, and oligonucleotides.

Environmental Chemistry Facility

Contact: David Murray, PhD

Analyzer - Discrete Analyzer

Westco Smartchem 200
Used to determine Nitrate/Nitrite, Phosphate, Ammonia, Silicate, and other nutrient concentrations in water samples and soil extracts.

Environmental Chemistry Facility

Contact: David Murray, PhD

Analyzer - Elemental Analyzer

CE Elantech, Carbon-Nitrogen NC2100
Analysis of carbon, nitrogen, and sulfur concentration of solid samples

Environmental Chemistry Facility

Contact: David Murray, PhD

Analyzer - Inorganic Carbon Analyzer

UIC, INC Inorganic Carbon Analyzer
Measures total inorganic carbon by automated acidification and coulometric detection in a wide variety of sample matrices. Solid samples ranging from low ppm to 100% inorganic carbon can be analyzed with this system.

Environmental Chemistry Facility

Contact: David Murray, PhD

Analyzer - Mercury Analyzer

Milestone DMA-80 Direct Mercury Analyzer
Determines mercury content of solid and liquid samples.

Environmental Chemistry Facility

Contact: David Murray, PhD

Analyzer - Water Isotope

Picarro L1102-I
Measures delta deuterium/hydrogen (D/H) ratio and delta 18O/16O in liquid water

Environmental Chemistry Facility

Contact: David Murray, PhD

Sample Preparation - Freeze Dry System

Labconco FreeZone 6 Liter
For removing water and other solvents from frozen samples by sublimation.

Environmental Chemistry Facility

Contact: David Murray, PhD

Liquid Chromatography System

Dionex DX500
Ion chromatography analysis of anions in marine and freshwater samples

Environmental Chemistry Facility

Contact: David Murray, PhD

Sample Preparation - Microwave Digestion System

Milestone Ultrawave
Used to digest solid samples (soils, sediments, rocks, plants, tissues), for elemental analysis.

Environmental Chemistry Facility

Contact: David Murray, PhD

Spectrometer - Atomic Absorption Spectrometer-Graphite Furnace (GFAAS)

Perkin Elmer AAnalyst 600 Graphite Furnace
This spectrometer is useful for measuring trace levels of metals in water and soil.

Environmental Chemistry Facility

Contact: David Murray, PhD

Spectrometer - Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES)

Thermo Scientific iCAP 7400 DUO ICP-OES
Analysis of most elements with atomic weights above 10.

Environmental Chemistry Facility

Contact: David Murray, PhD

X-Ray Fluorescence - Handheld

Innov-X Systems Alpha 4000 Handheld
Non-destructive elemental analysis on a variety sample types for concentrations of some metals ranging from about 20 ppm to 10%.

Environmental Chemistry Facility

Contact: David Murray, PhD

X-Ray Fluorescence - Handheld

Olympus Delta Professional Handheld
Non-destructive elemental analysis on a variety sample types for concentrations of elements greater than 10 ppm.

Mass Spectrometer Analytical Facility

Contact: Soumen Mallick

Analyzer - Laser Ablation

Photon-machines Analyte G2, 193 nm excimer laser ablation
This 193 nm wave-length excimer laser allows us to perform in-situ analysis on a solid sample with a beam diameter as small as 3µm. To determine the elemental abundances the laser is coupled with the single collector inductively coupled plasma mass spectrometer ICPMS and to determine the isotope ratios the laser is coupled with multi collector ICPMS.

Mass Spectrometer Analytical Facility

Contact: Soumen Mallick

Mass Spectrometer

Thermo Scientific Quadrupole inductively coupled plasma mass spectrometer, ICP-MS, X-series-2
This is a single collector ICP-MS that allows us to measure precise elemental composition at sub-ppb level concentration.

Mass Spectrometer Analytical Facility

Contact: Soumen Mallick

Mass Spectrometer

Thermo Scientific Multi-collector inductively coupled plasma mass spectrometer, ICP-MS, Neptune Plus
This is a multi-collector ICP-MS equipped with nine Faraday cups and eight ion counters, which allows us to monitor multiple masses simultaneously providing precise isotope ratio measurement.

Benedum Stable Isotope Facility

Contact: Steven Clemens

Mass Spectrometer, Isotope Ratio

ThermoFisher (Finnigan) MAT 252 dual inlet Isotope Ratio Mass Spectrometer with automated sample reaction device for up to 48 samples and with Kiel III Carbonate interface.
Instrument primarily dedicated to the measurement of the stable isotopes of carbon and oxygen on inorganic carbonates. The facility accommodates projects both internal and external to Brown including analysis of terrestrial and marine material. The vast majority of samples analyzed are funded through external grants but I also facilitate a significant number of small unfunded, exploratory, analyses to help construct proof-of-concept data sets in preparation for proposals.

Mass Spectrometer Analytical Facility

Contact: Soumen Mallick

Clean lab, Trace metal free

Pico Trace
This Clean Lab is equipped with Millipore water filtration system that provides greater than 18MΩ Milli-Q water. The working stations in this Clean Lab meet ISO class 4 standard (equivalent to FS class 10) allowing us to perform ultra-low blank chemical analysis.

Electron Microprobe Facility

Contact: Joseph S Boesenberg

Analyzer - Electron Microprobe

Cameca SX100 Electron Microprobe Analyzer
The Cameca SX-100 electron microprobe is equipped with 5 wavelength dispersive spectrometers (WDS) and a Rontec energy dispersive spectrometer (EDS).The WDS spectrometers each contain two or four diffracting crystals and presently include LTAP, TAP (2), LPET (2), PET, LLIF (2), LIF, LPCO, PC1 and PC2. The last three crystals are used to measure the light elements (boron to sodium). The absolute detection limits for the instrument are approximately 50-200 ppm, depending on the element. The EDS spectrometer is capable of detecting all elements above sodium (Na). X-ray element maps can easily be acquired on the microprobe. Using 512x512 pixel maps, up to nine element maps (5 elements on WDS, 4 with EDS), plus a backscattered electron (BSE) image, can be obtained simultaneously. Maximum resolution on any one map is one micron per pixel. Utilizing the coordinate system, maps of entire thin sections can be generated.

Mass Spectrometry Facility

Contact: Tun-Li Shen, PhD

Gas Chromatograph - Mass Spectrometer (GC - MS)

Agilent 5977A GC/MSD System
This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 1050 Da).

Mass Spectrometry Facility

Contact: Tun-Li Shen, PhD

Mass Spectrometer

Bruker Autoflex Speed Linear (L) Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometer (MALDI-TOF MS).
The Bruker autoflex Speed is a linear time-of-flight (TOF) mass spectrometer equipped with a matrix-assisted laser desorption ionization (MALDI) ion source. This instrument is routinely used for analysis of organic molecules, natural products, and macromolecules, including recombinant proteins, oligonucleotides, polysaccharides and synthetic polymers.

Good Manufacturing Practice (GMP)

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Cell Immunotherapy and Gene Therapy (CITGT) Good Manufacturing Practice (GMP) Facility

Services and Equipment
The Cell Immunotherapy and Gene Therapy GMP facility supports the manufacture of investigational new drug (IND) products for principal investigators under FDA rules and regulations. 

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Good Manufacturing Practice Facility-current (cGMP)

Contact: Clinton Chichester III, Ph.D.

Education

Clinical Research Service, GMP education
Providing GMP industrial experience in drug manufacturing and analytical testing for students in various related undergraduate, graduate and adult education programs, as well as industry-specific training in collaboration with pharmaceutical and biotechnology firms.

Good Manufacturing Practice Facility-current (cGMP)

Contact: Clinton Chichester III, Ph.D.

GMP analytical testing

Clinical Research Service, GMP analytical
Providing pharmaceutical testing services including turn-key stability studies

Good Manufacturing Practice Facility-current (cGMP)

Contact: Clinton Chichester III, Ph.D.

GMP manufacturing

Clinical Research Service, GMP manufacturing
Assisting academic, government and industry partners with the manufacture of solid dose forms for veterinary and human use

Good Manufacturing Practice Facility-current (cGMP)

Contact: Clinton Chichester III, Ph.D.

current Good Manufacturing Practice (cGMP) Facility

Service
Rapid expansion in the markets for biologics and small molecule pharmaceutical products has created a critical demand for skilled professionals (from equipment operators to advanced technical and quality assurance personnel) and additional infrastructure to support drug development and manufacturing.  The current Good Manufacturing Practice (cGMP) Facility at the University of Rhode Island (URI) offers a state-of-the-art training, development and manufacturing facility for GMP production of solid oral dosage forms.  

Histology & Pathology

Brown University
FacilityInstrument/Service/Resource Unit
Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Histology/Tissue Processing - Tissue Processor

Leica ASP300 S Automated Tissue Processor
Tissue processing for paraffin embedding

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Histology/Tissue Processing - Paraffin embedding Workstation

Leica EG1150C Paraffin Embedding Center
Paraffin embedding

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Microtome

Leica RM2265 Automated Microtome
Paraffin and plastic sectioning

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Microtome

Microm HM 355S Automated Microtome
Paraffin sectioning

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Cryostat

Leica CM3050S Cryostat
Sectioning of fixed and unfixed frozen samples

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Vibratome

Leica VT 1000S Vibratome
Sectioning of fixed and unfixed samples

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Histology/Tissue Processing - Sample Processing

Service
Paraffin Processing - automated and manual, Placing tissue in cassettes, Glycol Methacrylate Processing, Routine TEM processing, Enhanced contrast TEM, Immunogold labeling

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Histology/Tissue Processing - Sectioning

Service
Paraffin sectioning, Glycol sectioning Frozen prep and sectioning, TEM ultrathin sectioning

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Histology/Tissue Processing - Staining

Service
H&E staining, Cat 1 and 2 staining, PAS staining, Lectin staining, TUNEL staining, Immunohistochemistry (IHC), TEM heavy metal staining

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Cryostat

Reichert-Jung Cryocut 1800
Frozen tissue sectioning (used with Superfrost/Plus microscope slides (approximately 4-10 microns).

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Cryostat

Leica Cryostat CM1850
Frozen Tissue Sectioning. UVC disinfection and AgProtect minimizes contamination risk. Optional section waste and vacuum, disposable blade holder.

Multiplex Facility

Contact: Suzanne de la Monte

Cryostat

Leica Cryostat
Frozen Tissue Sectioning. UVC disinfection and AgProtect minimizes contamination risk. Optional section waste and vacuum, disposable blade holder.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Histology/Tissue Processing - Biosafety Cabinet

Laminar Flow Hood
Filter capable of removing 99.97% of particles greater than 0.3 microns.

BioBank, Tumor Tissue Bank

Contact: Murray Resnick

Histology/Tissue Processing - Freezing Bath

Low temp isopentane bath
Bath with min. temperature of -160 C by addition of liquid nitrogen to isopentane.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Histology/Tissue Processing - Histobath

Fisher Histobath 134
Prevents development of microscopic ice crystals and sample distortion.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Histology/Tissue Processing - Knife Sharpener

Hecker Instruments, Inc. Knife Sharpener
Used to sharpen microtome/cryostat knife.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Histology/Tissue Processing - Microwave Oven

Sharp Microwave Oven
Tissue microwave fixation.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Histology/Tissue Processing - Microwave Oven

Amana (RFS18MPS) Microwave Oven
Tissue microwave fixation.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Histology/Tissue Processing - Microwave Oven

GE Microwave oven (JE1460BF001)
Tissue microwave fixation.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Histology/Tissue Processing - Oven

Fisher Scientific Oven
Used to melt paraffin from paraffin- embedded sections.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Histology/Tissue Processing - Paraffin Embedding Workstation

Miles Scientific Tissue-Tek III
Paraffin embedding sample station (tissue, bone, cell pellet, etc.).

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Histology/Tissue Processing - Tissue Processor

Miles Scientific Tissue-Tek-VIP Tissue Processor
Automated sample processing (tissue, bone, cell pellet, etc.) for paraffin embedding purposes.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Incubator

Fisher Scientific Dry Bath Incubator
Precise temperature control for temperatures up to 130 C. Built in temperature sensing probe for improved temperature accuracy and control.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Microscope - Laser Capture Microdissection System

Arcturus XT Laser Capture Microdissection System
Automated IR and UV laser capture. Microdissection and cutting of cells for RNA, DNA and protein isolation. One modular platform with laser capture and cutting. Optional live-cell modules and camera. Any slide type. Wide range of objectives available, 2x-100x dry and 100x oil immersion.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microtome

Bausch Lomb Ultramicrotome
Sectioning resin-embedded tissue; micron-nm thickness.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microtome

Reichert-Jung Microtome
Paraffin embedded tissue sectioning (approximately 2-20 microns).

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Microtome

Finesse 325 Microtome
Used to prepare samples for observation under transmitted light or electron radiation. Microtome material varies depending on the specimen being sliced and the desired thickness of the sections cut.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Robotic Workstation - Barcoding

Ventana Discovery System
Automated staining module using bar code technology. Total automation in IHC staining of frozen/ paraffin embedded tissue, FISH and ISH using DNA, RNA or oligonucleotide probes on tissue or microarrays (gene expression).

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Suspension Array System

Beecher Manual Tissue Microarrayer
Generates multiple specimen slides that can contain hundreds of individual tissues. Up to 100 tissue cores per paraffin block. Use for same histochemical and molecular detection techniques as with regular sections.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Vacuum Oven

Napco Model 5831 vacuum oven
Capacity: 0.45 cu ft. Temp range: 35 C to 200 C. 30-in Hg vacuum capability. Vacuum bleed valves permit pulling of vacuums as high as 30 inches H. Full view observation window with latched door and built in safety to prevent thermal runaway.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Vibratome

Bausch Lomb Vibratomes
Sectioning agarose-embedded tissue.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Vibratome

Vibratome 3000 Sectioning System
Fresh tissue sectioning. Thickness: 3- 20 microns.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Microtome

Thermo Scientific Shandon Finesse 325 manual microtome
With a lightly balanced flywheel it is ideal for routine paraffin sectioning.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Sample Preparation - Cutter

Buehler-Isomet Cutter
The IsoMet Low Speed Cutter is a precision sectioning saw designed for cutting various types of materials with minimal deformation. Its low kerf loss capability and great versatility in holding all types of sample shapes and configurations, gives today's laboratory a precision sectioning tool capable of cutting viturally any material including brittle or ductile metals, composites, cements, laminates, plastics, electronic devices and biomaterials. The Cutter is equipped with a diamond studded carborundum wheel and Buehler Ecomet 4 grinder/polisher with Automet 2 powerhead.

Rhode Island College
FacilityInstrument/Service/Resource Unit
RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Sample Preparation - Knifemaker

LKB 7800 Knifemaker
Slide/Sample Preparation

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microtome

Leica RM2165 Motorized Rotary Microtome
Slide/Sample Preparation

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microtome

TBS Microtome plus Cryostat
Slide/Sample Preparation

The Providence VA Medical Center
FacilityInstrument/Service/Resource Unit
Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Analyzer - Cell Metabolism

Seahorse Biosciences - XF Extracellular Flux Analyzer
XF instruments analyze mitochondrial respiration and glycolysis in live cells, generating data in just minutes. XF Technology uses solid-state sensors to simultaneously measure both oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in every well. All platforms support injection of up to 4 unique compounds per well.

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Analyzer - Electrical Cell Impedance Sensing (ECIS) equipment

Applied BioPhysics, Model 100
Measures cell impedance using altering currents across cell monolayers and measuring the change in electrical potential. Impedance is calculated using Ohm's law.

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Analyzer - Electrical Cell Impedance Sensing (ECIS) equipment

Applied BioPhysics, Model ECIS Z Theta
Measures cell impedance using altering currents across cell monolayers and measuring the change in electrical potential. Impedance is calculated using Ohm's law.

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Evaporator

Buchi RotaVapor R215 Evaporator
Rotary evaporator for removing solvents.

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Measurement system - Lung function

SCIREQ FlexiVent FX2 system
Measures mouse lung compliance. Resistance and compliance measurements, mechanical properties of conducting airways, terminal airways and parenchyma. Contains a computer-controlled precision piston pump that can intersperse mechanical ventilation with a variety of volume and pressure controlled maneuvers to obtain accurate, reproducible measurement of respiratory mechanics for pulmonary research.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Centralized Research Core Facility

Contact: Al Bach

Analyzer - Live Cell

Roche xCELLigence Real-Time Cell Analysis System
Label free live cell analyzer

Centralized Research Core Facility

Contact: Al Bach

Biological Safety Cabinet

NuAire, Laminar Flow Hood
Cell culture facility

Centralized Research Core Facility

Contact: Al Bach

Cell Counter

Nexcellom Cellometer Vision Cell Counter
Automated cell counter

Genomics & Sequencing Center

Contact: Janet Atoyan

Cryostat

Vibratome 5000 Advanced Cryostat
Performs histological sectioning of unfixed frozen cells and tissues.

Centralized Research Core Facility

Contact: Al Bach

Electroporation System - Transfection Platform

Lonza Nucleofactor System
High-throughput transfection

Imaging

Brown University
FacilityInstrument/Service/Resource Unit
Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Analysis - Software

Software: Molecular Devices, MetaMorph (version 7.0)
Software for microscopy automation & image analysis

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Sample Preparation - Critical Point Dryer

Ladd Research Industries
Removes liquid from biological specimens for SEM

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Sample Preparation - Glow Discharge Unit

Emitech K100X
Adds a charge to make TEM samples hydrophilic

Magnetic Resonance Imaging Facility

Contact: Michael Worden, PhD

Imaging System - Magnetic Resonance Imaging (MRI) Scanner

Siemens 3 Tesla Prisma fit
Brain structure and function in normal and clinical populations as well as studies of other body systems, non-invasive animal imaging and materials science.

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope

Olympus FV-1000-MPE Multiphoton Laser Scanning Microscope
Deep optical sectioning of fluorescently labeled samples with SIM photoactivation

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope

Zeiss Axiovert 200M Fluorescence
Imaging of samples labeled with fluorescent indicators

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope

Zeiss Axiovert 200M Fluorescence
Imaging of samples labeled with fluorescent indicators

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope

Olympus FV3000 Confocal Microscope
Optical sectioning of samples labeled with fluorescent indicators. Equipped with a resonant scanner for fast optical sectioning

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope

Zeiss LSM 710 Confocal
Optical sectioning of samples labeled with fluorescent indicators

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope

Zeiss Lumar Stereo Fluorescence
Imaging of samples labeled with fluorescent indicators

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Microscope

Nikon Eclipse TE200 Inverted Microscope
Transgenics and gene targeting microinjection microscope

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Microscope

Nikon Eclipse TS100 (cell culture scope)
Transgenics and gene targeting cell culture scope

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Microscope

Nikon SMZ1500 Zoom Stereomicroscopes
Transgenics and gene targeting dissecting microscopes (2 units)

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Microscope

Nikon SMZ800 Zoom Stereomicroscopes
Transgenics and gene targeting surgical microscope

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Electron

FEI Apreo VS Scanning Electron Microscope (SEM) for serial block-face imaging
Equipped for standard scanning electron microscopy as well as serial-block face imaging. The automated system is capable of imaging large z-stacks at isotropic 10x10x10 nm resolution. The series of images can be processed for 3D reconstruction of cells and tissues, with sufficient resolution to identify small vesicles, organelles and neural connections.

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Electron

Philips 410 Transmission Electron Microscope (TEM)
Transmission electron microscopy with Advanced Microscopy Techniques (AMT) Camera Accessory

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microtome

Reichert Ultramicrotome
Ultrathin sectioning for light microscopy and transmission electron microscopy

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microtome Diamond Knife Set

Diatome DKS
Used on Reichert microtome to cut ultrathin sections for TEM

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Sample Preparation - Sputter Coater System

Emitech K550
Covers an EM specimen with a thin layer of conducting material

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Training and Technical Assistance - Bioimaging

Service
Service to provide Bioimaging technical assistance and training

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Imaging System

LiCor Odyssey Clx Infrared
Western blot analysis, EMSA, protein arrays, In-Cell Western Assays, On-Cell Westerns, in vivo imaging, Coomassie gel documentation, DNA gel documentation, and tissue section analysis.

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Microscope

Nikon Eclipse 50i light microscope with a projector
Collaborative analyses of histological slides and digital imaging capability

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Imaging System - Slide Scanner

Aperio ScanScope CS slide scanner
This microscope uses a 20x objective to produce high-resolution digital scans of histological slides.

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope

Zeiss LSM 800 Confocal
Optical sectioning of samples labeled with fluorescent indicators

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Imager and Microplate Reader

BioTek Cytation 3 Cell Imaging Multi-Mode Reader
UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence

Bryant University
FacilityInstrument/Service/Resource Unit
Bryant Unistructure Science Spaces

Contact: Dan McNally

Sample Preparation - Sputter Coater System

Denton Vacuum Desk V gold sputter coater and carbon coater
Coat non-conducting samples with gold or carbon for use on the SEM

Bryant Unistructure Science Spaces

Contact: Dan McNally

Microscope

Zeiss Primo Star with AxioCam
Recordable imaging

Bryant Unistructure Science Spaces

Contact: Dan McNally

Microscope

Zeiss Axiovert 40CFL Inverted Microscope
Recordable inverted microscopy

Bryant Unistructure Science Spaces

Contact: Dan McNally

Microscope

Zeiss A1 AXIO Polarized Light Microscope and Q imaging RETIGA 400R Imager
Recordable polarized light imaging

Bryant Unistructure Science Spaces

Contact: Dan McNally

Microscope - Electron

JEOL JSM 6010LA Scanning Electron Microscope (SEM)
Scanning electron microscope with EDS

Bryant Unistructure Science Spaces

Contact: Dan McNally

Sample Preparation - Critical Point Dryer

Tousimis Sandri-PVT-3D Critical Point Dryer (CPD)
Maintain structural integrity for soft tissue use of the SEM

Care New England - Women and Infants Hospital
FacilityInstrument/Service/Resource Unit
Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Leica MZ FLIII Stereo Fluorescent dissection microscope
Dissection microscope with Leica color camera DC300F.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Nikon 80i Upright Fluorescence Microscope
Upright microscope with color CCD camera Spot Insight 2

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Nikon TE2000E Inverted fluorescence,
A live cell imaging microscope, with cooled CCD camera Roper CoolSnap HQ

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Zeiss AxioImager M2 Upright Microscope,
Upright microscope with color CCD camera AxioCam MRC.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Nikon TE2000E Inverted fluorescence,
A Multicolor fluorescence widefield microscope, with stage incubator, specialized in live cell imaging

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Fluorescence Activated Cell Sorter (FACS)

Thermo Scientific Attune NXT
Analytical flow cytometer: 4 lasers, 14 colors, with 96 well plate handler capability

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope - Spinning disk

Andor CSU-W1 spinning disk confocal system
The Spinning disk confocal microscope is a Nikon Ti-E (inverted) with Perfect Focus and motorized stage, with an Andor Zyla 4.2 plus SCMOS camera, an Andor CSU-W1 spinning disk with 405, 488 and 561 nm laser lines, as well as a SpectraX LED widefield light source and controlled by NIS-Elements software. This system is suitable for fast confocal imaging and live cell imaging, with low phototoxicity and long term focus stability. A stage incubator with CO2 and temperature control is available for maintenance of physiological conditions during  live cell imaging.

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Imaging Core

Zeiss LSM 700 confocal, Zeiss Axioplan 2 optical, Zeiss Axiovert 200M optical, IVIS Model 100
The Imaging Core facility provides technical and logistical access for fixed and live cell fluorescence imaging via visual and digital fluorescent microscopes. This core also offers the ability to visualize fluorescent and bioluminescent markers in live animals via an IVIS imager.

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Imaging System

Omega Lum G Imaging System
Chemiluminescence, UV Fluorescence, Colorimetry, Densitometry, Gel Documentation

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Imaging System - Gel Imager

Bio-Rad Molecular Imager VersaDoc
Quantitative digital imaging system for single or multi-color images. Includes multiplexed samples (1-D or 2-D gels), chemiluminescent and chemifluorescent blots, and microplates.

Multiplex Facility

Contact: Suzanne de la Monte

Imaging System

Applied Scientific Instrumentation MS-1000
XY stage designed to provide a high resolution, and highly repeatable, means of controlling the X and Y position of a microscope stage

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Imaging System - Camera

Diagnostics SPOT 110-2 Digital Camera
Digital Imaging of samples.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Imaging System - Camera

Olympus SPOT IDEA 3.0 MP Digital Camera
Digital Imaging of samples. 1.3, 3.0, 5.0 megapixel available. Vivid colors, 12-bit image capture, high-speed readout, external trigger output, USB 2.0 interface for universal connections.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Imaging System - Camera

SPOT RT3 Slider -43C F-MT Digital Camera
Attached to Nikon TE-800. Digital Imaging of samples. Ideal for brightfield color imaging, fluorescence microscopy, FISH, GFP imaging, immuno- fluorescence, 3D convolution. CCD cooled to -43.3. 1.92 MP. 1-16x. 14-bit x 20MHz capture, 40MHz live mode, interline progressive scan, FireWire interface.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Imaging System - Camera

Polaroid camera
Instant recording of gels.

Multiplex Facility

Contact: Suzanne de la Monte

Imaging System - Camera

Olympus U-CMAD3 camera
Connected to Olympus Inverted CKX31 Fluorescent Microscope. Digital Imaging of samples. 1.3, 3.0, 5.0 megapixel available. Vivid colors, 12-bit image capture, high-speed readout, external trigger output, USB 2.0 interface for universal connections.

Multiplex Facility

Contact: Suzanne de la Monte

Imaging System - Camera

Sony 3CCD Exwave HAD Digital Camera
Connected to Olympus BX60. Digital Imaging of samples. 1.3, 3.0, 5.0 megapixel available. Vivid colors, 12-bit image capture, high-speed readout, external trigger output, USB 2.0 interface for universal connections.

Multiplex Facility

Contact: Suzanne de la Monte

Imaging System - Camera

Stereologer 200
1/3" type DSP 3-CCD PAL color video camera with improved camera sensitivity (F8 at 2000 lx). Resolution of 800 TVL and a high S/N ratio of 61 dB.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Imaging System - Dark Room

Dark Room Related equipment eg., automatic processors, dryers, et al
Sample photo development.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Imaging System - Photo Enlarger

Durst Laborator 1200 Photographic Enlarger
Sample digital imaging using high performance enlarger.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Imaging System - Slide Scanner

Aperio ScanScope Slide Scanner CS2
Generates full color, high resolution digital images (cells, tissues and tissue arrays). 5 slide capacity. Image analysis software available. Stored and catalogued in searchable image data base.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microscope

Bausch Lomb Stereomicrosopes
Visualization with incident light illumination.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microscope

NIKON E-800 Fluorescent /Brightfield Microscope
Fluorescence/Brightfield- micro- scope slides only. CFI60 optical system. 0.5x magnification with 50mm field of view. Can be coupled with 2x projection lens to permit macrophotography at 1:1 magnification. Tube lens focal length of 200mm. 10 types of condensers available.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microscope

Nikon TE 200 Inverted Fluorescent/Brightfield Microscope
Fluorescence/Brightfield Microscope- petri dish/microscope slides on cell/slice culture etc. Phase contrast and fluorescence.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microscope

Olympus BHTU Upright Light Microscope
Light Microscope for viewing tissue or cell samples on microscope slides. 45mm parfocal distance system, corrected for a mechanical tube length of 160mm. Two types of standard objectives, D Achromats and D Plan Achromats, magnifications of 4x, 10x, 20x, 40x, 100x. FN20. Equipped for epifluorescence microscopy.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microscope

Olympus IMT-2 Inverted Light Microscope
Light Microscope use to view cell/slice/tissue culture samples (microscope slide or petri dish). Inverted research microscope equipped with phase contrast optics.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microscope

Zeiss S-16 Light Microscope
Light Microscope used to view 1 micron sectioned resin-embedded samples.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microscope

NIKON C1Si Spectral Live Cell Confocal Inverted Microscope System
For use with microscope slide. Four diode lasers that excite at 402, 488, 561, & 638 and has spectral capabilities. Suitable for tissue, live cell imaging, time events, FRAP, FRET, deconvolutions, colocalization analysis and 3D reconstructions.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Microscope

Olympus Fluorescent Microscope BX41
Image Pro Imaging Software. Excitation available 330-385nm, 460-490nm, 510-550nm. Magnifications of 20,40, 100, 200 power. Both reflected light and sample fluorescence may be viewed through and recorded at the microscope.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Microscope

Olympus BX41 General Use Microscope
Optical system: UIS2. Built in transmitted Koehler illuminator, 6V/30W bulb. Stage height movement by roller guide, stroke per rotation: 36.8mm. Full stroke range: 25mm. FN20, tube inclination 30 degrees. Stage size: 188 x 134 mm.

Multiplex Facility

Contact: Suzanne de la Monte

Microscope

Olympus BX60
High-resolution digital pictures using conventional manual filter cubes or more versatile automated filter wheels, and can superimpose multi-color pictures

Multiplex Facility

Contact: Suzanne de la Monte

Microscope

Olympus Inverted CKX31 Fluorescent Microscope
Inverted microscope with the capability of a fluorescence illuminator for GFP; documentation of images with digital imaging and video monitoring. Use for petri dishes, culture flasks, and multi-well plates.

Multiplex Facility

Contact: Suzanne de la Monte

Microscope

Olympus Inverted Fluorescent microscope
FN22. 9mm stroke, coaxial coarse and fine focusing knobs. Long working distance universal condenser.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Microscope - Electron

Morgagni 268 Fully Digitized Transmission Electron Microscope (TEM)
Ultrastructural analysis (tissue, cells) on stained ultra-thin sections contrasted with uranyl acetate and lead citrate. Examined with Morgagni 268 transmission electron microscope that is fully digitized, high performance, 100 kv, and images collected with an AMT Advantage 542 CCD camera system.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Imaging System

LI-COR Odyssey Classic Infared Imaging system
This near-infared fluorescent detector can be used for quantitative western blots, gel shift assays, coomassie stains, tissue section and small animal imaging.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Imaging System - Gel Imager

UVP GelCam 310 Bioimaging digital gel documentation system
High resolution 2.0 GelCam 310 CCD with manual zoom lens for fluorscent and colorimetric gel imaging. EtBr filter included.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Microscope

Nikon Eclipse TS-100F Inverted Microscope
This phase contrast microscope used for tissue culture is also equipped with FITC and TRITC filters to capture fluorescent images in SPOT imaging software.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Microscope

Nikon Eclipse 90i Upright Research Microscope
This microscope is equipped with two cameras (color and monochromatic) and is ideal for brightfield and/or epi-fluorescent images of whole tissues etc with 4x, 10x, 20x and 40x dry objectives. The filter cubes available are DAPI, FITC, and TRITC.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Imaging System

PerkinElmer FMT 4000 Fluorescence Tomography System.
The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. The system comes with four excitation laser channels (635, 680, 750, and 790 nm) and is useful for a range of applications including oncology, inflammation, and cardiovascular disease. It is ideal for researchers who are well-versed in 3D fluorescence tomography and require the widest range of in vivo applications and imaging agents.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Imaging System

Faxitorn Pre-clinical imaging system
Ultra-high resolution x-ray imaging is an important tool in investigating�a variety of disease states. From metastatic cancer to arthritis and�osteoporosis, small animal models are commonly used. Both in vivo and�ex vivo planar imaging is used to screen, track, and evaluate structural�changes in these studies. Cabinet x-ray systems allow researchers to�take images directly in the vivarium to protect the integrity of the colony. �These planar imaging systems are less expensive, subject animals to�lower doses, and provide faster results than microCT systems.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Microscope

Olympus SZ61 Zoom Stereomicroscope
Greenough design with two optical paths inclined at an inward angle. Magnification range 0.67X to 4.5X; zoom ratio 6.7:1; FN 22. Working distance of 100mm; observation tube angle 45 degrees; right and left eyepiece tubes interlocked; interpupillary distance adjustment 50-76mm; forward positioned zoom adjustment knobs with zoom magnification graduations. With 0.5x cmount for documentation.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Imaging System

Xtreme back illuminated 4MP with x-ray for small animal imaging
High sensitivity luminescence, fluorescence, radioisotopic, and radiographic imaging for up to 5 mice at a time. Isofluarne and temperature controlled chamber for the mice.

Bioengineering Core

Contact: Braden Fleming, PhD

Imaging System - Camera

Qualisys Oqus 5-Series
The Oqus cameras are designed to capture accurate mocap data with very low latency and works with both passive and active markers.

Bioengineering Core

Contact: Braden Fleming, PhD

Microscope

Asylum Research MFP-3D-BIO
atomic force microscope

Bioengineering Core

Contact: Braden Fleming, PhD

Microscope

Nikon TiU inverted microscope
Inverted Microscope

Providence College
FacilityInstrument/Service/Resource Unit
PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Imaging System - Camera

Fastec HiSpec1, Low-Light High-Speed Camera
Innovative Low-Light High-Speed Camera. Monochrome with 2GB Memory, C-Mount, includes ImageBLITZ Auto Trigger, Burst Trigger Mode, Multi- Sequence Record Mode (1280 x 1024 at 506fps) 2 Units

PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Microscope - Electron

Philips EM-300 Transmission Electron Microscope (TEM)
Transmission electron microscopy

PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Sample Preparation - Laboratory - Prep Lab

Electron Microscopy Prep Lab
Laboratory space for preparing samples for electron microscopy

PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Microscope - Electron

Amray-1000 Scanning Electron Microscope (SEM)
Scanning Electron Microscope equipped with EDEX for elemental analysis and a digital imaging system, a Zeiss Axiophot equipped for bright field, dark field, DIC and fluorescence microscopy with a digital imaging system

PC - Sowa Hall Labs

Contact: Charles Toth

Microscope

Zeiss LMS 700 Flexible Confocal Microscope
Performs fluorescence measurements, creates optical sections of samples and combines them into 3D image stacks.

Rhode Island College
FacilityInstrument/Service/Resource Unit
RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microscope

American Optical Series 10 Fluorescence Microstart
Microscopy course

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microscope

Nikon E600 Epifluorescence with DIC/Phase and digital camera
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microscope

Olympus CKS41 Inverted Microscope
Tissue culture general use

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microscope

Olympus Compound Light Microscope
General use

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microscope

Olympus FluoView 1000 Laser Scanning Confocal Microscope
Research and Microscopy course

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microscope

Olympus Inverted Epifluorescence Microscope with digital camera
Tissue culture/Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microscope

Zeiss SteREO discovery V8 Microscope with Digital Camera
Research

Rhode Island School of Design
FacilityInstrument/Service/Resource Unit
RISD Nature Lab

Contact: Neal Overstrom

Microscope

Phenom G2Pro Scanning Electron Microscope (SEM)
Desktop Scanning Electron Microscope with ProSuite tiling and remote access software

RISD Nature Lab

Contact: Neal Overstrom

Microscope

Olympus SZX16 Stereomicroscope
Light microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software

RISD Nature Lab

Contact: Neal Overstrom

Microscope

Olympus IX51 Inverted Fluorescent/Brightfield Microscope
Fluorescence/brightfield microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software

RISD Nature Lab

Contact: Neal Overstrom

Microscope

Olympus CH30 Upright Light Microscope
Upright light microscope with 5 MP Jenoptik digital camera, Canon Vixia HFS20 HD video camera, computer workstation, graphics and imaging software (2 units)

RISD Nature Lab

Contact: Neal Overstrom

Microscope

Olympus SZ40 Stereomicroscope
Light microscope with 5 MP Jenoptik digital camera, computer workstation, graphics and imaging software

RISD Nature Lab

Contact: Neal Overstrom

Microscope

Olympus SZ30 Stereomicroscope
Light microscope with LED illuminator (24 units)

The Providence VA Medical Center
FacilityInstrument/Service/Resource Unit
Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Imaging System - Slide Scanner

Aperio ScanScope CS Digital Slide Scanner CS
Brightfield 5 slide scanner with two workstations with Aperio brightfield imaging analysis software.

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Imaging System - Slide Scanner

Aperio Scan Scope FL Fluorescent Digital Slide Scanner
5 slide scanner with Indica Labs fluorescence imaging analysis software.

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Imaging System - Echocardiograph

VisualSonics, Vevo 2100 Imaging System
A high-frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode. The Vevo 2100 Imaging System enables in vivo visualization, assessment, and measurement of anatomical structures and hemodynamic function in longitudinal imaging studies for small animal phenotyping.

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Microscope

Nikon Ni-E upright research microscope
Capture both phase, DIC, brightfield and fluorescence images at high magnification with enhanced features such as Z-stack imaging and multi-channel

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Imaging system - Laser Doppler

Moor instruments, laser Doppler imaging system
Laser Doppler Imaging examines blood flow non-invasively. Used to examine blow flow in capillary beds in response to pulmonary hypertension, exercise, and/or ischemia/reperfusion.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Marine Science Research Facility

Contact: Rodrique Spinette

Imaging System - Camera

Allied Digital Stingray Firewire Microscope Camera
Captures video and still images (C-mount)

Genomics & Sequencing Center

Contact: Janet Atoyan

Imaging System - Camera

Zeiss AxioCam HRc high-resolution imaging systems
A digital Zeiss AxioCam HRc high-resolution camera and for laser scanning microscopy with a Zeiss LSM 700 confocal module. For use on the AxioImager upright light microscope

Marine Science Research Facility

Contact: Rodrique Spinette

Analyzer - Fluid Particle Counter and Imager

Fluid Imaging Technologies FlowCam
Imaging Particle Analysis: counts and records images of particles in liquid samples

Centralized Research Core Facility

Contact: Al Bach

Imaging System - Gel Imager

GE Imagescanner II
Gel imager

Centralized Research Core Facility

Contact: Al Bach

Imaging System - Gel Imager

GE Typhoon FLA 9000 Multimode Imager
Gel imager

Centralized Research Core Facility

Contact: Al Bach

Imaging System - Gel Imager

Li-Cor Odyssey IR Imager
IR gel imager

Centralized Research Core Facility

Contact: Al Bach

Microplate Reader

BMG LabTech Microplate Reader
Fluorescence/UV/VIS

Centralized Research Core Facility

Contact: Al Bach

Microplate Reader

Molecular Devices SpectraMax M2
Fluorescence/UV/VIS

Centralized Research Core Facility

Contact: Al Bach

Microplate Reader

Promega GlowMax System
Chemiluminescence

Centralized Research Core Facility

Contact: Al Bach

Microscope

Nikon Eclipse E600 Upright Microscope
Microscope

Centralized Research Core Facility

Contact: Al Bach

Microscope

Nikon TE2000E /C2 Inverted Confocal
Confocal Microscope

Marine Science Research Facility

Contact: Rodrique Spinette

Microscope

Nikon inverted Microscope
Microscopy: Works with Stingray Camera

Marine Science Research Facility

Contact: Rodrique Spinette

Microscope

Olympus SZX16 Stereo Microscope
Microscopy. Works with Stingray Camera

Genomics & Sequencing Center

Contact: Janet Atoyan

Microscope

Zeiss AxioImager M2 Upright Light Microscope
For use with the AxioImager upright light microscope equipped for digital image acquisition with a Zeiss AxioCam HRc high-resolution camera and for laser scanning microscopy with a Zeiss LSM 700 confocal module

Cell Analysis and Sorting Core

Contact: Loren Fast, PhD

Imaging System - Plate Reader

Biotek Cytation 3
Imaging plate reader; 5 colors (brightfield, GFP, RFP, DAPI, Cy5); 10x, 20x, 60x objectives

Cell Analysis and Sorting Core

Contact: Loren Fast, PhD

Microscope

Life Technologies Evos FL, Fluorescence Microscope
Fluorescence microscope; 4 colors (GFP, RFP, DAPI, Cy5); 10x, 40x, 100x objectives

Imaging/Studio Production

Rhode Island School of Design
FacilityInstrument/Service/Resource Unit
RISD Media Resources

Contact: Neal Overstrom

Imaging System - Audio|Visual

Kodak zi 10 Video Camera (8 units)
Portable HD pocket camcorder, batteries, adaptor cables, cases, accessories

RISD Media Resources

Contact: Neal Overstrom

Imaging System - Audio|Visual

H4N ZOOM Audio Recorder (5 Units)
High performance portable digital audio recorder, batteries, adaptor cables, cases, accessories

RISD Media Resources

Contact: Neal Overstrom

Imaging System - Audio|Visual

ZOOM Q3 Video Camera (7 Units)
Portable palm camcorder, batteries, adaptor cables, cases, accessories

RISD Media Resources

Contact: Neal Overstrom

Imaging System - Audio|Visual

EPS-SonyPMWEX1R-01 (2 Units)
High performance HD CMOS solid state video camera, batteries, portable hard drive, adaptor cables, cases, studio lighting equipment, accessories

Informatics

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Bioinformatics Core

Contact: Christopher Hemme, PhD

Bioinformatics Analysis

Service
We provide bioinformatics consultation and services to the Rhode Island INBRE community and to the general scientific community of Rhode Island. In addition to traditional bioinformatic services, our Core is expanding to 3D/VR/AR visualization services in conjunction with the URI 3D Visualization Laboratory. We are currently developing 3D/VR visualization apps for a variety of platforms including smartphones, Vive/SteamVR, and others. We also have access to the 3D printer at the URI 3D Visualization Core for printing of marcomolecules at a reasonable price. Please contact us for inquiries, collaborations, demos or services at hemmecl@uri.edu.

Marine Science

Providence College
FacilityInstrument/Service/Resource Unit
PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Aquatic System

Aquatic Habitats Glass Tank System and Life Support Controller
Glass tank system and life support controller with low water level protection (18-10 gallon tanks)

Rhode Island College
FacilityInstrument/Service/Resource Unit
RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Aquatic System - Wet Lab / Aquarium room

Aquaria and related equipment
Research

Rhode Island School of Design
FacilityInstrument/Service/Resource Unit
RISD Nature Lab

Contact: Neal Overstrom

Aquatic System

Marine Ecological Habitats Closed-System Aquarium
560 L closed-system recirculating marine holding tanks with temperature control (2 units)

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Marine Science Research Facility

Contact: Rodrique Spinette

Analyzer - Dissolved Gas

Bay Instruments Membrane Inlet Mass Spectrometer- Dissolved Gas Analyzer
Mass Spectrometer: Quantifies dissolved gases

Marine Science Research Facility

Contact: Rodrique Spinette

Analyzer - Multiparameter Water Analyzer

YSI Professional Plus Hand Held Multiparameter Water Meter
Measures temperature, salinity, dissolved oxygen (DO), and pH

Marine Science Research Facility

Contact: Rodrique Spinette

Analyzer - Nutrient

Lachat QuickChem 8500 Flow Injection Nutrient Auto Analyzer
Measures dissolved nutrients in water, Ammonia, Phosphate, Nitrite, Nitrate, and Silicate

Marine Science Research Facility

Contact: Rodrique Spinette

Fluorometer

Satlantic Fluorescence Induction Relaxation Fluorometer (FIRE)
Measures variable fluorescence in phytoplankton

Marine Science Research Facility

Contact: Rodrique Spinette

Incubator

Percival Incubator/Growth Chamber
Temperature and light controlled incubator for environmental applications

Marine Science Research Facility

Contact: Rodrique Spinette

Radiometer

Biospherical Instruments Quantum Scalar Laboratory (QSL) Radiometer - PAR Light Meter
Measures Photosynthetically Active Radiation (PAR)

Marine Science Research Facility

Contact: Rodrique Spinette

Spectrometer

Ocean Optics Jaz Spectrometer
Optical sensing instrumentation that measures light wavelengths. Its unique features and expandable platform makes it uniquely suited for field applications, remote sensing, process flow and quality assurance.

Marine Science Research Facility

Contact: Rodrique Spinette

Vacuum Manifold

Vacuum Filter Manifold
Allows for filtration of 5 ports simultaneously, 25 and 47 mm filter cups available

Marine Science Research Facility

Contact: Rodrique Spinette

Aquatic Culture - Algae and Live Feed Room

Various manufacturers
K-walls, small rearing tanks for live feed, flowing seawater and freshwater

Marine Science Research Facility

Contact: Rodrique Spinette

Aquatic Culture - Phytoplankton Culture Wheels

Various manufacturers
Motorized and water driven, clear plexiglass, ambient and experimental temperature control, can accommodate culture bottles of differing sizes (1-3L)

Marine Science Research Facility

Contact: Rodrique Spinette

Aquatic System - Dechlorination System - Freshwater

Various manufacturers
2 Freshwater dechlorination tanks

Marine Science Research Facility

Contact: Rodrique Spinette

Environmental Chamber

EnvironAir Environmental Chamber
100 sq ft Temperature control, Two range 4-24 C, Two range -4-24 C (to simulate polar conditions), On generator back up and emergency monitoring systems. (4 Units)

Marine Science Research Facility

Contact: Rodrique Spinette

Aquatic System - Flowing Seawater System

Various manufacturers
Raw-Ambient temperature and Filtered- Chilled, Heated, Ambient. UV treated, air supply, emergency monitoring systems

Marine Science Research Facility

Contact: Rodrique Spinette

Biospecimen Banking - Freezer - Walk-in

-20 C Walk-In Freezer
185 sq ft Long term storage, On generator back up and emergency monitoring systems

Marine Science Research Facility

Contact: Rodrique Spinette

Photoperiod controller

Various manufacturers
Wattstopper controller(Blount), Various individual timers

Marine Science Research Facility

Contact: Rodrique Spinette

Pier Access

Access to Graduate School of Oceanography pier
Access to pier for deployment, collection, testing. Water depths 18-15 feet to intertidal zone

Marine Science Research Facility

Contact: Rodrique Spinette

Aquatic System - Laminar Flow Tank

Laminar Flow Tank
1000 gal, Seawater or Freshwater, Multiple speeds with precision control. Experimental chamber visable from 5 sides

Marine Science Research Facility

Contact: Rodrique Spinette

Aquatic System - Mesocosm Tank

Various manufacturers
10, 5 ft deep outdoor mesocosms, with available raw ambient seawater flow

Marine Science Research Facility

Contact: Rodrique Spinette

Worksation - Marine General Wet Lab

Various manufacturers
3 Buildings, 7,000 sq ft indoor, and nearly unlimited outdoor space, Multiple insulated tank sizes, various sized aquaria, possible to perform simultaneous replicates

Marine Science Research Facility

Contact: Rodrique Spinette

Workstation - Marine Pathology and Transgenics Laboratory and Systems

Various manufacturers
Ozone treated effluent and separate effluent drain

Microbiology

Bryant University
FacilityInstrument/Service/Resource Unit
Bryant Unistructure Science Spaces

Contact: Dan McNally

Biological Safety Cabinet

LABGARD ES class II, type A2 Biological Safety Cabinet
Maintain sterility and contain infectious work

Bryant Unistructure Science Spaces

Contact: Dan McNally

Workstation - Anaerobic Chamber

Microbiology International Whitley DG250 Anaerobic Workstation
Simulate anoxic environments for anaerobic work

Bryant Unistructure Science Spaces

Contact: Dan McNally

Workstation - Anaerobic Chamber

MBRAUN Labstar Anaerobic Glovebox Workstation
simulate anoxic environments for anaerobic work

Molecular & Cell Biology

Brown University
FacilityInstrument/Service/Resource Unit
Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Cell Counter

Life Technologies Automated Countess Cell Counter
Measure cell count and viability (live, dead, and total cells) using the standard trypan blue technique.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Bioanalyzer

Agilent Bioanalyzer 2100
Microfluidics-based platform for sizing, quantification and quality control of DNA, RNA, proteins and cells

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Analyzer - Fragment

Advanced Analytical, Fragment Analyzer
Capillary Electrophoresis - Analyze DNA fragments for Next-Gen Sequencing, genotyping, checking RNA quality and quantity, and working with microsatellite simple sequence repeats (SSRs).

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Centrifuge

Sorvall Legend T Benchtop
Low to medium speed centrifugation

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Centrifuge - Ultra

Beckman Coulter Optima Max UltraCentrifuge
High speed centrifugation with MLA130, TLA110 & TLA100 Rotors

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Disrupter

Covaris S220 High Performance Ultrasonicator
DNA, RNA, and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Imager and Microplate Reader

BioTek Cytation 3 Cell Imaging Multi-Mode Reader
UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence

Media Prep Kitchen

Contact: Kristi Wharton

Drosophila Media Preparation

Service
The Brown Fly Facility is dedicated to providing investigators with high quality media for Drosophila research. The media kitchen is equipped with a food service quality steam kettle fitted with stirring unit, a Steris autoclave and a Lancer Washer fitted with custom racks for glass vials. Media is dispensed using Filamatic and Materflex/ Digistalic pumps. In the centralized kitchen, a standard cornmeal, sucrose, yeast medium is prepared and dispensed into different sized culture vessels.  Media is prepared in a steam-jacketed food kettle and pumped into trays of glass vials (10ml), plastic vials (10ml) or into plastic bottles (30ml) depending on research needs. Media is prepared according to a strict protocol that ensures consistency in diet and the absence of any bacterial, fungal or insect contamination. Researchers using glass vials return them to the facility where they are autoclaved, washed, and filled again.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

PCR Thermal Cycler - Digital

QX200 Droplet Digital (ddPCR) PCR System
Provides absolute quantification of target DNA or RNA molecules for EvaGreen or probe-based digital PCR applications.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

PCR Thermal Cycler

Applied Biosystems ViiA 7 Real-Time PCR System
Medium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

PCR Thermal Cycler

Applied Biosystems ViiA 7 Real-Time PCR System
Medium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput

BioBank, Rhode Island

Contact: Garrett Sullivan

Robotic Workstation - Sample Preparation

Qiagen QiaCube
DNA, RNA or Protein Purification

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Spectrophotometer

Thermo Scientific Nanodrop One
A microvolume spectrophotometer for measuring DNA, RNA, and protein.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Technical Assistance - Affmetrix Microarray

Service
Service to provide Affymetrix gene expression array service

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Technical Assistance - NGS Library Quality Control

Service
Analysis of library size distribution and qPCR quantification

Bryant University
FacilityInstrument/Service/Resource Unit
Bryant Unistructure Science Spaces

Contact: Dan McNally

PCR Thermal Cycler

Bio-Rad PCR Thermocycler C1000 Touch; Fraction Collector model 2110
DNA amplifier

Bryant Unistructure Science Spaces

Contact: Dan McNally

Spectrophotometer

Thermo Scientific AquaMate Plus
UV/Vis spectrophotometer for quantifying concentrations

Bryant Unistructure Science Spaces

Contact: Dan McNally

Spectrophotometer

Shimazdzu HPLC--equipped with UV/Vis and Evaporative light scattering detectors
UV/Vis spectrophotometer for quantifying concentrations

Bryant Unistructure Science Spaces

Contact: Dan McNally

Biospecimen Banking - Freezer

Thermo Scientific Isotemp Basic U86-13A41 minus 70 degree freezer
Long term storage of biological specimens

Bryant Unistructure Science Spaces

Contact: Dan McNally

Sample Preparation - Freeze Dry System

Labconco FreeZone 4.5
Freeze dryer

Bryant Unistructure Science Spaces

Contact: Dan McNally

PCR Thermal Cycler

BioRad CFX96 touch RT-PCR
This real-time pcr instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format.

Care New England - Women and Infants Hospital
FacilityInstrument/Service/Resource Unit
Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Imaging System - Gel Imager

Bio-Rad Chemidoc XRS
The ChemiDoc XRS+ system is based on CCD high-resolution, high-sensitivity detection technology and modular options to accommodate a wide range of samples and support multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. The system is controlled by Image Lab software to optimize imager performance for fast, integrated, and automated image capture and analysis of various samples.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Imaging System - Gel Imager

Bio-Rad Molecular Imager FX system
Imager with 50 micron resolution and a 5 order of magnitude linear dynamic range for fluorescence and radioisotopic imaging. You can also image and accurately quantitate chemiluminescent samples.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Cell Sorter - Magnetic

Miltenyi AutoMACS Magnetic cell sorter
Automated cell sorter, for separating cell suspensions labeled with magnetic beads

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microplate Reader

Molecular Devices Spectramax Gemini EM Fluorescence Microplate Reader
Enables top and bottom reading of microplates over a greater range of fluorescence intensities all without the use of filters.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microplate Reader

Perkin Elmer TopCount NXT Microplate Scintillation and Luminescence Counter
TopCount NXT analyzes two, six, or twelve samples at a time, and counts samples in 24-, 96-, and 384-well microplates, as well as microcentrifuge tubes. It can count gammas, betas, or luminescent samples.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

PCR Thermal Cycler

Applied Biosystems ABI 7500
96-well quantitative PCR

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Spectrophotometer

Bio-Rad smartspec
90-260 V, UV/visible benchtop spectrophotometer for nucleic acid and protein quantitation, wavelength range 200–800 nm, built-in thermal printer

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Spectrophotometer

Thermo Scientific NanoDrop 2000
A full spectral microvolume UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Suspension Array System

Bio-Rad BioPlex 200
Detection and quantification of multiple analytes (proteins and peptides, or nucleic acids) in a single sample volume.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Fluorescence Activated Cell Sorter (FACS)

Thermo Scientific Attune NXT
Analytical flow cytometer: 4 lasers, 14 colors, with 96 well plate handler capability

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Analyzer - Nanoparticle counter

Malvern Nanosight NS300
Analysis of size distribution and concentration of nanoparticles from 10nm to 2000nm in diameter. A 532nm green laser also allows the detection of red fluorescent particles. A syringe pump allows sample analysis under constant flow, increasing reliability and reproducibility of data.

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Molecular Core

Applied Biosystem PRISM 7000 Sequence Detection System, Bio-Rad ChemiDoc Molecular Imager
The molecular core offers the capability of performing PCR analysis, quantitative real-time PCR analysis, and digital gel documentation. 

Community College of Rhode Island
FacilityInstrument/Service/Resource Unit
CCRI Biology Labs

Contact: David Vito

Autoclave

Consolidated Stills & Sterilizers 24D36
Sterilization. Chamber size is 24inch x36inch, Volume 9.4 cu. Ft

CCRI Biology Labs

Contact: David Vito

Balance - Analytical

Orion Analytical Balance
Weight determination with capacity of 60g.

CCRI Biology Labs

Contact: David Vito

Balance - Top Loading

EK-I Compact Balance
Weight determination (2 units)

CCRI Biology Labs

Contact: David Vito

Incubator

Fisher Scientific Isotemp Digital & Analog Dry Bath Incubator
Provide controlled dry heat environment for clinical & general chemistry applications

CCRI Biology Labs

Contact: David Vito

Electrophoresis System

Bio-Rad Mini-Protean Tetra Cell, Vertical protein electrophoresis gel boxes
Running Protein or DNA polyacrylamide gels

CCRI Biology Labs

Contact: David Vito

Microscope

Lieder MI-500 Series Compound Inverted Microscope
Tissue Culture

CCRI Biology Labs

Contact: David Vito

pH Meter

Thermo Scientific Orion 2-Star Bench Top pH Meter
General purpose measurements

CCRI Biology Labs

Contact: David Vito

Western Blotting System, Semi-Dry

Shelton Scientific Semi-Dry Blotting System
Transfer of protein, RNA & DNA gels to a solid membrane support for visualization, 24cmx30cm.

CCRI Biology Labs

Contact: David Vito

Spectrophotometer

Thermo Scientific Genesis 20 Visible Spectrophotometer
UV spectrophotometer for quantifying concentrations

CCRI Biology Labs

Contact: David Vito

Imaging System - Gel Imager - Transilluminator

FOTODYNE Foto Phoresis UV Transilluminator
Imaging-protein gel analysis, GFP Analysis

CCRI Biology Labs

Contact: David Vito

Incubator - Shaker

Lab Companion IS-971 Floor Model Incubator Shaker
Growing of bacteria, 250 L chamber

CCRI Biology Labs

Contact: David Vito

Biological Safety Cabinet

NuAire Class II Type A2
Maintain sterility and contain infectious work

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Chemical Hood

Labconco Protector Premier Fume Hood
Suitable for providing personal protection needed for general chemistry applications involving fumes and vapors.

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Incubator - Shaker

Lab Companion SI-600 Incubated Shaker
Bacterial culture shaker with a temperature of ambient to +60C.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

PCR Thermal Cycler

Bioer Life ECO thermal cycler
This thermal cycler has a 96 well format with a 2C/sec ramp rate.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Bioanalyzer

Agilent Bioanalyzer 2100
The Agilent 2100 Bioanalyzer system provides sizing, quantitation and quality control of DNA, RNA, proteins and cells on a single platform, providing high quality digital data.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Bioanalyzer

Agilent Bioanalyzer 2100
Microfluidics platform (electrophoresis and flow cytometry) for sizing, quantification, and QC of DNA, RNA, proteins, and cells. Sample size= 1-4 microliters.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Biological Safety Cabinet

HEPA filter and NuAire laminar flow hood
Filter capable of removing 99.97% of particles greater than 0.3 micronss.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Centrifuge

Eppendorf 5424 Microcentrifuge
Aerosol-tight rotor. Max rcf: 20,238 x g. Automatic lid opening following application sequence. Low access height: 23 cm. Short spin, rpm/rcf setting as required

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Centrifuge

ThermoForma refrigerated Microcentrifuge
Working temperatures from -5 C to +40 C.

Multiplex Facility

Contact: Suzanne de la Monte

Centrifuge

Beckman- Coulter Allegra 64R Refrigerated Centrifuge
For use with 50 mL conical tubes.

Multiplex Facility

Contact: Suzanne de la Monte

Disrupter

Siegen Tissue Lyser
Disrupts multiple biological samples through high speed shaking in plastic tubes with steel, tungsten carbide, or glass beads. Up to 48 samples can be processed simultaneously.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

High Performance Liquid Chromatography (HPLC)

Bio-Rad DuoFlow Biologic HPLC
Medium-pressure chromatography system. 100/120 V, F10 workstation, mixer, AVR7-3 valve, UV detector with flow cell and filters. Flow rate= 0.01-10 ml/min.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

High Performance Liquid Chromatography (HPLC)

Transgenomic Wave DHPLC System
Detect mutations/ polymorphisms by Denaturing High Performance Liquid Chromatography (DHPLC). Uses SURVEYOR nuclease cleavage. Identifies single nucleotide polymorphisms (SNPs) or small insertions/ deletions.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Histology/Tissue Processing - Balance

Mettler (PB303-S) semimicro balance
Mass range of 0.01 mg- 120 g.

Core Research Laboratories - Rhode Island Hospital

Contact: Suzanne de la Monte

Hybridization Oven

Panomics-Luminex Hybridization oven
Horizontal air flow oven for optimal temperature uniformity.

Multiplex Facility

Contact: Suzanne de la Monte

Microplate Reader

Molecular Dynamics M5 Spectracount
Cross talk (96-well): 3X 10-5, sensitivity: <20 attomol ATP per well, <0.2 firely luciferase per well, spectral range: 380-630 nm.

Multiplex Facility

Contact: Suzanne de la Monte

Microplate Reader

Packard-Perkin Elmer Topcount
Analysis of cell proliferation, receptor binding assays, solid phase RIA/LIA, reporter gene assays, 51Cr release assays, HPLC fraction analysis, scintillation proximity assays, etc.

Multiplex Facility

Contact: Suzanne de la Monte

Microplate Reader

Molecular Devices UV Max Microplate Reader
96-wellplate reader. Spectral range: 405-630 nm.

Multiplex Facility

Contact: Suzanne de la Monte

PCR Thermal Cycler

Roche Lightcycler 4810
Exchangeable 96 or 384 multiwell plate format. Ideal for multiplexing and automated workflows. Provides various methods for gene detection, gene expression analysis, genetic variation analysis and array data validation.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

pH Meter

Accumet pH meter
pH meter.

Multiplex Facility

Contact: Suzanne de la Monte

Robotic Workstation - DNA Extraction

QUIAGEN Biorobot EZ1
Fully automated purification of genomic DNA from human whole blood and viral nucleic acids from serum or plasma samples.

Multiplex Facility

Contact: Suzanne de la Monte

Robotic Workstation - Pipetting

Eppendorf EpMotion 5070
Automated pipetting. Four deck positions can hold tips, reagent reservoirs, single tubes, tube racks, micro-plates, or PCR plates with up to 384 wells. Suited for serial dilutions, reagent distribution, transfer from tubes to plates and normalization.

Multiplex Facility

Contact: Suzanne de la Monte

Robotic Workstation - Pipetting

Tecan Genesis 200 Robot
Automated robot for pipetting tasks. Two arms- the LiHa (liquid handler) and the RoMa (robot manipulator). LiHa- conductivity-sensing 8-channel pipetting arm dispenses volumes of 5-1000 L; RoMa- manipulating arm picks up and moves objects on the workstation.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Robotic Workstation - Liquid Handler

Perkin Elmer JANUS Automated Workstation
Automated Sterile Liquid Handler. 2 arm system, with 4- or 8-tip arm plus a 96/384 MDT arm. Arms include 4-tip or 8-tip dispense arms for transfer from tubes to vials to plates.

Multiplex Facility

Contact: Suzanne de la Monte

Spectrophotometer

Thermo Scientific NanoDrop 2000
Measures DNA, RNA, and protein concentrations, and purity (A260/A280 ratio). Conc. range= 2 ng/microliter-15,000 ng/microliter; Min Sample size = 0.5 microliter.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Spectrophotometer

Eppendorf BioPhotometer
50 microliter volumes. Automatic calculation of dilution factors. Measures wave lengths: 230, 260, 280, 340, 405, 490, 550, 595, 650 nm. Spectral bandwidth: 5nm at 230-340nm, 7nm at 405-650nm. Photometric random error +/- 0.002A at 0A, +/- 0.005A at 1A.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Spectrophotometer

Amersham Biosciences UV/Visible Spectrophotometer Ultrospec 1100
Wavelength range: 200-900 nm. Spectral bandwidth: 5 nm Wavelength accuracy - 2 nm. Wavelength reproducibility: - 0.5 nm.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Spectrophotometer

Thermo Scientific NanoDrop 2000
Measures DNA, RNA, and protein concentrations, and purity (A260/A280 ratio). Conc. range= 2 ng/microliter-15,000 ng/microliter; Min Sample size = 0.5 microliter.

Multiplex Facility

Contact: Suzanne de la Monte

Suspension Array System

Luminex Magpix
Reads magnetic bead-based immunoassays. Automated reading of 96-well plates (~60 min/plate). Multiplex analysis of up to 50 biomolecules in a single sample.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Waterbath

PolyScience refrigerated/heated (9106) circulating waterbath
These quality baths are ideal for calibration, electrophoresis, rotary evaporation, viscometry, or other applications requiring cooling or heating. Standard Digital Controller Bath features ±0.05°C temperature stability down to -20°C

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

PCR Thermal Cycler

Applied Biosystems ProFlex thermal cycler
This thermal cycler has a 3x32 well format that allows for 3 separate programs to be run. The ramp rate is 6C/sec.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

PCR Thermal Cycler

Applied Biosystems Veriti thermal cycler
This thermal cycler has a 96 well format with 3.9C/sec ramp rate.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

PCR Thermal Cycler

MJ Opticon 2 real-time PCR system.
This 96-well system accepts low-profile tubes or plates. There are two fluorophore channels with emission spectra in the 523-543 nm range and 540-700nm.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Incubator

(4) NuAire IR water-jacketed CO2 incubators (NU-8500)
This incubator provides an optimal in-vitro growth environment for both cell and tissue culture while minimizing dessication through a closed loop HEPA filtration system.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Biological Safety Cabinet

(4) NuAire Bio Safety Cabinets (Class II, Type A/B3)
These biological safety cabinets reduce exposure to airborne biological or particulate chemical agents in low to moderate risk-hazard research and/or drug preparations.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Centrifuge

Sorvall Legend X1R centrifuge
Process samples for diverse laboratory applications with rotors for 1.5ml eppendorf tubes, 15, and 50ml conical tubes. Refrigerated with a max speed of 152000 rpm.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Autoclave

Amerex HVE-50 top loading autoclave sterilizer
This is a 50L, self-contained, portable, top-loading autoclave with auto-exhaust and warming cycles.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Luminometer

Promega Glomax 20/20 luminometer with printer
Ultrasensitive luminescence detection in a single microcentrifuge tube (1.5ml) format.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Hybridization Oven

Fisher Scientific Isotemp hybridization chamber
Temperature range of +7C to 85C. Includes a rotisserie.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Microplate Reader

Molecular Devices SpectraMax M2e plate reader
Features top and bottom read capability for absorbance, fluoresence, luminescence, and time-resolved fluorescence.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Bioanalyzer

Invitrogen Luminex 200 with xMap technology
This is a versatile, efficient standard in multiplexing with the ability to use magnetic or polystyrene beads on up to 100 targets/sample.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

pH Meter

Orion pH meter 920
pH range of -2 to 19.99 and oxygen range of -2 to 19.99ppm. Autocalibration buffers of 4.01, 7, and 10.01.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

pH meter

Hanna Instruments 2209
This pH meter features manual pH calibration and temperature compensation.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Incubator

GQF 1502 Sportsman egg incubator
This is a complete incubator and hatching system with 3 automatically turned racks. It has an accurate digital thermostat with LCD of humidity and temperature.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Homogenizer

Fisher Scientific, Powergen 125 Tissue Homogenizer
Process volumes from 0.03 to 100mL. Variable speed control to 30,000rpm for efficient cell disruption. Disposable plastic generators eliminate sample cross-contamination. Flat-bottom stainless-steel generators process liquid or soft tissues.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Disrupter

Qsonica 700W sonicator with 5.5" cup horn
This sonicator has full amplitude control from 1-100%.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

PCR Thermal Cycler, Digital

RainDrop Digital PCR by RainDance
The RainDrop is composed of a Source instrument that can generate 10million droplets/sample and the Sense instrument, which can detect whether the PCR reactions are positive or negative for your fluorophore. Multiplexing is possible for the 8 samples that are run at a time on the microfluidics chip.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

PCR Thermal Cycler

BioRad CFX96 Real-Time PCR system
This real-time PCR instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Spectrophotometer

Thermo Scientific NanoDrop 2000c
This is a full spectrum, UV-Vis spectrophotometer used to quantify and assess the purity of DNA, RNA, protein, and more at sample volumes as low as 0.5ul.

Molecular Biology and Nanomedicine Facility

Contact: Qian Chen

Bioreactor

Flexcell FX5000 Tension System
This is a computer-regulated bioreactor that uses vacuum pressure to apply either cyclic or static strain to cells cultured on flexible-bottomed culture plates.

Providence College
FacilityInstrument/Service/Resource Unit
PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Microtome

Porter-Blum MT-2B Ultramicrotome
Porter-Blum MT-2B UltraMicrotomes, 2 Units

PC - Hickey Hall Labs

Contact: Charles Toth

PCR Thermal Cycler

Stratagene Mx3000p Real-time PCR Thermal Cycler
This instrument is available for gene expression analysis, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Agilent's qPCR software, MxPro, provides users with an intuitive interface, quick experiment design, powerful data analysis and easy report generation.

PC - Hickey Hall Labs

Contact: Charles Toth

Cold Room

Walk-In Cold Room

PC - Hickey Hall Labs

Contact: Charles Toth

Analyzer - Cell Metabolism

Seahorse Biosciencies, XFe Extracellular Flux Analyzers, XFe96
Platform for metabolic assays that simultaneously measures the two major energy producing pathways of the cell - mitochondrial respiration and glycolysis - in a microplate, in real-time.

PC - Hickey Hall Labs

Contact: Charles Toth

Laboratory - Tissue Culture

Tissue Culture Laboratory
Space and instrumentation for tissue culture preparation

PC - Hickey Hall Labs

Contact: Charles Toth

Imaging System - Gel Imager

Licor Odyssey IR (Infrared) Imaging System
Instrumentation for quantitating western blots.

PC - Hickey Hall Labs

Contact: Charles Toth

Fluorescence Activated Cell Sorter (FACS)

Cellometer Vision Image Cytometry
The Vision CBA System combines the simplicity of image cytometry with the power of flow analysis software to offer user-friendly cell-based assays

PC - Hickey Hall Labs

Contact: Charles Toth

Spectrophotometer

Thermo Scientific NanoDrop
UV/VIS

Rhode Island College
FacilityInstrument/Service/Resource Unit
RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Autoclave

Autoclave
Microbiology/Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Biological Safety Cabinet

Labconco class II Biological Safety Cabinet
Used for tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Biological Safety Cabinet

Sterile laminar flow hood
Microbiology prep

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Centrifuge

Eppendorf 5810R Refrigerated Centrifuge
Used for tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Centrifuge

Sorvall Discovery M120SE Mini Ultracentrifuge
Research/Cell fractionation

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Centrifuge

Sorvall Superspeed RC2 Centrifuge
General use

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Centrifuge

Sorvall Superspeed RC5 Plus Centrifuge
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Centrifuge

Thermo IEC Centra CL3R Refrigerated Centrifuge
Genetics and Cell & Molec courses

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Cold Room

Walk-In Cold Room
Large cold room for experimentation and storage

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Dishwasher

Dishwasher
Microbiology/Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Disrupter

French Pressure Cell Press
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Disrupter

Polytron Tissue Grinder
Slide/Sample Preparation

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Disrupter

Sonicator
General use and research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Disrupter

Sonicator with cup
Research and graduate courses

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Electroporation System

BioRad Micropulser Electroporator
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Sample Preparation - Freeze Dry System

ATMO VAC 5009 freeze dryer
Slide/Sample Preparation

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Biospecimen Banking - Freezer

Thermolyne Liquid Nitrogen cryogenic storage system
Cell storage

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Biospecimen Banking - Freezer

Ultralow Freezer
Used for freezing biological samples, 6 units

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Imaging System - Gel Imager

InGenius Syngene Gel Documentation System
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Ice Machine

Ice Machine
General use

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Imaging System - Dark Room

Imaging System - Dark Room
Gel imaging and analysis

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Incubator

Non CO2 Incubator
Used for tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Incubator

Thermo CO2 Incubators
Used for tissue culture, 2 units

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Incubator

Refrigerated Incubator
Used for tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Laboratory - Tissue Culture

Tissue Culture Room
A room outfitted with tissue culture instrumentation

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microplate Reader

Lenovo Automated Plate Reader
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Microplate Reader

Thermo Labsystems Multiskan MMCC/340 plate reader
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Sample Preparation - Oven

Drying Oven
General use

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

PCR Thermal Cycler

BioRad IQS Real time PCR thermocycler
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

PCR Thermal Cycler

Eppendorf Gradient Mastercycler
PCR instrumentation, 2 units

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Incubator - Shaker

Incubator/Shakers
Multiple units

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Spectrophotometer

BioRad SmartSpec Plus
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Spectrophotometer

Eppendorf Biophotometer
Gectrophotometerseral use

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Spectrophotometer

Spectronic 21 D UV/VIS
Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Spectrophotometer

Therm Spectronic Genesys UV/VIS Scanning
Research, 6 units

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Spectrophotometer

Thermo Scientific NanoDrop ND-1000
UV/VIS, 2 units

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Water Purification System

Barnstead Still Water Purifier
General use for teaching labs

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Water Purification System

Millipore DirectQ (X2)
Tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Water Purification System

Millipore NanoPure Diamond
2nd floor research use

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Imaging System - X-ray Film

X-ray film processor
Blot imaging

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Autoclave

Autoclave
Microbiology/Research

RIC - Fogarty Life Sciences Labs

Contact: Eric Hall

Autoclave

Autoclave
Microbiology/Research

The Providence VA Medical Center
FacilityInstrument/Service/Resource Unit
Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Autoclave

Tuttnauer
Equipment: consumable sterilization

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Bioanalyzer

Agilent Bioanalyzer
DNA size & quantification (quality check for downstream analyses, i.e. next gen sequencing)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Analyzer - Genetic

Applied Biosystems 3500 Genetic Analyzer
Capillary Electrophoresis - Analyze fragment length polymorphisms (96 format) (2),

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Centrifuge

Eppendorf Refrigerated Centrifuge
Alcohol precipitation

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Centrifuge

Eppendorf
For centrifuging 96/384 plates

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Mass Spectrometer

Sequenom
high throughput SNP genotyping, epigenetics

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Microplate Reader

BioTek
DNA quantification

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Microplate Reader

Fluidigm End Point Reader
High throughput SNP genotyping

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

PCR Thermal Cycler

Applied Biosystems
384 well DNA amplification for downstream analysis (i.e. sequenom processes) (2 units)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

PCR Thermal Cycler

Applied Biosystems
96 well DNA amplification for downstream analysis (i.e. fragment length polymorphisms)(2 units)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - DNA Extraction

Chemagen/Perkin Elmer Magnetic Separation Module
DNA extraction from blood & saliva

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Liquid Handler

Sequenom Liquid Handler
Transfers PCR chemistries to samples (96/384 format)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Liquid Handler

Sequenom Nanodispenser
Dispenses PCR product to Sequenom chip

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Sample Preparation

Iontorrent/Life Technologies Enrichment System
Simplifies the workflows for the Ion PGM system by providing an automated solution for scalable and reproducible template preparation.

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Sample Preparation

Iontorrent/Life Technologies One Touch
Simplifies the workflows for the Ion PGM system by providing an automated solution for scalable and reproducible template preparation.

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Sample Processing

Thermo Scientific Cap-it-All
Caps tubes to the optimal torque to maintain sample integrity and provide a hands free method to capping and decapping tubes quickly and easily.

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation -Liquid Handler

Beckman Coulter Lab Automation Workstation
Automated liquid handler

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Spectrophotometer

Thermo Scientific NanoDrop
DNA quantification

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Channel Cycling Metabolic System

OmniTech ElectronicsModel #80 AP4RAT AccuPacer 4 Channel Rat Treadmill and #75 MS8 8
For rodent cardiopulmonary exercise Testing

Cell Isolation & Organ Function Core

Contact: Elizabeth Harrington

Spectrophotometer

NanoDrop
Measures the concentration of peptides, DNA and RNA, purified protein, nanoparticles, perform protein assays and optical density measurements

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Marine Science Research Facility

Contact: Rodrique Spinette

Fluorometer

Turner Designs 10-AU (Chlorophyll) Field Fluorometer
Measures extracted or in vivo chlorophyll fluorescence of samples, Field-portable, can be set up for continuous-flow monitoring or discrete sample analyses

Marine Science Research Facility

Contact: Rodrique Spinette

Incubator - Shaker

Thermo Max-Q Orbital Shaker Table
Orbital shaker with 18x24 in platform and variety of clamps

Centralized Research Core Facility

Contact: Al Bach

Synthesizer, DNA/RNA

MerMade-4 Oligonucleotide synthesizer
DNA/RNA Synthesizer

Genomics & Sequencing Center

Contact: Janet Atoyan

Bioanalyzer

Agilent Bioanalyzer 2100
Provides fast and automated separation, sizing and quantification of DNA, RNA and proteins by miniaturized Lab-on-a-Chip electrophoresis

Genomics & Sequencing Center

Contact: Janet Atoyan

Bioinformatics Analysis - DNA Sequence and Protein Analysis

Software: DNAStar Lasergene Core Suite
Comprehensive suite of software modules for DNA, RNA, and protein sequence analysis

Genomics & Sequencing Center

Contact: Janet Atoyan

Bioinformatics Analysis - Next Generation DNA Sequence Assembly

Software: CLCbio Genomics Workbench
Software for analyzing, comparing, and visualizing Next Generation Sequencing data

Centralized Research Core Facility

Contact: Al Bach

Centrifuge

Beckman Avante High Speed Centrifuge
High speed centrifuge

Centralized Research Core Facility

Contact: Al Bach

Centrifuge

Thermo MultiFuge Centrifuge table-top
Centrifuge

Genomics & Sequencing Center

Contact: Janet Atoyan

Centrifuge

Beckman Coulter Allegra 25R Refrigerated Centrifuge
Centrifuge for pelleting cells, tissues and macromolecules

Genomics & Sequencing Center

Contact: Janet Atoyan

Centrifuge

Thermo Savant DNA110 SpeedVac Vacuum Centrifuge
Centrifugal concentration system for drying low-volume ethanol or isopropanol precipitates of DNA and RNA

Centralized Research Core Facility

Contact: Al Bach

Centrifuge - Ultra

Beckman Coulter Optima
Ultra centrifuge

Centralized Research Core Facility

Contact: Al Bach

Centrifuge - Ultra

Sorvall Micro Ultra Centrifuge
Ultra centrifuge

Marine Science Research Facility

Contact: Rodrique Spinette

Disrupter

Biospec Mini Bead Beater
Shakes tubes with beads to disrupt cells, DNA , RNA

Marine Science Research Facility

Contact: Rodrique Spinette

Disrupter

Branson Digital Ultasonic Liquid Sonifier
Disrupts cells

Genomics & Sequencing Center

Contact: Janet Atoyan

Disrupter

Covaris S220 High Performance Ultrasonicator
Automated acoustic disruption and homogenization of cells and tissue samples using focused ultrasonic energy at 500 KHz. Performs DNA Shearing

Genomics & Sequencing Center

Contact: Janet Atoyan

Disrupter

QIAGEN TissueLyser
Provides rapid and efficient disruption of cells and tissues

Genomics & Sequencing Center

Contact: Janet Atoyan

Electrophoresis System

Sage Science BluePippin DNA Electrophoresis System
A preparative electrophoresis platform that separates and extracts DNA fragments using pre-cast gel cassettes

Centralized Research Core Facility

Contact: Al Bach

Evaporator

Buchi RotaVap System
Rotary evaporator

Marine Science Research Facility

Contact: Rodrique Spinette

Fluorometer

Life Technologies Qubit Fluorometer
Quantifies DNA, RNA, and protein

Genomics & Sequencing Center

Contact: Janet Atoyan

Fluorometer

Invitrogen Qubit
Fluorometer that uses fluorescent dyes bound to specific molecules to quantify DNA, RNA and proteins

Marine Science Research Facility

Contact: Rodrique Spinette

Homogenizer

Polytron Homogenizer PT-10-35-GT
Breaks down plant and animal tissue for analysis, and performs homogenization, dispersion, mixing, and prepares emulsions

Genomics & Sequencing Center

Contact: Janet Atoyan

Sample Preparation - Library Preparation System

IntegenX Apollo 324 System NextGen Sequencing (NGS) Library Preparation System
Automated liquid handling instrument dedicated to the preparation of sample libraries for Next Generation Sequencing

Genomics & Sequencing Center

Contact: Janet Atoyan

Microarray Platform

BioLog OmniLog Phenotype Microarray System Plate Incubator/Reader
Uses Phenotype Microarrays in microtiter plates to test for unique phenotypes or cell functions

Marine Science Research Facility

Contact: Rodrique Spinette

Microplate Reader

Molecular Devices Spectramax M5
Measures Fluorescence Intensity, Absorbance, Time Resolved Fluorescence, Fluorescence Polarization and Luminescence in cuvettes and multiple sized microplates.

Centralized Research Core Facility

Contact: Al Bach

PCR Thermal Cycler

Applied Biosystems/Life Technologies ABI Vii7- RT-PCR
RT-PCR

Centralized Research Core Facility

Contact: Al Bach

PCR Thermal Cycler

Eppendorf Mastercycler PCR
PCR

Marine Science Research Facility

Contact: Rodrique Spinette

PCR Thermal Cycler

Eppendorf Master Cycler Pro
Replicates DNA

Marine Science Research Facility

Contact: Rodrique Spinette

PCR Thermal Cycler

Stratagene QPCR Mx3000P
Analysis of gene expression, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Quantitative PCR Filters- FAM/Syber Green, Rox, Hex, CY3, CY5

Genomics & Sequencing Center

Contact: Janet Atoyan

PCR Thermal Cycler

Agilent Mx3005P and Roche LC480 qPCR Systems
3 Quantitative PCR (qPCR) instruments. Used for highly accurate qualitative and quantitative detection of nucleic acids and gene expression .

Genomics & Sequencing Center

Contact: Janet Atoyan

PCR Thermal Cycler

Eppendorf Mastercycler ep Gradient S and MJ Research PTC-100
(3) Thermal cyclers in 96-well format; peltier elements control the temperature of the block for PCR chemistry

Genomics & Sequencing Center

Contact: Janet Atoyan

Workstation - PCR

AirClean Systems 600 PCR Workstation
Combination workstation provides an ISO 5 (FS209E) Class 100 clean air environment and UV light sterilization

Genomics & Sequencing Center

Contact: Janet Atoyan

Robotic Workstation - Automated Pipetting

Eppendorf epMotion 5075 VAC Pipetting Workstation
Automated pipetting workstation enables fast and reproducible liquid handling for a variety of applications

Centralized Research Core Facility

Contact: Al Bach

Robotic Workstation - Liquid Handler

BioTek Precision XS Sample Processor
Sample processor

Centralized Research Core Facility

Contact: Al Bach

Robotic Workstation - RNA/DNA

Fuji Film DNA/RNA Isolation System
DNA/RNA isolation

Genomics & Sequencing Center

Contact: Janet Atoyan

Robotic Workstation - Sample Preparation

QIAGEN QIAcube Spin Column Robot
Automated protocols for purification of plasmid DNA, genomic DNA, RNA, viral nucleic acids, and proteins

Centralized Research Core Facility

Contact: Al Bach

Radiometric Detectors - Scintillation Counter

PerkinElmer Microbeta1450 Scintillation Counter
Scintillation counter

Centralized Research Core Facility

Contact: Al Bach

Radiometric Detectors - Scintillation Counter

PerkinElmer Wizard 1470 Gamma Counter
Gamma counter

Marine Science Research Facility

Contact: Rodrique Spinette

Incubator - Shaker

Thermo Max Q Incubated Shaker
Heated incubated shaker

Centralized Research Core Facility

Contact: Al Bach

Spectrometer

PerkinElmer Luminescence Spectrometer LS55
Fluorescence

Centralized Research Core Facility

Contact: Al Bach

Spectrophotometer

Beckman UV/VIS DU800
UV/VIS

Centralized Research Core Facility

Contact: Al Bach

Spectrophotometer

Thermo Scientific NanoDrop
UV/VIS

Marine Science Research Facility

Contact: Rodrique Spinette

Spectrophotometer

Thermo Scientific NanoDrop 1000
Microvolume UV-Vis spectrophotometer that quantifies DNA, RNA, and protein from small 1-2 microliter sample size

Genomics & Sequencing Center

Contact: Janet Atoyan

Spectrophotometer

Thermo Scientific NanoDrop 8000
Spectrophotometer that accurately measures up to eight individual 1-2 microliter samples simultaneously

Centralized Research Core Facility

Contact: Al Bach

Water Purification System - Deionized (DI)

Millipore Milli-Q Water System
DI water System

Cell Analysis and Sorting Core

Contact: Loren Fast, PhD

Microplate Reader

Perkin-Elmer Envision
Multimodal plate reader- absorbance, luminescence, fluorescence, time-resolved fluorescence, AlphaScreen

Nuclear Science

Rhode Island State Agency
FacilityInstrument/Service/Resource Unit
Rhode Island Nuclear Science Center

Contact: Dr. Cameron Goodwin

Reactor, Research and Test

2 Mega-Watt, light water cooled, pool type reactor
Neutron and gamma irradiation and experimental set-up, as well as analysis

Proteomics

Brown University
FacilityInstrument/Service/Resource Unit
Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Analyzer - Calorimeter

Microcal Isothermal Titration 200 (ITC)
Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Analyzer - Calorimeter

Microcal VP Differential Scanning (DSC)
Measurement of heat changes that occur in biomolecules during controlled increase or decrease in temperature.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Fluorometer - Spectrofluorometer

Horiba Jobin Yvon FluoroMax-4
Fluorescence detection. A heated cell allows temperature studies.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

High Performance Liquid Chromatography (HPLC)

Agilent 1200 HPLC System
High performance liquid chromatography system with: quaternary pump, thermostatted autosampler, thermostatted fraction collector, and a multi-wavelength UV/Vis detector. It can be used for analytical detection of biomolecules and/or their purification.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Liquid Chromatography System

GE Healthcare AktaPrime Plus
The KTA Prime Plus is a low pressure chromatography system that performs simple purifications of tagged and untagged proteins.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Spectrophotometer

JASCO J-815 Circular Dichroism (CD) Spectrometer
Protein folding studies, Protein conformational studies, DNA/RNA interactions, Enzyme kinetics, Purity testing of optically active substances, quantitative analysis of pharmaceuticals, natural products chemistry, biochemistry and macromolecules, rapid scanning (time resolved) experiments. Peltier device for temperature studies.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Spectrometer

Thermo Scientific NanoDrop 8000
A full spectral microvolume (microliter) UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein of 8 samples simultaneously.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Analyzer - Surface Plasmon Resonance (SPR) Sensor

GE Healthcare Biosciences Biacore X 100
Label-free protein interaction analysis provides unique and comprehensive data on the interactions between biomolecules. Performs quantitative kinetic analysis (rate constants), quantitative determination of affinity constants, determination of binding specificity (yes/no), and concentration analysis.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Technical Assistance

Service
Service to provide Proteomics Technal Assistance

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Analyzer

Luminex MAGPIX Multiplexer
Performs up to 50 different tests in a single reaction volume and reads a 96-well-plate in just 60 minutes. MAGPIX features self-cleaning routines and magnetic bead compatibility

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Bioinformatics Analysis - MASCOT

Software: Matrix Science MASCOT Search Engine
Software for MS data analysis through statistical evaluation of matches between observed and projected peptide fragments.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Bioinformatics Analysis - ProteoIQ

Software: NuSep ProteoIQ Mass Spec Data Analysis
Software for post-analysis of MASCOT results. Protein and peptide probabilities generated and protein relative quantitation is performed by spectral counting. Normalized and with standard deviations.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Bioinformatics Analysis - Workstation

Hardware: HP HPZ 800 Workstation
Software (2 workstations available) used in conjunction with ProteoIQ, DXMS, MASCOT analysis.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

High Performance Liquid Chromatography (HPLC)

Dionex UltiMate3000 Nano HPLC
Single gradient and x2 dual configurations. Eluted directly into MS. Min detection= fmole; Min flow rate= 20 nL/min; Max pressure = 800 bar.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Liquid Chromatography- Mass Spectrometer (LC-MS)

Thermo Scientific Q Exactive Plus Mass Spectrometer
Benchtop LC-MS/MS. Combination of high-performance quadrupole with high resolution, accurate-mass (HR/AM) Orbitrap. Max resolving power= 140,000; max scan speed= 12Hz, Intra-scan dynamic range > 5000:, Quadrupole mass filter.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Mass Spectrometer

AB SCIEX QSTAR XL Mass Spectrometer
Identification and analysis of protein structure/conformational change by deuterium exchange mass spectrometry (DXMS). LC/MS/MS- Ionization by MALDI or ESI after HPLC (Dionex) and analyzed by quadrupole and TOF.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Mass Spectrometer

Brucker UltrafleXtreme: Imaging Mass Spectrometry
MALDI-IMS for tissue imaging, intact proteins analysis, protein spatial distribution, glycoproteomics, or biologics (1-2000 Hz repetition rates) of non-injured vs. injured tissues. MALDI/TOF/TOF analysis for proteomic profiling. Minimum diameter = 10 microns.

Multiplex Facility

Contact: Suzanne de la Monte

Suspension Array System

Bio-Rad BioPlex 100
Automated reading of 96-well plates, up to 9,600 data points in about 35 min. Multiplex analysis of up to 100 biomolecules in a single sample via suspension array.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Suspension Array System

Bruker ImagePrep matrix sprayer
Matrix deposition device for MALDI Imaging. Average droplet size ? 20 microns, all droplet dia. are < 50 microns. Lateral resolution of 50 microns in tissue.

Multiplex Facility

Contact: Suzanne de la Monte

Suspension Array System

Bio-Rad Vacuum manifold
Vacuum purification platform for single 96-well plates or individual luer-ended spin columns. Compatible with Bio-Plex 200 suspension array system.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - 1D SDS PAGE Coomasie

Service
Service to provide 1D gel (SDS-PAGE) Coomasie Staining.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - 1D SDS PAGE Silver Stain

Service
Service to provide 1D gel (SDS-PAGE) Silver Stain MS compatible.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Gel Imaging

Service
Service to provide Gel imaging by VersaDoc.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Mass Spectrometry

Service
Service to provide Imaging Mass Spectrometry Data Analysis.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Protein Determination

Service
Service to provide Protein Determination (BCA assay).

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Protein Extraction

Service
Service to provide ReadyPrep Protein Extraction Kit (Sequential Extraction).

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Protein Extraction

Service
Service to provide ReadyPrep Protein Extraction Kit (Total Protein).

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Protein In-Gel Digestion

Service
Service to provide In-gel digestion LC/MS analysis and protein database search.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Protein In-Solution Digestion

Service
Service to provide In-solution digestion LC/MS analysis and protein database search.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Protein Quantification

Service
Service to provide Data interpretation and protein quantification.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Protein Sample Clean-up

Service
Service to provide ReadyPrep 2D Cleanup Kit.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Proteomics Project Consultation

Service
Service to provide Project consultation with the Director of Proteomics - Subsequent Consultation

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Technical Assistance - Proteomics Project Consultation

Service
Service to provide Project consultation with the Director of Proteomics - Initial Consultation

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Mass Spectrometer

Thermo Scientific TSQ Quantiva - Triple Quadrupole Mass Spectrometer
Allows identification and absolute quantification of biomarkers, target proteins/peptides with their known post-translational modifications from any biological samples.

Proteomics Laboratory - Rhode Island Hospital

Contact: Nagib Ahsan, PhD

Microplate Reader

GloMax Discover - Multimode Detection System
Multi-mode detection instrument offering flexible use of filters and includes: high-performance, luminescence, fluorescence, UV-Visible absorbance, BRET and FRET, two-color filtered luminescence and kinetic measurement capabilities

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Centralized Research Core Facility

Contact: Al Bach

Chromatography

Metrohm Ion Chromatography 940 Vario
Ion Chromatography

Centralized Research Core Facility

Contact: Al Bach

Electrophoresis System - Gel Electrophoresis

Agilent Offgel Fractionator 3100
Liquid phase Isoelectric Focusing (IEF) System

Centralized Research Core Facility

Contact: Al Bach

Electrophoresis System - Gel Electrophoresis

Bio-Rad 2D Gel System
Two Dimensional (2D) Gel Electrophoresis

Centralized Research Core Facility

Contact: Al Bach

Electrophoresis System - Gel Electrophoresis

Bio-Rad PAGE Electrophoresis System
One Dimensional (1D) Gel Electrophoresis

Centralized Research Core Facility

Contact: Al Bach

High Performance Liquid Chromatography - Ultra High (UHPLC)

Hitachi UPLC System
UPLC

Centralized Research Core Facility

Contact: Al Bach

Liquid Chromatograph

GE AKTA Fast Protein Liquid Chromatograph (FPLC)
FPLC

Centralized Research Core Facility

Contact: Al Bach

High Performance Liquid Chromatography (HPLC)

Hitachi Analytical HPLC
HPLC

Centralized Research Core Facility

Contact: Al Bach

High Performance Liquid Chromatography (HPLC)

Hitachi Prep-HPLC System
HPLC

Centralized Research Core Facility

Contact: Al Bach

Chromatography

Teledyne-ISCO CombiFlash System
Flash Chromatography

Centralized Research Core Facility

Contact: Al Bach

Liquid Chromatography - Mass Spectrometer (LC - MS)

AB SCIEX TripleTOF 4600 and Shimadzu Prominence UFLC sytem
ESI-TOF MS

Centralized Research Core Facility

Contact: Al Bach

High Performance Liquid Chromatography (HPLC)

Shimadzu Nexera-i HPLC system
HPLC

Centralized Research Core Facility

Contact: Al Bach

Mass Spectrometer

Shimazu Axima MALDI-TOF MS/MS
MALDI MS

Centralized Research Core Facility

Contact: Al Bach

Mass Spectrometer

Thermo iCAPQ-a ICP-MS
Elemental Analyzer

Centralized Research Core Facility

Contact: Al Bach

Protein Sequencer

Shimadzu PPSQ-31A protein sequencer
N-terminal protein sequencer

Centralized Research Core Facility

Contact: Al Bach

Spectrophotometer

Jasco J-1100 Circular Dichroism (CD) Spectrophotometer
CD

Centralized Research Core Facility

Contact: Al Bach

Spectrometer

Thermo Nicolet 380 Fourier Transformed Infrared Spectrometer (FT-IR)
FT-IR

Centralized Research Core Facility

Contact: Al Bach

Western Blotting System

Bio-Rad Turbo Trans Blot system
Western Blotting

Centralized Research Core Facility

Contact: Al Bach

Western Blotting System

Life Technologies BenchPro Western System
Western Blotting processor

Centralized Research Core Facility

Contact: Al Bach

Western Blotting System

Protein Simple Simon Western
Liquid phase Western Blotting

Repository

Brown University
FacilityInstrument/Service/Resource Unit
BioBank, Rhode Island

Contact: Garrett Sullivan

Bioinformatics Analysis - Freezerworks

Software: Freezerworks version 2015Ascent
Sample management software

BioBank, Rhode Island

Contact: Garrett Sullivan

Biospecimen Banking

Service
Service to store biospecimens at -80 degrees, 4 degrees and in liquid nitrogen. All equipment is connected to back-up generator power and monitored 24/7 by a Rees alarm system.

BioBank, Rhode Island

Contact: Garrett Sullivan

Biospecimen Banking - Freezer - Liquid Nitrogen

Taylor Wharton LABS 40K Liquid Nitrogen Storage System
(2) Liquid nitrogen biospecimen storage system. Holds up to 40,000 1ml samples

Molecular Pathology Core - Brown

Contact: Paula Weston, M.A.

Biospecimen Banking - Freezer

Revco -80 degree C Freezer
Sample storage

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Tissue Bank Core

Biospecimen Banking - Tissue Banking and Specimen access
The Tissue Repository Core (TRC) is designed to facilitate translational cancer research by procuring and storing diseased and normal control tissues, with the associated clinical data, for RWMC investigators and outside clients.

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Incubators (2)

VWR Symphony CO2 incubator
CO2 incubators designed to maintain adequate interior moisture to prevent the drying out of cultures. 

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Freezer

Kenmore -20C Freezer
Sample storage

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Refrigerator

4C Glass Door
Sample storage

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Freezer

NuAire -85C Ultralow Temp Freezer
Sample storage

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
BioBank, Tumor Tissue Bank

Contact: Murray Resnick

Bioinformatics Analysis - Database

Software: Database developed in Filemaker Pro
Database and tissue inventory management on a Dell computer workstation

BioBank, Tumor Tissue Bank

Contact: Murray Resnick

Biospecimen Banking - Biosafety Cabinet

Dissecting hood
Hood dedicated to sterile tissue cutting with biohazard protection.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Biospecimen Banking - Freezer

ThermoForma Freezer - 80 C #8606
Sample storage

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Biospecimen Banking - Freezer

ThermoForma Freezer -20 C #3801
Sample storage

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Biospecimen Banking - Freezer

ThermoForma Refrigerator #3771
Sample storage

Multiplex Facility

Contact: Suzanne de la Monte

Biospecimen Banking - Freezer

HHP Barcoding Instrument
Barcode samples for identification. File Pro software.

BioBank, Tumor Tissue Bank

Contact: Murray Resnick

Biospecimen Banking - Freezer System

Forma 195878 LN2 backup for bank freezers
Systems inject liquid LN2 into cabinet when cabinet temperature warms to preset level, adjustable in 1 C increments to -150 C.

BioBank, Tumor Tissue Bank

Contact: Murray Resnick

Biospecimen Banking - Freezing Bath

Low temp isopentane bath
Bath with min. temperature of -160 C by addition of liquid nitrogen to isopentane.

Molecular Pathology Core Laboratory - Rhode Island Hospital

Contact: Murray Resnick

Biospecimen Banking - Refrigerator

ThermoForma Ultra 932 Lo Freezer -80 C (2)
Sample storage

Research Integrity and Compliance

Brown University
FacilityInstrument/Service/Resource Unit
Research Integrity and Compliance-Multi-institutions

IRB - University of Rhode Island

Human Subjects Protection
The University of Rhode Island Institutional Review Board (IRB) reviews research projects which involve human subjects to ensure that two broad standards are upheld: first, that subjects are not placed at undue risk; second, that they give uncoerced, informed consent to their participation.

Research Integrity and Compliance-Multi-institutions

IRB - Lifespan - Rhode Island Hospital and The Miriam Hospital

Human Subjects Protection
The Institutional Review Board (IRB) is a committee made up of physicians, scientists and community members who ensure that research involving human research subjects is well planned and ethical. All research that involves human subjects or their identifiable data must be reviewed by the IRB.

Research Integrity and Compliance-Multi-institutions

IRB - Care New England - Butler Hospital

Human Subjects Protection

Research Integrity and Compliance-Multi-institutions

IACUC - Care New England - Women and Infants

Animal Subjects Protection

Research Integrity and Compliance-Multi-institutions

IRB - Care New England - Women and Infants Hospital

Human Subjects Protection
Women & Infants Institutional Review Board (IRB) is a committee established to review and approve research involving human subjects. The purpose of the IRB is to protect the rights and welfare of human research subjects and to ensure that all human subject research be conducted in accordance with federal, state, institutional, and ethical guidelines.

Research Integrity and Compliance-Multi-institutions

IACUC - University of Rhode Island

Animal Subjects Protection
The URI Institutional Animal Care and Use Committee (IACUC) is responsible for overseeing the provisions for the care and well -being of animals used for research and educational purposes at the University and serves the public by ensuring compliance with all legal and ethical standards regarding the use of vertebrate animals in research and teaching at URI.

Research Integrity and Compliance-Multi-institutions

IRB - Care New England - Kent Hospital

Human Subjects Protection

Research Integrity and Compliance-Multi-institutions

IRB - The Providence VA Medical Center

Human Subjects Protection

Research Integrity and Compliance-Multi-institutions

IACUC - The Providence VA Medical Center

Animal Subjects Protection

Research Integrity and Compliance-Multi-institutions

IRB - Brown

Human Subjects Protection
The IRB is a diverse body of Brown faculty researchers, physicians, staff and unaffiliated community members appointed by Brown’s Vice President for Research and charged with reviewing human subject research protocols to uphold two broad standards To ensure that participants are not placed at undue risk; and To ensure that participants give informed consent to their participation free of coercion or undue influence To this end, projects that meet the regulatory definition of human subject research must be reviewed and approved by the IRB prior to initiation.

Research Integrity and Compliance-Multi-institutions

IACUC - Lifespan - Rhode Island Hospital

Animal Subjects Protection
The Animal Welfare Committee (IACUC) is a committee made up of scientists and community members who ensure that research involving animal subjects is well planned and ethical.

Research Integrity and Compliance-Multi-institutions

Export Controls - University of Rhode Island

Research Compliance, Export Controls
The Export Controls office ensures that all personnel, including employees, visiting scientists, postdoctoral fellows, students, and other persons retained by or working at or for URI conduct their affairs in accordance with U.S. laws and regulations, including compliance with U.S. export control laws and regulations applicable to its operations.

Research Integrity and Compliance-Multi-institutions

Biosafety - Lifespan - Rhode Island Hospital and The Miriam Hospital

Research Compliance, Biosafety
The Biohazards and Laboratory Safety Committee reviews and approves the use of potentially hazardous agents in the laboratory setting.

Research Integrity and Compliance-Multi-institutions

Export Controls - Brown

Research Compliance, Export Controls
Export Controls regulate the shipment or transfer, by whatever means, of controlled items, software, technology, or services out of the U.S. and also restricts the release of certain information to foreign nationals here in the U.S.

Research Integrity and Compliance-Multi-institutions

Biosafety - University of Rhode Island

Research Compliance, Biosafety
The Institutional Biosafety Committee (IBC) reviews and approves Biological Research protocols.

Research Integrity and Compliance-Multi-institutions

Biosafety - Brown

Research Compliance, Biosafety
The Institutional Biosafety Committee (IBC) evaluates and provides oversight of the use of biohazardous agents to ensure compliance with appropriate regulations and guidelines and to safeguard the health and safety of Brown University personnel, the community, and the environment.

Research Integrity and Compliance-Multi-institutions

IACUC - Brown University

Animal Subjects Protection
The ARPP is the administrative office dedicated to facilitating the submission, review and approval of IACUC protocols, supporting the various functions of the IACUC, and providing individual assistance to researchers whenever needed.

Statistics

Brown University
FacilityInstrument/Service/Resource Unit
Statistical Consulting Unit (SCU)

Contact: Zheng Zhang

Technical Assistance - Biostatistical Consulting / Statistical Consulting

Service
The Statistical Consulting Unit (SCU) at the Center for Statistical Sciences(CSS) and Department of Biostatistics is an approved service center located at 121 South Main Street. The mission of the SCU is threefold: to provide collaborative research assistance to faculty, research staff, and students in all departments of Brown University and its affiliated hospitals; to promote the growth of research collaborations between faculty at CSS and other units of the university and its affiliated hospitals; to provide a valuable educational experience to Biostatistics graduate students through training as statistical collaborators. The SCU consists of a faculty director (Dr. Zheng Zhang), faculty consultants from the Department of Biostatistics and Center for Statistical Sciences and student consultants who are enrolled in the graduate programs (MS, AM or PhD) offered by the Department of Biostatistics at Brown University School of Public Health.

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Statistics and Data Management Core

Contact: Jennifer Friedman, MD, PhD

Technical Assistance - Statistics and Data Management

Service
This Core provides consultation and assistance in managing and analyzing research data, such as the large datasets, and in linking these data with clinical predictors and outcomes collected in the field. The Core also performs more sophisticated data analytic approaches, including hierarchical, repeated measures modeling and Principal Components Analysis.

Statistics, Biostatistics Core at Rhode Island Hospital

Contact: Jason Machan, PhD 

Technical Assistance - Biostatistical Consulting

Service
The Biostatistics Core at Rhode Island Hospital offers centralized biostatistics consultation services to Clinical Research Center investigators, providing or steering investigators to a broad array of resources during all phases of research. During planning, the core can provide high quality trial design, including final sculpting of specific aims and hypotheses, measure selection, power analysis, data analysis planning, and grant/proposal preparation. At the beginning of a trial, the core can assist in construction of REDCap data collection tools, databases, and data management protocols, and provide help with special technology needs, such as purchasing non-standard equipment. Throughout the trial, the core can provide decision support, assessing the impact of potential design additions or changes on final statistical inference. It can serve on or help find individuals to serve on the trial’s data and safety monitoring board (DSMB). At the conclusion of the trial, the core can assist with implementation of the data analysis plan, either by providing access to contemporary statistical analysis software and coaching, or by conducting analyses for or with investigators. During reporting/publication preparation, the core can assist in write-up, data visualization, and integration of interpretations in the broader context of the project, and help address comments from peer reviewers.

Structural Biology & Chemistry

Brown University
FacilityInstrument/Service/Resource Unit
NMR Facility

Contact: Russell Hopson, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 300 Avance
z-BBI probe, (least sensitivte 1H and indirect detection to all broadband nuclei)

NMR Facility

Contact: Russell Hopson, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 600 Avance III HD Ascend
z-BBFO probe for all nuclei (most sensitive for all nuclei)

NMR Facility

Contact: Russell Hopson, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 400 Avance III Ultra-Shield
z-BBFO (2nd most sensitive for 1H and broadband nuclei)

NMR Facility

Contact: Russell Hopson, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 400 Avance Ultra-Shield
z-BBO (3rd best sensitivity for broadband nuclei)

Structural Biology Facility

Contact: Mandar T Naik, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 500 Avance II, with TCI cryoprobe
An NMR spectrometer optimized for studying proteins in solution. This spectrometer is most useful for tracking binding interactions, measuring dynamic properties of proteins, and assigning protein resonances. Capable of using 5 mm and 3 mm tubes. Also suitable for proton NMR of small molecules and natural products.

Structural Biology Facility

Contact: Mandar T Naik, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 850 MHz Avance III HD, with TCI cryoprobe
An NMR spectrometer optimized for studying proteins in solution. This spectrometer is ideal for determining protein structures and measuring protein dynamics. Its extreme sensitivity allows studies on otherwise intractable samples. Capable of using 5 mm, 3 mm, and shaped NMR tubes. Also suitable for proton NMR of small molecules and natural products

Structural Biology Facility

Contact: Mandar T Naik, PhD

X-Ray Diffraction System

Rigaku ACTOR robot and Saturn 944 HG CCD
An instrument useful for obtaining X-ray diffraction patterns of proteins and other biomacromolecules under cryogenic or room-temperature conditions. Rapid screening and sorting of up to 80 candidate crystals is possible.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Molecular Characterization Facility

Contact: Al Bach, Ph.D

Nuclear Magnetic Resonance (NMR) Spectrometer

Agilent NMRS 500 with OneNMR Probe
NMR Spectroscopy

Transgenics & Gene Targeting

Brown University
FacilityInstrument/Service/Resource Unit
Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Biological Safety Cabinet

NuAire Safety Cabinets Class 2 Type A/B3
Transgenics and gene targeting safety cabinets (2 units)

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Centrifuge

Thermo IEC Centra CL3R Refrigerated Centrifuge
Transgenics and gene targeting refrigerated centrifuge

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Electroporation System

Bio-Rad Gene Pulsar II
Transgenics and gene targeting electroporation system

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Biospecimen Banking - Freezer

Custom BioGenic Systems Liquid Nitrogen (LN2) Freezer
Transgenics and gene targeting liquid nitrogen freezer

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Biospecimen Banking - Freezer

Thermo Fisher Scientific -80 C
Transgenics and gene targeting -80 C freezer

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Biospecimen Banking - Freezer

Frigidaire -20 C Freezer
Transgenics and gene targeting freezer

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Gene Targeting

Service
Gene targeting services through transfection and microinjection of murine embryonic stem (ES) cells to produce germline knockout (KO) or knockin (KI) mice

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Incubator

NuAire CO2 water jacketed Incubators
Transgenics and gene targeting incubators (3 units)

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Cell Manipulator - Microinjection system

Eppendorf FemtoJet Microinjection System
Transgenics and gene targeting pronuclear injection system

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Micromanipulator

Eppendorf Transferman NK 2 Micromanipulators
Transgenics and gene targeting micromanipulators (2 units)

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Transgenics

Service
Service to provide custom services related to microinjection, ES cell culture, mouse surgery, or mouse reproduction. The core facility will provide services and/or training related to our capabilities that are not specifically covered by our service list. These services are available for an hourly fee. Examples include: production of MEFs (murine embryonic fibroblasts), polar body biopsy, reproductive surgery, blastomere injection, frozen embryo shipment, training

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Cryopreserved Mouse Embryo Recovery

Service
Service to thaw and implant previously cryopreserved mouse embryos

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Cryopreserved Mouse Embryo Storage

Service
Service to store cryopreserved mouse embryos in liquid nitrogen (LN2)

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Derivation of Mouse Embryonic Stem (ES) cell lines

Service
Service to produce embryonic stem (ES) cells from an existing mouse line key words: murine embryonic stem cells

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Embryonic Stem (ES) Cell Injection

Service
Service to produce chimeric mice for analysis through microinjection of murine embryonic stem (ES) cells into blastocyst stage embryos.

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Mouse Colony Expansion

Service
Service to use superovulation and surgical implantation to produce large cohorts of age matched mice for experimentation or to quickly expand a mouse colony

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Mouse Embryo Cryopreservation

Service
Service to cryopreserve valuable mouse lines for storage or shipment to other investigators.

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Mouse In vitro Fertilization (IVF)

Service
Service to perform in vitro fertilization of mouse embryos

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Rederivation of Mouse Lines

Service
Service to rederive mouse lines obtained from a source other than a Brown University approved vendor. Rederived mouse lines may be housed in any campus mouse facility.

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Transgenics and Gene Targeting - Transgenic Production

Service
Service to perform pronuclear microinjection of 0.5 dpc mouse embryos to produce transgenic or CRISPR founders on an FVB/N or C57/BL6 background. Custom backgrounds also available.

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Water Purification System

Milli Q Biocel
Transgenics and gene targeting water purification

Mouse Transgenic and Gene Targeting Facility

Contact: Youngwook Ahn

Waterbath

Thermo Scientific Precision 260 Circulating Waterbath
Transgenics and gene targeting circulating waterbath

Visualization

Brown University
FacilityInstrument/Service/Resource Unit
Center for Computation and Visualization (CCV)

Contact: Linnea Wolfe

Research Data Storage

Service
RData is a high-performance storage system for research data at CCV that is accessible from all CCV systems, can be mounted on PC or Mac computers on Brown’s campus network, is backed up on a nightly incremental basis.

Center for Computation and Visualization (CCV)

Contact: Linnea Wolfe

High Performance Computing Cluster

Various including IBM idataPlex High Performance Computing Cluster
HPC cycles, software development, storage, backups, high speed network hub, visualization, virtual reality, data management, server colocation, scientific support

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Three Dimensional (3D) Facility for Biomedical Sciences: Animation, Visualization and Printing

Contact: Bongsup Cho, Professor of Biomedical and Pharmaceutical Sciences

Imaging System - 3D Printer

Z650 3D System/Z-corp
Produces realistic color (Powder Based) models without paint to better evaluate the look, feel, and style of product designs. Five print heads provide the widest range of accurate colors, including true black and improved color consistency from part to part. 3D print text labels or images can be directly applied onto printed models.